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AsparagineAspartate-Ammonia LigaseNitrogen FixationAsparaginaseNitrogen IsotopesNitrogen CompoundsNitrogen CycleBlood Urea NitrogenGlutamineNitrogen DioxideAspartic AcidMolecular Sequence DataAmino AcidsReactive Nitrogen SpeciesAmino Acid SequencePeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseAmmoniaAspartate-tRNA LigaseNitrogen OxidesRNA, Transfer, AsnPII Nitrogen Regulatory ProteinsMutagenesis, Site-DirectedCarbonGlycosylationNitratesMutationBase SequenceFertilizersLigasesKineticsQuaternary Ammonium CompoundsGlutamate-Ammonia LigaseEscherichia coliBinding SitesCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorModels, MolecularHistidineUreaStructure-Activity RelationshipAmino Acid SubstitutionBacterial ProteinsSequence Homology, Amino AcidIsoaspartic AcidHydrogen-Ion ConcentrationSubstrate SpecificitySymbiosisSoilNitrogenous Group TransferasesNitrogen Mustard CompoundsCloning, MolecularCatalysisCulture MediaNitrogenasePlant RootsProtein ConformationKetoglutaric AcidsRecombinant ProteinsOligosaccharidesRoot Nodules, PlantAmidohydrolasesGlycopeptidesBiomassPlant LeavesDeaminationAmidesCarbohydratesGenes, BacterialAlanineGene Expression Regulation, BacterialSaccharomyces cerevisiaeProtein Structure, TertiaryGlutamatesCarbohydrate SequenceGlutaminaseChromatography, High Pressure LiquidFabaceaeHydrogen BondingAcetyleneProtein Processing, Post-TranslationalCell LineArginineCarbohydrate MetabolismOxidation-ReductionSequence AlignmentMedicago sativaPlant ProteinsNitrogenPlasmidsDigestionPeptidesCattleProtein BindingPolysaccharidesCrystallography, X-RayTemperatureGlutamic AcidAmmonium CompoundsGlutamate SynthaseSoybeansAllantoin

MetabolismSynthetaseAttached to the amide nitrogenAlanineAmino acid asparagineAmideAssimilationBiosynthesisHydrolysisFixationArginineMetabolic pathwaysAsparticCompoundsAssimilateConcentrationsMammalianAtomProteinLeukemicEnzymePathwayAmmoniumPlantsGenesInteractionStressIonsTransportLevelsHighNutrientsFormSpecificAmountsIncreasesSourceCellContentBodyEssential

Metabolism11

• This enzyme participates in nitrogen metabolism. (wikipedia.org)
• 1989). Furthermore, glutamine plays a major role in fetal nitrogen and carbon metabolism. (scialert.net)
• Asparagine functions in the plant's nitrogen metabolism, wound defence, and against microbial attack. (montphoto.com)
• Expression of these genes and others potentially involved in carbon and nitrogen metabolism was measured in roots, nodules producing nitrogen compounds, and nodules that were unable to fix nitrogen. (usda.gov)
• Genes for enzymes involved in organic acid synthesis (carbonic anhydrase, phosphoenolpyruvate carboxylase, malate dehydrogenase, and citrate synthase) along with genes involved in nitrogen metabolism (asparagine synthetase and glutamine synthetase) were co-expressed in effective nodules of M. truncatula. (usda.gov)
• The coordinated expression of genes for organic acid and nitrogen metabolism is expected to play a vital role in the regulation of nitrogen assimilation during Medicago symbiosis. (usda.gov)
• Nitrogen metabolism in plants in the post-genomic era (Annual Plant Reviews Volume 42) Blackwell Publishing Oxford. (rothamsted.ac.uk)
• May play a role in nitrogen metabolism and synaptic transmission. (wuxibiortus.com)
• relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases. (tourolib.org)
• Thus, ABA-dependent and ABA-independent regulatory systems would buy TPCA-1 seem to exist, differentially controlling development, water content, and nitrogen metabolism under water deficit. (srcsignaling.com)
• Aspartic Acid also connects the nitrogen and carbohydrate metabolism which is responsible for a large part of the energy cycle in the body. (thewellnessadvocate.com)

