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  • SNRA
  • A closely related type of drug is a serotonin-norepinephrine releasing agent (SNRA), for instance the withdrawn appetite suppressant fenfluramine/phentermine (Fen-Phen). (wikipedia.org)
  • Fenfluramine/phentermine (Fen-Phen), a combination formulation of fenfluramine, a serotonin releasing agent, and phentermine, a norepinephrine releasing agent, is a functional SNRA that was formerly used as an appetite suppressant for the treatment of obesity. (wikipedia.org)
  • SNDRAs
  • They are also very similar to serotonin-norepinephrine-dopamine releasing agents (SNDRAs) like MDMA ("ecstasy") and α-ethyltryptamine (αET) for the same reason, although they act via a different mechanism and have differing physiological and qualitative effects. (wikipedia.org)
  • amino
  • A single-nucleotide polymorphism (SNP) is a genetic variation in which a genome sequence is altered by a single nucleotide (A, T, C or G). NET proteins with an altered amino acid sequence (more specifically, a missense mutation) could potentially be associated with various diseases that involve abnormally high or low plasma levels of norepinephrine due to altered NET function. (wikipedia.org)
  • release
  • SNRAs primarily induce the release rather than inhibit the reuptake of serotonin and norepinephrine. (wikipedia.org)
  • Norepinephrine release is lowest during sleep, rises during wakefulness, and reaches much higher levels during situations of stress or danger, in the so-called fight-or-flight response. (wikipedia.org)
  • In the rest of the body, norepinephrine increases heart rate and blood pressure, triggers the release of glucose from energy stores, increases blood flow to skeletal muscle, reduces blood flow to the gastrointestinal system, and inhibits voiding of the bladder and gastrointestinal motility. (wikipedia.org)