Normal histocompatibility antigens class i. Medical search. Frequent questions

Constitutive expression of MHCclass II molecules is confined to professional antigen-presenting cells(APC) of the immune system, and in nonprofessional APCs MHC class IImolecules can be induced by a variety of immune regulators. (embl-heidelberg.de)
Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. (biomedcentral.com)
63. MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. (projekthouse.eu)

MHC class II molecules are comprised of two membrane-spanning chains, alpha and beta, of similar size. (embl-heidelberg.de)
class II molecules present exogenously derived antigenic peptides (~15 amino acids) to helper T cells. (embl-heidelberg.de)
MHC class I and II molecules are assembled and loaded with their peptide ligands via different mechanisms. (embl-heidelberg.de)
Function and regulation of MHC class II molecules in T-lymphocytes: ofmice and men. (embl-heidelberg.de)
Besides antigen presentation, growing evidence is showing thatligation of MHC class II molecules also activates intracellular signalingpathways, frequently leading to apoptosis. (embl-heidelberg.de)
Interestingly,activated T cells from many species, with the exception of mice,synthesize and express MHC class II molecules at their cell surface. (embl-heidelberg.de)
We show here that NK cells lacking inhibitory KIR for self MHC class I molecules are present in human peripheral blood. (nih.gov)
APCs then present the fragments to T helper cells ( CD4 + ) by the use of class II histocompatibility molecules [2] on their surface. (wikidoc.org)
The fragments are then presented on the cell surface in the complex with MHC class I molecules. (wikidoc.org)
Tumor antigens or Neoantigens are those antigens that are presented by MHC I or MHC II molecules on the surface of tumor cells . (wikidoc.org)
A small fraction of T cells recognizes alloantigen as antigenic peptide(s) presented by other major histocompatibility complex class I molecules and tolerance can be induced in this population by soluble alloantigen. (uni-muenchen.de)
Major histocompatibility complex (MHC) class II molecules are heterodimeric glycoproteins consisting of α and β chains, with approximate molecular mass of 33 kDa and 28 kDa respectively. (biomedcentral.com)
MHC class II molecules are specialized peptide receptors that play a critical role in initiating and regulating immune responses by binding peptide fragments that are 10-30 amino acids long [ 1 ] and present them on the surface of antigen-presenting cells for recognition by CD4 + T cells. (biomedcentral.com)
Sequence-based predictive systems, based on identifying patterns in peptides with experimentally determined binding strength, are widely used to facilitate the identification of binding peptides to MHC class II molecules. (biomedcentral.com)
Unlike conventional T cells that recognize peptide antigen presented by major histocompatibility complex (MHC) molecules, NKT cells recognize glycolipid antigen presented by a molecule called CD1d. (wikidoc.org)
However, γδ T cells are not MHC restricted and seem to be able to recognise whole proteins rather than requiring peptides to be presented by MHC molecules on antigen presenting cells. (wikidoc.org)
Some recognize MHC class IB molecules though. (wikidoc.org)
Some of these mutations preserve the normal binding to major histocompatibility complex class I molecules, but present an altered surface to the T-cell antigen receptor. (ox.ac.uk)
Although the nature of the antigens responsible for RA pathogenesis is unknown, there is evidence that the disease-associated HLA-DR (B1*0401, 0404, 0405 and 0101) molecules are involved in disease pathogenesis [ 2 ]. (biomedcentral.com)
In this state, DCs are highly adept at endocytosis and express lower levels of MHC class I and II molecules, as well as co-stimulatory molecules [14]. (jscimedcentral.com)
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response. (thermofisher.com)
TSAs and TAAs typically are portions of intracellular molecules expressed on the cell surface as part of the major histocompatibility complex. (msdmanuals.com)
The structure of the antigen-binding groove of gold forex forum histocompatibility complex class I molecules determines specific selection of self-peptides. (dpforex.com)

