AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Minor Histocompatibility AntigensHistocompatibility AntigensMajor Histocompatibility ComplexMinor Histocompatibility LociHistocompatibility Antigens Class IIHistocompatibility Antigens Class IHLA AntigensH-2 AntigensAntigensH-Y AntigenHistocompatibilityAntigens, SurfaceAntigens, NeoplasmT-Lymphocytes, CytotoxicT-LymphocytesAntigens, BacterialHLA-DR AntigensHLA-A AntigensHLA-B AntigensGenes, MHC Class IIEpitopesIsoantigensAntigens, ViralMice, Inbred StrainsHLA-D AntigensHLA-B7 AntigenCytotoxicity, Immunologicbeta 2-MicroglobulinImmunogeneticsHistocompatibility TestingHistocompatibility Antigen H-2DTransplantation ImmunologyHLA-A2 AntigenIsoantibodiesTransplantation, HomologousHLA-B40 AntigenGraft vs Host DiseaseBeta-GlobulinsSkin TransplantationHistocompatibility, Maternal-FetalHLA-A1 AntigenGenes, MHC Class ICytotoxicity Tests, ImmunologicReceptors, Antigen, T-CellMice, Inbred BALB CAmino Acid SequenceMice, Inbred C57BLLymphocyte ActivationGraft vs Leukemia EffectMolecular Sequence DataSpleenCell LineLymphocytesGraft vs Host ReactionAntibodies, MonoclonalAntigen PresentationB-LymphocytesLymphocyte Culture Test, MixedImmune ToleranceAntigen-Antibody ReactionsGraft RejectionHLA-C AntigensClone CellsInterferon-gammaAntigens, CD8Bone Marrow TransplantationCD8-Positive T-LymphocytesAntigen-Presenting CellsAntigens, CDHLA-DQ AntigensFlow CytometryPeptidesGraft vs Tumor EffectAntigens, ProtozoanBase SequenceChromium IsotopesCD4-Positive T-LymphocytesMice, Inbred C3HAntibody FormationCells, CulturedHLA-B38 AntigenAntigens, Polyomavirus TransformingAllelesHLA-B27 AntigenImmunity, CellularReceptors, Purinergic P2X5Dendritic CellsGenesCross ReactionsEpitopes, T-LymphocyteFluorescent Antibody TechniqueAntigens, FungalReceptors, Antigen, T-Cell, alpha-betaHematopoietic Stem Cell TransplantationRadiation ChimeraMice, Inbred CBAImmunodominant EpitopesAntigens, HelminthThymus GlandMice, Inbred AKR
Minor histocomProteinsMoleculeMoleculesCellsPeptideAntibodyGeneticReceptorMacrophagesMajorLeukocyteSelf antigensForeign antigensHumanIntracellularProteinLymphocytesEndogenousLymphocyteMiHAMolecularSubstancesClassGenesExogenousViralRecognitionImmunityImmunologySpeciesCellTSAsRecognizeDonorResponsesSpleenTumors
Minor histocom3
Proteins12
  • A histocompatibility antigen blood test looks at proteins called human leukocyte antigens (HLAs). (medlineplus.gov)
  • These peptides are normally around 9-12 amino acids in length and are bound to both the major histocompatibility complex (MHC) class I and class II proteins. (wikipedia.org)
  • This contrasts with MHC class II molecules's antigens which are peptides derived from phagocytosis/endocytosis and molecular degradation of non-self entities' proteins, usually by antigen-presenting cells. (wikipedia.org)
  • Even when a transplant donor and recipient are identical with respect to their major histocompatibility complex genes, the amino acid differences in minor proteins can cause the grafted tissue to be slowly rejected. (wikipedia.org)
  • The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. (nih.gov)
  • Genes coding immune system proteins such as the Human leucocyte antigen (HLA)-G are important candidates. (scirp.org)
  • The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. (cusabio.com)
  • Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). (cusabio.com)
  • Similar to normal cellular proteins, the pathogen is digested into peptides, which are displayed on the surface of the cell together with a MHC class II protein . (celiackidsconnection.org)
  • Antigens are usually proteins or polysaccharides . (wikidoc.org)
  • Non-microbial exogenous (non-self) antigens can include pollen, egg white, and proteins from transplanted tissues and organs or on the surface of transfused blood cells. (wikidoc.org)
  • In the normal synovium, SFs produce substrate proteins (e.g., fibronectin and collagen) and extracellular matrix (ECM)-degrading enzymes (e.g., proteases) to maintain the synovial structure. (biomedcentral.com)
Molecule8
  • 6-FPT and its analogue acetyl-6-FPT function as small molecule antigens, recognized by the major histocompatibility complex-related class I-like molecule, MR1, for presentation to mucosal-associated invariant T (MAIT) cells. (nih.gov)
  • Unable to induce an immune response by itself, they require carrier molecule to act as a complete antigen. (microbiologyinfo.com)
  • Any molecule capable of being recognized by the immune system is considered an antigen. (msdmanuals.com)