Synthetase3

• Other names in common use include asparagine synthetase (ADP-forming), and asparagine synthetase (adenosine diphosphate-forming). (wikipedia.org)
• Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. (sigmaaldrich.com)
• Lack of asparagine synthetase activity results in cytotoxicity specific for leukemic cells that depend on an exogenous source of the amino acid asparagine. (medscape.com)

Attached to the amide nitrogen2

• In N-linked glycosylation, oligosaccharides are attached to the amide nitrogen of an asparagine (Asn) residue in a consensus sequence Asn-X-Ser/Thr where X is any amino acid except proline. (themedicinemaker.com)
• Many of the proteins that are destined to become a part of plasma membrane or to be secreted from the cell, have carbohydrate chains attached to the amide nitrogen of asparagine(N linked) or the hydroxyl groups of serine, threonine(O linked). (microbenotes.com)

Alanine6

• Plasma concentrations of glutamine and alanine, the major nitrogen-carrying amino acids, usually are high and that of arginine is low. (nih.gov)
• Also recognizes histidine, asparagine and alanine. (wuxibiortus.com)
• Alanine transaminase has an important function in the delivery of skeletal muscle carbon and nitrogen (in the form of alanine) to the liver. (medmuv.com)
• In skeletal muscle, pyruvate is transaminated to alanine, thus affording an additional route of nitrogen transport from muscle to liver. (medmuv.com)
• The glucose-alanine cycle is used primarily as a mechanism for skeletal muscle to eliminate nitrogen while replenishing its energy supply. (medmuv.com)
• The requirement for nonspecific nitrogen for the synthesis of the nutritionally dispensable amino acids (aspartic acid, asparagine, glutamic acid, alanine, serine) and other physiologically important nitrogen-containing compounds akin to nucleic acids, creatine, and porphyrins. (jjsfolio.com)

Amino acid asparagine3

• Asparagine Asparagine is a non essential amino acid, Asparagine is made from Aspartic Acid plus ATP (adenosine tri-phosphate). (thewellnessadvocate.com)
• Aspartic Acid Aspartic Acid is a non essential amino acid that may be interconvertible with the amino acid Asparagine. (thewellnessadvocate.com)
• Chloramination of the amino acid asparagine produced an important amount of DCAcAm as compared to chlorination, indicating the existence of a specific reaction pathway. (edu.sa)

Amide1

• This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). (wikipedia.org)

Assimilation1

• We have carried out 1) NH4+-signal perception, 2) assimilation and remobilization of nitrogen, 3) metabolic balance between C and N, and 4) modeling of spikelet-ripening to understand molecular mechanisms of response. (nii.ac.jp)

Biosynthesis1

• L-asparagine is the most abundant metabolite for the storage and transport of nitrogen that is utilized in protein biosynthesis. (thepharmajournal.com)

Hydrolysis2

• Asparagine hydrolysis in plants is catalyzed by asparaginases with no homology to the bacterial-type enzymes. (thepharmajournal.com)
• The strains were screened for asparaginase production and the isolate AKNP03 2018 showing maximum L-asparagine hydrolysis was selected for further studies. (jrmds.in)

Fixation4

• Insights into the molecular mechanisms involved in rhizobial symbiosis have the potential to improve the efficiency of biological nitrogen fixation by plants and reduce costly fertilizer inputs. (usda.gov)
• Nitrogen fixation is carried out by bacterial nitrogenases forming reduced nitrogen, NH4+ which can then be used by all organisms to form amino acids. (medmuv.com)
• Nitrogen, nitrites and nitrates are acted upon by bacteria (nitrogen fixation) and plants and we assimilate these compounds as protein in our diets. (medmuv.com)
• See more studies on nitrogen fixation and. (naturalnews.com)

Arginine1

• Arginine supports the immune system as well as maintains a positive nitrogen balance in the body. (thewellnessadvocate.com)

