AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation SciencePublication Characteristics
Neurotransmitter AgentsAlanineAlanine TransaminaseMolecular Sequence DataAlanine RacemaseNeurotransmitter Transport ProteinsAmino Acid SequenceInterleukin-1betaMutationPlasma Membrane Neurotransmitter Transport ProteinsReceptors, NeurotransmitterKineticsBase Sequencebeta 2-MicroglobulinGlutamic AcidBiosynthetic PathwaysSynaptic VesiclesSynaptic TransmissionNeuronsAlanine DehydrogenaseCells, CulturedCloning, MolecularReceptors, Adrenergic, betagamma-Aminobutyric AcidSequence Homology, Amino AcidEscherichia coliBinding SitesRecombinant ProteinsRNA, MessengerCell LineIntegrin beta3Presynaptic TerminalsBacterial ProteinsMutagenesis, Site-DirectedStreptomycesBrainAmino AcidsSignal TransductionModels, MolecularSynapsesNerve Tissue ProteinsGlycineSerotoninMultigene FamilyTime FactorsRats, Sprague-DawleySubstrate SpecificityDopamineSequence AlignmentCalciumDose-Response Relationship, DrugModels, BiologicalTransforming Growth Factor betaChromatography, High Pressure LiquidExocytosisLiverMembrane ProteinsProtein ConformationMolecular StructureGenes, BacterialProtein BiosynthesisMagnetic Resonance SpectroscopySynapsinsCarrier ProteinsAmino Acid SubstitutionStructure-Activity RelationshipProtein Structure, TertiaryProtein BindingGene ExpressionTransfectionPhosphorylationNeuromuscular JunctionCell MembraneGABA Plasma Membrane Transport ProteinsSynaptotagmin IDNA PrimersGene Expression RegulationGlutamineMice, Inbred C57BLGlutamatesPhenotypeGenetic Complementation TestTranscription, GeneticMice, KnockoutPatch-Clamp TechniquesTransaminasesAcetylcholineNorepinephrineIntegrin alpha5beta1Rats, WistarIntegrin beta4Gene Expression Regulation, PlantBiological TransportSynaptosomesRecombinant Fusion ProteinsElectric StimulationAspartic AcidCatalysisDNA, ComplementaryIntegrin alpha6beta4
Supplementing with carnosineNitric oxideSupplementationPrecursorInhibitoryProteinsCarnosineCognitiveGlycineParaesthesiaSerotoninPEPTIDESCaffeineArginineNervous systemRegulateMetabolismConcentrationsDoseSubstrateAppetiteEnduranceIngredientImportantCreatinePerformanceBrainShownEnergyPhysicalHighBodyProvideBuildGoodProductResponse
Supplementing with carnosine2
  • Simply supplementing with carnosine is not as effective as supplementing with β-alanine alone since carnosine, when taken orally, is broken down during digestion to its components, histidine and β-alanine. (wikipedia.org)
  • Studies have shown that beta alanine supplementation is more effective at increasing carnosine levels than supplementing with carnosine alone. (supplementschester.co.uk)
Nitric oxide2
  • Studies show that agmatine has cardio-protective and supportive benefits through (among other actions) its impact on nitric oxide regulation, neuroprotective benefits through its role as a modulator and supportive agent for neurotransmitters, and cognitive/mood-supporting benefits through its combined influences on nitric oxide synthesis and neurotransmitter modulation. (infinitelabs.com)
  • The place L-arginine is the first substrate for nitric oxide biosynthesis. (kudratgamic.com)
Supplementation4
  • Supplementation with β-alanine has been shown to increase the concentration of carnosine in muscles, decrease fatigue in athletes, and increase total muscular work done. (wikipedia.org)
  • There is evidence that β-alanine supplementation can increase exercise and cognitive performance, for some sporting modalities, and exercises within a 0.5-10 min time frame. (wikipedia.org)
  • Beta Alanine is an incredibly well researched ingredient and studies have shown 3200mg of Beta Alanine supplementation can help reduce fatigue and significantly increase endurance. (supplementschester.co.uk)
  • This suggests that during high-intensity exercise, L-citrulline supplementation may support the total amount of work performed. (infinitelabs.com)
Precursor4
  • β-Alanine is the rate-limiting precursor of carnosine, which is to say carnosine levels are limited by the amount of available β-alanine, not histidine. (wikipedia.org)
  • 5-HTP is one step closer to serotonin t 5 Hydroxytryptophan is a derivative of the amino acid tryptophan and a precursor to the neurotransmitter serotonin, which is a key regulator of mood, sleep, and appetite. (thewellnessadvocate.com)
  • 5-HTP is a direct precursor of the important inhibitory neurotransmitter serotonin. (thewellnessadvocate.com)
