Neuroprotective cells rotenone. Medical search. Frequent questions

Furthermore, inhibition of NADPH oxidase or scavenging of superoxide significantly reduced the rotenone-induced neurotoxicity. (jneurosci.org)
A high concentration of CBDA reduced the rotenone-induced neurotoxicity. (veterinarycannabissociety.org)

The present investigation was an attempt to study the effect of low molecular weight sulfated chitosan (LMWSC) on in vitro rotenone model of Parkinson's disease (PD) by evaluating cell viability, oxidative stress, mitochondrial membrane potential, DNA fragmentation, and apoptosis. (elsevierpure.com)
Scientific Reports] Researchers investigated the neuroprotective potential of 4-octyl itaconate, a cell-permeable derivative of itaconate, in cellular models of Parkinson's disease. (stemcellsciencenews.com)
and 5) viral-mediated delivery of Nrf2 and/or transplantation of Nrf2 overexpressing progenitor cells into animal models of Alzheimer's Disease, ALS, Huntington's Disease and Parkinson's Disease. (wisc.edu)
Transcriptional control of neuroprotective genes and prevention of neurodegeneration in Parkinson's, Alzheimer's, Huntington's and neuromuscular disease. (wisc.edu)
His lab utilizes a combined approach of molecular genetics, pharmacology, biochemistry, cell and developmental biology to understand the role of gene-environment interactions between metal exposure and neurodevelopmental and neurodegenerative diseases including Parkinson's Disease, Alzheimer's Disease and Huntington's Disease. (purdue.edu)
Since rodent models cannot recapitulate many of the human disease features, human induced pluripotent stem cells derived from Parkinson's patients have been used to generate brain organoids, greatly contributing to our understanding of the disease pathophysiology. (nature.com)
To understand the multifaced aspects of Parkinson's disease, it may be desirable to expand the complexity of these models, to include different brain regions, vasculature, immune cells as well as additional diverse organ-specific organoids such as gut and intestine. (nature.com)
Parkinson's disease develops because the cell membrane in the brain's dopamine-producing cells is destroyed by a small naturally occurring protein - alpha-synuclein. (sciencenews.dk)
Baicalein is a small molecule that prevents the small, unstable protein alpha-synuclein from misfolding and accumulating in clusters and clumps that destroy brain cells and can lead to Parkinson's disease. (sciencenews.dk)
The clusters of alpha-synuclein interact with many proteins in the cell and thereby create many problems for people with Parkinson's disease. (sciencenews.dk)
As part of the study, the group also carried out research on mice exposed to Parkinson's disease via the pesticide rotenone and showed that baicalein is neuroprotective in animals. (sciencenews.dk)
Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson's Disease. (bmbreports.org)
A study investigated the potential neuroprotective effects of Pyrroloquinoline quinone (PQQ) in a rotenone-induced (rotenone is a pesticide that has been shown to cause degeneration of dopaminergic neurons and is often used as a model for Parkinson's Disease) PD model. (rcd.bio)

Incubation of SH-SY5Y cells with 100 nm rotenone resulted in neuronal cell death, redox imbalanced mitochondrial dysfunction, DNA fragmentation, condensation, and apoptotic cellular morphology. (elsevierpure.com)
Reduction of the intracellular reactive oxygen species (ROS) levels ensued due to pretreatment of LMWSC along with consequent normalization of antioxidant enzymes, mitigation of rotenone induced mitochondrial dysfunction and apoptosis. (elsevierpure.com)
The ability of CBD and CBG to attenuate the neurotoxicity induced by two insults involving oxidative stress (hydrogen peroxide, H2O2) and mitochondrial dysfunction (rotenone) was evaluated in neural cell cultures. (veterinarycannabissociety.org)

Our current findings suggested that LMWSC exhibit the pronounced neuroprotective effects, which could be due to its antioxidant, mitochondrial protection, and anti-apoptotic properties. (elsevierpure.com)