Menkes disease (Menkes kinky hair syndrome) (rare - UK incidence 1/100,000) Copper deficiency Aceruloplasminemia Zinc toxicity Greater-than-normal ceruloplasmin levels may indicate or be noticed in: copper toxicity / zinc deficiency pregnancy oral contraceptive pill use lymphoma acute and chronic inflammation (it is an acute-phase reactant) rheumatoid arthritis Angina Alzheimer's disease Schizophrenia Obsessive-compulsive disorder Normal blood concentration of ceruloplasmin in humans is 20-50 mg/dL. (wikipedia.org)
In humans, this "missing self" recognition is ensured by inhibitory receptors such as KIR, which dampen NK cell activation upon interaction with their MHC class I ligands. (nih.gov)
Proteins of the major histocompatibility complex (MHC) class I, or human leukocyte antigen (HLA) in humans interact with endogenous peptides and present them to T cell receptors (TCR), which in turn tune the immune system to recognize and discriminate between self and foreign (non-self) peptides. (ntu.edu.sg)
Natural killer (NK) cells were identified in the blood and lymphoid organs of humans and experimental animals as cells capable of killing tumors, virus-infected cells, and, in some instances, normal cells, in the absence of previous deliberate or known sensitization. (mhmedical.com)

Tumor antigens can also be on the surface of the tumor in the form of, for example, a mutated receptor, in which case they will be recognized by B cells . (wikidoc.org)
This technique has produced a MAb specific to the cell surface of the chick osteOcyte,'6) to the murine PTH receptor,") and to OB-restricted antigens. (docksci.com)
Finally, we observed that the A2-MelanA tetramer+ CTLs isolated from vitiligo patients expressed high levels of the skin homing receptor, cutaneous lymphocyte-associated antigen, which was absent from the CTLs seen in the single A*0201-positive normal control. (ox.ac.uk)
Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTK) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. (stanford.edu)
First, the major histocompatibility complex (MHC) and T-cell receptor (TCR) contact residues were identified by analysis of single site substituted analogue peptides for HLA-DR4 binding and cognate T cell recognition using both T hybridomas and polyclonal T cells from peptide-immunized HLA-DR4 transgenic mice. (biomedcentral.com)
This wide range of receptors allows for efficient receptor mediated phagocytosis of many foreign antigens. (jscimedcentral.com)

MHC class II proteins display these peptides to the immune system. (medlineplus.gov)
Of especial importance are peptides derived from tumor-associated antigens. (ntu.edu.sg)
Different MHC molecular forms, be they class I or II, can bind, and thus present, a different set of peptides.Apr 19, 2020 · Data for PD-L1 and MHC I are defined by median fluorescent intensity (MFI) of all cells, given the uniform induction of these proteins (online supplementary figure 1). (projekthouse.eu)

MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. (embl-heidelberg.de)
Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. (embl-heidelberg.de)
Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune responses. (embl-heidelberg.de)

The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)

Class II MHC glycoproteins are expressed on the surface of antigen-presenting cells (APC), including macrophages, dendritic cells and B cells. (embl-heidelberg.de)
Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)

Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
Host Response to Tumors The immune response to foreign antigens consists of Humoral mechanisms (eg, antibodies) Cellular mechanisms (See also Tumor Antigens. (msdmanuals.com)

1. The immunological mechanisms involved in sustaining normal semi-allogeneic pregnancies and in the enhancement of organ allografts were investigated in inbred rats. (portlandpress.com)
4. Alloantibodies produced as a consequence of multiple semi-allogeneic pregnancies (pregnancy-induced antisera) were directed only to RT1A antigens. (portlandpress.com)

Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)

responses to the latter three antigens could not be separated with available congenic recombinant inbred rat strains. (portlandpress.com)
A failure of DCs to mature, as witnessed during HIV uptake, however, leads to attenuation of antigen-specific immune responses and may significantly contribute to induction of T cell regulatory responses. (jscimedcentral.com)
The failure of DCs to properly process and present HIV antigens and stimulate specific adaptive responses can prevent viral clearance and aid in establishment of viral reservoirs, two of the main obstacles to a therapeutic cure. (jscimedcentral.com)

MHC class II receptors display antigens for recognition by helper T cells (stimulate development of B cell clones) and inflammatory T cells (cause the release of lymphokines that attract other cells to site of infection) ( PUBMED:15120183 ). (embl-heidelberg.de)
While CD4 T cells are by far the most abundant HIV-infected cell, DCs express a variety of HIV co-receptors and lectin receptors that modulate HIV uptake, antigen processing, and trans-infection to T cells, thus contributing to a wide variety of immunological outcomes. (jscimedcentral.com)
In addition, the ability of HIV to exploit DC surface receptors or intracellular routing mechanisms to avoid antigen-processing machinery also contributes to viral persistence and promotes trans or cis-infection of CD4 T cells. (jscimedcentral.com)
Immature DCs possess a wide variety of receptors, such as Fc receptors, lectins, and langerin, which allow them to efficiently bind and internalize antigen. (jscimedcentral.com)

