• sensitization
  • Here, using electrophysiological, extracellular, single-unit recording combined with laser-Doppler flowmetry measurements of dural blood flow (DBF), we examined whether CGRP and meningeal vasodilatation promote activation or sensitization of meningeal nociceptors. (wiley.com)
  • however, neither method of CGRP administration resulted in activation or sensitization of meningeal nociceptors. (wiley.com)
  • Collectively, these findings describe a novel mechanism of nociceptor sensitization and firmly establish reducing agents, as well as Zn 2+ , Zn 2+ -chelating amino acids, and Zn 2+ -chelating proteins as endogenous modulators of Ca v 3.2 and nociceptor excitability. (jneurosci.org)
  • Collectively, our data further support a role for Ca v 3.2 channels in peripheral nociception and identify a novel mechanism for Ca v 3.2 modulation that underlies nociceptor sensitization. (jneurosci.org)
  • suppress
  • Because myelinated nociceptors mediate anti-nociceptive reflexes, the data suggest that fine control of the MOR mRNA level contributes to a complex neural trait: the ability of opioids to suppress persistent pain without preventing response to a new injury. (jneurosci.org)
  • the research team decided to use DREADDs as a chemogenetic approach to suppress nociceptor function. (painresearchforum.org)
  • pain
  • In 8 neuropathy patients without pain, double spiking was found only in 4 of 90 nociceptors. (ad-astra.ro)
  • Pain from excitation of identified muscle nociceptors in humans. (semanticscholar.org)
  • Thermoception refers to stimuli of moderate temperatures (~24-28C), as anything beyond that range is considered pain and moderated by nociceptors. (wikipedia.org)
  • Superficial pain is initiated by activation of nociceptors in the skin or other superficial tissue, and is sharp, well-defined and clearly located. (wikipedia.org)
  • Tumors can cause pain by crushing or infiltrating tissue, or by releasing chemicals that make nociceptors responsive to stimuli that are normally non-painful (cf. allodynia). (wikipedia.org)
  • vitro
  • Last, we show that reducing agents, as well as synthetic and endogenous Zn 2+ chelators, sensitize Ca v 3.2 current-containing C-type nociceptors from wild-type mice but not C-type nociceptors from Ca v 3.2 −/− mice in vitro and in vivo . (jneurosci.org)
  • sensitize
  • The results of this study suggest that CGRP effects in the meninges, including meningeal vasodilatation, are not sufficient to activate or sensitize meningeal nociceptors. (wiley.com)
  • activity
  • We investigated painful neuropathy patients using microneurography and analysed nociceptors for the occurrence of multiple spiking and spontaneous activity. (ad-astra.ro)
  • The interval between the main action potential and the multiple spikes ranged from 13 to 100 ms. There was a significant association between spontaneous activity and multiple spiking in C nociceptors, with spontaneous activity being present in 9 of 11 fibres with multiple spiking, but only in 21 of 94 nociceptors without multiple spiking (P (ad-astra.ro)
  • Multiple spiking of nociceptors coincides with spontaneous activity in nociceptors of painful neuropathy patients. (ad-astra.ro)
  • We therefore conclude that rather than being a generic sign of neuropathy, multiple spiking is linked to axonal hyperexcitability and spontaneous activity of nociceptors. (ad-astra.ro)