Although little neurotoxicity was detected in neuron-enriched cultures after treatment for 8 d with up to 20 n m rotenone, significant and selective dopaminergic neurodegeneration was observed in neuron/glia cultures 2 d after treatment with 20 n m rotenone or 8 d after treatment with 1 n m rotenone. (jneurosci.org)
however, both compounds were more effective in attenuating the rotenone-induced neurotoxicity. (veterinarycannabissociety.org)
Tamoxifen eliminates estrogen's neuroprotective effect upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system. (omeka.net)
Neuroprotective Effect of Stearidonic Acid on Amyloid β-Induced Neurotoxicity in Rat Hippocampal Cells. (bmbreports.org)

The greatly enhanced neurodegenerative ability of rotenone was attributed to the presence of glia, especially microglia, because the addition of microglia to neuron-enriched cultures markedly increased their susceptibility to rotenone. (jneurosci.org)
Previous preclinical studies have demonstrated that cannabidiol (CBD) and cannabigerol (CBG), two non-psychotomimetic phytocannabinoids from Cannabis sativa, induce neuroprotective effects on toxic and neurodegenerative processes. (veterinarycannabissociety.org)
and studies have got confirmed that lithium provides neuroprotective results in a variety of neurodegenerative illnesses. (academicediting.org)
Early clinical trials stemming from basic science research are performed in the Imperial College Ophthalmology Research Group (ICORG) Clinical Trials Unit, and the aims of this work are to establish new methods of diagnosis of early disease to avoid disability, identify early markers of cell processes in neurodegenerative disease and investigate therapeutic approaches including novel modes of drug delivery and improved treatment strategies. (imperial.ac.uk)

mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mitochondrial complex I. However, the role of microglia, the resident brain immune cells in rotenone-induced neurodegeneration, has not been reported. (jneurosci.org)
Using primary neuron-enriched and neuron/glia cultures from the rat mesencephalon, we discovered an extraordinary feature for rotenone-induced degeneration of cultured dopaminergic neurons. (jneurosci.org)
This is the first report demonstrating that microglia play a pivotal role in rotenone-induced degeneration of dopaminergic neurons. (jneurosci.org)
reported that chronic administration of a common herbicide, rotenone, resulted in a selective destruction of the nigrostriatal dopaminergic system, formation of cytoplasmic inclusions in nigral neurons, and induction of hypokinesia and rigidity in rats, reproducing the key features of human PD. (jneurosci.org)
Purpose: In this narrative review, we attempt to link research findings concerning the hormetic relationship between neurons and germ cells, and translate these findings into clinically relevant concepts. (mdpi.com)
Nature Communications] Scientists systematically identified over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains and non-neuronal cells using ultra-deep, total RNA sequencing. (stemcellsciencenews.com)
Cell & Bioscience] To model the mechanism of tau propagation and synaptic toxicity of distinct tau conformers,scientists inoculated wild-type primary mouse neurons with structurally characterized Sarkosyl-insoluble tau isolates from the frontal cortex of six Alzheimer's disease cases and monitored the impact for 14 days. (stemcellsciencenews.com)
Immunohistochemcial data showed that rotenone injections significantly increased the loss of dopaminergic neurons in the substantia nigra, and decreased the striatal expression of tyrosine hydroxylase. (uaeu.ac.ae)
Epigallocatechin-3-gallate (EGCG): Clinical studies suggest that EGCG has neuroprotective qualities and can significantly suppress toxicity of dopamine neurons through antioxidation, anti-inflammation, iron-chelation, cell death regulation and modulation of signaling pathways (Zhou et al, 2019). (appetitesforlife.com)
To help expand validate results from previous reviews in a persistent disease model also to recognize neuroprotective systems connected with lithium we examined the consequences of low-dose lithium within an aged transgenic mouse model that expresses a parkin mutation selectively within dopamine neurons (Lu et al. (academicediting.org)
From the cover: Manganese and rotenone-induced oxidative stress signatures differ in iPSC-derived human dopamine neurons. (purdue.edu)
Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. (uibk.ac.at)
Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model. (uibk.ac.at)

