Animal Use AlternativesDisease Models, AnimalModels, AnimalNeurodegenerative DiseasesMice, TransgenicHuntington DiseaseNerve DegenerationMice, Inbred C57BLAlzheimer DiseaseBrainNeuronsParkinson Diseasealpha-SynucleinNeuroprotective Agentstau ProteinsAmyotrophic Lateral SclerosisNerve Tissue ProteinsMice, KnockoutAmyloid beta-PeptidesMutationTauopathiesHeredodegenerative Disorders, Nervous SystemParkinsonian DisordersCells, CulturedMicrogliaPhenotypeTrinucleotide Repeat ExpansionInclusion Bodies1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineOxidative StressCell DeathSignal TransductionModels, BiologicalMice, Inbred BALB CAmyloid beta-Protein PrecursorSpinocerebellar AtaxiasSynucleinsPrionsGene Expression RegulationImmunohistochemistryMitochondriaDopaminergic NeuronsPrion DiseasesNeuronal Ceroid-LipofuscinosesInflammationApoptosisNervous System DiseasesProteostasis DeficienciesPeptidesAutophagyMice, Mutant StrainsAgingAnimals, Genetically ModifiedNeurotoxinsSubstantia NigraBlotting, WesternDrug Evaluation, PreclinicalDisease ProgressionHippocampusCorpus StriatumCell LineCell SurvivalCentral Nervous SystemOxidopamineDopamineTime FactorsRotarod Performance TestFrontotemporal DementiaMolecular Sequence DataBehavior, AnimalFriedreich AtaxiaPlaque, AmyloidNuclear ProteinsReverse Transcriptase Polymerase Chain ReactionCerebral CortexFrontotemporal Lobar DegenerationRNA, MessengerPeptide FragmentsMotor NeuronsGene ExpressionParkinson Disease, SecondaryAmyloidMaze LearningAstrocytesCell DifferentiationLewy Body DiseaseGene Knock-In TechniquesNeurofibrillary TanglesMice, 129 StrainModels, GeneticPresenilin-1CytokinesUbiquitinSuperoxide DismutaseRats, Sprague-DawleyCell ProliferationGreen Fluorescent ProteinsTrinucleotide RepeatsInduced Pluripotent Stem CellsGenetic Diseases, Inborn