Neurological disease models animal. Medical search. Frequent questions

The rat brain has been heavily employed as an animal model for various neurological diseases, such as Parkinson's disease. (microscopyu.com)
In addition to AD, an increasing number of neurodegenerative disorders, including Parkinson's disease, familial British dementia, familial amyloid polyneuropathy, amyotrophic lateral sclerosis, and prion diseases, are associated with abnormal protein assembly processes. (nih.gov)
Leuven researchers led by professor Bart De Strooper (VIB-KU Leuven) have identified a new role for PARL, a protein that has been linked to Parkinson's disease. (news-medical.net)
Destruction of substantia nigra neurons is what causes motor symptoms in Parkinson's disease. (mit.edu)
Cavion's portfolio of T-type calcium channel modulators is being developed to restore the brain's natural rhythms in a variety of neurological diseases such as essential tremor, Parkinson's disease tremor, neuropathic pain, and epilepsy with absence seizures. (businesswire.com)
Having first developed its solutions for epilepsy, the company expanded its offerings in 2015 to address motor (Parkinson's disease) and cognitive (Alzheimer's disease, autism and schizophrenia) disorders, providing its international clients with Go/No-Go decision capability to progress the discovery of new treatments for CNS disorders. (businesswire.com)
Researchers at the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) identified a potential new drug target for the treatment of Parkinson's disease and possibly for other degenerative neurological disorders. (genengnews.com)
In an upcoming issue of Science , the investigators report that, in cellular and animal models, blocking the action of the enzyme, SIRT2, can protect the neurons damaged in Parkinson's disease from the toxic effects of alpha-synuclein, a protein that accumulates in the brains of patients. (genengnews.com)
For Parkinson's disease, we can now pursue a straightforward drug development process by identifying potent and selective candidates from this class of compounds," notes Dr. Kazantsev. (genengnews.com)
The overall theme of her current research concentrates on studying the roles and mechanisms of small molecules in neuronal networks, synaptic functions, neural stem cells and neurodegenerative diseases which include Alzheimer's disease (AD), Parkinson's disease (PD) and Charcot-Marie-Tooth (CMT) disease. (stanford.edu)
While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
By creating the first song bird models for vocal degeneration, we have achieved what I believe is a turning point for all kinds of diseases that affect speech, like Alzheimer's, Parkinson's, and autism. (neurosciencenews.com)
In the end, this technology would help us to understand what goes wrong in the brain in complex disorders such as Parkinson's disease and Schizophrenia. (dnva.no)
Lu AA47070 is a novel adenosine receptor antagonist that has been shown to be efficacious in a number of animal models for neurological diseases including models of Parkinson's disease. (worldpharmanews.com)
In cases of neurological diseases like Alzheimer's, stroke and Parkinson's, the function of these networks changes. (lu.se)
Cell Therapy for Parkinson's Disease: What Next? (lu.se)

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder characterized by amyloid deposition in the cerebral neuropil and vasculature. (nih.gov)
The team attempts to discover noninvasive ways to bypass the BBB for sustained protein delivery across the BBB, which may have broader implications in treating other neurological diseases such as Alzheimer's disease and stroke. (cincinnatichildrens.org)
Since the same sort of aggregation of misfolded proteins has been reported in Huntington's and Alzheimer's diseases as well as Lewy body dementia, which also involves alpha-synuclein deposits," he adds, "we plan to test this approach in those conditions as well. (genengnews.com)
Dr. Longo is chair of the Department of Neurology and Neurological Sciences, the George E. and Lucy Becker Professor of Medicine, and director of the Stanford Alzheimer's Translational Research Center. (stanford.edu)
His clinical interest include Alzheimer's disease and other neurodegenerative disorders. (stanford.edu)
One of the most gratifying contributions of her doctoral studies was the development of a new electrophysiology tool to assess synaptopathies and the establishment of long-term synaptic plasticity from prefrontal cortex slices to characterize the pathophysiology of novel mouse models of Alzheimer's disease. (stanford.edu)
Her projects involve neuronal plasticity, RNA-sequencing, molecular biochemistry, signaling mechanisms, target validation and drug development strategies for Alzheimer's disease with the objective of investigating neurotrophin receptor signaling pathways that contribute to synaptic degeneration and preservation. (stanford.edu)
She joined Dr. Frank Longo's laboratory as a Senior Scientist in the Stanford School of Medicine in 2008, where her research has focused on identifying mechanisms underlying HD and Alzheimer's disease (AD) and developing small molecule therapeutic strategies to target these mechanisms. (stanford.edu)
BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ42 variant that is thought to cause Alzheimer's disease (AD). (lu.se)
The latest results from the Rush Memory and Aging Project, an ongoing community-based cohort study of chronic conditions of aging, showed that in part, the link between ELCE and better late-life cognitive health was tied to fewer pathologic changes related to Alzheimer's disease (AD), including deposition of beta amyloid and tau proteins. (medscape.com)
Here, we are introducing a lifestyle factor that is associated with slower late-life cognitive decline not only through a higher reserve, but also through making the brain less vulnerable to the accumulation of Alzheimer's disease pathological changes. (medscape.com)
The association," he said, "is partly through upregulation of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B pathway that results in downregulation of glycogen synthase kinase-3-beta, which is implicated in the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease pathology. (medscape.com)

Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
Disorders in which intracellular material that cannot be metabolized is stored in lysosomes are called lysosomal storage diseases. (nih.gov)
Niemann-Pick disease is a group of autosomal recessive disorders caused by an accumulation of fat and cholesterol in cells of the liver, spleen, bone marrow, lungs, and, in some instances, brain. (nih.gov)
Along with a technique called TALENs, invented several years ago, and a slightly older predecessor based on molecules called zinc finger nucleases, CRISPR could make gene therapies more broadly applicable, providing remedies for simple genetic disorders like sickle-cell anemia and eventually even leading to cures for more complex diseases involving multiple genes. (technologyreview.com)
Next up is 9.24 Disorders and Diseases of the Nervous System, 1-4pm-the final elective I need to get my Course 9 - Brain and Cognitive Sciences minor . (mitadmissions.org)
9.24 Disorders and Diseases of the Nervous System is my last and most exciting class of the week (or even the past 3.5 years? (mitadmissions.org)
As a result, we get the most accurate and up-to-date yet intro-level overviews of topics in the field of neurological and neuropsychiatric disorders (which are really the same thing because neuropsychiatric disorders are just as valid). (mitadmissions.org)
Actually, we know pretty much nothing about most humans diseases and disorders, and, in fact, the only field in which we have a good grasp on the mechanisms of disease is infectious diseases (e.g. malaria-we know how people get it and how it works). (mitadmissions.org)
The Alvarez-Buylla lab at UCSF is part of a collaboration that is pioneering the investigation of therapeutic interneuron replacement for the correction of neurological disorders arising from defects in neural excitation/inhibition. (ca.gov)
Towards the therapeutic development of inhibitory neuron precursor transplantation for human neurological disorders, we have made significant progress in the differentiation of these cells from human ESCs and will complete optimization of this protocol. (ca.gov)
Evaluate the functional effects of therapeutic strategies for neurological disorders and injuries in vitro . (axionbiosystems.com)
Neuroregenerative medicine is a field of medicine focused on developing therapies and treatments to repair or replace damaged or lost nervous system tissue caused by injuries, neurodegenerative diseases, or other neurological disorders. (axionbiosystems.com)
The research team is also researching dominant genetic diseases, specifically the CAG repeat disorders, Huntington's disease and spinal cerebellar ataxia. (chop.edu)
The lab's research on childhood onset neurodegenerative diseases is focused on experiments to better understand the biochemistry and cell biology of proteins deficient in these disorders, and to develop small molecule- or gene therapy-based strategies for therapy. (chop.edu)
While IVS currently focuses on applications of the LITATM in cardiac safety and discovery projects, IVS has plans for developing a wide range of useful applications in treatment development for regenerative medicine, cancer, autoimmune disorders, and a wide range of rare diseases. (invivosciences.com)
Like humans, songbirds learn their vocalizations, suggesting they could be useful as models for certain disorders. (neurosciencenews.com)
Many neurological disorders can rob someone of the ability to speak clearly, causing them to stutter, mispronounce words, and struggle to put together coherent sentences. (neurosciencenews.com)
Rats and mice, the most common lab animals, can't tell us much about speech disorders, since their vocalizations are innate, not learned. (neurosciencenews.com)
Like humans, songbirds such as zebra finches (above) can learn vocalizations, and this similarity suggests they could serve as models for research on Huntington's disease and other neurodegenerative disorders that affect speech and vocalization. (neurosciencenews.com)
After beginning her research journey as a master's student within our Ph.D. Preparatory Program, she dedicated the last several years to developing more efficient methods that can be used to generate functional and mature astrocytes for disease modeling of neurological disorders. (lu.se)
It is very difficult to develop therapeutics for central nervous system disorders owing to several challenges in studying the human brain due to its exceptionally high complexity that is not present in other animal species, and inaccessibility to tissue samples from patients and healthy individuals. (lu.se)
Toxic substances such as heavy metals-for example, arsenic and nickel-are associated with epigenetic changes that may lead to cancer, cardiovascular diseases, autoimmune diseases, and neurological disorders. (medlineplus.gov)

Humans share many senses and cognitive processes with other animals, but not language. (the-scientist.com)
To address this challenge, humans and animals have evolved abilities to prioritize which pieces of information are processed based on context and goals. (rochester.edu)
With further development, the findings could inform a potential treatment that lowers oxygen levels in certain tissues in humans to reverse advanced disease. (broadinstitute.org)
That way the researchers could ensure that each bird developed the disease as it would manifest in humans. (neurosciencenews.com)
Epizootics in animals may signal an increase in virus activity and predict potential missed human outbreaks, as shown for West Nile virus neurologic infections in horses ( 2 - 4 ) and humans ( 5 ) and Rift Valley fever associated with abortion storms in livestock and cases of febrile and neurologic disease ( 6 ) and miscarriages in humans ( 7 , 8 ). (cdc.gov)
Although no reports of infection in humans have been documented, the expanding use of SIV as a model of HIV infection has raised concern about the potential risk of SIV transmission to humans. (cdc.gov)
Because of this, armadillos rapidly became the hosts-of-choice for in vivo propagation of leprosy bacilli, and, since armadillos and humans are the only hosts that can develop extensive neurological involvement with M. leprae, they're leading models for piloting new therapies and diagnostics. (cdc.gov)
Just how the disease was transferred from humans to armadillos, or armadillos to humans is not really known. (cdc.gov)
Instead, by developing models in the dish with high biological relevance and predictive value for the human brain, we can accelerate our knowledge about what occurs during diseases affecting humans. (lu.se)
Public health officials and project managers concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAEL) have been observed. (cdc.gov)
MRLs include adjustments to reflect human variability from laboratory animal data to humans. (cdc.gov)
Very little information is available on the health effects in humans or experimental animals after inhalation exposure to methyl mercaptan. (cdc.gov)
It has existed for hundreds of years and still occurs naturally in both animals and humans in many parts of the world, including Asia, southern Europe, sub-Sahelian Africa and parts of Australia. (who.int)
Humans generally acquire the disease directly or indirectly from infected animals, or through occupational exposure to infected or contaminated animal products. (who.int)

