• Aside from causing movement disorders, cognitive deterioration and dysfunction of the autonomic nervous system, neurotoxicity has also been shown to be a major contributor to progressive neurological disorders such as Alzheimer's disease. (news-medical.net)
  • One agent, reserpine, was used to assess developmental neurotoxicity and administered prenatally, while the other, MDMA, was used in the adult animal. (erowid.org)
  • There is a need for novel and innovative approaches including New Approach Methodologies (NAMs) that can provide effective ways to address current challenges and gaps in the assessment of Developmental Neurotoxicity (DNT). (nih.gov)
  • The strong parallels with established models endorse the zebrafish's relevance for mechanistic studies of EtOH's developmental neurotoxicity. (oregonstate.edu)
  • There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. (uu.nl)
  • Since models are limited to study the mechanism of the neurotoxicity of tranylcypromine, here we utilized an in vitro brain organoid culture system which mimics neurogenesis experimentally to investigate the mechanisms by studying the effect of brain development of tranylcypromine and monitoring the brain damage of different concentrations. (frontiersin.org)
  • An in vitro 3D brain microtissue model with improved longevity and better recapitulation of in vivo cellular physiology in combination with an automated multiparametric HCI and a cytotoxicity assay presents a viable screening strategy for the accurate in vivo relevant detection of novel therapeutics with neurotoxicity potential early in drug development. (cyprotex.com)
  • Some of the most common naturally occurring brain toxins that lead to neurotoxicity as a result of long term drug use are amyloid beta (Aβ), glutamate, dopamine, and oxygen radicals. (wikipedia.org)
  • The present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (DA) neurotoxicity in baboons and to ascertain whether positron emission tomography (PET) imaging with the DA transporter (DAT) ligand [ 11 C]WIN-35,428 ([ 11 C]2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) could be used to detect methamphetamine-induced DAT loss in living primates. (jneurosci.org)
  • citation needed] The presence of neurocognitive deficits alone is not usually considered sufficient evidence of neurotoxicity, as many substances may impair neurocognitive performance without resulting in the death of neurons. (wikipedia.org)
  • TY - JOUR T1 - Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents. (unboundmedicine.com)
  • 2014) Multiparametric high content analysis for assessment of neurotoxicity in differentiated neuronal cell lines and human embryonic stem cell-derived neurons. (cyprotex.com)
  • Regulation of Amyloid ß Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex. (bvsalud.org)
  • At present, the mechanism of neurotoxicity caused by immunotherapy has not been completely elucidated. (hindawi.com)
  • This discovery may potentially be the cause for neurotoxicity in patients undergoing CD19 directed CAR T cell immunotherapy, according to the research team led by Avery Posey, PhD, an assistant professor of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine at the University of Pennsylvania and Research Health Science Specialist at the Corporal Michael J. Crescenz VA Medical Center in Philadelphia, PA. (technologynetworks.com)
  • Chronic mold exposure in homes can lead to neurotoxicity which may not appear for months to years of exposure. (wikipedia.org)
  • Other conditions that may develop as a result of neurotoxicity include chronic fatigue syndrome, attention deficit hyperactivity disorder, chronic sinusitis and asthma that does not respond to therapies. (news-medical.net)
  • Organophosphorus ester-induced chronic neurotoxicity (OPICN) - also called chronic organophosphate-induced neuropsychiatric disorder (COPIND) - is a set of long-term, persistent, chronic neuropsychiatric findings that some have attributed to cholinesterase inhibitor toxicity. (cdc.gov)
  • There is a great deal of debate surrounding the subject of Organophosphorus ester-induced chronic neurotoxicity (OPICN). (cdc.gov)
  • PIPN includes acute neurotoxicity restricted to oxaliplatin, and chronic non-length-dependent sensory neuronopathy with positive and negative sensory symptoms and neuropathic pain in both upper and lower limbs. (iasp-pain.org)
  • 1998). Chronic organic solvent neurotoxicity. (bvsalud.org)
  • Some examples of toxins that occur naturally in the brain and can lead to neurotoxicity include oxygen radicals, beta amyloid and glutamate. (news-medical.net)
  • Several studies suggest that MDMA-induced acute toxicity and long-term neurotoxicity is dependent on the metabolic disposition of MDMA. (nih.gov)
  • There are indications that a glutathione metabolite of alpha-MeDA and/or 3,4-dihydroxymethamphetamine may be responsible for the neurotoxicity and some of the behavioural effects produced by MDMA and/or MDA. (mdma.net)
  • Studies have shown that acute neurotoxicity is similar for human and laboratory animal exposures and is characterized by narcosis, anesthesia, central nervous system depression, respiratory arrest, loss of consciousness and death. (cdc.gov)
  • Despite the prior identification of acrylamide as neurotoxic in animals, its neurotoxicity in humans was first recognized in the 1950s, when several Japanese workers involved in a pilot production project developed peripheral neuropathy. (cdc.gov)
  • Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. (wikipedia.org)
  • The term neurotoxicity refers to damage to the brain or peripheral nervous system caused by exposure to natural or man-made toxic substances. (news-medical.net)
  • Toxic neuropathies: chemotherapy-induced peripheral neurotoxicity. (iasp-pain.org)
  • Platinum-induced peripheral neurotoxicity: From pathogenesis to treatment. (iasp-pain.org)
  • Platinum-induced peripheral neurotoxicity (PIPN) is a common side effect of platinum-based chemotherapy that may cause dose reduction and discontinuation, with oxaliplatin being more neurotoxic. (iasp-pain.org)
