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ParaplegiaTuberculosisSpastic Paraplegia, HereditaryTuberculosis, PulmonarySpinal CordSpinal Cord InjuriesMycobacterium tuberculosisTuberculosis, SpinalTuberculosis, Multidrug-ResistantSpinal Cord IschemiaTuberculosis VaccinesSpinal Cord CompressionTuberculosis, MiliaryIsoniazidNeurologic ExaminationLatent TuberculosisTuberculosis, Lymph NodeTuberculosis, OsteoarticularParaparesisNervous System DiseasesTuberculosis, GastrointestinalQuadriplegiaSpinal Cord NeoplasmsTuberculosis, BovineSpinal DiseasesInjections, SpinalSpinal NeoplasmsTuberculosis, CutaneousLaminectomyTuberculin TestAortic Aneurysm, ThoracicThoracic VertebraeSpinal Cord DiseasesRifampinSpinal Nerve RootsSputumAnesthesia, SpinalSpinal NervesMycobacterium bovisTuberculosis, MeningealTuberculosis, PleuralExtensively Drug-Resistant TuberculosisTuberculosis, UrogenitalPyrazinamideAntibiotics, AntitubercularBCG VaccineSpinal FusionSpinal InjuriesSpinal CanalSpinal StenosisBacterial ProteinsMyelographyTuberculosis, OcularTuberculosis, SplenicHematoma, Epidural, SpinalTreatment OutcomeTime FactorsMycobacteriumTuberculosis, HepaticAntigens, BacterialTuberculosis, Female GenitalTuberculosis, Central Nervous SystemMagnetic Resonance ImagingEthambutolMycobacterium smegmatisWheelchairsMuscle SpasticityEpidural SpaceDirectly Observed TherapyTuberculosis, EndocrineHysteriaTuberculosis, LaryngealSpineDecompression, SurgicalRetrospective StudiesMotor NeuronsTomography, X-Ray ComputedTuberculosis, RenalSensitivity and SpecificityCervical VertebraeDNA, BacterialLumbar VertebraeCrutchesAortographyMuscular Atrophy, SpinalKyphosisBlood Vessel Prosthesis ImplantationPedigreeDisease Models, AnimalMyelitis, TransverseLumbosacral RegionAneurysm, DissectingSpinal FracturesCerebrospinal Fluid PressureNeurologic ManifestationsTuberculosis, OralPostoperative ComplicationsSpondylitisGanglia, SpinalArachnoiditis
MycobacteriumDeficitsInfectionDeformityLesionPulmonary TuberculosisSpineOsteomyelitisSerious neurologicVertebralAcuteLumbar spinal sEpidemiologyDeficitCervicalWeaknessInfarctionInstabilityCanalOccursMorbidityLungsTractsTuberculous meningitisDescribed as infectiDisordersPathologyDiseasesSensoryExtrapulmonaryIncidenceExogenousVertebraeBilateralIntervertebralLesionsDiseaseSymptomsHematogenous disseminationSurgeryPosteriorNerveWorkup
Mycobacterium7
Deficits5
  • Abscess location determines residual neurologic deficits. (pediatriconcall.com)
  • Tuberculous involvement of the spine has the potential to cause serious morbidity, including permanent neurologic deficits and severe deformities. (medscape.com)
  • The spinal canal can be narrowed by abscesses, granulation tissue, or direct dural invasion, leading to spinal cord compression and neurologic deficits. (medscape.com)
  • Patients with acute neurologic deficits within the previous 12-24 hours should definitely have surgery. (uab.edu)
  • Thus, a central spinal cord lesion may cause neurologic deficits in a descending order. (emcrit.org)
Infection22
  • Tuberculosis (TB) Tuberculosis is a chronic, progressive mycobacterial infection, often with an asymptomatic latent period following initial infection. (msdmanuals.com)
  • Regardless of the source of the infection, an infection of the spine should be quickly diagnosed in order to prevent structural instability or neurologic compromise. (wheelessonline.com)
  • The most common primary spinal infection is pyogenic vertebral osteomyelitis. (wheelessonline.com)
  • Three major routes of spread are: (1) hematogenous spread from a distant infection, (2) direct inoculation from trauma, (3) direct inoculation following invasive spinal diagnostic procedures and from spinal surgery. (wheelessonline.com)
  • Spinal Tuberculosis, also known as Pott's Disease, is a spinal infection caused by tuberculosis that can lead to osteomyelitis, kyphotic deformity, and spinal mechanical instability. (orthobullets.com)