Abnormal GABAergic function is associated with a variety of neurological diseases. (technologynetworks.com)

In particular, it highlights that recording evidence of excessive cytokine activations in patients in the wake of successful elimination of propagating viruses, such as coronaviruses, could be very informative for anticipating future cases of certain neurological diseases. (frontiersin.org)
Under the terms of the global agreement, Prevail will evaluate Sangamo's proprietary capsids by performing in vitro and in vivo studies, with an option to obtain an exclusive license to use the capsids for certain neurological targets. (businesswire.com)

However, when we added oxidative stress in the vulnerable brain region of PD (a double-hit model), by infusing mild neurotoxins at the peak of this cytokine activation (12 days after the viral RNA exposure), the brain dopaminergic neurons died at a much higher rate than without the cytokines-in this way representing a model of PEPD. (frontiersin.org)
We therefore did an experiment where we blocked IL1b systemically (using an IL1b receptor antagonist) in research model rodents and found that this prevented many of the vulnerable dopamine neurons from degenerating and dying. (frontiersin.org)
It may be of importance to revisit these findings in the context of how brain immune microglia and neurons can be activated in specific ways by viral RNA, independently or in the context of an infection that causes the flu like symptoms and disease ( 1 , 5 ). (frontiersin.org)
That was so because 47 percent more motor neurons survived there than in untreated model animals. (medindia.net)
Moreover, BDNF rescues injured GABAergic neurons in animal models of Huntington´s disease (9). (sld.cu)
Studies of Parkinson´s disease in animal models, have shown the ability of GDNF to rescue damaged dopaminergic neurons after a lesion with neurotoxins (11, 12). (sld.cu)
This poster highlights how human induced pluripotent stem cells (hiPSCs) can be precision reprogrammed to generate a highly pure population of GABAergic neurons for a more accurate model of neuronal circuits. (technologynetworks.com)
They note that one of these, AGK2, had 10 times the potency of B2 and protected dopamine-producing neurons from alpha-synuclein toxicity in cultured rat neurons and in an insect model. (genengnews.com)
As for the Lund researchers, the method provides a tool for studying how neurons cooperate inside a healthy brain and in animal models with different neurological diseases. (lu.se)
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)

The research goal of the Pan Laboratory is to combine translational and basic research on virus-mediated, in vivo and ex vivo, gene transfer into stem cells, as well as their potential application for gene therapy of patients with lysosomal storage diseases (LSDs). (cincinnatichildrens.org)
The lab is investigating recessive, childhood-onset neurodegenerative diseases, such as the lysosomal storage diseases mucopolysaccharidoses and Battens disease. (chop.edu)

Together, they had been studying how the gene GFAP was regulated in mouse models. (wisc.edu)
The fact that the only change they had made in the mice to cause them to have Rosenthal fibers was to add additional copies of the GFAP gene, led Messing and Brenner to suggest that some malfunction of the GFAP gene was what caused Alexander disease. (wisc.edu)
In Griscelli syndrome type 1, a defect in the myosin Va gene leads to the pigment dilution and neurological sequelae. (medscape.com)
A disease caused by a single mutation, in a single gene, that involves only a single cell type. (technologyreview.com)
Research with the rodents has also been critical in testing new drug treatments for the disease, as well as investigations of other potential therapeutic approaches, such as gene therapy. (microscopyu.com)
Injections of the new drugs also delayed the age at which mice carrying a disease-mutant SOD1 gene had trouble balancing on a rotating rod and appeared to prevent muscle weakness and loss of connections between nerves and muscles, suggesting it could treat the muscle activation problems caused by ALS. (nih.gov)
For more than two decades, mutations in a gene located in the DNA of mitochondria have been classified as a mitochondrial disease and linked to a particular set of symptoms. (news-medical.net)
Explore the role your gene of interest has on neural network activity in patient-derived iPSCs or animal models. (axionbiosystems.com)
June 10, 2020 Researchers have identified how certain gene mutations cause amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. (sciencedaily.com)
Gene-editing tools are now being used to understand how gene variants are linked to disease in mammalian cells and whole animal models, indicating the potential for this technology to be used to understand and treat human disease (see FIG. 3). (royalsociety.org.nz)
In the US, hornless dairy cattle have been produced using gene editing to avoid the need for painful de-horning and to prevent animals injuring each other during transport. (royalsociety.org.nz)
In Scotland, ZFN has been used by the University of Edinburgh to modify a gene in pigs to the version of the gene found in warthogs, to produce pigs that are potentially resilient to the disease. (royalsociety.org.nz)
Generated through Sangamo's AAV capsid engineering platform, SIFTER (Selecting In vivo For Transduction and Expression of RNA), these capsids have demonstrated a potential for high efficiency delivery of investigatory gene therapy constructs to the central nervous system in pre-clinical animal models following administration into the cerebrospinal fluid and seek to optimize delivery of therapeutics to a range of previously inaccessible areas. (businesswire.com)
We carry out translational gene therapy studies targeting several neurological and metabolic diseases. (umassmed.edu)
We also develop platform technologies to facilitate AAV-based gene therapy, such as animal modeling and AAV vector production. (umassmed.edu)
In October 2020, Amira was appointed Instructor of Neurodegenerative Disease Research at Stanford Neurology, to help develop improved and more powerful approaches that will better reveal key synaptic mechanisms and candidate modules associated with neuroplasticity and affected in AD mouse models, by identifying activity-dependent gene expression signatures that will ultimately serve as a platform for potential therapeutics and animal to human translation. (stanford.edu)
Dr. Davidson works to understand the molecular basis of childhood onset neurodegenerative diseases and the development of gene and small molecule therapies for treatment. (chop.edu)
Liu's experiments began by breeding finches with a singular genetic mutation-the introduction of mHTT, the mutant human gene responsible for Huntington's disease. (neurosciencenews.com)
Another NIH-funded study, Utilizing In Vitro Functional Genomics Advances for Gene-Environment (GxE) Discovery and Validation , aims to better understand the connection between environmental exposure and human disease. (medlineplus.gov)
Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)