By endocytosis or phagocytosis , these antigens are taken into the antigen-presenting cells (APCs) and processed into fragments. (wikidoc.org)
T cells cannot bind native antigens, but require that they are processed by APCs, while B cells can be activated by native ones. (wikidoc.org)
14 As the strongest antigen presenting cell (APCs), DCs play an important role in the immunity of the ocular surface. (bmj.com)

Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. (genscript.com)

0.01), resolution of complement deposits on capillaries, and a reduction in the expression of intercellular adhesion molecule 1 and major-histocompatibility-complex class I antigens. (nih.gov)
An antigen (from antibody-generating ) or immunogen is a molecule that sometimes stimulates an immune response. (wikidoc.org)
Cells present their antigens to the immune system via a histocompatibility molecule . (wikidoc.org)
Depending on the antigen presented and the type of the histocompatibility molecule, several types of immune cells can become activated. (wikidoc.org)
In contrast, only transgenic mice failed to generate a cytolytic T-cell response to soluble H-2Kk antigen expressed by recombinant vaccinia virus and presented by the H-2Db molecule. (uni-muenchen.de)
The majority of T cells, however, require the whole cell membrane-expressed class I molecule for recognition. (uni-muenchen.de)
This population is not affected by tolerance induction to the soluble major histocompatibility complex class I molecule. (uni-muenchen.de)
Major histocompatibility complex (MHC) is a cell-surface molecule encoded by a large gene family in all vertebrates. (projekthouse.eu)
Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)

Endogenous antigens are antigens that have been generated within the cell, as a result of normal cell metabolism , or because of viral or intracellular bacterial infection . (wikidoc.org)
They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. (lookformedical.com)

Natural killer (NK) cells recognize the absence of self MHC class I as a way to discriminate normal cells from cells in distress. (nih.gov)
2.8 cells recognize antigens, some of which are restricted to osteoblasts and chondrocytes. (docksci.com)

A potential mode of resistance is immune evasion of T cell immunity involving aberrant major histocompatibility complex class I (MHC-I) antigen presentation (AP). (stanford.edu)
Background Major histocompatibility complex class-1-related protein (MR1), unlike human leucocyte antigen (HLA) class-1, was until recently considered to be essentially monomorphic. (bmj.com)

Despite the presence of H-2Kk antigen, these mice were still able to generate an H-2Kk-specific T-cell response. (uni-muenchen.de)
Normal uninfected mice treated with Pam3CSK4 or untreated were used as controls. (bvsalud.org)

While specific DP, DQ or DR alleles at the HLA class II locus have been shown to correlate with particular autoimmune diseases, a variety of confounding factors including strong linkage disequilibrium between the different HLA alleles, especially DR and DQ, complicates the exact identification of MHC susceptibility alleles. (biomedcentral.com)

Expression of major histocompatibility antigens in human chronic pancreatitis. (bmj.com)
The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens. (nordicmubio.com)
Human leukocyte antigen B27 ( HLA-B27 ) is the major genetic susceptibility marker in AS. (molvis.org)
Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)
Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2-MelanA tetramer+ CTLs) in seven of nine HLA-A*0201-positive individuals with vitiligo. (ox.ac.uk)
Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. (thermofisher.com)

The main function of major histocompatibility complex (MHC) class IImolecules is to present processed antigens, which are derived primarilyfrom exogenous sources, to CD4(+) T-lymphocytes. (embl-heidelberg.de)
Non-microbial exogenous (non-self) antigens can include pollen, egg white, and proteins from transplanted tissues and organs or on the surface of transfused blood cells. (wikidoc.org)
Exogenous antigens are antigens that have entered the body from the outside, for example by inhalation, ingestion, or injection. (wikidoc.org)

The HLA-DQB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
MHC class II genes provide instructions for making proteins that are present on the surface of certain immune system cells. (medlineplus.gov)
In particular, susceptibility to several autoimmune disorders, including type I diabetes mellitus and rheumatoid arthritis, is linked to genes within the MHC and strong population associations are demonstrable between certain HLA class II alleles and these conditions. (ox.ac.uk)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (genscript.com)