  • Spinal cord infection: myelitis and abscess formation. (pediatriconcall.com)
  • Without application of effective treatment for latent infection, new cases of tuberculosis can be expected to develop from within this group. (cdc.gov)
  • Within the past decade it also has become clear that of the pasteurization of milk and effective tuberculosis control the spread of HIV infection and the immigration of persons programs for cattle (13). (cdc.gov)
  • Skeletal tuberculosis is thought to result from hematogenous dissemination from a primary site and occurs 6 months to 3 years after primary infection. (uab.edu)
  • If left untreated, this infection has high morbidity leading to spinal deformity, paraplegia, and even death. (nih.gov)
  • Tuberculosis (TB) is the most common cause of infection-related death worldwide. (medscape.com)
  • See Medscape Drugs & Diseases articles Tuberculosis, Miliary Tuberculosis, Primary Tuberculosis Imaging, Pediatric HIV Infection, and HIV Disease for more information on these topics. (medscape.com)
  • Case rates for persons who are dually infected with HIV and M tuberculosis exceed the lifetime risk of persons with TB infection who are not infected with HIV. (medscape.com)
  • The spinal canal can narrow due to the protrusion of granulation tissue, lesions like cold abscesses developed in the course of the TB infection, or because of direct infiltration. (cessspinemumbai.com)
  • Bone TB and especially spinal Tuberculosis is challenging to diagnose because it's painless in the early stages, and therefore one may not exhibit any symptoms, onset of symptoms of tuberculous spondylitis is more insidious than pyogenic infection. (cessspinemumbai.com)
  • Infection of spine occurs due to tuberculosis, atypical tuberculosis, pyogenic, fungal and parasitic infestation (e.g.hydatid cyst). (ijsonline.co.in)
  • Method: According to the inclusion criteria, 314 cases of spinal infection (SINF) and 314 cases of non-infected spinal disease (NSINF) were collected from January 1, 2016 to December 31, 2021 at Xiangya Hospital, Central South University, and the differences between the two groups in terms of postoperative DVT were analyzed by chi-square test. (bvsalud.org)
  • The spinal infection cases were divided into a thrombotic group (DVT) and a non-thrombotic group (NDVT) according to whether they developed DVT after surgery. (bvsalud.org)
  • Result: The incidence of postoperative DVT in patients with spinal infection was 28%, significantly higher than 16% in the NSINF group, and statistically different from the NSINF group (P (bvsalud.org)
  • Five predictor variables for postoperative DVT in patients with spinal infection were screened by LASSO regression, and plotted as a nomogram. (bvsalud.org)
  • Conclusion: In this study, a nomogram prediction model was developed for predicting postoperative DVT in patients with spinal infection. (bvsalud.org)
  • The nomogram included five preoperative predictor variables, which would effectively predict the likelihood of DVT after spinal infection and may have greater clinical value for the treatment and prevention of postoperative DVT. (bvsalud.org)
Deformity2
  • Destruction of the anterior endplates ensues with anterior collapse leading to a wedge deformity seen clinically, as well demonstrated in this case, as the spinal deformity known as a gibbus. (uab.edu)
  • Spinal TB is a dangerous form of skeletal TB because it is associated with a neurologic deficit due to compression of the adjacent neural structures and cause significant spinal deformity. (cessspinemumbai.com)
Lesion6
  • Sood V, Aggarwal M. Spinal Lesion. (pediatriconcall.com)
  • Differential diagnosis of the clinical syndrome and spinal lesion seen in our patient includes other forms of bacterial osteomyelitis and metastatic cancer. (uab.edu)