Experimental therapies for HD currently are being tested in animal models and human trials. (medscape.com)
Advances in stem cell research and regenerative medicine have led to the potential use of stem cell therapies for neurodegenerative, developmental and acquired brain disease. (ca.gov)
The poster being presented today in the Anticonvulsant and Antiepileptic Therapies Session (289.21) of the Society for Neuroscience Annual Meeting held in San Diego, CA, also described CX-8998's preclinical efficacy against seizure as tested previously in the WAG/Rij rat model. (businesswire.com)
Cavion, Inc . is a privately held clinical stage biotechnology company creating therapies aimed at modulating the T-type calcium channel for the treatment of chronic and rare neurological diseases. (businesswire.com)
She also focuses on how noncoding RNAs participate in neural development and neurodegenerative disease processes, and how they can be harnessed for therapies. (chop.edu)

This technology could potentially enable precise investigation of neurological disease pathology in preclinical models, and more effective treatment in human patients. (mit.edu)

The potential therapeutic benefits of findings originating from in vitro experiments are being further determined by preclinical evaluation in animal disease models. (cincinnatichildrens.org)
She further discovered significant therapeutic properties of those small molecules that prevented neuronal degeneration, dendrites dystrophy and spine loss in both diseases of in vitro cell models and in vivo animal models. (stanford.edu)
Our tissues are reproducible, uniform, have long-term consistent and accurate functionality and responsiveness to cardio-active and cardio-toxic substances and will be an ideal in vitro model for the study of acute and chronic toxicity. (invivosciences.com)
The goal is to find new in vitro approaches to understand and treat human diseases caused by the environment. (medlineplus.gov)

This "reactive" state of the astrocyte can be induced by a diverse array of toxic substances as well as by neurological disease states and traumatic or ischemic injuries. (cdc.gov)
If there is any kind of injury to the CNS - be it a traumatic injury, disease, or genetic defect - GFAP tends to be upregulated in astrocytes," Brenner says. (wisc.edu)
The therapeutic potential of BMSC for the treatment of cerebral ischemia (2, 3), traumatic brain injury (4), and Parkinson´s disease (5) has been evaluated. (sld.cu)
She has worked with animal models of human neurological disease, in healthy volunteers and patients (mainly traumatic brain injury, preterm birth, and ischemia) MRI and MRS to elucidate brain structural, metabolic and functional correlates and plasticity. (dnva.no)

Dysfunction of these structures and circuits linking them are common causes of many neurologic and neuropsychiatric diseases. (mit.edu)
Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)

The signaling mechanisms underlying the astroglial response to injury remain largely unknown but progress is being made through molecular analyses, e.g. by using inducible transgenic mice and the application of expression arrays to injury models. (cdc.gov)
Using rats and mice genetically modified to carry normal or disease-mutant versions of human SOD1, a team of researchers led by Timothy M. Miller, M.D., Ph.D., Washington University, St. Louis, MO, discovered that newer versions of the drug may be more effective at treating ALS than the earlier one that had been tested in a phase 1 clinical trial. (nih.gov)
For instance, injections of the newer versions were more efficient at reducing normal, human SOD1 mRNA levels in rats and mice and they helped rats, genetically modified to carry a disease-causing mutation in SOD1, live much longer than previous versions of the drug. (nih.gov)
Previous work from his lab suggested that hypoxia could prevent ataxia - impaired balance and coordination - in Friedreich's ataxia mice, and the new findings now show that the approach can even reverse it in animals with more advanced disease. (broadinstitute.org)
In 2019, Mootha's team found that continuously exposing young mice with Friedreich's ataxia to 11 percent oxygen, as opposed to 21 percent at sea level, early in the disease prevented ataxia. (broadinstitute.org)
Although most animals are highly resistant to M. leprae and will rapidly dispose the organisms, laboratory mice will develop a very limited infection when they are inoculated into the cool temperatures of their hind foot pads. (cdc.gov)
Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