Interferon secreted by leukocytes , fibroblasts , or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens , or allo-antigens. (lookformedical.com)
The enzyme gamma-interferon-inducible lysosomal thiol reductase (GILT) plays an important role in promoting the processing and presentation of major histocompatibility complex (MHC) class II-restricted antigens. (bvsalud.org)

Cytotoxic T lymphocytes that recognize these antigens may be able to destroy the tumor cells before they proliferate or metastasize . (wikidoc.org)
Immunohistochemical studies of antigen localization on cryostat sections of rat calvaria, long bone, and soft tissues demonstrated that five of these MAbs, UBIM 1,2,3,12, and 17, recognize antigens that are restricted to normal rat osteoblasts and chondrocytes. (docksci.com)
In vitro, these MAbs recognize cell surface antigens present on two additional cell lines, ROS 24/1 and Rat 2 cells, and on the adherent cell population cultured from rat long bone marrow. (docksci.com)
We have generated a panel of 15 MAbs to ROS 17/2.8 cells, 5 of which recognize antigens restricted to normal rat OBs and chondrocytes in vivo. (docksci.com)

More common are antigens that are presented by tumor cells and normal cells, and they are called tumor-associated antigens (TAAs) . (wikidoc.org)
Tumor-associated antigens (TAAs) are relatively restricted to tumor cells. (msdmanuals.com)

ABSTRACT We have raised a panel of 15 monoclonal antibodies (MAbs) recognizing cell surface antigens of the rat osteoblast-like cell line ROS 17/2.8. (docksci.com)
In this way it was hoped to select antibodies to antigens associated specifically with the OB phenotype and eliminate those of housekeeping or transformation antigens. (docksci.com)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

Since the immune response to antigen requires clonal proliferation, agents that block mitosis are effective inhibitors of the immune response. (nanomedicine.com)

In this case, they are called tumor-specific antigens (TSAs) and, in general, result from a tumor-specific mutation. (wikidoc.org)
Tumor-specific antigens (TSAs) are unique to tumor cells. (msdmanuals.com)

3. Alloantibodies produced by leucocyte immunization (conventionally induced antisera) were directed only to RT1-encoded (major histocompatibility complex, MHC) antigens. (portlandpress.com)
Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (medlineplus.gov)
An autoantigen is usually a normal protein or complex of proteins (and sometimes DNA or RNA) that is recognized by the immune system of patients suffering from a specific autoimmune disease . (wikidoc.org)
Associations between a large number of diseases and markers within the major histocompatibility complex (MHC) have been described. (ox.ac.uk)
A mouse monoclonal antibody to rat major histocompatibility complex (MHC) class 1 antigens, MRC 0 x 1 8 , was purchased from Serotec (Oxfordshire, UK). (docksci.com)
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (genscript.com)
In rheumatoid arthritis (RA), articular cartilage is destroyed by chronic inflammation that is characterised by activated lymphocytes and major histocompatibility complex (MHC) class II expressing cells in synovial tissue. (biomedcentral.com)
Major histocompatibility complex (MHC) class II deficiency, also called the bare lymphocyte syndrome, is a rare primary immunodeficiency disease characterized by a virtual absence of MHC class II expression associated with a variable reduction in MHC class I expression. (projekthouse.eu)
Meaning: major histocompatibility complex.Dec 24, 2022 · 11.11A: MHC Polymorphism and Antigen Binding. (projekthouse.eu)
However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)

These cells harbor a mature NK cell phenotype but are hyporesponsive to various stimuli, including MHC class I-deficient target cells. (nih.gov)
4.5)The object of our study was to raise MAbs to antigens restricted to the plasma membrane of the normal rat OB and to use these MAbs to further characterize the cell surface phenotype of the OB. (docksci.com)
Silva E, Yang JM, Li Y et al (2000) A CRX null mu- tation is associated with both Leber congenital amaurosis and a normal ocular phenotype. (dpforex.com)

The article Skeletal Muscle - Structure and Histology provides a review of normal skeletal muscle histology and ultrastructure, including the histologic appearance of normal muscle with some of the various stains that are used for the processing of muscle biopsies. (medscape.com)

