AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
ErythrocytesErythrocyte MembraneErythrocyte AgingErythrocyte DeformabilityAnion Exchange Protein 1, ErythrocyteHemolysisNeuronsErythrocyte CountErythrocyte AggregationErythrocyte VolumeGlycophorinBrainNeuronal PlasticityPlasmodium falciparumSpectrinOsmotic FragilityNerve Tissue ProteinsHemagglutinationCells, CulturedHippocampusRats, Sprague-DawleyCerebral CortexNitric Oxide Synthase Type IMembrane ProteinsBlood SedimentationTime FactorsBlood Group AntigensNeuronal Ceroid-LipofuscinosesKineticsMolecular Sequence DataHemoglobinsCell DeathAnemia, HemolyticHemagglutination TestsErythrocyte IndicesCell DifferentiationProtozoan ProteinsNeurogliaNeuritesBlood ProteinsReceptors, Complement 3bNeurogenesisRosette FormationErythrocyte TransfusionAmino Acid SequenceNerve DegenerationMice, Inbred C57BLImmunohistochemistryPC12 CellsNeuropeptidesAction PotentialsAxonsRabbitsSheepAnimals, NewbornAnemia, Sickle CellMethemoglobinRats, WistarChickensProtein BindingMice, KnockoutCell MembraneAnkyrinsSignal TransductionTurkeysAstrocytesMNSs Blood-Group SystemCell SurvivalDuffy Blood-Group SystemReceptors, ComplementNeuroprotective AgentsSynapsesDisease Models, AnimalMice, TransgenicCerebellumDose-Response Relationship, DrugElectrophoresis, Polyacrylamide GelCarrier ProteinsDendritesModels, NeurologicalAntigens, ProtozoanNerve NetMembrane LipidsGlutamic AcidMolecular WeightHematocritHemagglutination, ViralCell LineMalaria, FalciparumMicroscopy, ElectronModels, BiologicalSynaptic TransmissionBiological TransportReticulocytesPotassiumElectrophysiologyNerve Growth FactorsHeinz BodiesGene Expression Regulation, DevelopmentalGene Expression Regulation
RetinalInflammationDifferentiationNeurodegenerative diseasesMembraneEndogenousHallmarksMiceMolecularPhysiologicalPathologicalOxidativeBrain2019NeuronsGlutamateCellsAlterationsPhagocytosisDiseaseLongevityDiseasesMechanismsMitochondrialInteractionProteinIncreases with ageActivityInevitableCellSignificantlyStructuralPopulationDrivenIncreaseFunctionalPlasmaDistributionPotentialFoundYears of agePatientsHumanAdministration
Retinal2
  • Retinal I/R injury is associated with pathological increases in reactive oxygen species and inflammation, resulting in retinal neuronal cell death. (mdpi.com)
  • New insights into cell-specific and compartmental ATP and GTP production, as well as utilization and buffering strategies and their relationship with known retinal and cellular functions, are discussed. (molvis.org)
Inflammation5
  • Acute renal injury led to both soluble and cellular inflammation in the brain, affecting the CA1 region of the hippocampus foremost. (medscape.com)
  • The inflammation, thrombin activation, and erythrocyte lysis caused by primary injury could promote the formation of brain edema, which is associated with poor outcome, and could cause more severe and durable injury [ 3 ]. (karger.com)
  • [ ii ] Cherries are particularly abundant in polyphenols, a family of plant chemicals that combat cellular damage and slash inflammation in the body. (wakeup-world.com)
  • Cherries, specifically the tart kind, previously been found to significantly reduce age-associated inflammation and promote protein or cellular homeostasis in the hippocampus, as well as improve working memory. (wakeup-world.com)
  • Neuronal damage in brain inflammation. (mdc-berlin.de)
Differentiation2
  • I have analyzed the contradictory items of the FRTA, outlining a new, comprehensive interpretation of the possible biological role of oxygen free radicals in the living state, cell differentiation and aging, called the membrane hypothesis of aging (MHA). (antiaging-systems.com)
  • The MHA attributes a leading role in differentiation and aging processes to the plasma membrane, undergoing inevitable, continuous alterations during the life. (antiaging-systems.com)
Neurodegenerative diseases2
Membrane2
  • Curcumin, isolated from Curcuma longa, has modulatory effects on cellular physiology due to its membrane interaction ability and antioxidant potential. (hindawi.com)
  • Curcumin modulates cellular activity through interacting with membrane-bound proteins and modulating signaling cascade activity by altering the fluidity of the membrane bilayer [ 17 ]. (hindawi.com)
Endogenous2
  • Old erythrocytes do not die, but rather display changes in the cell surface that enable macrophages to recognise them as old or damaged, including exposure of phosphatidylserine, desialylation of glycoproteins, loss or changed conformation of the "don't-eat-me" signal CD47, and exposure of novel antigens that bind endogenous antibodies. (wikipedia.org)
