Neurons syndrome. Medical search. Frequent questions

For instance, previous efforts have revealed the importance of medulla and spinal cord neurons in breathing problems in Rett syndrome 3 . (spectrumnews.org)
This "mirror pain" is thought to reflect secondary involvement of spinal cord neurons (nerve cells). (nih.gov)

The saying refers to lower motor neuron symptoms in the upper extremity (arm) and upper motor neurons symptoms in the lower extremity (leg). (wikipedia.org)
Signs and symptoms reflect frontal and temporal lobe dysfunction with lower motor neuron-type weakness, muscle atrophy, and fasciculations. (medscape.com)
PMA most commonly affects males and involves lower motor neuron damage. (healthline.com)

The patient's symptoms vary, depending on which set of motor neurons is involved. (medscape.com)
A new study suggests that most of these symptoms stem from MeCP2 loss in just two types of these so-called 'inhibitory' neurons. (spectrumnews.org)
The findings, published 18 November in Neuron , begin to reveal the cell types underlying specific sets of Rett-related symptoms 1 . (spectrumnews.org)
You may be able to perhaps one day develop ways to target and restore the function of those neurons, and thereby treat certain symptoms of the disorder," he says. (spectrumnews.org)
Postpoliomyelitis Syndrome Postpoliomyelitis syndrome is a group of symptoms that develops years or decades after paralytic poliomyelitis and usually affects the same muscle groups as the initial infection. (msdmanuals.com)
Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease. (news-medical.net)
Several conditions with signs and symptoms overlapping those of Rett syndrome have been found to result from mutations in other genes. (medlineplus.gov)
However, a small number of males with a genetic change involving MECP2 have developed signs and symptoms similar to those of Rett syndrome, including intellectual disability, seizures, and movement problems. (medlineplus.gov)
The reason for this is that the symptoms of DiGeorge syndrome vary considerably. (scienceblogs.com)
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by multiple endocrine, metabolic, respiratory, cognitive, and behavioral/psychiatric symptoms. (biomedcentral.com)
Blocking the activity of interleukin-1 in mouse models of complex regional pain syndrome (CRPS) helped reverse symptoms. (neurosciencenews.com)
As the majority of patients with Fragile X Syndrome also display autism-like symptoms, the findings offer hope for treating both conditions. (sciencedaily.com)
3. Assess symptoms and differentiate between the 3 dysexecutive syndromes. (psychiatrictimes.com)
Broken-heart syndrome has symptoms similar to a heart attack, including chest pain and shortness of breath. (livescience.com)
Experts have noted that the terminology "chronic fatigue syndrome" can trivialize this illness and stigmatize persons who experience its symptoms ( 1 ). (cdc.gov)

To reveal the neurobiological mechanism that P2X 3 receptor of colonic primary sensory neurons in the dorsal root ganglia of the lumbosacral segment is involved in the alleviation of visceral hypersensitivity by EA in an IBS rat model. (hindawi.com)
Especially, P2X 3 receptors play an important role in mediating the occurrence and maintenance of pain in neurons of the intestinal myenteric plexus, dorsal root ganglia (DRG), spinal dorsal horn, prefrontal cortex, and anterior cingulate cortex in a rat model of IBS with visceral hypersensitivity [ 14 ], and acupuncture can achieve visceral pain relief through purinergic receptors at different levels of the brain-gut axis. (hindawi.com)
Our objectives were to decipher the expression and functionality (calcium signaling) of PARs in human dorsal root ganglia (DRG) neurons, and to define mechanisms involved in human sensory neuron signaling by IBS patient mediators. (edu.au)

First the scientists revealed a dysfunction of the GnRH neurons in an animal model of Down syndrome and its impacts on the cognitive function impairment associated with the condition. (scienceblog.com)
This article focuses on CNS dysfunction that produces dysexecutive syndromes. (psychiatrictimes.com)

When later studying the brain development of these mice, the team noticed that certain neurons in the growing cortex were not behaving normally. (nature.com)
Specifically, studies suggest that changes in the MeCP2 protein may reduce the activity of certain neurons and impair their ability to communicate with one another. (medlineplus.gov)