Drosophila melanogaster is a genetic model organism that has contributed to the discovery of numerous genes whose human homologues are associated with diseases. (nih.gov)
Although kindling is a widely used model, its applicability to human epilepsy is controversial. (wikipedia.org)
However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does occur. (wikipedia.org)
Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. (wikipedia.org)
Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases. (wisc.edu)
Precise and easy ways to rewrite human genes could finally provide the tools that researchers need to understand and cure some of our most deadly genetic diseases. (technologyreview.com)
Many human illnesses, including heart disease, diabetes, and assorted neurological conditions, are affected by numerous variants in both disease genes and normal genes. (technologyreview.com)
Bioethics tends to be dominated by discourses concerned with the ethical dimension of medical practice, the organization of medical care, and the integrity of biomedical research involving human subjects and animal testing. (erudit.org)
Jacques Derrida has explored the fundamental question of the "limit" that identifies and differentiates the human animal from the nonhuman animal. (erudit.org)
One understands a philosopher only by heeding closely what he means to demonstrate, and in reality fails to demonstrate, concerning the limit between human and animal. (erudit.org)
To pursue this question, however, means that our movement in language should be more radical than what has been undertaken to date, in which case we may well have to rectify our language by eschewing the very concepts "human" and "nonhuman," as well as the more basic concept "animal," which has its provenance in the Latin renditions of classical Greek philosophical nomenclature. (erudit.org)
Transplantation of interneuron precursors therefore holds therapeutic potential for treatment of human neurological diseases involving an imbalance in circuit inhibition/excitation. (ca.gov)
Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. (mdpi.com)
More recently, the role of Th1 and Th17 CD4 + cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model for human MS, has been challenged, and it has been demonstrated that the transcription factor T-bet (also known as Tbx21 ) is critical for controlling Th1/Th17-mediated autoimmunity 12 . (nature.com)
Of the approximately 25,000 identified genes in the human genome so far, mutations in over 3,000 have been linked to disease. (royalsociety.org.nz)
Ayla Annac, InvivoSciences: InvivoSciences (IVS) is a leading developer of proprietary, award-winning platform technologies that creates human 3D cell/tissue culture models and their automated phenotype analyzers for drug discovery and precision medicine development. (invivosciences.com)
IVS's functional 3D tissue models reconstitute the physiological properties of human cardiac, smooth and skeletal muscle as well as connective tissues that support cancer growth. (invivosciences.com)
Tailored to represent diverse human populations and specific diseased states, our cardiac tissue model can offer an exceptional ability to predict potential cardiac safety issues and drug efficacy in clinical studies. (invivosciences.com)
human beings have developed innovative technologies to treat and cure disease, to enhance human living conditions, and to protect or improve the environment. (jcpa.org)
In recent years, songbirds' similarities to human vocal learning have piqued researchers' interests in using them as a functional animal model to study the neurological basis for Huntington's disease. (neurosciencenews.com)
We describe Shuni virus (SHUV) detection in human neurologic disease cases in South Africa. (cdc.gov)
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. (cdc.gov)
OBJECTIVE: To characterize the brain-wide expression of Aβ42 throughout the life span of outbred Wistar rats, and to relate these findings to brains of human subjects without neurological disease. (lu.se)
This, taken together with our human results, indicate that the McGill rat model in fact models the underlying wild-type neuronal population-specific vulnerability to Aβ42 accumulation. (lu.se)
My Ph.D. studies have focused on developing ways to generate human astrocytes from pluripotent stem cells and fibroblasts for modeling diseases affecting the human brain. (lu.se)
Researchers seek to use this information to understand the causes of diseases and the effects of environment, diet, lifestyle, and genetic factors on human health. (medlineplus.gov)
Findings were done using mouse models, which will be used to inform human studies. (medlineplus.gov)
Routine cross-notification between the veterinary and human health surveillance systems should be part of any zoonotic disease prevention and control programme, and close collaboration between the two health sectors is particularly important during epidemiological and outbreak investigations. (who.int)
The highly pathogenic avian influenza is a highly contagious disease affecting wild birds and poultry with occasional infections in human. (who.int)
Since it was first reported in Vietnam in 2003, the disease has been responsible for human outbreaks and deaths in 15 countries in Asia, Europe, Middle East and Africa resulting in 603 human cases including 356 deaths. (who.int)
Egypt has been the most affected country in the EMR where the disease has remained endemic, with frequent epizootic and 167 human cases that include 60 deaths. (who.int)

We use electrophysiological methods (EEG, neural population recordings, electrical stimulation) and computational models to investigate the mechanisms of attention and memory and potential avenues for intervention. (rochester.edu)
In addition, the lab aims to better understand how changes in the transcriptome impact neural development and neurodegenerative disease processes. (chop.edu)
In appropriate circumstances, hUC-MSCs can differentiate into neuron-like cells, when transplanted into different animal models of neurological diseases can promote the recovery of neural function. (hanspub.org)
when it comes to neurological diseases (and even if the damage is local, as in the case of stroke) the entire neural network is disrupted. (lu.se)