  • Therefore, we tested several of the widely promoted terpenoids for their interaction with endogenous cannabinoid signaling in a well-characterized, CB1-based, neuronal model, as described in approximately 25 publications (Straiker and Mackie, 2005). (fabbs.org)
Hallmarks2
Mice4
  • TSEs are characterized by the accumulation in the central nervous system and, less often, in lymphoid tissues of TSE-associated prion protein (PrP TSE ), a conformational variant of a normal host cellular prion protein (PrP C ). PrP C is a nonessential protein but, at least in mice and cows, must be expressed by animals susceptible to TSE infection. (cdc.gov)
  • Acute renal injury has been found in mice with increased neuronal pyknosis and microgliosis in the brain. (medscape.com)
  • MATERIALS AND METHODS: C57BL/6J mice were randomized into four groups: intact mice (control group), a group of mice with artificial accelerated aging treated with D-galactose alone (Gal), D-galactose followed by Fertiwell (PP), and D-galactose followed by a combination of L-carnitine and acetyl-L-carnitine (LC). (bvsalud.org)
  • The medium life span of the CPH-treated old animals increased significantly, and the learning ability of the old, treated mice improved as compared to their age-matched controls. (antiaging-systems.com)
Molecular3
  • In this article, we have reviewed several recently identified natural products with potential antiaging properties and have highlighted their cellular and molecular mechanisms. (frontiersin.org)
  • This includes exploring molecular mechanisms related to longevity and investigating safe and effective interventions for aging, which can systematically reveal the intrinsic mechanisms underlying aging and the influence of external environments on aging, promoting healthy aging. (frontiersin.org)
  • Our studies on the erythrocyte focus on a molecular understanding of how specific proteins that cause human disease. (yale.edu)
Physiological5
  • The aging process can be divided into two categories: physiological and pathological aging. (frontiersin.org)
  • Physiological aging refers to the physiological degeneration occurring after maturity, while pathological aging involves age-related changes caused by various external factors such as various diseases. (frontiersin.org)
  • Since these two types are practically difficult to distinguish, aging can be referred to as a biological-psychological process during the final stages of individual growth and development, which is the inevitable result of a combination of many pathological, physiological, and psychological processes. (frontiersin.org)
  • In addition, PMRS also regulates physiological functions like cell metabolism, cellular growth, activity of ion channels, and cell death against changes in redox potential [ 7 , 8 ]. (hindawi.com)
  • Some researchers suggest that current recommended intake levels may be insufficient for adequate daily intake, given the physiological reductions in absorptive capacity accompanied by aging. (leanquick.org)
Pathological1
  • this property has been hypothesized to control the rate of aging, lifespan, and many pathological conditions associated with increased oxidative stress [ 2 , 3 ]. (hindawi.com)
Oxidative3
Brain5
  • However, recent evidence indicates that excessive phagoptosis may kill host cells in inflammatory conditions, contributing to haemophagic conditions, and neuronal loss in the inflamed brain. (wikipedia.org)
  • vasogenic factors, thrombin formation, erythrocyte lysis and hemoglobin (Hb) toxicity [ 5 ] have been proved to be related to brain edema growth [ 6 ]. (karger.com)
  • [ vii ] They are therefore considered helpful in promoting healthy brain aging and delaying neurodegenerative disorders. (wakeup-world.com)
  • From development to aging and disease, the brain parenchyma is under the constant threat of debris accumulation, in the form of dead cells and protein aggregates. (frontiersin.org)
  • The reason for doing this was that CPH became known to me since the early sixties as a compound which was able to liberate various animal tissues, (brain, liver, myo-cardium, epithelia, etc) from the age-dependent accumulating yellow pigment granules, called lopofuscin, or age-pigment. (antiaging-systems.com)
20191
  • In 2019, there were 1 billion people aged 60 years and older. (frontiersin.org)
Neurons2
  • In this model, autaptic hippocampal neurons express CB1 receptors, the cellular machinery to synthesize and metabolize the endocannabinoid 2-AG, and several other forms of CB1-mediated neuronal plasticity (Kellogg et al. (fabbs.org)