Female Sprague-Dawley rats received either DA neuron neurotoxic lesion by bilateral intra-cannula injection of 6-hydroxydopamine (2-4 μg/side) or vehicle treatment at the area surrounding the SCN at 20 min post protriptyline ip injection (20 mg/kg) to protect against damage to noradrenergic and serotonergic neurons. (biomedcentral.com)
As brainstem serotonergic neurons play important roles in respiratory maturation and regulation, studies using Ndn tm1-Mus mice showed that necdin deficiency led to serotonergic neuroarchitectural changes and increased spontaneous firing of serotonergic neurons, which led to increased expression and activity of serotonin transporters [ 12 ]. (biomedcentral.com)

ALS, also known as Lou Gehrig disease, is the most common neurodegenerative disease of adult onset involving the motor neuron system. (medscape.com)
In 110 patients with sporadic adult-onset upper motor neuron syndromes, a novel REEP1 mutation was identified in one patient. (rug.nl)
Progressive muscular atrophy (PMA) is a rare adult-onset motor neuron disease. (healthline.com)

Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei, or a combination. (msdmanuals.com)
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND). (msdmanuals.com)
Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis. (ox.ac.uk)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which there is preferential loss of both the upper and lower motor neurons. (bmj.com)

Leigh Syndrome affects one in every 40,000 newborns and is produced by deficits in the mitochondria, which are in charge of providing the energy needed for cells to function correctly. (news-medical.net)
We found that the sequestering agent transthyretin is able to bind the toxic Aβ(1-42) species and attenuated the loss of neurons and memory deficits. (nih.gov)
provide evidence that thyroid hormone receptors are essential for the formation of a population of parvalbuminergic neurons in the anterior hypothalamus, linking, for the first time, impaired thyroid hormone signaling during development to cellular deficits in the hypothalamus. (jci.org)
Researchers now have a much clearer understanding of how mutations in a single gene can produce the complex cognitive deficits characteristic of Fragile X Syndrome, the most common inherited form of intellectual disability. (sciencedaily.com)

PAR1, PAR2 and PAR4 were all expressed in human DRG, respectively in 20%, 40% and 40% of the sensory neurons. (edu.au)
Supernatants from colonic biopsies of IBS patients induced calcium flux in human sensory neurons compared to HC, this induction was reversed by a PAR1 antagonist. (edu.au)

However, a diagnosis of "spasticity" is still often used interchangeably with upper motor neuron syndrome, and it is not unusual to see patients labeled as spastic who demonstrate an array of UMN findings. (wikipedia.org)
The confusion in the use of the terminology complicates assessment and treatment planning by health professionals, as many confuse the other findings of upper motor neuron syndrome and describe them as spasticity. (wikipedia.org)
The findings underscore the important role of GABA signals in Rett syndrome, says Zhong-wei Zhang , associate professor at The Jackson Laboratory in Bar Harbor, Maine, who was not involved in the study. (spectrumnews.org)
These findings indicate that reduced dopaminergic neuronal activity in neurons at the area of and communicating with the SCN contributes significantly to increased sympathetic tone and the development of metabolic syndrome, without effect on feeding. (biomedcentral.com)
Taken together, the findings unveil oscillations of hyper- and hypo-responses to IFN-I in Down syndrome, predisposing to both lower incidence of viral disease and increased infection-related morbidity and mortality. (medicalxpress.com)
These promising findings now justify the launch of a larger study - with the inclusion of women - to confirm the efficacy of this treatment in people with Down syndrome, but also for other neurodegenerative conditions such as Alzheimer's disease. (scienceblog.com)
Ghadri said she hopes that future research will be able to disentangle these findings, and also help doctors understand who is at risk for broken-heart syndrome and why. (livescience.com)

Electroacupuncture (EA) has been confirmed effectiveness in the treatment of irritable bowel syndrome (IBS), and P2X 3 receptors in the peripheral and central neurons participate in the acupuncture-mediated relief of the visceral pain in IBS. (hindawi.com)
Irritable bowel syndrome is a chronic functional bowel disorder [ 1 , 2 ]. (hindawi.com)
Proteases and Protease-Activated Receptors (PARs) are major mediators involved in irritable bowel syndrome (IBS). (edu.au)

