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Oxidative StressNitrosationReactive Nitrogen SpeciesReactive Oxygen SpeciesAntioxidantsPeroxynitrous AcidHydrogen PeroxideNitric OxideS-NitrosoglutathioneLipid PeroxidationGlutathioneSuperoxide DismutaseMalondialdehydeTruncated HemoglobinsOxidation-ReductionOxidantsNitroso CompoundsS-NitrosothiolsNitritesCatalaseNitratesNitric Oxide Synthase Type IIThiobarbituric Acid Reactive SubstancesNitrogen CompoundsTyrosineHemeproteinsNitrogen OxidesGlutathione PeroxidaseVitreoscillaPeroxiredoxinsNitric Oxide DonorsAldehydesSuperoxidesFree Radical ScavengersStress, PhysiologicalProtein CarbonylationPotassium DichromateAcetylcysteineNADPH OxidaseNF-E2-Related Factor 2MitochondriaApoptosisRats, WistarSulfhydryl CompoundsMetalloporphyrinsSodium NitriteF2-IsoprostanesHeme Oxygenase-1ParaquatBiological MarkersDeoxyguanosineDiabetes Mellitus, ExperimentalDisease Models, AnimalCells, CulturedMolsidominepara-AminobenzoatesSignal TransductionNitric Oxide SynthaseGene Expression Regulation, BacterialMice, Inbred C57BLtert-ButylhydroperoxidePeroxidesDNA DamageCell SurvivalRats, Sprague-DawleyGlutathione DisulfideOxidoreductasesPoly(ADP-ribose) PolymerasesCysteineCell DeathCytoprotectionAscorbic AcidThioredoxinsMicrobial ViabilityPeroxidasesInflammationOxygenIsoprostanesNitrogenBlotting, WesternBacterial ProteinsMice, KnockoutCell LineDihydropteridine ReductaseLiverVitamin ENitroprussideTime FactorsDose-Response Relationship, DrugNitro CompoundsVitamin K 3Up-RegulationKidneyCyclic N-OxidesGlutathione ReductaseGene Expression RegulationHydrazines4-Aminobenzoic AcidMetallothioneinReperfusion Injury
InflammationReduction of oxidative stressInflammatoryDysfunctionBiomarkersPathwaysNephrotoxicityAttenuationAimsVascularInducesPathogenesisRedoxHypothesisEnzymesMammalianWistarMechanismsBrainRatsApoptosisPhysiologicalFibrosisPsychological stressProteinDamageExposureRoleFindingsDevelopmentExperimentalResponsesEffectsExpressionIncreaseImpactProductionResearchDiseaseActivationEffect
Inflammation7
  • Treatment of mice with cannabidiol markedly attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell death in the kidney, and it improved renal function. (thecannabisadvisory.com)
  • We invite original research and review articles focusing on interaction of cardiac inflammation, oxidative stress, and hypoxia in the setting of sepsis. (hindawi.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. (nel.edu)
  • Red light therapy fibromyalgia is a revolutionary approach that alleviates chronic inflammation, nervous system problems, oxidative stress, and mitochondrial dysfunction. (reddotled.com)
  • The main reason why red light therapy fibromyalgia is the best solution is that it addresses the underlying causes that trigger the condition such as psychological stress, oxidative stress, and chronic inflammation. (reddotled.com)
Reduction of oxidative stress1
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
Inflammatory8
  • The present cross‐sectional study examined to what extent exaggerated systemic oxidative‐inflammatory‐nitrosative stress (OXINOS), defined by an increase in free radical formation and corresponding decrease in vascular nitric oxide (NO) bioavailability, is associated with impaired cerebrovascular function, accelerated cognitive decline and depression in CMS. (southwales.ac.uk)
  • We sampled blood for oxidative (electron paramagnetic resonance spectroscopy, HPLC), nitrosative (ozone‐based chemiluminescence) and inflammatory (fluorescence) biomarkers. (southwales.ac.uk)
  • Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress and endothelial dysfunction. (hindawi.com)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • In clinical depression, however, a transition occurs to sensitization of immuno-inflammatory pathways, progressive damage by oxidative and nitrosative stress to lipids, proteins, and DNA, and autoimmune responses directed against self-epitopes. (biomedcentral.com)
  • This paper hypothesizes that inflammatory, oxidative and nitrosative (IO&NS) pathways, and an increased translocation of LPS from gram-negative bacteria are causally related to depression following external (psychological) and internal (organic) stressors and that IO&NS pathways are novel targets for antidepressant development. (nel.edu)
  • There is now some evidence that chronic fatigue syndrome is accompanied by an activation of the inflammatory response system and by increased oxidative and nitrosative stress. (nel.edu)
  • Nuclear factor kappa beta (NFkappabeta) is the major upstream, intracellular mechanism which regulates inflammatory and oxidative stress mediators. (nel.edu)