In a paper published last year in the Proceedings of the National Academy of Sciences , a research team led by Aleksey Kazantsev, Ph.D., director of MGH-MIND drug discovery laboratory, analyzed ways to reduce the size of inclusions containing misfolded versions of alpha-synuclein or of the Huntington's disease-associated protein huntingtin. (genengnews.com)
In many visits, care providers for patients with dementia, who are mostly patients' family members, are anxious and ask the clinicians what they can do for prevention of dementia in themselves or in their children," study investigator Shahram Oveisgharan, MD, assistant professor of neurological sciences at Rush University, Chicago, Illinois, told Medscape Medical News . (medscape.com)

CD4 + T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD + ) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ + IL-10 + T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. (nature.com)
Our findings unravel a new pathway orchestrating CD4 + T-cell differentiation and demonstrate that NAD + may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. (nature.com)
In contrast, regulatory T cells (Tregs) play a cardinal role in protecting against autoimmune diseases, inflammation and tissue damage 13 through secretion of IL-10 (ref. 14 ) and other mechanisms. (nature.com)

Uganda experienced five Ebola disease outbreaks caused by Bundibugyo virus (n = 1) and Sudan virus (SUDV) (n = 4) from 2000 to 2021. (cdc.gov)

Stimulation of AT2 R and the receptor Mas has been shown to reduce infarct size and ameliorate neurological deficits in various animal models of stroke. (monash.edu)
We also study the brain blood vessel response to stroke in aging, and in longer term models of dementia. (stanford.edu)

Optogenetics has been widely used to interrogate the causal functions of the activity and plasticity of specific neuronal circuits in behaviors and neurological diseases (e.g. (frontiersin.org)

Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. (lu.se)

A startling rise in asthma prevalence has occurred over the past 2 decades, making it one of the most common chronic diseases of industrialized countries. (jci.org)
The independent judging panel of the Eloquium Award has today named three journalists as winners of the 2007 competition for excellence in reporting on chronic obstructive pulmonary disease (COPD) the fastest growing cause of death in the world's most advanced economies. (worldpharmanews.com)
These results were demonstrated in patients with or without chronic kidney disease, metabolic syndrome or type 2 diabetes. (worldpharmanews.com)
In rhesus monkeys and other susceptible nonhuman primate species (e.g. pig-tailed macaque, crab-eating macaque), SIV infection leads to a chronic wasting disease syndrome with depletion of CD4 (T4) lymphocytes and lymphadenopathy. (cdc.gov)
SIV isolates are clearly distinct from Type D primate retrovirus (i.e., simian retrovirus 1)that also causes a form of chronic wasting immunodeficiency disease in several primate species (ll). (cdc.gov)
Asthma is the most common chronic respiratory disease, especially among children. (who.int)
Although asthma has a relatively low fatality rate compared to other chronic diseases, according to WHO estimates, 300 million people suffer from asthma and 255 000 people died of asthma in 2005. (who.int)

A renaissance in natural language modeling may help researchers explore how the brain extracts and organizes meaning. (the-scientist.com)
Experiments conducted on rat models of ALS, also called Lou Gehrig's disease, have shown that transplanting a new line of stem cell-like cells reduces neuron loss, and extends life, Johns Hopkins researchers have revealed. (medindia.net)
During the study, the researchers had transplanted about 900,000 glial restricted precursors overall to specific sites in the cervical spinal cord of each model rat in early stages of disease. (medindia.net)
Researchers from Children's Hospital of Philadelphia (CHOP) developed two new zebrafish models for studying a specific genetic form of mitochondrial disease that represents the most common cause of Leigh syndrome. (news-medical.net)
Implanting these cannulas with micropumps allowed the researchers to remotely control the behavior of animals. (mit.edu)
Chinese researchers have similarly used TALENs and CRISPR to modify a range of agriculturally important plants and animals, including maize, rice, and wheat. (royalsociety.org.nz)
Now, researchers at the Broad Institute of MIT and Harvard have found that treatment with continuous hypoxia - low-oxygen conditions comparable to levels at a Mount Everest base camp - restores balance and coordination in a mouse model of Friedreich's ataxia. (broadinstitute.org)
However, most patients are diagnosed later in the disease, after symptoms develop, so the researchers wanted to test whether hypoxia could reverse - rather than simply prevent - advanced disease. (broadinstitute.org)
Recent work at The Rockefeller University may give researchers a new tool to better study these vocal and speech impairments, particularly in Huntington's disease. (neurosciencenews.com)
Researchers can use ENCODE data-which has been combined with other data, such as environmental information-to better understand diseases and drugs, how an individual's genetic makeup interacts with the environment, and how those affect their health. (medlineplus.gov)

The results, published in the Journal of Clinical Investigation, suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. (nih.gov)
NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. (nih.gov)
Not least, the variability and inaccuracy of traditional model systems can result in the failure to translate data into successful clinical trials. (technologynetworks.com)
A total of 7 of 130 (5.4%) CSF samples tested positive with an Orthobunyavirus rRT-PCR targeting the S segment and were confirmed by DNA sequencing to represent SHUV ( Figure , panel A). A longer region was obtained for a CSF sample taken from a patient who was confirmed to have had neurologic diseases (meningitis, encephalitis, and seizures) with a clinical diagnosis of TB meningitis. (cdc.gov)
Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)

