• rats
  • In comparison, adult rats undergoing a series of 25 flurothyl-induced seizures had a significant increase in neurogenesis compared with controls. (jneurosci.org)
  • Prenatal buprenorphine exposure decreases neurogenesis in rats. (sigmaaldrich.com)
  • This study provides evidence of decreased neurogenesis and depression-like consequences following prenatal exposure to buprenorphine and sheds light on mechanisms of action in a rat model involving administration of intraperitoneal injection to pregnant rats starting from gestation day 7 and lasting for 14 days and a cultured neurosphere model. (sigmaaldrich.com)
  • Brain
  • Unfortunately, the methods used in this study, and in fact all methods currently available to selectively reduce neurogenesis, are likely to have additional affects on brain function, making results less than conclusive. (bioedonline.org)
  • Indeed, the discovery of a dynamic neurogenesis in the adult brain (in both humans and animals) was a kind of extraordinary revelation. (plos.org)
  • Taken together, our results suggest that prenatal exposure to buprenorphine might result in depression-like phenotypes associated with impaired BDNF action and decreased neurogenesis in the developing brain of weanlings. (sigmaaldrich.com)
  • The zebrafish displays a strong neurogenerative capacity capable of regenerating a variety of tissues and complete neuronal diversity (with the exception of astrocytes, as they have yet to be identified within the zebrafish brain) with continued neurogenesis through the life span. (wikipedia.org)
  • In the late 1970s Steven Goldman used this technique to examine the vocal control centers of songbirds, and he found widespread evidence of adult neurogenesis in this area of a canary's brain. (wikipedia.org)
  • pathway
  • GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. (wikipedia.org)
  • Disease
  • recently identified that neurogenesis is compromised prior to any overt signs of AD-like pathology in a triple-transgenic mouse model of the disease. (frontiersin.org)
  • functional
  • Although the functional significance of abnormal neurogenesis in these and other medical conditions is not yet understood, it is an intense area of research that may one day yield new treatments for these disorders. (bioedonline.org)
  • This page discusses the methods utilized in studying adult neurogenesis, the pros and cons of presently used animal models of this research, and the possible functional roles it plays in humans. (wikipedia.org)
  • reduction
  • These and other observations suggest that a reduction of neurogenesis could be an underlying cause of depression. (bioedonline.org)
  • Suga and Wasterlain, 1980 ) demonstrated a reduction of cell number with seizures during early development, suggesting that neonatal seizures may result in a reduction rather than an increase in neurogenesis. (jneurosci.org)
  • response
  • Extensive research has been implemented in several classical animal models to further the understanding of neurogenesis, particularly in response to damage. (wikipedia.org)