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  • MYCN
  • Malfunction of the MYCN transcription factor is a key feature of neuroblastoma biology and is involved in almost every aspect of tumor formation such as unrestricted proliferation, differentiation inhibition, reprogramming of cellular energetics, angiogenesis, infiltration/metastasis and genomic instability. (dkfz.de)
  • In addition, we use high-throughput si/shRNA screens to disclose neuroblastoma-specific vulnerabilities associated with distinct genetic aberrations, such as amplified MYCN, TERT rearrangements, or ATRX deletions (project NB Achilles). (dkfz.de)
  • LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. (springer.com)
  • Pathology
  • After discussing the risk-grouping system for pNT patients, recent progress of molecular pathology in precision medicine especially for children with high-risk neuroblastomas is summarized. (springer.com)
  • lymph nodes
  • Regional neuroblastoma has extended beyond its original site, to regional lymph nodes, and/or surrounding organs or tissues, but has not spread to distant sites in the body. (encyclopedia.com)
  • molecular
  • Overall aim of our work is to integrate next-generation molecular diagnostics for a more precise patient risk stratification and to develop molecularly targeted therapies based on a better understanding of the molecular mechanisms underlying neuroblastoma tumorigenesis. (dkfz.de)
  • International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee. (springer.com)
  • genetic
  • Neuroblastomas are associated with some congenital abnormalities and genetic diseases such as Hirschsprung disease, central hypoventilation and neurofibromatosis. (eapsa.org)
  • Peripheral
  • Each antibody is made of both mouse and human components and targets glycolipid GD2, expressed on neuroblastoma cells and on normal cells of neuroectodermal origin, including the central nervous system and peripheral nerves. (wikipedia.org)