Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. (elifesciences.org)
Encoded by the ASAH2 gene2
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. (wikipedia.org)
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. (musc.edu)
Acid3
This study provides evidence that murine acid ceramidase (Ac) is required for normal erythropoiesis and the development of rodent malaria. (elifesciences.org)
Palmitic acid is a very hydrophobic molecule, practically insoluble in water and relatively neutral. (foodb.ca)
Acid and neutral sphingomyelinases: roles and mechanisms of regulation. (musc.edu)
Murine1
Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. (musc.edu)
Sphingomyelinase2
GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS. (musc.edu)
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. (musc.edu)
Mice2
Neutral- Ceramidase (N-CDase) nude mice do not have significant phenotype, even the N-CDase nude MEFs only show around 10% weak cytotoxic toleration as compared to wild type MEFs by FACS analysis (unpublished data), whereas Drosophila N-CDase knockout is lethal [4]. (symbiosisonlinepublishing.com)
Quantification of renal cysts Kidneys were eliminated from control mice at 12?weeks of age, fixed in 10% neutral buffered formalin and bisected before handling and paraffin embedding. (immune-source.com)
Note1
Footnotes Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. (angiogenesis-blog.com)
Basic2
Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function. (nih.gov)
The type IIcytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratinchains coexpressed during differentiation of simple and stratified epithelial tissues. (thebiotechdictionary.com)
Enzyme5
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. (wikipedia.org)
4. Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (nih.gov)
The enzyme neutral ceramidase (nCDase) is a zinc-containing hydrolase and mediates the metabolism of ceramide to sphingosine (Sph), both in cells and in the intestinal lumen. (bvsalud.org)
Farber's disease is caused by the deficiency of the enzyme called ceramidase. (nih.gov)
To elucidate the mechanisms that are involved in the decrease of ceramide levels in atopic dry skin and in aged skin, we examined both the activities of beta-glucocerebrosidase, which is a major enzyme in ceramide production, and of ceramidase, which is an essential enzyme in ceramide degradation, in the stratum corneum of atopic dry skin and aged skin. (medicaljournals.se)
10. Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. (nih.gov)
14. Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. (nih.gov)
15. Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls. (nih.gov)
19. Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. (nih.gov)
A majority of small molecule nCDase inhibitors contained pharmacophores capable of zinc interaction but retained specificity for nCDase over zinc-containing acid and alkaline ceramidases, as well as matrix metalloprotease-3 and histone deacetylase-1. (bvsalud.org)
HN - 2009 MH - Alkaline Ceramidase UI - D055574 MN - D8.811.277.87.250.300 MS - A ceramidase subtype that is active at alkaline pH. (nih.gov)
Mitochondrial ceramidase1
16. Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase. (nih.gov)
1.231
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. (utsouthwestern.edu)
Sphingosine1
1. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (nih.gov)
The induced expression of ATGL leads to increased lipolysis and a decrease in lipid droplet content and bioavailability of neutral lipid. (biomedcentral.com)
Production1
To achieve carbon-neutral RA production based on photosynthesis without the supply of organic carbon, microalgae could be a good biological material. (cell-metabolism.com)
Disease1
3. Ceramidases, roles in sphingolipid metabolism and in health and disease. (nih.gov)