5. Liu C, Huang Y, Zhang Y, Chen X, Kong X, Dong Y. Intracellular methylglyoxal induces oxidative damage to pancreatic beta cell line INS-1 cell through Ire1α-JNK and mitochondrial apoptotic pathway. (ac.ir)
Presence of iron is a double-edged sword, it is extremely indispensable to carry various important metabolic processes at the same time its slight excess induces oxidative stress due to production of free radicals, especially the hydroxyl radical which is highly reactive and provoke critical and even irreversible cell injury. (biomedres.us)

Here we explore the neuroprotective effect afforded by the absence of sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1), a prodegenerative NADase, in a rotenoneinduced mouse model of retinal ganglion cell loss and visual dysfunction. (tcd.ie)
The motor symptoms are attributed to dopaminergic cell loss within the substantia nigra (SN) pars compacta, resulting in subsequent dysfunction of the basal ganglia, a cluster of deep nuclei that participate in the initiation and execution of movements [ 3 ]. (nature.com)
Methylglyoxal (MG) provokes endoplasmic reticulum (ER) stress in β-cells and triggers pancreatic β-cell dysfunction. (ac.ir)

Theanine: Theanine protects brain cells against damage from exposure to the pesticide rotenone, commonly linked with PD (Cho, et al 2008). (appetitesforlife.com)
Rotenone is a commonly used pesticide that can function as an environmental neurotoxin. (omeka.net)

Several studies have proven that the activation of glial cells, presence of alpha-synuclein aggregates, and oxidative stress, fuels neurodegeneration, and currently there is no definitive treatment for PD. (uaeu.ac.ae)

WAY100635 (5-HT1A receptor antagonist) but not AM251 and AM630 (CB1 or CB2 receptor antagonists, respectively) significantly diminished the neuroprotective effect induced by CBG only against rotenone. (veterinarycannabissociety.org)
Sarm1 knockout mice retain visual function after rotenone insult, displaying preservation of photopic negative response following rotenone treatment in addition to significantly higher optokinetic response measurements than wild type mice following rotenone. (tcd.ie)
Compounds derived from PS127 significantly upregulated production of reactive oxygen species (ROS) in AML cells and triggered ferroptotic, necroptotic, and/or apoptotic cell death in AML cell lines and refractory/relapsed AML primary samples. (nature.com)

Neuronal cell death was evaluated by immunohistochemical staining. (biomedcentral.com)
We demonstrate that administration of DMF following status epilepticus increased Nrf2 activity, attenuated status epilepticus-induced neuronal cell death, and decreased seizure frequency and the total number of seizures compared to vehicle-treated animals. (biomedcentral.com)

Rotenone exposure enhanced the expression of preapoptotic (cytochrome C (cyto c), caspase-3, -8, -9, and Bax) and down-regulated the expression of anti-apoptotic (Bcl-2) markers. (elsevierpure.com)

The current study is framed to evaluate the effect of Psidium guajava and Madhuca indica extract and fraction in Rotenone (RTN) induced Parkinson disease (PD) in mice. (jptcp.com)
Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients. (uibk.ac.at)

Animal models of the disease, created using neurotoxins such as rotenone or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or transgenic mice that overexpress human SYN gene (for ï ¡-synuclein) mutations, do not faithfully replicate the structure and antigenicity of the Lewy bodies found in PD (Dickson 2001). (ukessays.com)

The neuroprotective effect of their respective acids forms, cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA), was also analyzed. (veterinarycannabissociety.org)
Our results contribute to the understanding of the neuroprotective effect of CBD and CBG, showing differences with their acid forms, and also highlight the role of 5-HT1A receptors in the mechanisms of action of CBG. (veterinarycannabissociety.org)
Neuroprotective effect is achieved at the serum concentrations that can be achieved with the doses approved for human use. (touchneurology.com)
PQQ has been shown to induce antileukemia effect leukemia cells in a dose-dependent manner through the production of hydrogen peroxide (H2O2). (rcd.bio)

The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. (nature.com)

