The CD56 antibody, clone NCAM16.2, is derived from the hybridization of P3X-63- Ag8.653 mouse cells with lymph nodes from BALB/c mice immunized with immunoaffinity-enriched adult human brain NCAM. (bdbiosciences.com)
The CD56 (NCAM16.2) antibody recognizes an extracellular immunoglobulin-like domain common to three molecular weight forms-120, 140, and 180 kilodaltons (kDa)-of the neural cell adhesion molecule (NCAM). (bdbiosciences.com)
CD56 is a single transmembrane glycoprotein also known as NCAM (neural cell adhesion molecule), Leu-19, or NKH1. (biolegend.com)
The antibody MEM-188 reacts with an extracellular epitope on a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. (exbio.cz)
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. (exbio.cz)
Mouse monoclonal to CD56.COC56 reacts with CD56, a 175-220 kDa Neural Cell Adhesion Molecule (NCAM), expressed on 10-25% of peripheral blood lymphocytes, including all CD16+ NK cells and approximately 5% of CD3+ lymphocytes, referred to as NKT cells. (forgetmenotinitiative.org)
Neural Cell Adhesion Molecule, NCAM, also known as the cluster of differentiation CD56, is a hemophilic binding glycoprotein. (rockland.com)
Epithelial membran1
The nodules stained positive for neural cell adhesion molecule (CD56) and progesterone receptor with weakly positive epithelial membrane antigen and smooth muscle actin. (bvsalud.org)
The CD45 antibody recognizes a 180- to 220-kDa human leucocyte antigen that is a member of the leucocyte common antigen (LCA) family. (bdbiosciences.com)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
Extracellular1
Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel immunotherapy which modifies T cells with CAR, an artificial fusion protein that incorporates an extracellular antigen recognition domain, a transmembrane domain, and an intracellular domain including costimulation and signaling components [ 4 , 5 ]. (biomedcentral.com)
Myeloid leukemias1
Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal derived tumors, myelomas, and myeloid leukemias also express CD56. (biolegend.com)
FITC1
Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-CD56 (MEM-188) FITC. (exbio.cz)
Isoform1
PrP Sc is a conformational isoform of PrP C , but this orientation tends to accumulate in compact, protease -resistant aggregates within neural tissue. (wikidoc.org)
CD1381
Several antigens have been used as targets for CAR-T cell therapy against MM, including B cell maturation antigen (BCMA), CD19, CD138, signaling lymphocytic activation molecule 7 (SLAM7), and immunoglobulin light chains. (biomedcentral.com)
Bone marrow1
BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)
Tumors1
McCluggage WG, McKenna M, McBride HA: CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors. (exbio.cz)
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (bdbiosciences.com)
Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). (bdbiosciences.com)
Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. (bdbiosciences.com)
Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. (exbio.cz)
CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours. (exbio.cz)
Jakovcevski I, Mo Z, Zecevic N: Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain. (exbio.cz)
Lanier LL, Chang C, Azuma M, Ruitenberg JJ, Hemperly JJ, Phillips JH: Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). (exbio.cz)
There is an unmet need to develop novel therapies for refractory/relapsed MM. In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in preclinical and clinical studies. (biomedcentral.com)
Two main advantages of BCMA as an antigen for CAR-T therapy are the potential reduction of on-target/off-tumor toxicity and the lack of antigen-dependent reduction in CAR-T cell expansion [ 16 ]. (biomedcentral.com)
PCa samples from the 66 patients were analyzed using immunohistochemical staining for the detection of chromogranin, neural cell adhesion molecule 1, and synaptophysin. (biomedcentral.com)
Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. (tcd.ie)
Our cell cultures were strongly positive for CD46, CD47, CD56 and CD63 and were also strongly positive for some markers never described before in mesothelioma cell lines, including CD55, CD90 and CD99. (biomedcentral.com)
Aliquot1
Aliquot 0.1ml per well of the 10000pg/ml, 5000pg/ml, 2500pg/ml, 1250pg/ml, 625pg/ml, 312pg/ml, 156pg/ml human CD56 standard solutions into the precoated 96-well plate. (rockland.com)