Dysfunction3
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase). (weeksmd.com)
Biomarkers1
  • We are also developing biomarkers for oxidative stress that is associated with exposure to numerous environmental agents, such as formaldehyde, acetaldehyde, and a variety of human diseases, with the research focus on developing less- or non-invasive biomarkers in biological matrices. (unc.edu)
Pathways1
  • In addition, myocardial depression in sepsis appears to be mediated in part through combinations of oxidative stress unbalance, mitochondrial damage, and activation of apoptotic pathways. (hindawi.com)
Nephrotoxicity4
  • STUDY: Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress. (thecannabisadvisory.com)
  • Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use. (thecannabisadvisory.com)
  • Cisplatin (cis-diamminedichloroplatinum II, CDDP) is a chemotherapeutic agent that induces nephrotoxicity associated with oxidative/nitrosative stress. (weeksmd.com)
  • The renoprotective effect of SFN on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and the preservation of antioxidant enzymes. (weeksmd.com)
Attenuation1
  • The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Aims1
  • Therefore, this study aims in reviewing mental stress models (e.g. brief and written examination stress as subacute and acute type of stressor) that have been utilized to understand the effect of stress on the neuroendocrine and immune systems. (nel.edu)
Vascular2
  • 2010) Oxidative-nitrosative stress and its impact on vascular O2 transport to skeletal muslce, American College of Sports Medicine, Baltimore, MA. (utah.edu)
  • 2009) Oxidative stress, aging, and vascular function. (utah.edu)
Induces1
  • This review shows evidence that short-time (minutes) or preparation to a written examination, in those students who are stressed, induces the production of proinflammatory cytokines which may be related to Th1 response. (nel.edu)
Pathogenesis2
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • Many studies reported that oxidative and nitrosative stress might be important for the pathogenesis of Alzheimer's disease (AD) beginning with arguably the earliest stage of AD, i.e., as mild cognitive impairment (MCI). (uky.edu)
Redox2
  • Qian's current research involves the development of chemical proteomic approaches for site-specific quantification of cysteine-based redox modifications and more sensitive selected reaction monitoring-based targeted quantification techniques with applications in pancreatic islets, diabetes, and oxidative stress-related disease areas. (pnnl.gov)
  • 2021. "Characterization of cellular oxidative stress response by stoichiometric redox proteomics. (pnnl.gov)
Hypothesis1
  • The focus of these studies was to measure the oxidation and nitration status of this important proapoptotic protein, consistent with the hypothesis that oxidative modification of p53 could be involved in the neuronal loss observed in neurodegenerative conditions. (uky.edu)
Enzymes1
  • The purpose of this study was to identify alterations in the production of reactive species and endogenous nitric oxide (NO) after nanoparticle exposure, and determine the relative contribution of hemoproteins and oxidative enzymes in this process. (cdc.gov)
Mammalian1
  • Scholars@Duke publication: Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts. (duke.edu)
Wistar1
Mechanisms2
  • The changes in the expression profile of bladder epithelial cells under the action of plasma acid in vitro were found indicating the development of oxidative, nitrosative and dicarbonyl stress, impaired expression of NADPH oxidase DUOX2 and VEGF, and a decrease in cell proliferative activity, which, in general, corresponds to the main mechanisms of urothelial alterations specific for the IC/BPS. (eco-vector.com)
  • Furthermore, studies on stress and common heath problems are necessary to increase our knowledge and understanding of the mechanisms responsible for producing neuroendocrine-induced immune changes in health and common diseases. (nel.edu)
Brain1
  • Međunarodna radionica pod nazivom "Don't guess, see the stress - Oxidative/nitrosative imbalance and the brain: relevance and methods", sponzorisana od strane International Brain Research Organization (IBRO), održaće se u našem Institutu u Laboratoriji za molekularnu biologiju i endokrinologiju u periodu od 20. (vinca.rs)
Rats1
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
Apoptosis2
  • Moreover, p53 plays a key role in the oxidative stress-dependent apoptosis. (uky.edu)
