• cytokines
  • Because nerve growth factor (NGF) plays a cardinal role in inflammation and pain, and because it interacts with multiple proinflammatory cytokines, we hypothesized that NGF acts as a key endogenous molecule involved in the orchestration of cancer-related inflammation. (aacrjournals.org)
  • In addition, altered expression of cytokines, chemokines, and angiogenic and apoptotic related factors has been identified in the vitreous of patients with DME and PDR [ 23 - 27 ]. (hindawi.com)
  • neuronal
  • Our previous studies have demonstrated that diabetes-induced oxidative stress alters homeostasis of retinal nerve growth factor (NGF) resulting in accumulation of its precursor, proNGF, at the expense of NGF which plays a critical role in preserving neuronal and retinal function. (hindawi.com)
  • stimulation
  • This pathway of SCG innervation is shown through stimulation of the cervical sympathetic nerve, which invokes action potentials in both the external and internal carotid nerves. (wikipedia.org)
  • kinase
  • Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. (wikipedia.org)
  • cardiac
  • GAB2 has been shown to be important in physiological functions such as growth in bone marrow and cardiac function. (wikipedia.org)
  • cells
  • As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). (wikipedia.org)
  • Direct effects of nerve growth factor on thecal cells from antral ovarian follicles. (biomedsearch.com)
  • They belong to a class of growth factors, secreted proteins that are capable of signaling particular cells to survive, differentiate, or grow. (wikipedia.org)
  • In the peripheral and central neurons, neurotrophins are important regulators for survival, differentiation, and maintenance of nerve cells. (wikipedia.org)
  • They are small proteins that secrete into the nervous system to help keep nerve cells alive. (wikipedia.org)
  • It was there that, in 1952, she did her most important work: isolating nerve growth factor (NGF) from observations of certain cancerous tissues that cause extremely rapid growth of nerve cells. (wikipedia.org)
  • The ANS is composed of pathways that lead to and from ganglia, groups of nerve cells. (wikipedia.org)
  • CIPA is caused by a genetic mutation which prevents the formation of nerve cells which are responsible for transmitting signals of pain, heat, and cold to the brain. (wikipedia.org)
  • chronic
  • List of investigational analgesics Monoclonal Antibodies Targeted Against Nerve Growth Factor For the Treatment of Chronic Pain, By Ken Verburg, PhD - Medicines Development Group, Pfizer Inc., Arthritis Advisory Committee Meeting, 12 March 2012 "Statement On A Nonproprietary Name Adopted By The USAN Council: Fulranumab" (PDF). (wikipedia.org)
  • role
  • In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. (dovepress.com)
  • It appears to be certain that, in addition to environmental factors, genetic mutations also play a role in the emergence of the disease. (healthcanal.com)
  • cell
  • Endothelial cell death and acellular capillary formation further impair the retinal blood supply leading to proliferative diabetic retinopathy (PDR) which is characterized by growth of fragile, leaky blood vessels and loss of vision [ 7 , 8 ]. (hindawi.com)
  • Neurotrophic factors are secreted by target tissue and act by preventing the associated neuron from initiating programmed cell death - thus allowing the neurons to survive. (wikipedia.org)