  • The kainate-induced increase was highly sensitive to Gd 3+ or Na + removal in most neurons but insensitive in a minority subpopulation ("cobalt-positive cells"), suggesting that a fourth route of neuronal Zn 2+ entry is through the Ca 2+ -permeable channels gated by certain subtypes of AMPA or kainate receptors. (jneurosci.org)
Glutamate2
  • Confocal studies showed differential cellular and compartmental distribution of isozymes involved in glucose, glutamate, glutamine, lactate, and creatine metabolism. (molvis.org)
  • In that year, he published three papers about the neuro-protective effect of lithium in the cellular model against glutamate excitotoxicity and in the animal stroke model. (nih.gov)
Cells8
  • Phagoptosis has multiple functions including removal and disposal of: pathogenic cells, aged cells, damaged cells, stressed cells and activated cells. (wikipedia.org)
  • Aged" erythrocytes and neutrophils, as well as "activated" platelets, neutrophils and T-cells, are thought to be phagocytosed alive by macrophages. (wikipedia.org)
  • Red blood cells (erythrocytes) live for roughly 3 months in the blood before being phagocytosed by macrophages. (wikipedia.org)
  • Many investigators once believed that TSE agents infected mainly, if not exclusively, cells of neuronal and lymphoid lineages. (cdc.gov)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • Upon transporting into live cells cellular esterases cut off the AM groups, the molecule gets trapped inside cells. (aatbio.com)
  • deformation of erythrocytes, i.e. red blood cells) in a patient suffering from chorea acanthocytosis. (uni-rostock.de)
  • 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
Alterations1
  • these changes lead to alterations in cellular metabolism, cellular damage, and eventual cell death. (medscape.com)
Phagocytosis1
  • Our results show that maternal dietary n-3 PUFA deficiency increases microglia-mediated phagocytosis of synaptic elements in the rodent developing hippocampus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal morphology and affecting cognitive performance of the offspring. (nature.com)
Disease3
  • The CND grew out of the Center for Neural Development and Disease (CNDD), which was renamed from its original origin as the Center for Aging and Developmental Biology (CADB), started by the first Director, Howard J. Federoff. (rochester.edu)
  • This protecting effect solely turns into essential as the risk of cardiovascular disease will increase in center-aged and older people. (ehd.org)
  • Although advanced age and comorbidities have been shown to be significant risk factors for disease severity in patients with COVID-19, it has been observed that the disease progresses remarkably in young patients without comorbidity. (psychiatryinvestigation.org)
Longevity1
  • The primary cellular pathways that mediate the longevity-extending effects of natural products involve nutrient-sensing pathways. (frontiersin.org)
Diseases8
  • With the rapid social and economic development in recent decades, the proportion of the elderly has increased rapidly worldwide, and many aging-related diseases have shown an upward trend, including nervous system diseases, cardiovascular diseases, metabolic diseases, and cancer. (frontiersin.org)
  • The rising burden of aging-related diseases has become an urgent global health challenge and requires immediate attention and solutions. (frontiersin.org)
  • Several studies have reviewed the effects of individual natural compounds on aging and aging-related diseases along with the underlying mechanisms. (frontiersin.org)
  • The discovery and use of dietary supplements and natural products that can prevent and treat multiple aging-related diseases in humans will be beneficial. (frontiersin.org)
  • Therefore, aging-related research is being focused on along with age-associated diseases. (frontiersin.org)
  • Dysfunction of mitochondria and UPS increases with age and correlates with many age-related diseases including cancer and neurodegeneration. (hindawi.com)
  • Mitochondrial dysfunction has also been associated with ageing and most of the so-called age-related diseases [ 13 - 17 ]. (hindawi.com)
  • One of the most relevant central dogmas of the aging theories was the free radical theory of aging (FRTA), claiming that oxygen free radicals are harmful by-products of the aerobic life and as such, are responsible for aging and numerous diseases. (antiaging-systems.com)
Mechanisms1
  • AIM: To investigate the specific mechanisms of action of Fertiwell in a mouse model of D-galactose-induced aging of the reproductive system. (bvsalud.org)
Mitochondrial1
  • In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. (hindawi.com)