  • 6) Normally, your immune system would never produce lymphocytes whose binding sites fit any normal molecule of the body? (albertkharris.com)
  • Cytotoxic T-lymphocyte antigen-4 (CTLA-4), a molecule expressed predominantly on activated T cells, plays an important role in the down-regulation of T-cell activation. (researchgate.net)
  • An antigen (from antibody-generating ) or immunogen is a molecule that sometimes stimulates an immune response. (wikidoc.org)
  • Cells present their antigens to the immune system via a histocompatibility molecule . (wikidoc.org)
  • Depending on the antigen presented and the type of the histocompatibility molecule, several types of immune cells can become activated. (wikidoc.org)
Molecules12
  • However, there is death by apoptosis of thymocytes that do not interact with MHC molecules or have high-affinity receptors for self MHC plus self antigen a process referred to as negative selection. (wikipedia.org)
  • During phase 1 (Afferent phase), tissue injured by chemotherapy and irradiation releases proinflammatory cytokines such as tumor necrosis factor (TNF) alpha and interleukin (IL)-1, which subsequently increases expression of adhesion molecules, major histocompatibility complex (MHC) molecules, and costimulatory molecules. (medscape.com)
  • TSAs and TAAs typically are portions of intracellular molecules expressed on the cell surface as part of the major histocompatibility complex. (msdmanuals.com)
  • We describe a mutant human cell line (LBL 721.174) that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. (ox.ac.uk)
  • This phenotype suggests a defect in the association of intracellular antigen with class I molecules similar to that described for the murine mutant RMA-S (ref. 5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6. (ox.ac.uk)
  • 9) B-lymphocytes do not produce any antibody molecules until they come in contact with antigen molecules? (albertkharris.com)
  • When helper T cells recognize a peptide on an antigen presenting cell , they become activated and begin to produce molecules called cytokines that signal to other immune cells. (celiackidsconnection.org)
  • Although cytotoxic T lymphocyte (CTL)-directed epitopes binding to human histocompatibility leukocyte antigen (HLA)-A molecules have been well characterized, those binding to HLA-B molecules have not, largely due to their large diversity. (elsevierpure.com)
  • In this study we report a unique cancer antigen gene, tentatively named Testin-related gene (TRG), which encodes CTL-directed epitopes on the HLA-B52 molecules most frequently expressed in Asians. (elsevierpure.com)
  • APCs then present the fragments to T helper cells ( CD4 + ) by the use of class II histocompatibility molecules [2] on their surface. (wikidoc.org)
  • Tumor antigens or Neoantigens are those antigens that are presented by MHC I or MHC II molecules on the surface of tumor cells . (wikidoc.org)
  • Cancer immunotherapy harnesses a patient's CD4+ and CD8+ T cell responses toward peptide neoantigens, which are displayed on the surface of tumor cells by major histocompatibility complex molecules [MHC, termed human leukocyte antigen (HLA) in humans] ( 1 ). (frontiersin.org)
Cells60
  • MiHA antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells. (wikipedia.org)
  • The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
  • Although graft or bone marrow rejection can have detrimental effects, there are immunotherapy benefits when cytotoxic T lymphocytes are specific for a self antigen and can target antigens expressed selectively on leukemic cells in order to destroy these tumor cells referred to as graft-versus- leukemia effect (GVL). (wikipedia.org)
  • Some of these antigens are ubiquitously expressed in nucleated male cells, and the presence of these antigens has been associated with a greater risk of developing GVHD allogeneic stem cell transplantation for a HLA matched gene when there's a male recipient and female donor. (wikipedia.org)
  • A major impediment to the identification and characterization of the MiHA antigens is that they are not recognized by B cells, resulting in the inability to produce antibodies to them. (nih.gov)
  • 18. Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells. (nih.gov)
  • Graft-versus-host reaction occurs when donor immune cells recognize disparate host antigens. (medscape.com)
  • These cytokines further activate host antigen-presenting cells (APCs). (medscape.com)