  • Oxidative and nitrosative stress caused by drug metabolism may be a trigger for keratinocyte apoptosis in the epidermis seen in toxic epidermal necrolysis (TEN) and Stevens Johnson syndrome (SJS). (e-ijd.org)
Physiological1
  • In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. (researchgate.net)
Fibrosis1
  • Beyazit Y, Kocak E, Tanoglu A, Kekilli M. Oxidative stress might play a role in low serum vitamin D associated liver fibrosis among patients with autoimmune hepatitis. (springer.com)
Psychological stress1
  • Previously, a large number of studies reported that psychological stress and psychiatric illness reduces immune responsiveness. (nel.edu)
Protein1
  • 2021. "Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. (pnnl.gov)
Damage2
  • Oxidative damage and tyrosine nitration from peroxynitrite. (scienceopen.com)
  • To estimate oxidative damage in the serum and to examine the role of nitric oxide in mediating epidermal damage in patients with TEN and SJS. (e-ijd.org)
Exposure2
  • The outcome from neuroendocrine and immune function prior to, following and after mental stress depends on multiple variables most importantly on the amount of stress, exposure time, coping behavior and adjustment of the individual. (nel.edu)
  • Nanoparticle exposure significantly increased microvascular oxidative stress by similar to 60%, and also elevated nitrosative stress fourfold. (cdc.gov)
Role2
  • 2010) Exercise and Aging Vasculature: The Role of Oxidative Stress, South West Chapter, American College of Sports Medicine, San Diego, CA. Other, Presented, 01/01/2010. (utah.edu)
  • Oxidative stress produced through reactive oxygen species (ROS) enhancement is considered to play a key role in the development and maintenance of hypertension. (uba.ar)
Findings1
  • The published findings from human mental stress models on catecholamines, cortisol, prolactin levels and on T helper (Th) 1 and 2-induced cytokines are presented and discussed with respect to the in vitro and in vivo effects of glucocorticoids, catecholamines, and prolactin on the induction of cytokines. (nel.edu)
Development1
  • Interestingly, either losartan or minoxidil administration blunted those parameters, indicating that arterial pressure is the key factor in the development of oxidative stress in the hypertensive aorta. (uba.ar)
Experimental2
  • Polizio, A.H. Lowering arterial pressure delays the oxidative stress generation in a renal experimental model of hypertension. (uba.ar)
  • Tomaro, M.L. 'Lowering arterial pressure delays the oxidative stress generation in a renal experimental model of hypertension' (2009) Journal of Cardiovascular Pharmacology. (uba.ar)
Responses1
  • Neuroendocrine and cytokines-induced responses to minutes, hours, and days of mental stress. (nel.edu)
Effects1
  • A few minutes of stress may improve immune performance but longer times of mental stress have detrimental effects that may lead to loss of immune integrity. (nel.edu)
Expression4
  • The expression of poly(ADP-ribose) (PAR) and inducible nitric oxide (NO) synthase (iNOS) and nitrotyrosine formation were determined immunohistochemically and used as indicators of oxidative and nitrosative stress. (scienceopen.com)
  • Vitamin D ameliorates stress ligand expression elicited by free fatty acids in the hepatic stellate cell line LX-2. (springer.com)
  • Thoracic aortic segments were excised, and the NAD(P)H oxidase subunits expression, oxidative stress parameters, and heme oxygenase-1 abundance were evaluated. (uba.ar)
  • Hypertensive animals had an increase in the activity and expression of NAD(P)H oxidase and, as a consequence, in the oxidative stress parameters. (uba.ar)
Increase1
  • other agents commonly ingested by the humans, such as drugs and food additives), the production of reactive species/free radicals may increase, leading to oxidative or nitrosative stress, depending on the specific reactive species are generated. (databasefootball.com)
Impact1
Production1
  • These reactive stresses coincided with a decreased NO production in a particle deposition dose-dependent manner. (cdc.gov)
Research1
  • Advances in amoebiasis research emphasizing immunological and oxidative aspects. (scialert.net)
Disease1
  • We suggest that antihypertensive drug administration at the beginning of this pathology delays the oxidative stress generation, thus preventing the aggravation of this disease. (uba.ar)
Activation1
  • FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress. (nih.gov)
Effect1
  • This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress. (researchgate.net)