By performing proximity labeling and proteomic analysis, we identified scavenger receptor CD36 as a cell surface protein interacting with Siglec-E. Further experiments performed in HEK293T cells transiently overexpressing Siglec-E and CD36 and peritoneal macrophages demonstrated that depletion of cell surface sialic acids by treatment with sialyltransferase inhibitor or sialidase did not affect interaction between Siglec-E and CD36 but retarded Siglec-E-mediated inhibition on oxidized LDL uptake. (biomedcentral.com)
Enzymes2
Neuraminidase enzymes, also known as sialidases, are responsible for removal of terminal sialic acids in a process known as desialylation. (bvsalud.org)
download Dopamine in the Pathophysiology and Treatment involves a histone of endonucleases, receptor effects catalyzed in solar enzymes. (evakoch.com)
The ability of the GLB1-derived elastin binding protein and the elastin receptor complex to influence cell proliferation appears to be indirect and involve removal of sialic acid from extracellular and cell surface proteins such as growth factor receptors. (wikipedia.org)
Proteins1
We conclude that whether peptidoglycan binding proteins do not appear to be major adhesins, most of the choline-binding proteins interact with host proteins (elastin and C reactive proteins are the major Cbp partners). (biomedcentral.com)
Peripheral1
The S-Gal protein is a peripheral membrane protein that functions as part of an elastin receptor complex on the surface of cells. (wikipedia.org)
Cells2
The elastin receptor complex includes S-Gal, neuraminidase and Cathepsin A. When elastin-derived peptides bind to the S-Gal protein then the associated neuraminidase enzyme activity is activated and responding cells can have altered signal transduction involving extracellular signal-regulated kinases and regulated matrix metallopeptidase production. (wikipedia.org)
Siglecs are a family of sialic acid-binding immunoglobulin-like receptors predominantly expressed on cells of immune system to regulate their functions through recognizing their glycan ligands [ 5 ]. (biomedcentral.com)
Host2
Because pathogen-derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regulate the neutrophil dysregulation observed in severe infections. (bvsalud.org)
At actin there allow mainly specific NPs, far the host of complexes signalling Nursing Council pathway is to be. (evakoch.com)
Assembly2
The S-Gal protein functions during the normal assembly of elastin into extracellular elastic fibers. (wikipedia.org)
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)
Peptides8
The binding of elastinpeptides on the elastin receptor complex leads to the formation of intracellular signals but how this is achieved remains totally unknown. (nih.gov)
Using pharmacological inhibitors of the enzymatic activities of its subunits, we show here that the elastin peptide-driven ERK1/2 activation and subsequent pro-MMP-1 production, observed in skin fibroblasts when they are cultured in the presence of these peptides, rely on a membrane-bound sialidase activity. (nih.gov)
Finally, we report that N-acetyl neuraminic acid can reproduce the effects of elastinpeptides on both ERK1/2 activation and pro-MMP-1 production. (nih.gov)
Elastin peptides signaling relies on neuraminidase-1-dependent lactosylceramide generation. (nih.gov)
The elastin receptor complex includes S-Gal, neuraminidase and Cathepsin A. When elastin-derived peptides bind to the S-Gal protein then the associated neuraminidase enzyme activity is activated and responding cells can have altered signal transduction involving extracellular signal-regulated kinases and regulated matrix metallopeptidase production. (wikipedia.org)
Elastin-derived peptides are chemotactic for some cell types and can alter cell cycle progression. (wikipedia.org)
But beyond this fundamental role, a huge amount of works from the last decade highlighted that elastin plays also a pivotal role in various pathophysiological processes through the release of elastin-derived peptides (EDP), including vascular and metabolic diseases. (biomedcentral.com)
Elastic fibers3
This complex plays a role in building elastic fibers, which are a component of the connective tissue that forms the body's supportive framework. (medlineplus.gov)
The S-Gal protein functions during the normal assembly of elastin into extracellular elastic fibers. (wikipedia.org)
Elastin, the major component of elastic fibers, represents one of the main structural matrix components of the vascular wall together with collagens. (biomedcentral.com)
Enzymatic activity2
Altogether, our results indicate that the enzymatic activity of the Neu-1 subunit of the elastin receptor complex is responsible for its signal transduction, presumably through sialic acid generation from undetermined substrates. (nih.gov)
This membrane receptor brings together the elastin binding protein (EBP), protective protein/cathepsin A (PPCA) and neuraminidase-1 (NEU1) [ 13 ]. (biomedcentral.com)
Sialidase1
As lactose blocked this effect, the elastin receptor sialidase subunit, Neu-1, seemed to be involved. (nih.gov)
Extracellular1
These extracellular matrix degradation products have been shown to trigger biological activities through the elastin receptor complex (ERC) and data from the last decade have brought significant insights on the critical role played by its NEU1 subunit in the biological effects mediated by EDP and the ERC in vascular and metabolic diseases. (biomedcentral.com)
GLB12
The GLB1 gene also provides instructions for making the elastin-binding protein. (medlineplus.gov)
L37pA peptide targeting CD36 receptor attenuated Tr-OxPL-induced endothelial cell permeability in young and old mLEC and ameliorated KOdiA-PC-induced vascular leak and lung inflammation in vivo. (bvsalud.org)
Membrane3
The S-Gal protein is a peripheral membrane protein that functions as part of an elastin receptor complex on the surface of cells. (wikipedia.org)
Moreover, by its ability to interact with and to modulate the sialylation of key membrane glycoproteins through NEU1, new biological functions are anticipated for EDP and the ERC in elastin remodeling-associated disorders. (biomedcentral.com)
2000), negatively by membrane at the S3 complex pathway( Saxena et al. (evakoch.com)
Vascular1
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
Production1
These variants often affect the production of both β-galactosidase and elastin-binding protein. (medlineplus.gov)
Effects1
download Dopamine in the Pathophysiology and Treatment involves a histone of endonucleases, receptor effects catalyzed in solar enzymes. (evakoch.com)
Activities1
Elastin degradation releases EDP, also known as elastokines, that trigger biological activities. (biomedcentral.com)