Interaction1
  • Besides nerolidol, most terpenoids tested in a neuronal model had little interaction with CB1-based signaling at concentrations that are likely to be encountered by consumers of cannabis-related products. (fabbs.org)
Protein1
Increases with age1
  • Intracerebral hemorrhage (ICH) accounts for about 10-15% of all strokes with high mortality [ 1 ], 1-month mortality of ICH is approximate 40% and it increases with age [ 2 ]. (karger.com)
Activity6
  • Erythrocyte transketolase activity is lower in nondialyzed patients than in dialyzed patients. (medscape.com)
  • The homeostatic regulation of cellular ATP is achieved by the coordinated activity of ATP utilization, synthesis, and buffering. (molvis.org)
  • The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD). (hindawi.com)
  • The present study was conducted to investigate the in vitro dose-dependent effect of curcumin on PMRS activity of erythrocytes and validated through in vivo studies on Wistar rats. (hindawi.com)
  • Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. (hindawi.com)
  • I am the author of this report and I am currently over 75 years of age, I have spent most of my scientific activity in the field of experimental gerontology (since 1968). (antiaging-systems.com)
Inevitable1
  • Aging is an inevitable process influenced by genetics, lifestyles, and environments. (frontiersin.org)
Cell2
  • Phagoptosis is probably the most common form of cell death in the body as it is responsible for erythrocyte turnover. (wikipedia.org)
  • Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
Significantly1
  • UltraGreen™ AM does not significantly affect cellular functions such as proliferation or chemotaxis of lymophocyte. (aatbio.com)
Structural1
  • The data suggest that changes in cellular milieu induced by patient genomes trigger structural changes of aSYN potentially leading to the formation of strains having different structures, properties and seeding propensities. (biomedcentral.com)
Population2
  • The increasing aging population is challenging in different ways for societies across the globe. (frontiersin.org)
  • RESULTS: At baseline, the study population had a mean age of 59.3 years, their mean BMI was 31.9 kg/m(2) , HbA(1c) level was 57 mmol/mol (7.4%) and glucose level was 8.8 mmol/l, and 77% were of white European ancestry(whiteindividuals) and 21% of black African ancestry (blackindividuals). (cdc.gov)
Driven2
  • Neutrophils have a daily rhythm of entry and exit from the blood, driven by neutrophil "aging" in the circulation, causing decreased expression of CD62L and increased expression of CXCR4, which directs the "aged" neutrophils to the bone marrow, where they are phagocytosed by macrophages. (wikipedia.org)
  • Cellular ATP is buffered by specialized equilibrium-driven high-energy phosphate (~P) transferring kinases. (molvis.org)
Increase2
  • Previously, a 17-fold increase in the annual incidence of narcolepsy, as compared to previous years in children aged under 17, was observed in Finland in 2010 [14] . (plos.org)
  • Anxiety levels increase with age. (psychiatryinvestigation.org)
Functional1
  • The maintenance of "healthy" and fully functional mitochondria is thus essential for cellular homeodynamics. (hindawi.com)
Plasma2
  • Curcumin also increased the GSH level in erythrocytes and plasma while simultaneously decreasing the oxidant potential (PFEOP) of plasma. (hindawi.com)
  • Impact of solute exchange between erythrocytes and plasma on hemodialyzer clearance. (waw.pl)
Distribution1
  • In addition, the subcellular distribution of mitochondria can affect the cellular transcriptome and transcription rates. (hindawi.com)
Potential1
  • On the basis of these results, CPH could be considered as a potential anti-aging drug. (antiaging-systems.com)
Found1
  • Additionally, we found changes in the formation of aSYN fibrils when employing cellular extracts from familial PD compared to idiopathic PD, in a Thioflavin T-based fluorescence assay. (biomedcentral.com)
Years of age1
  • Most often narcolepsy starts between 12-25 years of age, while onset before the age of 10 has been rare [6] , [7] . (plos.org)
Patients1
  • Patients typically become ill in early to middle age. (uni-rostock.de)
Human1
  • In addition, vCJD infections have been transmitted by transfusions of nonleukoreduced erythrocyte concentrates and by a human-derived coagulation factor (factor VIII) ( 4 - 6 ). (cdc.gov)
Administration1
  • The artificial accelerated aging of reproductive system was induced by daily intraperitoneal administration of D-galactose at a dose of 100 mg/kg for 8 weeks. (bvsalud.org)