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  • Embryo
  • The spatial distribution of the cranial paraxial mesoderm and the neural crest cells during craniofacial morphogenesis of the mouse embryo was studied by micromanipulative cell grafting and cell labelling. (biologists.org)
  • distinct
  • Within the hindbrain region, neural crest cell migration is organized into three streams that follow the segmentation of the neuroepithelium into distinct rhombomeric compartments. (ox.ac.uk)
  • cells
  • Semaphorin/neuropilin signaling influences the positioning of migratory neural crest cells within the hindbrain region of the chick. (ox.ac.uk)
  • Although the streaming of neural crest cells is known to involve signals derived from the neuroepithelium, the molecular properties underlying this process are poorly understood. (ox.ac.uk)
  • Both Semaphorins are expressed within rhombomeres at levels adjacent to crest-free mesenchyme and expression of the receptor components essential for Semaphorin activity by neural crest cells suggests a function in restricting neural crest cell migration. (ox.ac.uk)
  • Attenuation of Semaphorin signaling by expression of soluble Neuropilin-Fc resulted in neural crest cells invading adjacent mesenchymal territories that are normally crest-free. (ox.ac.uk)
  • Thus, Sema 3A and 3F, expressed and secreted by the hindbrain neuroepithelium contributes to the appropriate positioning of neural crest cells in proximity to the neural tube, a process crucial for the subsequent establishment of neuronal connectivity within the hindbrain region. (ox.ac.uk)
  • Results of this study show that the paraxial mesoderm and neural crest cells arising at the same segmental position share common destinations. (biologists.org)
  • Mesodermal cells from somitomeres I, III, IV and VI were distributed to the same craniofacial tissues as neural crest cells of the forebrain, the caudal midbrain, and the rostral, middle and caudal hindbrains found respectively next to these mesodermal segments. (biologists.org)
  • Neural crest cells colonised the periphery of the branchial arches and enveloped the somitomere-derived core tissues on the rostral, lateral and caudal sides of the arch. (biologists.org)
  • induction
  • At least in part, the segregation of the crest into these streams involves the focal depletion of neural crest from rhombomeres 3 and 5 through large-scale apoptosis, mediated by the induction of Bmp-4 expression in the crest primordia of these two rhombomeres. (biomedsearch.com)
  • Little is known about the signal cascade that promotes neural crest induction. (wikipedia.org)
  • mesodermal
  • The ability of neural crest to contribute mesodermal derivatives to the bauplan has raised questions about how this apparent gain in potential is achieved. (sciencemag.org)
  • specification
  • Neurogenin 2 (Ngn2) is a bHLH transcription factor involved in both neurogenesis and neural specification. (wikipedia.org)
  • This protein binds to enhancer-box regulatory elements on the promoters of many genes related to neurogenesis and neural specification. (wikipedia.org)
  • tube defects
  • Neural tube defects occur before the eighth week of gestation when many women may not be aware of the pregnancy. (wisegeek.com)
  • Most women are advised to begin a daily supplement of folic acid and prenatal vitamins several months before trying to become pregnant to help prevent neural tube defects from occurring. (wisegeek.com)
  • Mutations in this gene may be associated with sporadic cases of neural tube defects. (wikipedia.org)
  • chick
  • Experiments in which the Hox -negative neural fold (NF) was removed before NCC emigration ( Fig. 1 A - C ) resulted in the complete absence of facial skeleton, whereas only a third of the anterior, Hox -negative territory left in situ (or grafted from quail to chick) was sufficient to generate a complete face. (pnas.org)
  • emergence
  • This event has coincided with the emergence of a transient and pluripotent structure, the neural crest (NC), which is absent in protochordates. (pnas.org)
  • defects
  • Waardenburg syndrome, or more fully, the van der Hoeve-Halbertsma-Waardenburg-Klein syndrome, is a rare genetic disorder most often characterized by varying degrees of deafness, minor defects in structures arising from the neural crest, and pigmentation anomalies. (wikipedia.org)
  • originate
  • These conditions can be distinguished by the color of the retina, whose cells do not originate in the neural crest (red in albino, wild-type in leucistic and progressive graying) and ontogenetic changes incolor (Raven et al. (thefreedictionary.com)
  • role
  • The crest may have played a role in mating rituals, aided in clamping to the belly of larger marine animals, or been used to frighten potential predators. (wikipedia.org)
  • toward
  • These behavioral alterations have been useful in identifying neural circuits altered by moderate PAE 1 , and may hold importance for progressing toward a more complete understanding of the neural bases of PAE-related alterations in social behavior. (jove.com)
  • target
  • During predation, bats first spend a few minutes in the air circling the target prey, eventually landing on the back or neck crest of the animal, and sometimes the ground. (wikipedia.org)