Metabolic pathways2

• A cDNA filter array was constructed using putative symbiosis-specific ESTs as well as ESTs representing selected carbon and nitrogen metabolic pathways. (usda.gov)
• In silico protein-protein interaction analysis suggests that these filament-forming proteins can be clustered into several groups, including translational initiation machinery and glucose and nitrogen metabolic pathways. (ox.ac.uk)

Aspartic2

• Asparagine functions as a neurotransmitter, of particular interest is that Aspartic Acid and Asparagine have high concentrations in the hippocampus and the hypothalamus. (thewellnessadvocate.com)
• Catalyzes deamidation of asparagine to aspartic acid and ammonia, thereby reducing circulating levels of asparagine. (medscape.com)

Compounds3

• Presence of particular rhizobia causes formation of a unique structure on legume roots called nodules in which the bacteria reside and convert or "fix" nitrogen gas into compounds that can be transferred to the plant. (usda.gov)
• Also, genes for enzymes in the pathways for production of organic acids and for nitrogen uptake compounds were simultaneously expressed at similar levels in nitrogen-fixing nodules. (usda.gov)
• Furthermore, Plasmodium GGPP synthase (GGPPS) can bind nitrogen-containing bisphosphonates (N-BPs) strongly with the energetically favorable cooperation of three Mg(2+), resulting in inhibition by this class of compounds at IC(50) concentrations below 100 nM. (ox.ac.uk)

Assimilate1

• 2014. Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection. . (cornell.edu)

Concentrations1

• The asparagine concentrations ranging from 10 -1 to 10 -9 M were studied. (thepharmajournal.com)

Mammalian1

• Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. (medmuv.com)

Atom3

• One resonance structure has a double bond between the nitrogen atom and the carbonyl carbon. (preparingtobecome.com)
• It consists of the covalent attachment of an oligosaccharide to the nitrogen atom of specific asparagine residues. (biomedcentral.com)
• of relevance here is N-linked glycosylation , where the glycan is covalently bound to a nitrogen (N) atom in an asparagine (N) amino acid in the protein. (cureffi.org)

Protein3

• Reduced nitrogen enters the human body as dietary free amino acids, protein, and the ammonia produced by intestinal tract bacteria. (medmuv.com)
• The transfer of one-carbon methyl groups to nitrogen or oxygen to amino acid side chains increases the hydrophobicity of the protein and can neutralize a negative amino acid charge when bound to carboxylic acids. (microbenotes.com)
• Selective killing of leukemic cells it thought to be due to depletion of plasma asparagine, the amino acid required for protein synthesis. (medscape.com)

Leukemic1

• The level of asparagine in leukemic blood was 10 -2 M and that in normal blood was in the range of 10 -7 - 10 -5 M. Plant Biosensors possess advantages such as reliability, sensitivity, accuracy, ease of handling, and low-cost compared with conventional detection methods. (thepharmajournal.com)

Enzyme1

• In enzymology, an aspartate-ammonia ligase (ADP-forming) (EC 6.3.1.4) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + NH3 ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + L-asparagine The 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine. (wikipedia.org)

Pathway2

• We also demonstrated that yeast cell death under micronutrient limitation is controlled by the availability of residual nitrogen, and that this involved the nitrogen signaling pathways, mainly the TOR pathway that controls the triggering of an appropriate stress response. (oeno-one.eu)
• The development of a pathway for nitrogen disposal in a species appears to depend chiefly on the availability of water. (medmuv.com)

Ammonium2

• The results obtained show that various nitrogen sources (amino acids, ammonium) can trigger cell death but with different intensities. (oeno-one.eu)
• As nitrogen supplementation - usually performed with ammonium salt but more complex organic sources are also proposed - is a common practice in oenology, a better knowledge of the effect of supplementation with different nitrogen sources and considering the interactions with micronutrient limitations is required for enhanced nitrogen management. (oeno-one.eu)