  • Evaluating for a sensory level using a pin to detect pain sensation is more sensitive to detect a spinal level originating from a lesion in the spinothalamic tract. (emcrit.org)
  • Motor weakness may be used to evaluate the level of a spinal lesion that involves the corticospinal tract. (emcrit.org)
  • Brown-Séquard syndrome is an incomplete spinal cord lesion characterized by a clinical picture reflecting hemisection injury of the spinal cord, often in the cervical cord region. (medscape.com)
  • This condition is usually caused by a lesion in the upper BRAIN STEM which injures the descending cortico-spinal and cortico-bulbar tracts. (lookformedical.com)
Pulmonary Tuberculosis4
Spine7
Osteomyelitis3
  • Vertebral osteomyelitis (additionally referred to as spinal osteomyelitis or spondylodiskitis) accounts for approximately 3% to 5% of all cases of osteomyelitis annually. (nih.gov)
  • [2] Conversely, coagulase-negative staphylococci and Propionibacterium acnes are the most common pathogens in cases of exogenous osteomyelitis after spinal surgery, particularly with the use of spinal fixation devices. (nih.gov)
  • Spinal tuberculosis affects the vertebrae and spreads to adjacent spinal structures, resulting in osteomyelitis, and arthritis in several vertebrae. (cessspinemumbai.com)
Serious neurologic3
  • Serious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. (recallguide.org)
  • These serious neurologic events have been reported with and without use of fluoroscopy. (recallguide.org)
  • Cauda equina syndrome (CES) is a serious neurologic condition in which damage to the cauda equina causes loss of function of the lumbar plexus (nerve roots) of the spinal canal below the termination (conus medullaris) of the spinal cord. (gloucestershirespinalsurgery.com)
Vertebral4
Acute3
  • With longer standing neurologic deficit there is not well-controlled data to show better outcomes with surgery but where neurosurgical intervention is accessible it is often undertaken in conjunction with medical therapy.should be considered for very severe paraplegia especially in the acute stage. (uab.edu)
  • As a person with spinal cord injury (SCI) advances through acute rehabilitation, physical therapy addresses mobility issues. (medscape.com)
  • The burden of acute traumatic spinal cord injury among adults in the United States: an update. (neurosurgery.directory)
Lumbar spinal s3
Epidemiology2
Deficit4
Cervical2
Weakness1
  • 12250 ='Vertigo - dizziness' 12300 ='Weakness (neurologic)' 12350 ='Disorders of speech, speech disturbance' 12351 ='Stuttering, stammering' 12352 ='Slurring' 12400 ='Other symptoms referable to the nervo. (cdc.gov)
Infarction1
Instability1
  • Treatment is usually bracing and anti-tuberculosis antibiotics in the absence of neurological defects or mechanical instability. (orthobullets.com)
Canal1
  • After the conus medullaris, the canal contains a mass of nerves (the cauda equina or "horse-tail") that branches off the lower end of the spinal cord and contains the nerve roots from L1-5 and S1-5. (gloucestershirespinalsurgery.com)
Occurs2
Morbidity1
  • Traumatic spinal cord injuries (TSCIs) affect up to 500,000 people worldwide each year, and their high morbidity is associated with substantial individual and societal burden and socioeconomic impact 1) 2) . (neurosurgery.directory)
Lungs2
Tracts3
  • Therefore, a sensory level to light touch may be absent unless both of these are involved (e.g., a complete injury that involves all spinal cord tracts). (emcrit.org)
  • Three major tracts run through the spinal cord, as shown below. (emcrit.org)
  • Interruption of the lateral corticospinal tracts, the lateral spinal thalamic tract, and at times the posterior columns produces a picture of a spastic, weak leg with brisk reflexes and a strong leg with loss of pain and temperature sensation. (medscape.com)
Tuberculous meningitis1
  • Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. (nih.gov)
Described as infecti1
