• coronary
  • You should not use nifedipine if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks. (healthbanks.com)
  • Nifedipine is a known material which possesses a coronary dilator activity and is useful for the treatment of so-called angina pectoris attack. (google.com)
  • Regarding to the underlying mechanism, we examined whether (1) nifedipine changed the mRNA and protein levels of the constitutive endothelial NO synthase (NOS) in endothelial cell cultures or (2) nifedipine exerts an NO protective effect via its antioxidative properties, as revealed in a cell culture model and with native endothelium from porcine coronary arteries. (ahajournals.org)
  • bioavailability
  • The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered. (google.com)
  • The present invention relates to a solid composition of nifedipine (4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine) and, more particularly, the invention relates to a novel nifedipine-containing solid composition having high bioavailability and small bulk for facilitating the administration thereof. (google.com)
  • Furthermore, because NO is rapidly deactivated by reactive oxygen species (ROS) 20 and the DHPs may act as scavengers as known from different in vitro models, 21 22 23 we also determined the antioxidative potency of nifedipine in endothelial cell cultures as well as in native cells to reveal a potential NO-protection effect as an underlying mechanism of the increased NO bioavailability. (ahajournals.org)
  • basal
  • The hypotensive effect of captopril was highly predictable by basal PRA values, and that of nifedipine by age, while PRA increments induced by captopril were unrelated to those induced by nifedipine. (ahajournals.org)
  • Nifedipine induced a significant time- and concentration-dependent increase (132±47%, 1 μmol/L, 40 minutes' incubation) in the basal NO liberation (oxyhemoglobin assay). (ahajournals.org)
  • However, nifedipine (both short- and long-term treatment) significantly reduced the basal and glucose (20 and 30 mmol/L)-stimulated formation of reactive oxygen species (lucigenin assay) of endothelial cell cultures and native cells. (ahajournals.org)
  • patients
  • The patients will then receive either 25 mg of oral indomethacin every 6 hours for 48 hours, or 20 mg of oral nifedipine every 6 hours for 48 hours. (clinicaltrials.gov)
  • Beta blockers were used prior to enrollment in 13% of patients assigned nifedipine and 21% of patients assigned placebo. (acc.org)
  • Of the 227 patients who were randomly assigned treatment, 112 received nifedipine and 115 placebo. (acc.org)
  • Early treatment with nifedipine in patients with AMI did not appear to reduce infarct size as determined by enzyme level. (acc.org)
  • captopril
  • Captopril plus nifedipine further reduced blood pressure and increased PRA, did not change heart rate, and reduced aldosterone to values similar to those after captopril alone. (ahajournals.org)
  • 3) nifedipine does not influence the aldosterone inhibition induced by captopril. (ahajournals.org)
  • Hemodynamic
  • We studied hemodynamic, renal, and hormonal effects of monotherapy with nifedipine XL (n = 37) in liver transplant recipients within a year after transplant (median, 4.4 months). (ahajournals.org)
  • composition
  • 1. A nifedipine-containing solid composition comprising a coprecipitate (a) of nifedipine and (b) about 1 to 20 times its weight of a member selected from the group consisting of polyvinylpyrrolidone, methylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose. (google.com)
  • placebo
  • Following randomization, the patient will be given either 50 mg oral indomethacin with two pills of placebo, or 3 pills each containing 10 mg oral nifedipine for a total of 30 mg. (clinicaltrials.gov)
  • Nifedipine 10mg sublingually, then 10mg po qid for 6 weeks, or placebo. (acc.org)
  • Infarct size index (CK-MB geq/m 2 ) was 25 +/- 16 (n = 71) in the nifedipine group and 23 +/- 13 (n = 77) in the placebo group (NS). (acc.org)
  • vascular
  • 01). Despite the fall in systemic vascular resistance, glomerular filtration rates were not changed during nifedipine therapy, as measured by both creatinine and iothalamate clearances. (ahajournals.org)
  • Hence, vascular and functional regulation of the kidney was dissociated from the systemic circulation during nifedipine administration after transplantation. (ahajournals.org)
  • group
  • A total of 68.3% of women in the atosiban group remained undelivered at 7 days or more, compared with 64.7% in the nifedipine group. (wikipedia.org)
  • agent
  • Forty-eight (68.6%) women allocated to atosiban and 39 (52%) to nifedipine did not deliver and did not require an alternate agent at 48 hours respectively (P=.03). (wikipedia.org)