  • l -DOPA is the precursor to the neurotransmitters dopamine , norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines . (cloudfront.net)
Inhibitory1
Proteins4
  • Because β-alanine dipeptides are not incorporated into proteins, they can be stored at relatively high concentrations. (wikipedia.org)
  • The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS . (lookformedical.com)
  • L-glutamic acid (abbreviated Glu or E), also referred to as glutamate (the anion), is a non-essential amino acid, one of the 20 amino acids used in the biosynthesis of proteins. (foodb.ca)
  • The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
Carnosine5
  • In terms of its biosynthesis, it is formed by the degradation of dihydrouracil and carnosine. (wikipedia.org)
  • It is a component of the peptides carnosine and anserine and also of pantothenic acid (vitamin B5), which itself is a component of coenzyme A. β-alanine is metabolized into acetic acid. (wikipedia.org)
  • β-alanine is converted within muscle cells into carnosine, which acts as a buffer for the lactic acid produced during high-intensity exercises, and helps delay the onset of neuromuscular fatigue. (wikipedia.org)
  • Beta alanine is more bioavailable than carnosine so is more effective at elevating carnosine levels in your muscles. (supplementschester.co.uk)
  • This ingredient may help cut back muscle fatigue and enhance work capability by growing carnosine ranges. (kudratgamic.com)
Cognitive2
  • This work was designed to examine the effects of Afobazole on cognitive rigidity in BALB/c mice. (epiphanyasd.com)
  • However, Sigma1R receptors regulate cognitive processes under disturbed neurotransmitter balance only. (epiphanyasd.com)
Glycine1
  • β-alanine has five known receptor sites, including GABA-A, GABA-C a co-agonist site (with glycine) on NMDA receptors, the aforementioned GlyR site, and blockade of GAT protein-mediated glial GABA uptake, making it a putative "small molecule neurotransmitter. (wikipedia.org)
Paraesthesia2
  • Ingestion of β-alanine can cause paraesthesia, reported as a tingling sensation, in a dose-dependent fashion. (wikipedia.org)
  • If you're not used to supplementing with beta alanine please be aware of the 'tingling' (paraesthesia) sensation. (supplementschester.co.uk)
Serotonin2
  • a natural legume that is high in the neurotransmitter L-Dopa as well as trace amounts of serotonin. (thebestzeolite.com)
  • 5 HTP ( 5-hydroxy-l-tryptophan, 5-hydroxytryptophan ) 5-HTP (5-Hydroxytryptophan) is an amino acid that is the intermediate step between tryptophan and the important neurotransmitter serotonin, an important neurotransmitter that helps regulate appetite, mood and sleep. (thewellnessadvocate.com)
PEPTIDES1
Caffeine2
  • We included CarnoSyn® beta-alanine, to provide you muscle energy and endurance - along with the caffeine in our Drive™ energy blend. (tigerfitness.com)
  • One of the active ingredients often mentioned as a candidate for interactions with caffeine is the beta-amino acid, taurine. (researchgate.net)
Arginine1
  • Agmatine biosynthesis by arginine decarboxylation is well positioned to compete with the principal arginine-dependent pathways, namely: Nitrogen metabolism (urea cycle), polyamine and NO synthesis, as well as protein synthesis. (infinitelabs.com)
Nervous system2
  • Alanine ( 2-aminopropanoic acid, l-Alanine ) Alanine is a non essential amino acid, important for the metabolism of tryptophan and pyridoxine and as a source of energy for muscle tissue and nervous system. (thewellnessadvocate.com)
  • Glutamate is the most abundant fast excitatory neurotransmitter in the mammalian nervous system. (foodb.ca)
Regulate1
  • We have used key ingredients in each of our products that have been shown to work synergistically to help lower blood pressure, improve blood flow, regulate the heart rate and boost energy production. (cardiostrong.co)
Metabolism4
  • It not only supports the pump that will flood the targeted muscle with blood, and essentially, nutrients, but it may also assists with insulin sensitivity and glucose metabolism, and may support secretion of beta-endorphin (which is essentially a 'feel-good' neurotransmitter). (infinitelabs.com)
  • Alanine strengthens the immune system by producing antibodies, and helps in the metabolism of sugars and organic acids. (thewellnessadvocate.com)