It is characterized by pyramidal cell loss in the frontal and temporal lobes and degeneration of motor neurons in the hypoglossal nucleus and spinal motor neurons. (medscape.com)
Pyramidal neurons in the premotor cortex usually are preserved. (medscape.com)
Action potential waveforms and miniature excitatory synaptic currents recorded in CA1 pyramidal neurons were unaffected by ant?134. (cureepilepsy.org)

Rett syndrome is part of a spectrum of disorders with the same genetic cause. (medlineplus.gov)
Other disorders on the spectrum include PPM-X syndrome , MECP2 duplication syndrome , and MECP2 -related severe neonatal encephalopathy . (medlineplus.gov)
The inability to analyze gene expression in living neurons from Angelman (AS) and Duplication 15q (Dup15q) syndrome subjects has limited our understanding of these disorders at the molecular level. (biomedcentral.com)
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. (nature.com)
Motor neuron diseases are a group of disorders characterized by progressive damage to your motor neurons - cells in your nervous system that allow you to perform functions such as speech, breathing, and movement. (healthline.com)
Research in my lab is focused on two genetic developmental disorders, Down syndrome and Fragile X syndrome. (wisc.edu)
Yunus proposes a class of disorders called central sensitivity syndromes (CSSs), which result from changes in the central nervous system (CNS). (medscape.com)

Mice missing the Rett syndrome gene, MeCP2 , from neurons that dampen brain activity have hallmark signs of the disorder , such as social abnormalities, repetitive behaviors and poor motor coordination. (spectrumnews.org)
In 2010, Huda Zoghbi and her colleagues at Baylor College of Medicine in Houston, Texas, showed that mice lacking MeCP2 in inhibitory neurons that send signals through the chemical messenger gamma-aminobutyric acid (GABA) show a range of Rett-like features. (spectrumnews.org)
Rett syndrome is a brain disorder that occurs almost exclusively in girls. (medlineplus.gov)
The most common form of the condition is known as classic Rett syndrome. (medlineplus.gov)
After birth, girls with classic Rett syndrome have 6 to 18 months of apparently normal development before developing severe problems with language and communication, learning, coordination, and other brain functions. (medlineplus.gov)
Researchers have described several variant or atypical forms of Rett syndrome, which can be milder or more severe than the classic form. (medlineplus.gov)
Mutations in a gene called MECP2 underlie almost all cases of classic Rett syndrome and some variant forms of the condition. (medlineplus.gov)
It is unclear how these changes lead to the specific features of Rett syndrome. (medlineplus.gov)
These conditions, including FOXG1 syndrome and CDKL5 deficiency disorder , were previously thought to be variant forms of Rett syndrome. (medlineplus.gov)
In more than 99 percent of people with Rett syndrome, there is no history of the disorder in their family. (medlineplus.gov)
For example, both Fragile X and Rett syndrome have elucidated atypical biology associated with autism and have led to novel neurobiologically-based clinical trials. (biomedcentral.com)

Spasticity is a common feature of muscle performance after upper motor neuron lesions, but is generally of much less clinical significance than other features such as decreased strength, decreased control and decreased endurance. (wikipedia.org)
Lesions at or distal to the superior cervical ganglion-that is, the postganglionic (third-order) neuron-result in anhidrosis limited to the ipsilateral forehead. (aao.org)

In Horner syndrome, little or no norepinephrine is released into the synaptic cleft. (aao.org)

Expression of FOS-IR in MNCs with attenuated ER-β-IR, and the absence of FOS-IR in parvocellular neurons that retain ER-β-IR suggest a role for neuronal activation in the regulation of ER-β expression in MNCs. (jneurosci.org)

Data now suggest that delocalization, accumulation, and ubiquitination of TDP-43 in the cytoplasm of motor neurons are early dysfunctions in the cascade of the events leading to motor neuron degeneration in ALS. (medscape.com)