Purity1
Purity Affinity purified on immobilized antigen. (alomone.com)
Tissue1
Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
Detection1
Useful in Sandwich ELISA for Quantitative Detection of Antigen. (rockland.com)
Cells4
Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. (bdbiosciences.com)
The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. (bdbiosciences.com)
The EasySep™ Human CD56 Positive Selection Kit II is designed to isolate CD56+ cells from fresh or previously frozen peripheral blood mononuclear cells and human skeletal muscle (myoblasts and fibroblasts) cultures by positive selection. (stemcell.com)
Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
We recommend that each human CD56 standard solution and each sample is measured in duplicate. (rockland.com)
Surface1
The CD69 antigen is a surface homodimer formed by the association of 28-kDa and 32-kDa chains that are held together by disulfide bridges. (bdbiosciences.com)
Common1
Cobbold SP, Hale G, Waldmann H. Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters. (bdbiosciences.com)
Overview1
Additionally, a comprehensive overview of antigen selection is presented along with preliminary results and future directions of CAR-T therapy development. (biomedcentral.com)
Potential1
LewisY blood antigen or simply BG8, is a blood group antigen that has been identified in studies as a potential marker for differentiating pulmonary adenocarcinoma (PACA) from epithelioid mesothelioma (EM). (neuromics.com)
Receptor4
The lymphoma cells are CD2 + , cytoplasmic CD3ɛ + and CD56 + , with germline T-cell receptor gene. (medscape.com)
These antibodies have been made into different formats of therapeutic including Antibody Drug Conjugate (ADC), Bispecific T cell engager (BiTE) ae well as Chimeric Antigen Receptor (CAR)-T cells. (nih.gov)
Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut. (nature.com)
CD14 belongs to the family of LPS receptor antigens and is strongly expressed on the majority of Monocytes. (zen-bio.com)
Antibody4
In this study, we generated a monoclonal antibody, termed SZK1, reactive to feline CD56 (fCD56) molecules (140 kDa form of N-CAM) expressed by the baculovirus expression system and investigated fCD56 expression in feline lymphoid cells. (elsevierpure.com)
Chimeric antigen receptors (CARs) are hybrid proteins consisting of an antibody binding fragment fused to protein signaling domains that cause T-cells which express the CAR to become cytotoxic. (nih.gov)
A big proportion of beforehand recognized NPC circumstances by routine H and E stains had been confirmed to not be so by a minimal IHC antibody pan el of pan - cytokeratin cocktail (AE1/AE3) and leukocyte frequent antigen (CD45). (inacj.com)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com.cn)
CD572
NK cells also express a number of 'NK lineage-associated' markers, including CD16, CD56 and CD57. (medscape.com)
12. Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. (nih.gov)
Transmembrane glycoprotein1
CD56 is a 140 kDa transmembrane glycoprotein also known as Leu-19 or NKH1. (m-entrepreneurship.com)
Tissues2
However, CD56 is not specific for NK cells, and can also be expressed on NK-like T cells, neural and neuroendocrine tissues, and occasionally on skeletal muscles. (medscape.com)
The principal functions of B cells are to make antibodies against antigens, perform the role of antigen-presenting cells (APCs) and eventually develop into memory B cells after activation by antigen interaction. (zen-bio.com)
DIFFERENTIATION1
A la I Conferència i Taller Internacional sobre diferenciació dels antígens leucocitaris humans , celebrada a París el 1982, fou aprovada la terminologia CD (cúmul o grup de diferenciació [18] o cluster of differentiation en anglès). (wikipedia.org)
Affinity1
Purity Affinity purified on immobilized antigen. (alomone.com)
Viral1
Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com.cn)
Role1
CD56 plays a role in homophilic and heterophilic adhesion via binding to itself or heparin sulfate. (biolegend.com)
Analysis1
Partnering with Diagnostic Biochips, we now provide solutions for in vivo electrophysiology recordings, including high-quality multi-channel electrodes and other products to facilitate high-quality, efficient analysis of neural circuit structure and function. (acrobiosystems.com.cn)