  • In phase 2 (Donor-T-cell activation, differentiation, and migration), the infused donor T lymphocytes are responsible for triggering GVHD and proliferate after activation by the recipient antigens expressed on host cells. (medscape.com)
  • Interferon enhancement of HLA-DR antigen expression on epidermal Langerhans cells. (cdc.gov)
  • Langerhans cells (LCs) are dendritic epidermal cells whose ability to function as accessory/stimulatory cells in initiating the immune response is, like that of macrophages, dependent on the expression of class II major histocompatibility antigens. (cdc.gov)
  • these cells are highly effective killers of both tumor cells and virally infected cells without the need for prior sensitization or recognition of a specific antigen. (nih.gov)
  • Since early breast cancer DCCs often display close-to-normal genomes 5 , 15 , we use mammary epithelial cells isolated from reduction mammoplasties and available immortalized premalignant breast cancer cell lines as cellular models for functional testing of candidate mechanisms in vitro. (nature.com)
  • We identified interleukin-6 (IL-6) trans-signaling as a pathway that (i) activates normal and premalignant cells, (ii) induces a proliferative stem/progenitor-like phenotype in mammary epithelial cells, and (iii) whose activation in DCCs depends on regulatory niche cells in BM. (nature.com)
  • 6-FPT can exhibit variable pro/anti-oxidative roles depending on the cell type and its environment (acting as a cell protector in normal cells, or as an enhancer of drug-induced cell death in cancer cells). (nih.gov)
  • Priming and boosting responders with the male antigen, H-Y, paired with the H-4.2, H-7.1, or H-3.1 antigens, resulted in the generation of cytolytic T cells specific for the autosomal H antigens but not the H-Y antigen. (elsevierpure.com)
  • Furthermore, co-immunization and boosting of C57BL/6 female responder spleen cells with BALB.B male cells resulted in the generation of cytolytic T cells specific for the BALB.B immunodominant antigens but not H-Y. No dominance was observed in H-4-plus H-7-incompatible combinations. (elsevierpure.com)
  • In fact, immunization with H-3.1 and H-Y presented on different cells resulted in normal generation of H-Y-specific cytolytic T cels, but no generation of H-3.1-specific cytolytic T cells resulted unless H-Y-specific cells were stimulated in the mixed lymphocyte cultures. (elsevierpure.com)
  • Antigen is a substances usually protein in nature and sometimes polysaccharide, that generates a specific immune response and induces the formation of a specific antibody or specially sensitized T cells or both. (microbiologyinfo.com)
  • Heterophile antigens are identical antigens found in the cells of different species. (microbiologyinfo.com)
  • These antigens enters the body or system and start circulating in the body fluids and trapped by the APCs (Antigen processing cells such as macrophages, dendritic cells, etc. (microbiologyinfo.com)
  • The endogenous antigens are processed by the macrophages which are later accepted by the cytotoxic T - cells. (microbiologyinfo.com)
  • Dendritic cells (DCs) are considered to be professional antigen presenting cells (APCs), each containing a variety of subsets that can reside in organs or migrate amongst the lymphoid and non-lymphoid organs. (innovitalife.com)
  • Recently, several studies have been undertaken to improve antigen presentation potency to elicit more powerful immune responses against tumor cells. (innovitalife.com)
  • AB - A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13 20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. (nih.gov)
  • Cells from normal H mice gave a stronger oxidative burst when triggered with phorbol myristate acetate, and were more cytotoxic for tumour cells than cells from L mice. (nih.gov)
  • Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
  • Tumor-associated antigens (TAAs) are relatively restricted to tumor cells. (msdmanuals.com)
  • Tumor-specific antigens (TSAs) are unique to tumor cells. (msdmanuals.com)
  • However, several antigens with selective expression on the surface of tumor cells are not associated with the major histocompatibility complex and may be candidates for therapeutic targeting. (msdmanuals.com)
  • References Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
  • Regarding internal T cell mechanics, Anjana Rao, PhD -a former CRI fellow who is now a CRI Scientific Advisory Council member at the La Jolla Institute for Immunology-highlighted her team's work showing how knocking out genes for certain pathways in chimeric antigen receptor (CAR) T cells could improve their anti-cancer activity and the survival of mice. (cancerresearch.org)
