• coronary
  • Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. (fpnotebook.com)
  • You should not use nifedipine if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks. (healthbanks.com)
  • Nifedipine is a known material which possesses a coronary dilator activity and is useful for the treatment of so-called angina pectoris attack. (google.com)
  • Regarding to the underlying mechanism, we examined whether (1) nifedipine changed the mRNA and protein levels of the constitutive endothelial NO synthase (NOS) in endothelial cell cultures or (2) nifedipine exerts an NO protective effect via its antioxidative properties, as revealed in a cell culture model and with native endothelium from porcine coronary arteries. (ahajournals.org)
  • bioavailability
  • The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered. (google.com)
  • The present invention relates to a solid composition of nifedipine (4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine) and, more particularly, the invention relates to a novel nifedipine-containing solid composition having high bioavailability and small bulk for facilitating the administration thereof. (google.com)
  • We conclude that the calcium antagonist nifedipine enhances the bioavailability of endothelial NO without significantly altering the NOS (type III) mRNA and protein expression, possibly via an antioxidative protection. (ahajournals.org)
  • Furthermore, because NO is rapidly deactivated by reactive oxygen species (ROS) 20 and the DHPs may act as scavengers as known from different in vitro models, 21 22 23 we also determined the antioxidative potency of nifedipine in endothelial cell cultures as well as in native cells to reveal a potential NO-protection effect as an underlying mechanism of the increased NO bioavailability. (ahajournals.org)
  • pulmonary
  • Data from a limited number of patients studied suggest that nifedipine may be beneficial for the prevention and treatment of high altitude pulmonary edema [Bartsch , [Oelz . (drugs.com)
  • A more recent prospective cross-sectional study demonstrated that nifedipine treatment did not have a beneficial effect when used as an adjunct to descent and oxygen therapy in patients with high altitude pulmonary edema [Deshwal . (drugs.com)
  • Additional trials may be necessary to further define the role of nifedipine in the prevention and treatment of high altitude pulmonary edema. (drugs.com)
  • For prevention, nifedipine should only be considered for those with a prior history of high altitude pulmonary edema (especially multiple episodes). (drugs.com)
  • Nifedipine is also used in high-altitude medicine to treat high altitude pulmonary edema. (wikipedia.org)
  • oral
  • Following randomization, the patient will be given either 50 mg oral indomethacin with two pills of placebo, or 3 pills each containing 10 mg oral nifedipine for a total of 30 mg. (clinicaltrials.gov)
  • The patients will then receive either 25 mg of oral indomethacin every 6 hours for 48 hours, or 20 mg of oral nifedipine every 6 hours for 48 hours. (clinicaltrials.gov)
  • A number of persons have developed toxicity due to acute overdosage with nifedipine, either accidentally or intentionally, and via either oral or parenteral administration. (wikipedia.org)
  • severe
  • Talk to your doctor before using this form of nifedipine if you have galactose intolerance, or severe problems with lactose (milk sugar). (healthbanks.com)
  • basal
  • The hypotensive effect of captopril was highly predictable by basal PRA values, and that of nifedipine by age, while PRA increments induced by captopril were unrelated to those induced by nifedipine. (ahajournals.org)
  • Nifedipine induced a significant time- and concentration-dependent increase (132±47%, 1 μmol/L, 40 minutes' incubation) in the basal NO liberation (oxyhemoglobin assay). (ahajournals.org)
  • However, nifedipine (both short- and long-term treatment) significantly reduced the basal and glucose (20 and 30 mmol/L)-stimulated formation of reactive oxygen species (lucigenin assay) of endothelial cell cultures and native cells. (ahajournals.org)
  • Because patients usually take calcium antagonists for a longer period of time, we investigated whether long-term treatment of endothelial cell cultures with nifedipine may alter the basal endothelial NO release as well as the expression of the constitutive endothelial NO synthase (ecNOS) mRNA and protein. (ahajournals.org)
  • acute
  • Based on the Wilderness Medical Society consensus guidelines for the prevention and treatment of acute altitude illness, the use of nifedipine ER is an effective and recommended option for the prevention and treatment (as an adjunct to descent, oxygen, or portable hyperbaric therapy) of this condition. (drugs.com)
  • Nifedipine found to be more effective as first line treatment for acute fissure. (thefreedictionary.com)
  • calcium channel
  • Based on the American College of Gastroenterology (ACG) guidelines on the diagnosis and management of achalasia , the use of calcium channel blockers, such as nifedipine, may be considered for patients with achalasia who cannot use or refuse more definitive therapies (pneumatic dilation or surgical myotomy) and patients who have failed botulinum toxin injections [ACG [Vaezi . (drugs.com)
  • Nifedipine is in a group of drugs called calcium channel blockers. (healthbanks.com)
  • At least one clinical study suggested that nifedipine, a calcium channel blocker used to treat high blood pressure, may reduce mast cell degranulation in patients with urticaria pigmentosa. (wikipedia.org)
  • captopril
  • Captopril plus nifedipine further reduced blood pressure and increased PRA, did not change heart rate, and reduced aldosterone to values similar to those after captopril alone. (ahajournals.org)
  • 3) nifedipine does not influence the aldosterone inhibition induced by captopril. (ahajournals.org)
  • composition
  • 1. A nifedipine-containing solid composition comprising a coprecipitate (a) of nifedipine and (b) about 1 to 20 times its weight of a member selected from the group consisting of polyvinylpyrrolidone, methylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose. (google.com)