Still, many people with PMA later develop damage to upper motor neurons, which originate in the brain. (healthline.com)

Worldwide, frontotemporal lobe dementia with motor neuron disease (FTD/MND) is a sporadic condition with an unknown etiology. (medscape.com)

The researchers found that increased IFNAR2 expression was sufficient for the hypersensitivity to IFN-I observed in Down syndrome, independent of trisomy 21. (medicalxpress.com)
The changes cause hyperexcitability escalation of other neurons, giving rise to hypersensitivity to peripheral stimuli. (medscape.com)

This syndrome affects multiple organ systems , causing a mixed clinical presentation that includes intellectual disability, developmental delays, congenital heart and gastrointestinal abnormalities, and Alzheimer's disease in older individuals. (medicalxpress.com)

Upper motor neuron syndrome (UMNS) is the motor control changes that can occur in skeletal muscle after an upper motor neuron lesion. (wikipedia.org)
Health professionals' understanding of impairments in muscles after an upper motor neuron lesion has progressed considerably in recent decades. (wikipedia.org)
Improved understanding of the multiple features of the upper motor neuron syndrome supports more rigorous assessment, and improved treatment planning. (wikipedia.org)
The upper motor neuron syndrome signs are seen in conditions where motor areas in the brain and/or spinal cord are damaged or fail to develop normally. (wikipedia.org)
While multiple muscles in a limb are usually affected in the Upper Motor Neuron Syndrome, there is usually an imbalance of muscle activity (muscle tone), such that there is a stronger pull on one side of a joint, such as into elbow flexion. (wikipedia.org)
Upper MNDs (eg, primary lateral sclerosis) affect neurons of the motor cortex, which extend to the brain stem (corticobulbar tracts) or spinal cord (corticospinal tracts). (msdmanuals.com)
The presence of a lesion at any point along the oculosympathetic pathway results in Horner syndrome, which is characterized clinically by ipsilateral miosis (from unantagonized action of the iris sphincter), facial anhidrosis, ipsilateral upper eyelid ptosis, and mild lower eyelid elevation (upside-down ptosis). (aao.org)
Though experts aren't sure of the exact numbers, many people with PMA eventually develop upper motor neuron damage, which more resembles an ALS diagnosis. (healthline.com)
Surgical Management of Upper Extremity Deformities in Patients With Upper Motor Neuron Syndrome. (bvsalud.org)

Many of these mRNAs encode proteins that function at neurons' connection points. (sciencedaily.com)

In animals, alcohol, cocaine and viral infections can also disrupt the neurons' migration and affect behaviour. (nature.com)
The scientists are not sure how the ultrasound waves disrupt neuron migration. (nature.com)
Mutations in the MECP2 gene alter the MeCP2 protein or result in the production of less protein, which appears to disrupt the normal function of neurons and other cells in the brain. (medlineplus.gov)

Neuron 2017 Jun 94 (6): 1101-1111.e7. (cdc.gov)
Neuron 2017 May 94 (3): 486-499.e9. (cdc.gov)

Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)
By 6 weeks of age, mice lacking MeCP2 in parvalbumin neurons begin to lose motor skills. (spectrumnews.org)
By contrast, mice that lack MeCP2 in somatostatin neurons perform normally on tests of motor, social and cognitive abilities. (spectrumnews.org)
Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. (biomedcentral.com)
and 0.009 for motor neuron disease. (nih.gov)
Lower motor neurons transmit signals between your spinal cord and muscles. (healthline.com)
Previous studies indicated that it may start at a younger age than other motor neuron diseases. (healthline.com)
Riluzole is an ALS drug that may help slow down damage to motor neurons in PMA. (healthline.com)
There's not much recent research on life expectancy for people with PMA, but according to the United Kingdom-based Motor Neurone Disease Association , many people live at least 5 years from the onset of the condition. (healthline.com)
ALS is a motor neuron disease also known as Lou Gehrig's disease. (alz.org)