  • 20) "Natural killer" T-lymphocytes serve the function of attacking cells that have foreign antigens? (albertkharris.com)
  • Epithelial cells from normal pig bladders proliferated when cocultured with lethally irradiated feeder cells of the LA7 rat mammary tumor line. (bioone.org)
  • HLA-G has a restricted distribution and is mainly expressed in trophoblastic cells, thymic epithelium, pancreas, cornea, nail matrix, and erythroid and endothelial precursors under normal physiological condition [12]. (scirp.org)
  • Specifically, the series provides in-depth discussion on a selection of emerging immunotherapies now available to patients for hematologic diseases, including cancer vaccines, chimeric antigen receptor T cells, and immunotherapies to regulate inflammation in nonmalignant blood disorders. (ashpublications.org)
  • The field has grown exponentially since Science designated cancer immunotherapy, including checkpoint inhibitors and chimeric antigen receptor T cells (CARTs), as "breakthrough therapy" of the year for 2013. (ashpublications.org)
  • 3-5 They also understood that B cells made antibodies that recognized a normal protein in the intestine called tissue transglutaminase or tTG . (celiackidsconnection.org)
  • Like all immune cells, T cells have receptors (in this case called T cell receptors) that recognize antigens . (celiackidsconnection.org)
  • How do T cells recognize antigens? (celiackidsconnection.org)
  • Unlike other immune cells, T cells are not able to recognize antigens on their own. (celiackidsconnection.org)
  • or 2) by professional antigen presenting cells . (celiackidsconnection.org)
  • Dendritic cells, macrophages, and B cells are professional antigen presenting cells that process pathogens. (celiackidsconnection.org)
  • Like the MHC class I protein, the MHC class II protein displays the peptide (antigen) and interacts with certain T cells. (celiackidsconnection.org)
  • This bridge allows cytotoxic T cells to recognize normal cells that are infected by a pathogen . (celiackidsconnection.org)
  • This allows helper T cells to recognize pathogen peptides that have been displayed by antigen presenting cells. (celiackidsconnection.org)
  • This prevents excessive damage to the normal cells and tissues in the body. (celiackidsconnection.org)
  • TRG mRNA was expressed in the majority of cancer cells and cancer tissue tested, whereas it was scarcely expressed in the majority of normal tissues, and only low-level expression of TRG was detected in the heart, liver, and pancreas. (elsevierpure.com)
  • The OX-18 monoclonal antibody specifically recognizes a non-polymorphic determinant of rat MHC class I antigen on erythrocytes and most nucleated cells, except normal neurons and glial cells. (bdbiosciences.com)
  • By endocytosis or phagocytosis , these antigens are taken into the antigen-presenting cells (APCs) and processed into fragments. (wikidoc.org)
  • These antigens can sometimes be presented by tumor cells and never by the normal ones. (wikidoc.org)
  • More common are antigens that are presented by tumor cells and normal cells, and they are called tumor-associated antigens (TAAs) . (wikidoc.org)
  • Cytotoxic T lymphocytes that recognize these antigens may be able to destroy the tumor cells before they proliferate or metastasize . (wikidoc.org)
  • Tumor antigens can also be on the surface of the tumor in the form of, for example, a mutated receptor, in which case they will be recognized by B cells . (wikidoc.org)
  • T cells cannot bind native antigens, but require that they are processed by APCs, while B cells can be activated by native ones. (wikidoc.org)
  • Host pre-treatment with six monoclonal antibodies targeting CD47, T cells, NK cells, and HSCs followed by donor HSC transplantation enabled stable hematopoietic system reconstitution in recipients with mismatches at half (haploidentical) or all major histocompatibility complex (MHC) genes. (ca.gov)
  • Through this process, a large and heterogeneous pool of p/MHC antigens is continuously generated in healthy, pathogen infected, or tumor cells as a means of displaying a cell's peptide repertoire to the immune system ( 4 ). (frontiersin.org)
  • The process of gene rearrangements is prone to errors which could lead to the development of either non-functional T-cells or T-cells which react strongly to self-antigens (autoreactive T-cells). (world-of-peptides.com)