  • Primary spinal infections are described as infections of the vertebrae that are not secondary to an operation. (wheelessonline.com)
Disorders2
  • It is one of the most common neurologic disorders of the cranial nerves (see the image below). (medscape.com)
  • Bell palsy is one of the most common neurologic disorders affecting the cranial nerves, and it is the most common cause of facial paralysis worldwide. (medscape.com)
Pathology2
  • The first step towards diagnosis and therapy is recognizing that the patient has some sort of spinal cord pathology. (emcrit.org)
  • He was a establisher of the Orthopedic Scrutinize and Lore Raison d'etre in 1956 and served as its ?rst secretaryвЂ"treasurer It was while at Stanmore that he made his incipient contribution to the pathology of paraplegia in spinal tuberculosis [url=https://www.cabrachtrust.org/wp-content/periodic/examination-1/viagra-super-active/]buy 100 mg viagra super active mastercard[/url]. (arelys-photos.fr)
Diseases3
  • Pott disease is one of the oldest demonstrated diseases of humankind, having been documented in spinal remains from the Iron Age in Europe and in ancient mummies from Egypt and the Pacific coast of South America. (medscape.com)
  • Tuberculosis remains one of the deadliest diseases in the world. (cdc.gov)
  • Thus, diseases affecting the anterior horn of the spinal cord cause flaccid paralysis. (emcrit.org)
Sensory1
  • Spinal nerves and corresponding sensory dermatomes are shown above. (emcrit.org)
Extrapulmonary4
Incidence3
Exogenous1
Vertebrae1
  • The spinal lesions of advanced brucellosis include bridging osteophytes, simultaneous with the presence of both osteoblastic lesions and loss of bony mass in the same vertebrae [see Gorgas Case 2001-02 ]. (uab.edu)
Bilateral1
  • General hypotonia, bilateral pyramidal signs consistent with paraplegia, as well as meningismus. (uab.edu)
Intervertebral1
  • Tuberculosis may spread from that area to adjacent intervertebral disks. (medscape.com)
Lesions1
  • Spinal column affection by neoplastic lesions include primary (benign or malignant ) or secondary metastasis. (ijsonline.co.in)
Disease9
  • Since the advent of antituberculous drugs and improved public health measures, spinal tuberculosis has become rare in industrialized countries, although it is still a significant cause of disease in developing nations. (medscape.com)
  • The "Diagnostic Standards and Classification of Tuberculosis and disease (2). (cdc.gov)
  • in Adults and Children" is a joint statement prepared by the In the United States, an estimated 15 million people are in- American Thoracic Society and the Centers for Disease Con- fected with M. tuberculosis (3). (cdc.gov)
  • Although the tuberculosis case trol and endorsed by the Infectious Disease Society of America. (cdc.gov)
  • Tuberculosis is a social disease with medical implications. (cdc.gov)
  • See Tuberculosis: Diagnostic Imaging and Treatment Challenges, a Critical Images slideshow, to help determine the best approach for patients with this multisystemic disease. (medscape.com)
  • Most persons infected with M tuberculosis do not develop active disease. (medscape.com)
  • Tuberculosis has been reported in patients treated for arthritis, inflammatory bowel disease, and other conditions with tumor necrosis factor (TNF)-alpha blockers/antagonists. (medscape.com)
  • This may be harder than it sounds, because spinal cord disease is uncommon and not generally high on our list of considerations. (emcrit.org)
Symptoms2
Hematogenous dissemination1
  • Tuberculosis outside the lung usually results from hematogenous dissemination. (msdmanuals.com)
Surgery1
Posterior1
  • Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. (lookformedical.com)
Nerve1
Workup1
  • Workup includes cultures with sensitivities from abscess aspirate including tests for aerobic and anaerobic bacteria, fungi, and tuberculosis and parasites. (pediatriconcall.com)