  • Here we describe the syndrome of irreversible lithium-effectuated neurotoxicity in a patient within therapeutic doses and levels, which persisted after discontinuation of Lithium. (physiciansweekly.com)
  • In the absence of predisposing factors, Lithium has resulted in neurotoxicity at therapeutic doses and levels. (physiciansweekly.com)
  • citation needed] Amyloid beta (Aβ) was found to cause neurotoxicity and cell death in the brain when present in high concentrations. (wikipedia.org)
  • Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)
  • These findings suggest that (R)-ketamine can protect against MPTP-induced neurotoxicity in the mouse brain via TrkB activation. (unboundmedicine.com)
  • Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. (snacc.org)
  • The researchers' discovery of CD19 molecules in the brain provides evidence that this increase in neurotoxicity is due to CD19-directed CAR T cell immunotherapies. (technologynetworks.com)
  • Brain malfunction (encephalopathy) is fairly common with neurotoxicity but is generally mild and rarely lasts more than a few days. (neurology-clinics.com)
  • Detect neurotoxicity of novel therapeutics with enhanced in vivo relevance using Cyprotex's 3D brain microtissue combined with high content imaging (HCI) end points. (cyprotex.com)
  • The prevalence of adverse neurotoxic reactions of the brain in response to drugs or environmental hazards continues to prompt the development of novel cell-based assays for accurate neurotoxicity prediction 1 . (cyprotex.com)
  • Neurotoxicity prediction of 10 reference compounds categorised according to literature data and normalized to total plasma C max in immature and matured brain microtissues. (cyprotex.com)
  • Utilising the 3D neurotoxicity assay approach 80% of reference compound toxicities were correctly predicted within a 100x C max cut off with a 336 hour exposure period in both immature and matured brain microtissues. (cyprotex.com)
  • The treatment approach to neurotoxicity is elimination or reduction of the toxic substance and therapy to relieve symptoms or provide support. (news-medical.net)
  • As most evidence for household mold causing neurological symptoms due to supposed neurotoxicity is anecdotal, more research is needed. (neurology-clinics.com)
  • Depending on the source of neurotoxicity, signs and symptoms may be short- or long-lasting. (neurology-clinics.com)
  • Symptoms usually include stiffness, hypersensitive reflexes, and poor coordination, and recovery from this type of neurotoxicity is usually possible (though slow). (neurology-clinics.com)
  • Clinically, symptoms and signs of neurotoxicity can be diverse. (cdc.gov)
  • These neurochemical biomarkers can be correlated with neuropathological and behavioral biomarkers to aid in the understanding of mechanisms of neurotoxicity. (erowid.org)
  • Our commentary also highlights potential targets for further investigations into the mechanisms which underpin La-induced neurotoxicity, with a focus on the crucial role of the hippocampus. (gla.ac.uk)
  • 1987). Organic solvent neurotoxicity. (cdc.gov)
  • Neurotoxicity can result from organ transplants, radiation treatment, certain drug therapies, recreational drug use, exposure to heavy metals, bites from certain species of venomous snakes, pesticides, certain industrial cleaning solvents, fuels and certain naturally occurring substances. (wikipedia.org)
  • The outcome of neurotoxicity depends on the duration and extent of exposure to the toxic substance, as well as the degree of neural damage. (news-medical.net)
  • An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats. (fluoridealert.org)
  • The purpose of the present study was to determine the neuroprotective potential of pomegranate juice on Al induced neurotoxicity. (researchgate.net)
  • Some of the effects of neurotoxicity may appear immediately, while others can take months or years to manifest. (news-medical.net)
  • The timely and accurate identification of neurotoxicity helps clinicians detect and treat these complications early, thereby enhancing treatment efficiency and improving the prognosis of patients. (hindawi.com)
  • Dark soy sauce has a protective effect against acrylamide-induced neurotoxicity in rats by antioxidative activity. (greenmedinfo.com)
  • Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? (gla.ac.uk)
  • Zarros, A. , Byrne, A.-M. , Boomkamp, S.D. , Tsakiris, S. and Baillie, G.S. (2013) Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? (gla.ac.uk)
  • His team sought to investigate the higher incidence of neurotoxicity in CD19-directed immunotherapies, compared to treatments targeting other B cell proteins, such as CD20. (technologynetworks.com)
  • Neurotoxic disorders are on the NIOSH list of Ten Leading Work-Related Diseases and Injuries because of their potential severity--as exemplified by the neurotoxicity of chlordecone--and because of the large number of workers potentially at risk. (cdc.gov)
  • Our work has revealed that there is CD19 expression in a subset of cells that are, one, not B cells, and two, potentially related to the neurotoxicity we observe in patients treated with CAR T cell therapy targeting CD19," Posey said. (technologynetworks.com)
  • When we treated the mouse model with CAR T cells targeting the mouse version of CD19, we found what looks like the start of neurotoxicities," Posey said. (technologynetworks.com)
  • The effects of neurotoxicity depends on various different factors such as the characteristics of the neurotoxin, the dose a person has been exposed to, ability to metabolise and excrete the toxin, the ability of affected mechanism and structures to recover and how vulnerable a cellular target is. (news-medical.net)
  • For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
  • Some examples of therapies used in the treatment of neurotoxicity include massage, exercise and immune modulaiton. (news-medical.net)
  • 2009) A neuronal and astrocyte co-culture assay for high content analysis of neurotoxicity. (cyprotex.com)
  • An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. (oregonstate.edu)
  • In these studies, we examined the effectiveness of creatine therapy on models of Mn neurotoxicity. (uncg.edu)