These are a type of free radicals that can damage cells in two ways: nitrosylation of proteins (adding nitric oxide to a thiol molecule), and oxidation, which results in more lasting effects on synaptic structures. (bipolarnews.org)
The chemical compound rotenone damages mitochondria by producing ROS, and Andreason found that lithium was able to reverse this production and reverse the adverse effects of oxidative stress. (bipolarnews.org)
Rotenone produces opposite effects upon mouse striatal dopamine function as a result of environmental temperature. (omeka.net)
Fig. 2: Mitochondria-related mechanistic effects of PS hit compounds on cancer and normal blood cells. (nature.com)
The neuroprotective effects of oxygen therapy in Alzheimer's disease: a narrative review. (bmbreports.org)
Iron deficiency also exerts negative effects on the cells [8]. (biomedres.us)
8. Goverdhan P, Sravanthi A, Mamatha T. Neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress. (jptcp.com)

Mechanistically, rotenone stimulated the release of superoxide from microglia that was attenuated by inhibitors of NADPH oxidase. (jneurosci.org)
Mechanistically, all hit compounds reduced ATP and selectively impaired both basal and ATP-linked oxygen consumption in leukemic cells. (nature.com)

Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line. (purdue.edu)

MethodAmong the 80 male SD rats， 10 were randomly selected as normal group and the rest were treated with long-term low-dose subcutaneous injection of rotenone in the neck and back combined with chronic unpredictable mild stress （CUMS） to establish PDD rat model. (bvsalud.org)

Vismione E showed high cytotoxic activity against human breast cancer MCF-7 cells, with an IC50 of 9.0 µM, in comparison with low toxicity for normal human breast MCF-10A cells, with an IC50 of 65.3 µM. (bvsalud.org)

However, rotenone-injected rats that were orally treated with lycopodium (50 mg/kg) were protected against dopaminergic neuronal loss by diminishing the expression of matrix metalloproteinase-3 (MMP-3) and MMP-9, as well as reduced activation of microglia and astrocytes. (uaeu.ac.ae)

NRF2-transfected (+, including 3xFlag-tag) and HEK-293T whole cell extracts. (abcam.com)
Absence of Nrf2 or its selective over-expression in neuronal and muscle cells does not affect survival in ALS-linked mutant hSOD1 mouse models. (wisc.edu)
Therefore, the functionality of the Nrf2-kelch-like erythroid-cell-derived protein with the CNC homology (ECH)-associated protein1 (Nrf2-Keap1) axis is necessary for protection against diseases that involve oxidative stress and ROS as a pathophysiological mechanism. (biomedcentral.com)

Structure-activity relationship studies identified six analogs from two original scaffolds that had over an order of magnitude difference between LD50 in AML and healthy peripheral blood mononuclear cells. (nature.com)

In this study, a rotenone-induced rat model of PD was used to understand the neuroprotective potential of Lycopodium (Lyc), a commonly-used potent herbal medicine. (uaeu.ac.ae)
The lab employs a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal cultures and mouse models. (purdue.edu)
Pilot in vivo efficacy studies indicate anti-leukemic efficacy in a MOLM14/GFP/LUC xenograft model, including extended survival in mice injected with leukemic cells pre-treated with PS127B or PS127E and in mice treated with PS127E at a dose of 5 mg/kg. (nature.com)

These results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events that occur in cultured embryonic axons might be restricted to the cell body in vivo, in the intact nervous system. (sdbonline.org)

This neuroprotective mechanism not only involves reduction in pro-inflammatory response and α-synuclein expression, but also synergistically enhanced antioxidant defense system by virtue of the drug's multimodal action. (uaeu.ac.ae)
5 One proposed mechanism is α-synuclein-induced impairment of the ubiquitin-proteasomal system (UPS), resulting in protein accumulation and leading to cell degeneration. (touchneurology.com)
Cell has got inbuilt mechanism to protect itself from oxidative stress-induced by iron. (biomedres.us)
Interactions with mitochondrial activity and cell signaling pathways are part of the mechanism of action. (rcd.bio)

Oxid Med Cell Longev 2019;2019. (ac.ir)