  • We incorporated measures of mitochondrial oxidative stress (mtOx) and oxygen consumption rate (mtOCR) with TMWAS of cells with varied manganese (Mn) concentration and found that adverse neuroinflammatory signaling and fatty acid metabolism were connected to mtOx, while beneficial ion transport and neurotransmitter metabolism were connected to mtOCR. (emory.edu)
  • Copper enzymes are important in the Significance biosynthesis of natural products, hormones and neurotrans- mitters, proton pumping for adenosine triphosphate synthesis, The bioinorganic chemistry of copper is currently confined to a and the metabolism of iron and copper (1, 2). (docslib.org)
Concentrations1
Dose3
  • Hence, by weight, only about 40% of the dose is available as β-alanine. (wikipedia.org)
  • The medical dose vary for beta alanine is 2-5g, so a dosage of three.2g per scoop could also be intense for people who don't like that sensation. (kudratgamic.com)
  • More importantly, 3e lacked acute toxicity in mice even at high dose (2500 mg/kg, P.O.). CONCLUSION: This work indicated that compound 3e with a six-carbon atom linker and a piperidine moiety at terminal position was a promising candidate and was worthy of further study. (inrae.fr)
Substrate1
  • The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide. (lookformedical.com)
Appetite1
  • The ingredients of TrimScience™ aid in weight management by burning fat (thermogenesis), blocking carbohydrate absorption (alpha-amylase inhibition), preventing the creation of new fat (lipid biosynthesis), appetite suppression (satiety) and systemic detoxification, including removal of obesogens. (thebestzeolite.com)
Endurance1
  • Following beta alanine on the label is one other endurance assist, betaine, which is at 2.5g per scoop. (kudratgamic.com)
Ingredient2
  • The subsequent ingredient is beta alanine, which is likely one of the hottest elements in pre exercises. (kudratgamic.com)
  • This creates somewhat of a cascading , "trickle-down" effect - for example, an ingredient taken in Pre-Kaged is still working when more of it comes via Intra-Kaged. (priceplow.com)
Important3
  • Aside from this, no important adverse effect of β-alanine has been reported, however, there is also no information on the effects of its long-term usage or its safety in combination with other supplements, and caution on its use has been advised. (wikipedia.org)
  • Our comprehensive blend of important vitamins work in concert to help promote energy generation for cells, better immunity, stronger bones and improved cellular and nerve function. (cardiostrong.co)
  • Alanine is an important cofactor in the storage of energy from the body's Kreb cycle. (thewellnessadvocate.com)
Creatine1
Performance2
  • Simply speaking supplementing with Beta alanine can yield higher repetitions and superior performance in the gym. (supplementschester.co.uk)
  • Ingredients have been carefully selected to work in concert to help boost performance and deliver maximum benefit during your athletic endeavor. (cardiostrong.co)
Brain1
Shown1
  • Isolated, perfused hearts from rats that were fed the ketone diet had greater free energy available from ATP hydrolysis during increased work than did hearts from rats on the other diets as shown by using [ 31 P]-NMR spectroscopy. (epiphanyasd.com)
Energy1
Physical1
  • Agmatine is a neurotransmitter that works in a variety of ways to support mental and physical health. (infinitelabs.com)
High1
  • Excitotoxicity occurs when neurons are exposed to high levels of glutamate or other neurotransmitters, causing persistent activation of the and Œ±-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors and voltage-gated calcium channels. (foodb.ca)
Body1
  • β-Alanine ethyl ester is the ethyl ester which hydrolyses within the body to form β-alanine. (wikipedia.org)
Provide1
  • The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. (mdpi.com)
Build1
  • This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. (bmj.com)
Good1
Product1
  • The first commercial product was developed based on the work of researchers at Oxford University in the UK, but the resulting product cannot legally be sold in the UK. (epiphanyasd.com)
Response1
  • These changes encompass a coordinated response involving lipolysis, beta-oxidation, and the citric acid cycle, required for the production of energetic molecules such as ATP, NADH, NADPH, and FADH. (bvsalud.org)