• meningeal nociceptors
  • During migraine, CGRP is thought to be released from peripheral endings of perivascular meningeal nociceptors primary and to promote vasodilatation. (wiley.com)
  • Here, using electrophysiological, extracellular, single-unit recording combined with laser-Doppler flowmetry measurements of dural blood flow (DBF), we examined whether CGRP and meningeal vasodilatation promote activation or sensitization of meningeal nociceptors. (wiley.com)
  • however, neither method of CGRP administration resulted in activation or sensitization of meningeal nociceptors. (wiley.com)
  • The results of this study suggest that CGRP effects in the meninges, including meningeal vasodilatation, are not sufficient to activate or sensitize meningeal nociceptors. (wiley.com)
  • To investigate the basis for this selective inhibitory effect, and further explore the mechanism of action of CGRP-mAbs, we tested the effect of fremanezumab on the cortical spreading depression-evoked activation of mechanosensitive primary afferent meningeal nociceptors that innervate the cranial dura, using single-unit recording in the trigeminal ganglion of anesthetized male rats. (jneurosci.org)
  • These findings identify Aδ meningeal nociceptors as a likely site of action of fremanezumab in the prevention of headache. (jneurosci.org)
  • In the current paper, we report that CGRP-mAbs prevent the activation of Aδ but not C-type meningeal nociceptors by CSD. (jneurosci.org)
  • As the main CGRP-mAb site of action appears to be situated outside the brain, we conclude that the initiation of the headache phase of migraine depends on activation of meningeal nociceptors, and that for selected patients, activation of the Aδ-HT pain pathway may be sufficient for the generation of headache perception. (jneurosci.org)
  • suppress
  • Because myelinated nociceptors mediate anti-nociceptive reflexes, the data suggest that fine control of the MOR mRNA level contributes to a complex neural trait: the ability of opioids to suppress persistent pain without preventing response to a new injury. (jneurosci.org)
  • the research team decided to use DREADDs as a chemogenetic approach to suppress nociceptor function. (painresearchforum.org)
  • pain
  • In 8 neuropathy patients without pain, double spiking was found only in 4 of 90 nociceptors. (ad-astra.ro)
  • Pain from excitation of identified muscle nociceptors in humans. (semanticscholar.org)
  • Thermoception refers to stimuli of moderate temperatures (~24-28C), as anything beyond that range is considered pain and moderated by nociceptors. (wikipedia.org)
  • Superficial pain is initiated by activation of nociceptors in the skin or other superficial tissue, and is sharp, well-defined and clearly located. (wikipedia.org)
  • Tumors can cause pain by crushing or infiltrating tissue, or by releasing chemicals that make nociceptors responsive to stimuli that are normally non-painful (cf. allodynia). (wikipedia.org)
  • vitro
  • Last, we show that reducing agents, as well as synthetic and endogenous Zn 2+ chelators, sensitize Ca v 3.2 current-containing C-type nociceptors from wild-type mice but not C-type nociceptors from Ca v 3.2 −/− mice in vitro and in vivo . (jneurosci.org)
  • action
  • The interval between the main action potential and the multiple spikes ranged from 13 to 100 ms. There was a significant association between spontaneous activity and multiple spiking in C nociceptors, with spontaneous activity being present in 9 of 11 fibres with multiple spiking, but only in 21 of 94 nociceptors without multiple spiking (P (ad-astra.ro)
  • METHODS: We recorded action potentials from rat joint nociceptors after intraarticular injection of IL-17A. (biomedsearch.com)
  • activity
  • We investigated painful neuropathy patients using microneurography and analysed nociceptors for the occurrence of multiple spiking and spontaneous activity. (ad-astra.ro)
  • Multiple spiking of nociceptors coincides with spontaneous activity in nociceptors of painful neuropathy patients. (ad-astra.ro)
  • We therefore conclude that rather than being a generic sign of neuropathy, multiple spiking is linked to axonal hyperexcitability and spontaneous activity of nociceptors. (ad-astra.ro)