Neuropilins are cell surface receptors for members of the VEGF family as well as for members of the semphorin family of axonal guidance mediators. (harvard.edu)
Semaphorins, a family of about 20 secreted, transmembrane and GPI-linked glycoproteins, and their cognate receptors (plexins and neuropilins) play a pivotal role in the crosstalk between cancer and stromal cells present in the tumor microenvironment. (biomedcentral.com)
Semaphorins were originally identified in the nervous system for their ability to regulate axon guidance through the interaction with their receptors, plexins and neuropilins [ 1 ]. (biomedcentral.com)
Consistently, increased Sema 3A levels have been detected in brain of patients with schizophrenia and many polymorphisms in Sema 3A or in the Sema 3A receptors, Neuropilins (Npn 1 and 2) and Plexin As (Plxn As), have been associated to autism. (biomedcentral.com)
Neurons3
Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases. (harvard.edu)
Lentivirus (LV)-NRP-1 was transfected into rat primary cortical neuronal cultures before a 2-h oxygen-glucose deprivation and reoxygenation (OGD/R) injury to neurons. (biomedcentral.com)
The sensory root (nervus intermedius) consists of (1) central projections of neurons located in the geniculate ganglion (general somatic fibers that synapse in the spinal nucleus of the trigeminal nerve and special afferent fibers that synapse in the nucleus solitarius) and (2) axons of parasympathetic neurons from the superior salivatory (lacrimal) nucleus. (medscape.com)
Axon2
In netrin-1 deficient mice, trochlear axon projections are normal, suggesting the existence of other redundant guidance cues working in tandem with netrin-1 to repel trochlear axons. (wikipedia.org)
SIGNIFICANCE STATEMENT Striatal axon pathways mediate complex physiological functions and are an important therapeutic target, underscoring the need to define how these connections are established. (jneurosci.org)
Semaphorins1
netrins, slits, ephrins and semaphorins are four well-studied tropic cues (Fig.1). (wikipedia.org)
Studies in C. elegans revealed a possible mechanism for netrin acting as a chemorepulsive agent (Fig.2). (wikipedia.org)
The expression and function of NRP-1 and its specific protective mechanism were investigated by Western Blot, immunofluorescence staining, flow cytometry, magnetic resonance imaging, transmission electron microscopy, etc. (biomedcentral.com)
The molecular mechanism underlying TAZ-AS202 function does not involve change of TAZ expression or activity, but increases the protein level of the transcription factor E2F1, which in turn regulates the expression of a large set of target genes, including the EPHB2 receptor. (bvsalud.org)
Guidance2
this experiment established the importance of Netrin-1 in guidance decisions. (wikipedia.org)
During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration and mediating new contacts during anastomosis. (biologists.com)
Glycoproteins1
Membrane glycoproteins that constitute the ZONA PELLUCIDA in mammals and function in the recognition and binding of SPERMATOZOA. (bvsalud.org)
Neural1
[ 2 ] Primary neurulation is a process that leads to the development of the neural tube from the neural plate. (medscape.com)
Interaction1
Netrin (unc-6, Caenorhabditis elegans homologue) and its corresponding receptor DCC (Deleted in Colorectal Cancer) were initially identified as an attractive interaction. (wikipedia.org)
Development2
They have been also heavily implicated in cancer development and progression, with both oncogenic and tumor suppressor functions. (bvsalud.org)
The dramatic emergence of SARS-CoV-2 into our lives and the subsequent COVID-19 pandemic have spawned the active development of nearly 200 vaccine candidates. (regenerativemedicine.net)
In this work, we identified and characterized a novel lncRNA, TAZ-AS202, expressed from the TAZ genomic locus and exerting pro-oncogenic functions in non-small cell lung cancer. (bvsalud.org)
Description: A sandwich ELISA kit for detection of Plasminogen Activator Inhibitor 2 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Plasminogen Activator Inhibitor 2 (PAI2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (jsce-ip.com)
Mammals1
In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted proteins in mammals, thereby exerting both autocrine and paracrine functions. (biomedcentral.com)
Reveals1
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. (neurotree.org)
Human1
These grants will specifically identify genes that cause human developmental brain disorders, and investigate their function. (edu.au)
Specific1
The consortium will also collect brain MRI data and neuropsychological data to try to understand the relationship between specific patterns of brain wiring and brain function. (edu.au)