  • In addition, monocytes serve as antigen-presenting cells and migrate into tissues. (pocketdentistry.com)
  • In tissue, these antigen-presenting cells are known as dendritic cells (in lymph nodes) or Langerhans cells (in skin and mucosa). (pocketdentistry.com)
Peptide2
  • This leads to the development of unique peptide: MHC (Major Histocompatibility Complex) combinations of the receptor and this mediates central tolerance. (world-of-peptides.com)
  • His Antigen research is multidisciplinary, incorporating elements of Cancer and Peptide library. (research.com)
Antibody5
  • AB - The faster degradation of antigen by macrophages in Biozzi low (L) responder mice, compared to Biozzi high (H) responder mice, is thought to be responsible for their lower antibody response. (nih.gov)
  • 10) Antigens control the shape of the antibody binding sites produced by whatever B-lymphocyte that it comes into contact with. (albertkharris.com)
  • Fully mismatched chimeric mice developed antibody responses to nominal antigens, showing preserved functional immunity. (ca.gov)
  • His Antigen research incorporates elements of Antibody, Melanoma, Immune system and Transplantation. (research.com)
  • His Antigen research includes themes of Antibody, Melanoma and Immunotherapy. (research.com)
Genetic4
  • The discovery of a genetic test for hereditary hemochromatosis has identified many individuals who are homozygous for the C282Y mutation of the HFE gene with a normal transferrin saturation and serum ferritin level. (nih.gov)
  • Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU). (hindawi.com)
  • Spondyloarthropathies (SpA) embrace different chronic inflammatory diseases sharing common genetic (association with HLA-B27 antigen) and clinical features. (hindawi.com)
  • These antigens should not be, under normal conditions, the target of the immune system, but, due mainly to genetic and environmental factors, the normal immunological tolerance for such an antigen has been lost in these patients. (microbiologyinfo.com)
Receptor2
Macrophages3
  • PMID- 3894221 TI - Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. (nih.gov)
  • Consistent with this finding, DP but not DR or DQ antigens were observed on vascular elements and macrophages in the villi of 16-week placenta. (nih.gov)
  • Peritoneal macrophages obtained from normal mice were compared with those from groups of mice given Mycobacterium bovis BCG or Propionibacterium acnes. (nih.gov)
Major13
Leukocyte5
  • Human leukocyte antigen and human neutrophil antigen systems. (medlineplus.gov)
  • A strong pharmacogenetic association has been reported in Chinese patients with these HR and Human Leukocyte Antigen (HLA)-B*1502 and with HLA- A*3101 in caucasians. (usp.br)
  • The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (nih.gov)
  • Examples: Blood group antigens, HLA (Histocompatibility Leukocyte antigens), etc. (microbiologyinfo.com)
  • The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. (frontiersin.org)
Self antigens1
Foreign antigens1
Human8
  • 2. Ultrastructural localization of gap junction protein connexin 43 in normal human skin, basal cell carcinoma, and squamous cell carcinoma. (nih.gov)
  • 15. CD44 standard and variant isoform expression in normal human skin appendages and epidermis. (nih.gov)
  • 20. Differential antigen expression between human eccrine sweat glands and hair follicles/pilosebaceous units. (nih.gov)
  • This article describes the structure, histologic features, and ultrastructural features of normal adult human skeletal muscle and addresses the results of improper specimen handling during muscle biopsy. (medscape.com)
  • In normal human skin approximately 50% of LCs identified by cell surface T6 antigenicity also express HLA-DR histocompability determinants. (cdc.gov)
  • We report here that recombinant DNA-derived human interferon (IFN)-gamma, but not IFN- alpha2, induces the expression of HLA-DR antigens by the population of human epidermal LCs on which such antigens normally are not detected. (cdc.gov)
  • RESULTS: Human scalp hair grown in nude mice showed long-term persistence of human features including the expression of histocompatibility antigens (KAB 3, W 6/32, SF 1-1.1.1) and normal hair morphometry. (nih.gov)
  • The clear functional relevance of SON in coordinating essential cellular processes and its presence in diverse human tissues suggests that intact SON might be crucial for normal growth and development. (nih.gov)
Intracellular1
