• patients
  • To explore potential positive or negative impact of fipamezole on disease characteristics, the MSA and PD patients are assessed with UMSARS and UPDRS scales, respectively. (clinicaltrials.gov)
  • The recent description of an association between loss of brainstem serotonin neurons and sudden death in patients with MSA reinforced the hypothesis of a critical role played by this neurotransmitter in the pathophysiology of this disease. (clinicaltrials.gov)
  • About 1 in 5 MSA patients will fall in their first year of disease. (wikipedia.org)
  • multiple
  • It should also not be confused with multiple organ dysfunction syndrome (sometimes referred to as multiple organ failure), or with multiple organ system failure (an often-fatal complication of septic shock or other very severe illnesses or injuries). (wikipedia.org)
  • onset
  • Any factor inducing or limiting a metal dyshomeostasis, ROS production and cell injury may contribute to the onset of neurodegenerative diseases or play a neuroprotective action. (frontiersin.org)
  • In this review, metal role in the onset of prion and prion-like diseases is dealt with from a nutritional, cellular, and molecular point of view. (frontiersin.org)
  • include
  • Non-neurogenic causes of postural hypotension which include intravascular volume depletion (blood or fluid loss and Addison's disease), vasodilatation (drugs such as levodopa or glyceryl trinitrate), and cardiac impairment, 3 should be considered. (bmj.com)
  • Inherited conditions include: Arnold-Chiari malformations, Dandy-Walker syndrome, craniosynostosis, Klippel-Feil (fused cervical segments) occipitalization (fused upper cervical spine and skull), as well as others. (wordpress.com)
  • clinical
  • Healthy and disease control subjects may give permission at the Baseline visit to be contacted and followed in the previously established PSG FOUND study using mail and telephone contact to assess clinical status. (clinicaltrials.gov)
  • neurotransmitter
  • Neurogenic orthostatic hypotension in these diseases results from decreased delivery of the sympathetic neurotransmitter noradrenaline (or hormonal adrenaline) to vascular adrenergic receptors, either because of blunted CNS control or impaired function of postganglionic sympathetic neurons. (clinicaltrials.gov)
  • controls
  • This is a case control study, in which PD subjects will be compared to neurologically healthy controls and disease controls (MSA and PSP). (clinicaltrials.gov)