Expression1
The expression of AAV-NRP-1 markedly ameliorated the cerebral I/R-induced damage to the motor function and restored the mitochondrial morphology. (biomedcentral.com)
Triggered via1
on the other hand, the chemorepellent response is triggered via netrin-1 binding to unc-5/DCC heterodimers. (wikipedia.org)
inhibiting netrin/DCC signaling interferes with the attractive turning of retinal growth cones. (wikipedia.org)
The mean blur rate in the vessel (MV) and tissue (MT) regions and retinal vessel diameters in the ONH were measured by laser speckle flowgraphy before and 1, 2, and 4 weeks after administration of aldosterone or vehicle. (jsce-ip.com)
Receptor5
Netrin (unc-6, Caenorhabditis elegans homologue) and its corresponding receptor DCC (Deleted in Colorectal Cancer) were initially identified as an attractive interaction. (wikipedia.org)
it was determined that unc-5 acts as a repulsive receptor for Netrin (unc-6). (wikipedia.org)
However, it remains unknown how PlexB functions during neural development and which ligands serve to activate this receptor. (silverchair.com)
SARS-CoV-2, the virus responsible for the disease, utilizes the ACE2 receptor found on host cells to mediate entry, replication, and infection. (jsce-ip.com)
We summarize the current literature on ocular RAAS with specific focus on the ACE2 receptor and its interplay with the SARS-CoV-2 virus. (jsce-ip.com)
Mice3
In netrin-1 deficient mice, trochlear axon projections are normal, suggesting the existence of other redundant guidance cues working in tandem with netrin-1 to repel trochlear axons. (wikipedia.org)
Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in mice. (ouhsc.edu)
PnPP-19 improved the erectile function of normotensive rats and mice, without eliciting side effects, and no signs of toxicity were observed. (envite.org)
Axons4
Netrin-1 has also been shown to act as a chemorepellent in vivo for trochlear motor axons that migrate dorsally away from the floor plate. (wikipedia.org)
The switch between attractive and repulsive netrin signaling can be mediated by misexpression of unc-5 in commissural axons. (wikipedia.org)
The sensory root (nervus intermedius) consists of (1) central projections of neurons located in the geniculate ganglion (general somatic fibers that synapse in the spinal nucleus of the trigeminal nerve and special afferent fibers that synapse in the nucleus solitarius) and (2) axons of parasympathetic neurons from the superior salivatory (lacrimal) nucleus. (medscape.com)
Torigoe M, Yamauchi K, Tamada A , Matsuda I, Aiba A, Castellani V, Murakami F . Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons. (neurotree.org)
Vitro1
This study has supported the validity of the predicted structure-function determinants with several in vitro, ex vivo and in vivo approaches and demonstrated the regulatory role of the IRHD for iRhom-ADAM17 complex cohesion and forward trafficking. (sdbonline.org)
Axonal1
PlexB does not directly bind to the cytosolic semaphorin signaling component MICAL (molecule that interacts with CasL), but requires MICAL for certain axonal guidance functions. (silverchair.com)
Growth1
Robo3 has two isoforms, 3.1 and 3.2, and these isoforms interact with Robo1 and Robo2 (Robo1/2) through cis interactions at the leading edge of the growth cone. (wikipedia.org)
Role1
Our results demonstrate that this new synthetic peptide potentiates erectile function via nitric oxide activation and reinforce its role as a new pharmacological tool for the treatment of erectile dysfunction. (envite.org)
Cells1
IL-33 is selectively induced in PLP139 151-immunized males and activates type 2 innate lymphoid cells (ILC2s), cells that promote and sustain a nonpathogenic Th2 myelin-specific response. (regenerativemedicine.net)
Demonstrate1
Taken together, these results demonstrate a differentiation-promoting activity of the classical cell cycle activator CDK4 and support the concept that ß cell mass can be expanded without compromising function. (bvsalud.org)
Mouse1
ß cell failure in the IRS2-deletion mouse type 2 diabetes model is, in part, due to loss of CDK4 regulator cyclin D2. (bvsalud.org)
Relationship2
This study used AI-based modelling to gain insights into the structure-function relationship of this complex. (sdbonline.org)
The coexistence of renin-independent aldosterone secretion and MEN1 within this family suggests a relationship between the 2 entities. (jsce-ip.com)
Responsible1
Different regions were identified in the iRhom homology domain (IRHD) that are differentially responsible for iRhom functions. (sdbonline.org)
Administration1
PnPP -19 Peptide Restores Erectile Function in Hypertensive and Diabetic Animals Through Intravenous and Topical Administration. (envite.org)