However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneumonia). (mdpi.com)
People who live near farms, who visit farms during the application of fertilizer, or who live near cattle feedlots, poultry confinement buildings, or other areas where animal populations are concentrated can also be exposed to ammonia. (cdc.gov)

Interneuron replacement has been used in animal models to modify plasticity, prevent spontaneous epileptic seizures, ameliorate hemiparkinsonian motor symptoms, and prevent PCP-induced cognitive deficits. (ca.gov)

For Albee Messing , VMD, PhD, Waisman investigator, the decision to pursue what others deemed a ridiculous idea has led to a potential treatment for a devastating neurological disease. (wisc.edu)
The only possibility is when patients are undergoing treatment for neurological diseases such as epilepsy. (the-scientist.com)
In view of the data reviewed in this article, it can be assumed that the protective arms of the RAS are putative targets in the treatment of neurological diseases, which involve tissue damage or cognitive impairment. (monash.edu)
The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
Although no therapy is currently available to delay the onset of symptoms or prevent the progression of the disease, symptomatic treatment of patients with Huntington disease (HD) may improve the quality of life and prevent complications. (medscape.com)
Scientists at the University of Exeter have identified a way to "rescue" cells that have genetically mutated, paving the way to a possible new treatment for rare terminal childhood illness such as mitochondrial disease. (news-medical.net)
Neuroregenerative medicine offers new hope for the treatment of neurodegenerative diseases and the repair of spinal and peripheral nerve injuries. (axionbiosystems.com)
Using ground-breaking science, including our proprietary zinc finger genome engineering technology and manufacturing expertise, Sangamo aims to create new genomic medicines for patients suffering from diseases for which existing treatment options are inadequate or currently don't exist. (businesswire.com)
Most morbidity and all mortality from asthma is the result of acute exacerbations (commonly known as asthma attacks), and treatment of these exacerbations accounts for the majority of the economic burden attributable to this disease. (jci.org)
Disease areas Broad brings people together to advance the understanding and treatment of disease. (broadinstitute.org)
Mootha's lab has been studying hypoxia as a potential treatment for rare neurological diseases since 2016. (broadinstitute.org)

Alexander disease (AxD) is an extremely rare neurological disorder that can cause the destruction of white matter in the brain. (wisc.edu)
There hasn't been a good animal model for any kind of speech disorder," says study author Wan-chun Liu, a senior research associate in Fernando Nottebohn's Laboratory of Animal Behavior. (neurosciencenews.com)

In recent work, the lab demonstrated that the application of recombinant viral vectors to various models of storage disease reversed CNS deficits and improved life span. (chop.edu)

To build a language decoder, Huth first needed functional MRI (fMRI) data to input into the model. (the-scientist.com)
Neuroleptics may worsen other features of the disease, such as bradykinesia and rigidity, leading to further functional decline. (medscape.com)

Linear regression models showed that every one-unit increase in ELCE score was associated with a lower global AD pathology score (estimate, −0.057) and lower levels of tau (estimate, −0.188) and beta amyloid (estimate, −0.136). (medscape.com)
Early white matter pathology in the fornix of the limbic system in Huntington disease. (lu.se)

It is characterized by slowly progressive yet milder neurologic symptoms compared to type 2 Gaucher disease. (nih.gov)
Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease. (news-medical.net)
However, the molecular and neurological dysfunctions that cause these symptoms aren't well understood. (neurosciencenews.com)

For a considerable portion of her career, she has been working in the lab, and contributing to important research to find cures for neurological diseases. (stanford.edu)

First, such models require a large amount of labeled data but the labeling of behaviors frame by frame is a laborious manual process that is not easily scalable. (bvsalud.org)
The method has the potential to reduce the bottleneck of scarce labeled videos for training and improve performance of supervised behavioral classification models for the study of interaction behaviors in animals. (bvsalud.org)

In addition to targeting specific diseases, we develop therapeutic platforms based on molecular approaches such as genome editing and RNA-based methods. (umassmed.edu)

We will continue our investigation of rodent-derived interneuron transplantation to obtain relevant preclinical data for dose response, safety and efficacy in animal models. (ca.gov)

A linear regression model adjusted for potential confounders suggested that increased ELCE was associated with less annual cognitive decline compared with lower levels of ELCE. (medscape.com)

A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)

On 20 September 2022, Uganda declared a fifth Sudan virus disease outbreak in the Mubende district, resulting in 142 confirmed and 22 probable cases by the end of the outbreak declaration on 11 January 2023. (cdc.gov)

Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. (wikipedia.org)
Kindling is also referred as an animal visual model of epilepsy that can be produced by focal electrical stimulation in the brain. (wikipedia.org)
Kindling (sedative-hypnotic withdrawal) Epileptogenesis Racine stages (a method by which seizure severity is quantified in animal models of epilepsy) Bertram E (2007). (wikipedia.org)
Kindling: An experimental model of epilepsy" (PDF). (wikipedia.org)
CX-8998 was more effective than the commonly prescribed anti-epileptic drug ethosuximide in reducing absence seizures in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), a highly predictive model of absence epilepsy. (businesswire.com)

Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors. (frontiersin.org)