The properties of transmembrane and soluble transplantation antigens were compared with respect to the induction of tolerance and the selection of the T-cell repertoire. (uni-muenchen.de)

this will not present instruction on the subtleties of advanced muscle biopsy diagnosis. (medscape.com)
Most DCs in tissues and blood are present in an immature state, but upon antigen acquisition and activation they mature. (jscimedcentral.com)

This response is in contrast to NK cells that express a single inhibitory KIR specific for self MHC class I, which are functionally competent when exposed to the same stimuli. (nih.gov)

The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. (qxmd.com)
Once the graft has escaped the initial acute phase rejection reactions, a cumulative unresponsiveness to the graft develops as the recipient is continually exposed to donor MHC, a stable state that sometimes depends on the development of antigen-specific T-suppressor cells [ 371 , 5349 - 5354 ]. (nanomedicine.com)
The most general pre-nanomedical method to suppress immune system acute responsiveness is called antigen nonspecific immunosuppression. (nanomedicine.com)

The localization of the HKE2 gene to the class II region, its cytoplasmic expression and putative protein-binding domain suggest that HKE2 may function in adaptive immunity and cancer. (genscript.com)

The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1 . (medlineplus.gov)
Each MHC class II gene has many possible variations, allowing the immune system to react to a wide range of foreign invaders. (medlineplus.gov)
This gene belongs to the HLA class I heavy chain paralogues. (nih.gov)
The association between the expression of immune-process DEGs and abundance of immune infiltrates from gene signatures in normal colorectal tissues was estimated from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) project. (biomedcentral.com)

Naturally occurring T reg cells (also known as CD4 + CD25 + FoxP3 + T reg cells) arise in the thymus , whereas the adaptive T reg cells (also known as Tr1 cells or Th3 cells) may originate during a normal immune response. (wikidoc.org)

Critically, in both diseases, upstream immunological processes have been poorly characterised ex vivo , particularly with respect to the site and nature of antigen presentation. (biomedcentral.com)
These antigens should, under normal conditions, not be the target of the immune system, but, due to mainly genetic and environmental factors, the normal immunological tolerance for such an antigen has been lost in these patients. (wikidoc.org)

It is also involved in MHC I-restricted antigens catalyzing disulfide bond reduction in fishes' adaptive immunity. (bvsalud.org)

Novel surface antigens expressed on dividing cells but absent from non-dividing cells. (nordicmubio.com)

As expression of major histocompatibility (MHC) antigens is a prerequisite for organ specific autoimmunity, the expression of HLA class I (beta 2-microglobulin) and class II (HLA-DR) determinants have been analysed, together with the presence of T-lymphocytes, in 93 patients (64 men and 29 women, mean age 40.6 years) having an operation for chronic pancreatitis. (bmj.com)
CD71 antigen expression is low on normal resting lymphocytes and is expressed on all cells upon activation. (nordicmubio.com)

These results show the involvement of KIR-MHC class I interactions in the calibration of NK cell effector capacities, suggesting its role in the subsequent "missing self" recognition. (nih.gov)
The identification of dystrophic (senescent) microglia has created an ostensible conflict with prior work claiming a role for activated microglia and neuroinflammation during normal aging and in AD, and this has raised a basic question: does the brain's immune system become hyperactive (inflamed) or does it become weakened (senescent) in elderly and demented people, and what is the impact on neuronal function and cognition? (biomedcentral.com)
A key role of the immune system is detection of these antigens to permit subsequent targeting for eradication. (msdmanuals.com)

We hypothesize that the underlying difference may arise from post-translational glycosylation of p161 in normal individuals, likely masking it against recognition by TCR. (ntu.edu.sg)

Polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) typing combines the ability to define the finest of HLA specificities, by analysis of the corresponding DNA sequences, with the possibility of study large populations of normal and affected individuals. (ox.ac.uk)

Tolerogen - An antigen that invokes a specific immune non-responsiveness due to its molecular form . (wikidoc.org)

Immature DCs in SF may contribute to the perpetuation of inflammation via sampling of the inflamed synovial environment, and in situ presentation of arthritogenic antigen. (biomedcentral.com)

Genetic mapping of HLA susceptibility loci has traditionally relied on the use of phenotypic markers defined by alloantisera, cellular typing reagents and biochemical analysis of histocompatibility antigens. (ox.ac.uk)

This study has also identified cell surface antigens of ROS 17/2.8 cells that are not expressed by osteoblasts in vivo. (docksci.com)

Anatomy33

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