EA can regulate the P2X 3 receptor protein and mRNA expression levels in the colon and related DRG of IBS rats with visceral pain and then regulate the excitatory properties of DRG neurons. (hindawi.com)
Liver monocyte chemoattractant protein 1 (a proinflammatory protein associated with metabolic syndrome) gene expression was also significantly elevated in peri-SCN area dopaminergic lesioned rats. (biomedcentral.com)
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. (jneurosci.org)
To address this knowledge gap , the researchers compared fibroblasts and white blood cells derived from individuals with and without Down syndrome, at both the mRNA and protein levels. (medicalxpress.com)

Zoghbi and her team engineered two strains of mice that lack MeCP2 in inhibitory neurons. (spectrumnews.org)
Rakic marked some of these migrating neurons with a dye and then exposed the growing mice to between 5 minutes and 7 hours of ultrasound over the final three days of gestation, using a machine identical to that used for humans. (nature.com)
The more ultrasound the mice received, the more scattered their neurons. (nature.com)
On slice electrophysiology, LC-NE neurons of Ndn tm1ky mice with necdin deficiency showed significantly decreased spontaneous activities and impaired excitability, which was mediated by enhanced A-type voltage-dependent potassium currents. (biomedcentral.com)

Our previous clinical and animal studies have also confirmed the effectiveness of acupuncture in the treatment of IBS [ 11 - 13 ] and initially revealed that the P2X 2 , P2X 3 , and P2Y 1 receptors in the peripheral neurons of the colon and in central neurons participate in the acupuncture-mediated relief of the visceral pain in IBS. (hindawi.com)
One of the clinical challenges in diagnosing Horner syndrome is differentiating it from physiologic anisocoria, because the pupillary reaction to light is normal with both conditions, and physiologic anisocoria may also be greater in dim light. (aao.org)
Down syndrome, also known as trisomy 21, affects around one in 800 births and results in a variety of clinical manifestations, including decline in cognitive capacity. (scienceblog.com)
This study assessed parents' perceptions of the ability of their son or daughter with fragile X syndrome (FXS), an inherited form of intellectual disability, to participate in the consent process for clinical trials. (cdc.gov)

Dusan Bogunovic et al, Excessive Negative Regulation of Type I Interferon Disrupts Viral Control in Individuals with Down Syndrome, Immunity (2022). (medicalxpress.com)

In patients with Horner syndrome, the α1-agonist effect dominates because of the supersensitivity of the α1-receptors, resulting in relative mydriasis by contraction of the dilator muscle. (aao.org)
Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome. (cdc.gov)

Deleting MeCP2 (green) from two different neuron subtypes (red) leads to divergent sets of problems. (spectrumnews.org)
In the new study, Zoghbi's team further defined that role by creating two additional mouse models, each of which lacks MeCP2 in just one type of GABA neuron. (spectrumnews.org)

Müller-Vahl KR, Kaufmann J, Grosskreutz J, Dengler R, Emrich HM, Peschel T. Prefrontal and anterior cingulate cortex abnormalities in Tourette Syndrome: evidence from voxel-based morphometry and magnetization transfer imaging. (medscape.com)
Lack of association between SLC5A7 polymorphisms and Tourette syndrome in a Chinese Han population. (cdc.gov)
Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. (cdc.gov)
Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry. (cdc.gov)
Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome. (cdc.gov)
Association of a Variant of CNR1 Gene Encoding Cannabinoid Receptor 1 With Gilles de la Tourette Syndrome. (cdc.gov)
Family-Based Analysis Combined with Case-Controls Study Implicate Roles of PCNT in Tourette Syndrome. (cdc.gov)

between nerve cells (neurons). (medlineplus.gov)

however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. (nih.gov)

This supernumerary chromosome then leads to abnormalities in the neurons that secrete GnRH. (scienceblog.com)

Their basic scientific discoveries suggest two different overall strategies for treating Fragile X Syndrome: by lowering the activity of particular proteins normally kept under wraps by FMRP or by replacing FMRP's ability to stall ribosomes. (sciencedaily.com)
FMRP is one of many regulatory proteins in the neuron. (sciencedaily.com)