Further, rotenone administration activated microglia and astroglia, which in turn upregulated the expression of α-synuclein, pro-inflammatory, and oxidative stress factors, resulting in PD pathology. (uaeu.ac.ae)
Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer's Disease: Possible Therapeutic Role of KV1.3 Channel Blockade. (bmbreports.org)

Fig. 6: Flow cytometry evaluation of viable cell number and apoptosis induction in primary AML samples and healthy bone marrow cells. (nature.com)
Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. (nature.com)
6. Suantawee T, Thilavech T, Cheng H, Adisakwattana S. Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity. (ac.ir)

Editor's Note: The ability of lithium to protect mitochondria (the energy storehouse of a cell) adds to an increasingly long list of lithium's neurotropic and neuroprotective benefits. (bipolarnews.org)
Lithium increases cell survival factors BDNF and Bcl-2, increases markers of neuronal integrity such as N-Acetylaspartic acid (NAA), increases the volume of the hippocampus and cortex, and now helps protect mitochondria from oxidative stress. (bipolarnews.org)
This protein is found in a cellular compartment called the mitochondria, which is responsible for supplying energy to the rest of the cell and therefore plays an important role in metabolic processes. (elifesciences.org)
found that when this variant form of ATP5G1 was introduced into the cells of mice, their mitochondria was better at coping with stress conditions, such as low oxygen, low temperature and poisoning. (elifesciences.org)
We identified six mitochondria-affecting compounds (PS compounds) that exhibit selective cytotoxicity against AML cells in vitro. (nature.com)
Inflammation and metabolism in cancer cell-mitochondria key player. (nature.com)
The underestimated role of mitochondria in vitiligo: From oxidative stress to inflammation and cell death. (bmbreports.org)
Iron is an essential element, which is abundant in the red blood cells and plays a key role during oxidative phosphorylation in the mitochondria of all cells. (biomedres.us)
Mitochondria is the powerhouse of the cell, PQQ has been found to play a crucial role in supporting healthy mitochondrial structure and cellular mitochondria function, ultimately contributing to increased energy production in the body. (rcd.bio)
In the reduction-oxidation process of cells inside the mitochondria, PQQ may function as a REDOX agent, reducing oxidants (an antioxidant activity) and then being recycled by glutathione back into an active form. (rcd.bio)

Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions. (stemcellsciencenews.com)
Matter] Researchers introduced chitosan scaffolds as an alternative culture platform to costly animal-sourced feeders, Matrigel, and Geltrex for human neural stem cell expansion. (stemcellsciencenews.com)
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. (stemcellsciencenews.com)
Through cell survival-based cDNA expression screens in neural progenitor cells, we identify a genetic variant of AGS Atp5g1 that confers cell resilience to metabolic stress. (elifesciences.org)
Typically, the basic organization of cerebellar cortex neural circuitry is also well conserved in vertebrates, which mainly comprises of two types of input systems: mossy and climbing fibers in addition to the granule cells, modulatory interneurons including stellate, golgi and basket cells which regulate the discharge of single output Purkinje neuron [9,11,12]. (als-journal.com)

Protection of spatial vision is sustained over time in both sexes and is accompanied by increased RGC survival and additionally preservation of axonal density in optic nerves of Sarm1−/− mice insulted with rotenone. (tcd.ie)

The isolated compounds showed low cytotoxicity against human prostate and breast cancer cells but felicarnezoline B (2) protected rat cardiomyocytes H9c2 and human neuroblastoma SH-SY5Y cells against CoCl2-induced damage. (bvsalud.org)
Compounds 3, 4 and 5 exhibited moderate cytotoxic activity in LNCaP, DU145 and 22Rv1 human prostate cancer cells. (bvsalud.org)
Fig. 5: PS compounds induced synergistic cytotoxicity when combined with other anti-cancer drugs in AML cell lines and primary AML samples. (nature.com)

Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)

