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  • modulate
  • NF-κB signaling is known to modulate activity of WNT and SHH signaling at early stages of hair follicle development, but these roles do not fully account for the phenotypes observed when this pathway is blocked. (biologists.org)
  • active
  • To identify additional NF-κB target genes we developed a novel method to isolate and transcriptionally profile primary hair follicle placodes with active NF-κB signaling. (biologists.org)
  • activity
  • In the epidermis of mice lacking NF-κB activity, initiation of primary hair follicle pre-placode formation is observed, but these primitive structures fail to proliferate and generate placodes. (biologists.org)
  • genes
  • Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). (uniprot.org)
  • Given the role of NF-κB-related genes in cell proliferation, invasiveness, angiogenesis and inflammation, we postulated that they might be deregulated in IBC. (pubmedcentralcanada.ca)
  • We measured the mRNA expression levels of 60 NF-κB-related genes by using real-time quantitative RT-PCR in a well-defined series of 35 IBCs, by comparison with 22 stage IIB and III non inflammatory breast cancers. (pubmedcentralcanada.ca)
  • Thirty-five (58%) of the 60 NF-κB-related genes were significantly upregulated in IBC compared with non IBC. (pubmedcentralcanada.ca)
  • We identified a five-gene molecular signature that matched patient outcomes, consisting of IL8 and VEGF plus three NF-κB-unrelated genes that we had previously identified as prognostic markers in the same series of IBC. (pubmedcentralcanada.ca)
  • Some upregulated NF-κB-related genes might serve as novel therapeutic targets in IBC. (pubmedcentralcanada.ca)
  • These 109 genes, some of which were NF-κB-related, were mainly associated with signal transduction, cell motility, invasion, angiogenesis and local inflammatory processes. (pubmedcentralcanada.ca)
  • Another genome-wide expression profiling study comparing 16 IBCs with 18 non stage-matched non IBCs identified a large number of overexpressed NF-κB-related genes [ 10 ]. (pubmedcentralcanada.ca)
  • Following cardiopulmonary bypass (CPB) and cardiac global ischemia and reperfusion, proinflammatory genes are up-regulated, and nuclear factor (NF)-kappaB is involved in this regulation. (semanticscholar.org)
  • In the presence of the NBD peptide, the IKK complex remains inactive and IκBα sequesters NF-κB dimers in the cytoplasm inhibiting transcription of NF-κB responsive genes. (wikipedia.org)
  • These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). (wikipedia.org)
  • gene
  • In gene transfer studies, we identify two high affinity NF-kappa B-binding sites, kappa B1 (located at -872 to -861 nucleotides) and kappa B2 (-106 to -96 nucleotides), and although both bind with high affinity to Rel A, only kappa B2 is required for NF-kappa B-dependent induction of the native BCL-3 promoter. (uniprot.org)
  • our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. (nih.gov)
  • inhibitors
  • Reporting in Molecular Cancer Therapeutics , the researchers found that inhibitors of NF-kappa B not only protected against radiation toxicity when given before exposure to treatment, but also lessened the radiation toxicity when given one to two hours post-exposure. (medicalxpress.com)
  • In the study, both NF-kappa B inhibitors and proteasome inhibitors were examined for their potential to alleviate the negative effects of radiation. (medicalxpress.com)
  • Although proteasome inhibitors demonstrate activity against NF-kappa B, they also target many other pathways," said Ulrich Rodeck, M.D., Ph.D., professor of Dermatology and Cutaneous Biology at Jefferson Medical College of Thomas Jefferson University. (medicalxpress.com)
  • The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells. (biomedsearch.com)
  • regulates
  • Thus, here, we tested whether the ubiquitous transcription factor NF-κB, which regulates myogenic differentiation and is also a promising therapeutic target in the treatment of other types of tumors, might be an interesting candidate for the development of novel rhabdomyosarcoma treatment strategies. (biomedsearch.com)
  • DDRGK1 regulates NF-?B activity by modulating I?B? (nih.gov)
  • bind
  • However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. (nih.gov)
  • In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning. (wikipedia.org)
  • tumor
  • Two observations are interpreted to indicate that bcl-3 is transactivated by NF-kappa B/Rel A: 1) expression of a dominant negative NF-kappa B inhibitor blocks tumor necrosis factor-alpha-induced BCL-3 expression and 2) expression of constitutively active Rel A is sufficient to induce BCL-3 expression. (uniprot.org)
  • IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-?B-mediated signalling. (nih.gov)
  • stimuli
  • NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (lsbio.com)
  • activate
  • TL1A and DR3 activate NF-κB in vascular endothelial cells, and can be an important regulator of renal interstitial vascular injury. (biomedcentral.com)
  • Since IKBKG helps activate NF-κB, which protects cells against TNF-alpha induced apoptosis, a lack of IKBKG (and hence a lack of active NF-κB) makes cells more prone to apoptosis. (wikipedia.org)
  • inhibitory
  • Together, these data suggest the presence of an NF-kappa B-BCL-3 autoregulatory loop important in terminating NF-kappa B1 action and that individual NF-kappa B isoforms are actively terminated through coordinate induction of inhibitory I kappa B molecules to restore cellular homeostasis. (uniprot.org)
  • While NF-κB inhibitory drugs have previously been attractive to disease such as chronic inflammation and diabetes, specific cancers have been shown to have constitutive NF-κB activity. (wikipedia.org)
  • Despite the potential for NBD peptide as a viable NF- κB inhibitory drug, disadvantages arise because of its peptide form. (wikipedia.org)
  • inflammatory
  • Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, Fullerton DA, Meng X. Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-?B pathway. (ucdenver.edu)
  • curcumin
  • However, after treatment of the cells with two different small-molecule NF-κB-inhibiting compounds, the IKK inhibitor curcumin and the proteasome inhibitor lactacystin, we found that neither curcumin nor lactacystin promoted myogenic differentiation in either normal myoblasts or rhabdomyosarcoma cells. (biomedsearch.com)