EA also regulated the electrical properties of the membranes, including the resting membrane potential, rheobase, and action potential of colon-associated DRG neurons in the IBS rats. (hindawi.com)

Expressed in lateral ganglion and neurons. (wormbase.org)

The goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral outcomes in patients with fragile X syndrome (FXS). (nature.com)
Longitudinal profiles of adaptive behavior in fragile X syndrome. (nature.com)
Fragile X syndrome. (nature.com)
As a result, they may have mild versions of the physical features seen in fragile X syndrome (described above), such as prominent ears, and may experience emotional problems such as anxiety or depression . (medlineplus.gov)
Men, and some women, with an FMR1 gene premutation are at increased risk of developing a disorder known as fragile X-associated tremor/ataxia syndrome (FXTAS). (medlineplus.gov)
Almost all cases of fragile X syndrome are caused by an expansion of the CGG trinucleotide repeat in the FMR1 gene. (medlineplus.gov)
Down syndrome is caused by an extra chromosome (Trisomy 21), while Fragile X syndrome is due to a single gene mutation (fmr1 gene). (wisc.edu)

Researchers from Children's Hospital of Philadelphia (CHOP) developed two new zebrafish models for studying a specific genetic form of mitochondrial disease that represents the most common cause of Leigh syndrome. (news-medical.net)
I enjoy following the tremendous research being done all over the world in connection with DiGeorge Syndrome, which is by all accounts the most common chromosomal genetic deletion syndrome. (scienceblogs.com)
Rare genetic and genomic syndromes have provided insights into the molecular, cellular and circuit changes that underlie autism and associated developmental delay syndromes. (biomedcentral.com)

Individuals with Down syndrome have less-frequent viral infections, but when present, these infections lead to more severe disease. (medicalxpress.com)

Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. (biomedcentral.com)

Here, we describe a previously unknown population of parvalbuminergic neurons in the anterior hypothalamus that requires thyroid hormone receptor signaling for proper development. (jci.org)
Dysexecutive syndromes result from damage to the anterior regions of the brain and present as a combination of disinhibition, disorganization, or apathy. (psychiatrictimes.com)

Around one in 4000 is born with this syndrome, which arises from a deletion of a short segment of chromosome 22. (scienceblogs.com)
Down syndrome is typically caused by triplication of chromosome 21. (medicalxpress.com)
While people with Down syndrome show clear signs of immune disturbance, it has yet to be elucidated how a supernumerary chromosome 21 leads to dysregulation of viral defenses. (medicalxpress.com)

The impact of targeted lesioning of dopamine (DA) neurons specifically at the area surrounding (and that communicate with) the SCN (but not within the SCN itself) upon glucose metabolism, adipose and liver lipid gene expression, and cardiovascular biology in normal laboratory animals has not been investigated and was the focus of this study. (biomedcentral.com)

Researchers from the Mitochondrial Medicine Frontier Program at Children's Hospital of Philadelphia have found that developmental delays associated with Leigh syndrome, the most common pediatric mitochondrial disorder, may occur earlier than previously recognized - even before metabolic stroke and regression - which could provide clinicians with an opportunity for earlier diagnosis and therapeutic interventions. (news-medical.net)

Anatomy3

Diseases2

Spinal cord neurons2

Lower motor3

Symptoms15

Dorsal root ga3

Dysfunction2

Certain neurons2

Serotonergic neurons2

Adult onset3

Amyotrophic4

Deficits4

Sensory2

Findings7

Irritable bowel sy3

Pyramidal3

Disorders7

Rett11

Lesions2

Synaptic1

Neuronal1

Degeneration1

Originate1

Sporadic1

Hypersensitivity2

Congenital1

Upper9

Encode1

Disrupt3

20172

Motor10

Protein4

Mice4

Clinical4

20221

Receptors2

MeCP22

Tourette Syndrome7

Nerve1

Mutations1

Abnormalities1

FMRP2

Rats1

Lateral1

Fragile7

Genetic3

Viral infections1

Neurodevelopmental disorder characterized1

Anterior2

Chromosome3

Gene expression1

Developmental1