Plants3

• Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. (sigmaaldrich.com)
• Under nitrogen starved conditions, rice plants reduce their active tiller number in vegetative stage and their spikelet number in reproductive stage. (nii.ac.jp)
• Plants in the legume family obtain much of the needed nitrogen through a symbiotic relationship with soil bacteria collectively called rhizobia. (usda.gov)

Genes4

• The barrel medic, a legume plant closely related to the crop plant alfalfa, is a useful model for identifying the genes important in nitrogen uptake and use. (usda.gov)
• One group of genes that were found to have enhanced expression in nitrogen-fixing nodules were similar to plant disease resistance genes. (usda.gov)
• These techniques are useful tools for identifying genes involved in the symbiotic interaction and nitrogen uptake and for measuring expression of many genes simultaneously. (usda.gov)
• Lotus Japonicus como Modelo para la Identificaci n de Nuevos Genes Implicados en la Respuesta a Estr s Abi tico y Productividad en Leguminosas. (us.es)

Interaction1

• The impact of the nitrogen content of grape musts has thus to be considered for potential interaction with micronutrient limitations in wine alcoholic fermentation management. (oeno-one.eu)

Stress1

• Leaf Amino Acid Supply Affects Photosynthetic and Plant Nitrogen Use Efficiency under Nitrogen Stress. (uni-bielefeld.de)

Ions1

• It was further modified in terms of nitrogen, carbon sources, effect of metal ions and pH. (jrmds.in)

Transport2

• Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport. (sigmaaldrich.com)
• Source and sink mechanisms of nitrogen transport and use. (uni-bielefeld.de)

Levels2

• Low levels of assimilable nitrogen in grape must can lead to sluggish or stuck fermentation, a situation which is generally avoided by supplementing musts with nitrogen salts ( Sablayrolles, 2009 ). (oeno-one.eu)
• Lodging is affected by obvious factors such as variety, nitrogen rate and weather, but low potash levels also increase the risk of lodged crops with the associated loss of yield and quality. (pda.org.uk)

High2

• We found that yeast cell death was triggered by starvation for a set of micronutrients, including oleic acid, ergosterol, pantothenic acid and nicotinic acid whenever the level of nitrogen was high, but not in low nitrogen conditions. (oeno-one.eu)
• It is generally believed that high nitrogen content in grape musts enhances the fermentation process. (oeno-one.eu)

Nutrients1

• Nitrogen is one of the most important nutrients needed for plant growth. (usda.gov)

Form1

• Imine carbon is susceptible to nucleophilic addition reaction and is thus attacked by the CN - anion to form a nitrile group (carbon triple bonded to nitrogen). (preparingtobecome.com)

Specific1

• A majority (53%) of the putatively symbiosis-specific TCs were derived exclusively from nitrogen-fixing and senescent nodules. (usda.gov)

Amounts1

• 19 amino acids or NH 4 + were added, in amounts corresponding to 354 mg/L assimilable nitrogen, to an oenological medium that was low in nitrogen and oleic acid. (oeno-one.eu)

Increases1

• Double bond between the carbon and nitrogen limits the rotation of this bond and thus increases the rigidity and stability of the backbone for proteins. (preparingtobecome.com)

Source1

• We examined here the impact of the nature of the nitrogen source supplementation in the light of these previous results. (oeno-one.eu)

Cell3

• L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research. (sigmaaldrich.com)
• We also provide evidence that the timing of nitrogen addition has a strong impact on cell death in musts with micronutrient limitations: an early nitrogen addition is more likely to trigger cell death than a late addition. (oeno-one.eu)
• This showed the importance of nitrogen in regulating cell death during wine fermentation. (oeno-one.eu)

Content1

• The nitrogen content of camel milk was found to be 15.6 g/100 g. (scialert.net)

Body1

• Humans are totally dependent on other organisms for converting atmospheric nitrogen into forms available to the body. (medmuv.com)

Essential2

• Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. (sigmaaldrich.com)
• Nitrogen availability is an essential parameter for wine alcoholic fermentation. (oeno-one.eu)