Lithium also increases the length of telomeres, which cap the ends of chromosome and protect them from damage during the DNA replication that occurs each time a cell divides. (bipolarnews.org)
The results of today's research also provide additional validation that lithium could possibly be re-purposed being a therapy for PD and claim that anti-inflammatory results may donate to its neuroprotective systems. (academicediting.org)
2013 Youdim and Arraf 2004 lithium can avoid the neurotoxic ramifications of MPP+ and rotenone two agencies associated with PD degeneration (Ruler et al. (academicediting.org)
Furthermore parkin-related glial cell activation is attenuated with lithium treatment. (academicediting.org)

MTT and immunocytochemistry assays were used to evaluate cell viability. (veterinarycannabissociety.org)
however, high concentrations of CBD, CBDA, or CBGA were toxic since a 40-50% reduction of cell viability was observed. (veterinarycannabissociety.org)

The long-term goal is to use a personalized medicine approach to investigate patient-specific toxicant vulnerabilities and develop neuroprotective strategies that mitigate neurological diseases with environmental etiologies. (purdue.edu)

Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells. (purdue.edu)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

While there is a widespread distribution of neuropathologic changes in the brain responsible for the spectrum of the motor and non-motor manifestations of PD, degeneration of dopamine-producing cells in the substantia nigra pars compacta (SNc) is central to the primary motor signs of the disease. (touchneurology.com)

Scientific Reports] Investigators examined how NSC-exos could protect human neuroblastoma cells SH-SY5Y. (stemcellsciencenews.com)

Iron and iron salts are poorly water soluble however, it is an essential micronutrient, which is required for numerous biological reactions including mammalian cell growth, heme and DNA biosyntheses, oxygen transport, cell proliferation, cytochrome p450 enzyme activity, and hypoxic response reactions [8]. (biomedres.us)

Acute manganese treatment restores defective autophagic cargo loading in Huntington's disease cell lines. (purdue.edu)

Hydrogen sulfide (H 2 S) is involved in many biological systems, and like nitric oxide and carbon monoxide, it is a signaling molecule in mammalian cells [ 12 ]. (biomedcentral.com)

It was found that vismione E inhibits MCF-7 cell proliferation and arrests the cell cycle in the G1 phase. (bvsalud.org)
12. Li Y, Qian J, Yang L. Inhibition of YBX1 by miR-216a Suppresses Proliferation and Invasion of Diffuse Large B-Cell Lymphoma. (ac.ir)

Cell Death & Disease] Using an integrative and comprehensive analysis of the TCGA database and the transcriptome of glioblastoma (GBM) biopsies, the authors identified three critical and clinically relevant miRNAs for GBM, miR-17-3p, miR-222, and miR-340. (stemcellsciencenews.com)
A neuroprotective agent that could slow the progression of the disease has been the holy grail of research in PD. (touchneurology.com)
Soluble cell adhesion molecules in monocytes of Alzheimer´s disease and mild cognitive impairment. (uibk.ac.at)

These findings provide the first evidence of a protein variant that is responsible for protecting cells during the metabolic stress conditions caused by hibernation. (elifesciences.org)

Anatomy16

Organisms5

Diseases18

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology2

Phenomena and Processes15

Reduced the rotenone-induced neurotoxicity2

Parkinson's13

Mitochondrial dysfunction3

Pronounced neuroprotective effects1

Neurotoxicity4

Neurodegenerative4

Neurons13

Induces2

Dysfunction3

Pesticide2

Neurodegeneration1

Significantly3

Neuronal cell death2

Apoptotic1

Parkinson2

Neurotoxins1

Effect4

Pathway1

Effects7

Mechanistically2

Striatal1

Chronic1

Toxicity1

Astrocytes1

NRF23

Peripheral blood mononuclear cells1

Model3

Vivo1

Mechanism4

20191

Microglia2

Apoptosis3

Mitochondria10

Neural5

Mice1

Compounds3

Cellular1

Lithium4

Viability2

Neurological1

Receptors1

Knockout1

Primary1

Human neuroblastoma1

Cytochrome1

Huntington's1

Molecule1

Proliferation2

Disease3

Findings1