  • Endogenous antigens are antigens that have been generated within the cell, as a result of normal cell metabolism , or because of viral or intracellular bacterial infection . (wikidoc.org)
Protein2
  • It is noteworthy that even an allelic difference, involving a single conservative amino acid substitution in a normal protein, can change it into a minor antigen. (nih.gov)
  • Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (nih.gov)
Lymphocytes5
Endogenous1
Lymphocyte2
  • Normally, the normal T-lymphocyte population is achieved early in life and this leads to involution of the thymus in early adulthood. (world-of-peptides.com)
  • His Immunology and T lymphocyte, Immune system, T cell, Spleen and Tumor antigen investigations all form part of his Immunology research activities. (research.com)
MiHA2
Molecular3
  • It will support basic, pre-clinical, and clinical studies using molecular and cellular approaches to dissect the immune response to these antigens. (nih.gov)
  • Tolerogen - An antigen that invokes a specific immune non-responsiveness due to its molecular form . (wikidoc.org)
  • Immunology, Antigen, Molecular biology, Cytotoxic T cell and CTL* are his primary areas of study. (research.com)
Substances1
  • An antigen must be a foreign substances to the animal to elicit an immune response. (microbiologyinfo.com)
Class3
Genes1
Exogenous1
  • Exogenous antigens are antigens that have entered the body from the outside, for example by inhalation, ingestion, or injection. (wikidoc.org)
Viral1
  • If a cell has been infected by a foreign pathogen, such as a virus that lives inside the cell, viral peptides (antigens) will be displayed on the surface of the infected cell. (celiackidsconnection.org)
Recognition2
Immunity2
  • Adaptive immunity (learned immunity) is antigen specific, depends on antigen exposure or priming, and can be of very high affinity. (mhmedical.com)
  • Recipients that received grafts from very immunologically different donors still developed normal immune responses, demonstrating preservation of functional immunity after this procedure. (ca.gov)
Immunology2
  • His primary areas of study are Immunology, Cytotoxic T cell, CD8, Antigen and T cell. (research.com)
  • His scientific interests lie mostly in CD8, Immunology, Cytotoxic T cell, Antigen and Immune system. (research.com)
Species1
Cell6
  • Immunodominance in the T cell response to multiple non-H-2 histocompatibility antigens. (elsevierpure.com)
  • These observations suggest that in vitro T cell responses to paired, non-H-2 H antigens may be independent, competitive, or synergistic, depending on the identity of the antigens and the priming and boosting conditions. (elsevierpure.com)
  • The whole antigen does not evoke immune response and only a small part of it induces B and T cell response. (microbiologyinfo.com)
  • Once the antigen is recognized, the T cell becomes activated. (celiackidsconnection.org)
  • When an antigen presenting cell bumps into a pathogen, it brings it inside the cell using a process called phagocytosis (cell eating). (celiackidsconnection.org)
  • His biological study spans a wide range of topics, including Cell biology, Tumor antigen, Immunotherapy and Cytolysis. (research.com)
TSAs1
  • In this case, they are called tumor-specific antigens (TSAs) and, in general, result from a tumor-specific mutation. (wikidoc.org)
Recognize1
  • Failure of this immune system to recognize the body's normal constituents as "self" will result in inflammation and tissue damage. (jyoungpharm.org)
Donor2
  • In non-rejector combinations, liver allografts possess remarkable properties of tolerance induction and antigen-specific immunosuppression, leading to a state of donor-specific unresponsiveness in which grafts of other organs are also accepted. (nih.gov)
  • Moreover, liver transplantation can terminate ongoing rejection reactions in other organs and convert an existing state of sensitization against donor antigens into one of unresponsiveness. (nih.gov)
Responses1
  • These results suggest that IFN-gamma may play a role in regulating skin -associated immune responses through enhanced expression of HLA-DR antigens on LCs and that such enhancement may be mediated by alterations in arachidonic acid metabolism. (cdc.gov)
Spleen1
  • Liver and spleen size were measured within normal range. (nih.gov)
Tumors2
  • 4. Immunohistochemical demonstration of breast-derived and/or carcinoma-associated glycoproteins in normal skin appendages and their tumors. (nih.gov)
  • 9. Expression of Bcl-x in normal skin and benign cutaneous adnexal tumors. (nih.gov)