• mammalian
  • They found that the response in blood and in skin was the same in 60% of cases.The researchers then generated pluripotent stem cells from fibroblasts of both a VPA responder and a non-responder, and differentiated them into GABAergic neurons (neurons that produce the amino acid GABA, the chief neurotransmitter in the mammalian nervous system). (medindia.net)
  • neurons
  • Prototypic examples are anti- N-methyl-D-aspartate receptor (NMDAR) encephalitis which is induced by an immune response against the NMDAR expressed on neurons or neuromyelitis optica (NMO) in which the disease is induced by antibodies directed against aquaporin-4 expressed on astrocytes. (frontiersin.org)
  • drugs
  • Lorenz and Bleckwenn also focused on neurosyphilis with respect to their research endeavors, and, as the preeminent neurologist of the group, Reese was asked to evaluate the side-effects of experimental antisyphilitic drugs on nervous system function. (wikipedia.org)
  • syndromes
  • Paraneoplastic syndromes can also affect other organ systems including hormone (endocrine), skin (dermatologic), blood (hematologic) and joints (rheumatologic). (drugs.com)
  • Depending on where the nervous system is affected, paraneoplastic syndromes can cause problems with muscle movement or coordination, sensory perception, memory or thinking skills, or even sleep. (drugs.com)
  • findings
  • Recent research has identified some possible new variants, like the possibility to separate primary progressive MS, PPMS, after recent findings seem to point that it is pathologically a very different disease. (wikipedia.org)
  • brain
  • That makes PEDF a strong drug-therapy candidate, because it appears to encourage the regeneration of a type of brain cell called oligodendocyte and is able to repair the damage caused by demyelinative diseases, including MS. (ucdavis.edu)
  • This is inflammation affecting a region of the brain known as the limbic system, which controls emotions, behaviors and certain memory functions. (drugs.com)
  • infectious
  • The most common diseases caused by acute viral infections are encephalitis, flaccid paralysis, aseptic meningitis, post infectious and encephalomyelitis. (wikipedia.org)
  • Retroviruses can can exist as two different forms: endogenous which consist of normal genetic components and exogenous which are horizontally transferred genetic components that are usually infectious agents that cause disease i.e. (wikipedia.org)
  • adult
  • The human T-lymphotropic virus, human T-cell lymphotropic virus, or human T-cell leukemia-lymphoma virus (HTLV) family of viruses are a group of human retroviruses that are known to cause a type of cancer called adult T-cell leukemia/lymphoma and a demyelinating disease called HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). (wikipedia.org)
  • acute
  • While acute viral diseases come on quickly, chronic viral conditions have long incubation periods inside the body. (wikipedia.org)
  • Subacute sclerosing panencephalitis Progressive multifocal leukoencephalopathy West Nile Virus can produce aseptic meningitis, encephalitis, and acute flaccid paralysis Poliomyelitis Herpes simplex encephalitis Enteroviral disease Most forms of aseptic meningitis are viral in origin, though neoplastic and lyme meningitis are also aseptic. (wikipedia.org)
  • viruses
  • Most viruses that enter can be opportunistic and accidental pathogens, but some like herpes viruses and rabies virus have evolved in time to enter the nervous system efficiently, by exploiting the neuronal cell biology. (wikipedia.org)
  • Development of new therapies has been hindered by the lack of appropriate animal model systems for some important viruses and also because of the difficulty in conducting human clinical trials for diseases that are rare. (wikipedia.org)
  • It is not yet known how much further transmission has occurred among humans, or whether the viruses can cause disease. (wikipedia.org)
  • lesions
  • The disease is characterized by microscopic lesions found in muscle biopsies that show infiltration of muscle tissue by PAS-positive macrophages. (wikipedia.org)
  • Clinical
  • Lyme disease has a broad spectrum of clinical manifestations and severity, thought to be due, in part, to differences in the infecting species. (uptodate.com)
  • In 2000, the first study of the disease was released, and in 2007, enough patients had been gathered to complete a comprehensive study and give it a detailed clinical description. (wikipedia.org)
  • mechanisms
  • Addiction is a disorder of the brain's reward system which arises through transcriptional and epigenetic mechanisms and occurs over time from chronically high levels of exposure to an addictive stimulus (e.g., morphine, cocaine, sexual intercourse, gambling, etc. (wikipedia.org)
  • several
  • Several carrier or transport systems, enzymes, and receptors that control the penetration of molecules have been identified in the BBB endothelium. (mdtmag.com)
  • common
  • The third most common site is the nervous system, which is involved in 10 to 15 percent of infected individuals in both Europe and the United States [ 2 ]. (uptodate.com)
  • The most common diseases caused by chronic viral infections are subacute-sclerosing panencephalitis, progressive multifocal leukoencephalopathy, retrovirus disease and spongiform encephalopathies. (wikipedia.org)
  • The disease is more common in female toy dogs of young and middle age. (wikipedia.org)
  • often
  • ADHD (often highly debated & controversial) is now largely considered to be a genuine organic disorder of the nervous system, according to the United States government. (wikipedia.org)
  • cause
  • Heart scans to ID stroke risk, insomnia reduces quality of life, air pollution may be a cause, women think of stroke as a man's disease-see these and other developments in stroke science and patient care. (patientcareonline.com)
  • B. burgdorferi is the principal cause of the disease in the United States. (uptodate.com)