Friedreich's ataxia is a rare, inherited disease that causes progressive nervous system damage, impairing balance and coordination and leaving patients unable to walk by early adulthood. (broadinstitute.org)
Patients with Friedreich's ataxia have fewer of these clusters than people without the disease, resulting in impaired energy production in the affected cells. (broadinstitute.org)
To look for other possible regimens, Mootha's team, in their latest study, tested seven different hypoxia treatments in the same mouse model of Friedreich's ataxia and included animals in later stages of the disease. (broadinstitute.org)

Research in the Davidson Laboratory is focused on inherited genetic diseases that cause central nervous system dysfunction. (chop.edu)

The event, called excitotoxicity, also occurs in other neurological diseases. (medindia.net)

African swine fever is a highly contagious disease that kills up to two-thirds of infected animals. (royalsociety.org.nz)

The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. (nih.gov)

Examine the role of glial cells and other non-neuronal cells in disease pathogenesis and progression. (axionbiosystems.com)
The IVIS Spectrum CT enables longitudinal workflows to characterize disease progression and therapeutic effect in animals throughout the complete experimental time frame with both quantitative CT and optical reconstructions. (lu.se)

Three new studies at the University of Michigan Health System seek to help people with the terminal illness known as Lou Gehrig's disease live and breathe more comfortably. (medindia.net)
Our animal studies show that volume is a critical factor when delivering drugs to the brain, as important as the total dose delivered. (mit.edu)
These studies demonstrated that implanting BMSC into the injured brain induced a therapeutic improvement in animal models. (sld.cu)
Limited studies of wild-caught African green monkeys from Central Africa indicate a seroprevalence of approximately 30%-50%, apparently without associated immunodeficiency disease. (cdc.gov)
Early studies found the disease mainly in Texas and Louisiana, but armadillos in the southwestern United States appeared to be free of infection. (cdc.gov)
Oveisgharan said there are data from animal studies that suggest environmental enrichment is associated with lower levels of tau, phosphorylated tau, and oligomeric amyloid beta. (medscape.com)

Her post-graduate work focused on the role of neurotrophin receptor signaling and neuroinflammation in Huntington's Disease (HD). (stanford.edu)
Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients. (lu.se)
IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)

Anthrax is a disease caused by a bacterium called Bacillus anthracis. (who.int)

Indicated for chorea associated with Huntington disease. (medscape.com)
Tetrabenazine is the first drug approved specifically to treat chorea associated with Huntington disease. (medscape.com)
Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model. (lu.se)

As is the case with other neurological diseases, HD makes individuals more vulnerable to side effects from medications, particularly cognitive adverse effects. (medscape.com)

Type 2 (acute infantile neuropathic Gaucher disease) typically begins within three months of birth. (nih.gov)

As research efforts have been expanded to further elucidate disease pathogenesis, vast arrays of inflammatory mediators and proinflammatory pathways have been discovered, and pharmacological interruption of many of these pathways has been proposed. (jci.org)
The endogenous purine nucleoside adenosine is one proinflammatory mediator that has garnered interest as a contributor to asthma pathogenesis, particularly with regard to acute exacerbations of the disease. (jci.org)

In research starting in 2007 ( 3 , 4 ) we developed a mouse model system to infuse synthetic viral RNA (Poly I:C) in brain regions that typically are vulnerable in PD ( 4 ). (frontiersin.org)
What Can ChatGPT-like Language Models Tell Us About the Brain? (the-scientist.com)
The model made guesses of what the participant was thinking and ranked these guesses based on how well they corresponded to the participant's brain activity. (the-scientist.com)
In Huth's study, he used a large language model called GPT1, an early version of the engine that runs ChatGPT, to decode brain activity. (the-scientist.com)
Parkinson s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. (medindia.net)
Lastly, I will present how an epidemiological approach to brain MRI can elucidate new relationships of disease risk and possibility of delaying brain atrophy. (dnva.no)
In this interview, we learn more about her efforts to facilitate future research that explores the role of astrocytes in disease and could lead to the development of new efficient treatments for many diseases affecting the brain. (lu.se)
There is extremely limited access to brain tissue for research purposes, both from healthy individuals as well as from patients with brain disease. (lu.se)

Anatomy11

Organisms9

Diseases36

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology3

Phenomena and Processes5

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science1

Parkinson's16

Alzheimer's12

Disorders22

Humans14

Variety of neurological diseases1

Certain neurological2

Neurons10

Lysosomal storage2

Gene20

Therapies5

Preclinical models1

Vitro4

Traumatic4

Neuropsychiatric2

Mice7

Human31

Neural4

Sciences2

Autoimmune3

20211

Stroke2

Neuronal circuits1

Transgenic1

Chronic7

Researchers10

Clinical5

Populations2

Ameliorate1

Treatment11

Disorder2

Deficits1

Functional2

Pathology2

Symptoms3

Cures1

Behaviors2

Molecular1

Transplantation1

Potential1

Drosophila1

20231

Epilepsy5

Neuroscience1

Ataxia3

Genetic diseases1

Excitotoxicity1

Highly contagious disease1

Nervous System1

Progression2

Studies6

Huntington's Disease3

Caused by a bacterium1

Huntington3

Cognitive1

Neuropathic1

Pathogenesis2

Brain8