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  • tibial nerve
  • Further, the degree of the RI reduction after tibial nerve crush was much less than that after sciatic nerve crush indicatig that the neuron-muscle disconnection time is vital to the recovery of the spinal neuronal circuit function during reinnervation. (hindawi.com)
  • Tarsal tunnel syndrome (TTS), also known as posterior tibial neuralgia, is a compression neuropathy and painful foot condition in which the tibial nerve is compressed as it travels through the tarsal tunnel. (wikipedia.org)
  • The posterior tibial artery, tibial nerve, and tendons of the tibialis posterior, flexor digitorum longus, and flexor hallucis longus muscles travel in a bundle through the tarsal tunnel. (wikipedia.org)
  • If the entrapment is high, the entire foot can be affected as varying branches of the tibial nerve can become involved. (wikipedia.org)
  • regeneration
  • The findings that motoneuron was able to resubject muscle by regeneration and finally full or nearly full recovery in adult animals with sciatic nerve injury [ 12 ], but with reduced excitatory postsynaptic potentials, indicated the plasticity of motoneuron central synapses after transiently losing a link between motoneuron and its controlled muscle [ 13 - 15 ]. (hindawi.com)
  • Nerve crush injuries are commonly used models for axonotmesis to examine peripheral nerve regeneration. (hindawi.com)
  • Regeneration of axons and myelin in nerve fibre in the EPO-treated group developed better and faster than in the control group. (hindawi.com)
  • One of these proteins, PEA-15, mediates major optic nerve astrocytic functions, which likely affect retinal neuronal survival and regeneration after injury. (unt.edu)
  • The objective of the present study was to evaluate the effects of immune system augmentation with use of the antigen glatiramer acetate, which is known to affect T-cell immunity, on peripheral nerve regeneration. (ebscohost.com)
  • The recruitment of an endogenous mechanism, the immune system, to better coordinate the regeneration of nerves after injury is a different approach to this difficult clinical problem. (ebscohost.com)
  • The ganglioside 9-O-acetyl GD3 is overexpressed in peripheral nerves after lesioning, and its expression is correlated with axonal degeneration and regeneration in adult rodents. (ebscohost.com)
  • The events that occur in peripheral regeneration occur with respect to the axis of the nerve injury. (wikipedia.org)
  • If the nerve has been completely divided, axonal regeneration causes a neuroma to form in the proximal stump. (wikipedia.org)
  • As a result of this high incidence of neurological injuries, nerve regeneration and repair, a subfield of neural tissue engineering, is becoming a rapidly growing field dedicated to the discovery of new ways to recover nerve functionality after injury. (wikipedia.org)
  • spinal
  • Our current research was designed to investigate the change of the recurrent inhibitory function in the spinal cord after the peripheral nerve crush injury in neonatal rat. (hindawi.com)
  • In conclusion, our results suggest that peripheral nerve injury during neonatal early development period would cause a more sever spinal cord inhibitory circuit damage, particularly to the Renshaw recurrent inhibition pathway, which might be the target of neuroregeneration therapy. (hindawi.com)
  • Epo has also been reported to enhance nerve recovery after spinal trauma. (wikipedia.org)
  • The nervous system is divided into two parts: the central nervous system, which consists of the brain and spinal cord, and the peripheral nervous system, which consists of cranial and spinal nerves along with their associated ganglia. (wikipedia.org)
  • regenerate
  • Based on his clinical work, he breaks down his highly effective methods, showing how dietary changes reducing sugar and wheat, coinciding with an increase of good fats, can dramatically help regenerate nerves and rehabilitate their normal function.Sugar Crush includes a quiz to assess your nerve damage, practical dietary advice, and the latest thinking on ways to prevent and reverse neuropathy. (dymocks.com.au)
  • Based on his clinical work, he breaks down his highly effective methods, showing how dietary changes reducing sugar and wheat, coinciding with an increase of good fats, can dramatically help regenerate nerves and rehabilitate their normal function. (dymocks.com.au)
  • bundles
  • From these results, the down-regulation of RhoA/Rho kinase pathway might lead to the decreased bladder contractility after crushing injury of nerve bundles from MPG to the bladder despite of the compensated up-regulation of M2 muscarinic receptor. (mdpi.com)
  • neurons
  • As most of fluorescent retinal neurons in this system are RGCs, these findings indicate that repeated brimonidine treatments may protect RGC health following optic nerve crush. (biomedcentral.com)
  • Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. (wikipedia.org)
  • As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). (wikipedia.org)

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  • peripheral nervou
  • Background: Despite the regenerative potential of the peripheral nervous system, severe nerve lesions lead to loss of target-organ innervation, making complete functional recovery a challenge. (ebscohost.com)
  • Erythropoietin and its receptor are also reported in the peripheral nervous system, specifically in the bodies and axons of ganglions in the dorsal root, and at increased levels in Schwann cells after peripheral nerve injury. (wikipedia.org)
  • injury
  • Peripheral nerve injury is a common disease in clinic. (hindawi.com)
  • Sciatic nerve injury is a common disease of peripheral nerve in clinic with complex pathophysiological mechanism. (hindawi.com)
  • Following nerve injury, the regenerated muscle and motoneuron were functionally disturbed, such as denervated amyotrophy and myoceptor degeneration [ 11 ]. (hindawi.com)
  • Clinical Relevance: Peripheral nerve injury may result in severe loss of sensation, weakness, and pain. (ebscohost.com)
  • After crushing injury, significantly increased M2 muscarinic receptor expression was observed and this might be regarded as the compensatory response. (mdpi.com)
  • The expression of RhoA, ROCK-α, and ROCK-β was significantly increased after one, two, and four-week crushing injury. (mdpi.com)
  • Nerve injury is injury to nervous tissue. (wikipedia.org)
  • There is no single classification system that can describe all the many variations of nerve injury. (wikipedia.org)
  • In 1941, Seddon introduced a classification of nerve injuries based on three main types of nerve fiber injury and whether there is continuity of the nerve. (wikipedia.org)
  • The study of peripheral nerve injury began during the American Civil War and has greatly expanded to the point of using growth-promoting molecules. (wikipedia.org)
  • This is the least severe form of nerve injury, with complete recovery. (wikipedia.org)
  • Mainly seen in crush injury. (wikipedia.org)
  • There is currently no treatment for recovering human nerve function after injury to the central nervous system. (wikipedia.org)
  • significantly
  • The RI in both LG-S and MG motoneuron pools was significantly reduced to virtual loss (15-20% of the normal RI size) even after a long recovery period upto 30 weeks after nerve crush. (hindawi.com)
  • In contrast, the parameters of the neurite outgrowth and Sholl analysis were significantly lower in the optic nerve crush eyes when compared to contralateral controls. (arvojournals.org)
  • PEA-15 knockdown significantly promoted optic nerve astrocyte migration and suppressed phagocytosis. (unt.edu)
  • injuries
  • The last (extreme) degree of neurotmesis is transsection, but most neurotmetic injuries do not produce gross loss of continuity of the nerve but rather internal disruption of the architecture of the nerve sufficient to involve perineurium and endoneurium as well as axons and their covering. (wikipedia.org)
  • conduction
  • In electrodiagnostic testing with nerve conduction studies, there is a normal compound motor action potential amplitude distal to the lesion at day 10, and this indicates a diagnosis of mild neuropraxia instead of axonotmesis or neurotmesis. (wikipedia.org)
  • disturbances
  • In conclusion, EPO supplementation may be beneficial as a therapeutic option for disturbances of nerve interaction. (hindawi.com)
  • Inflammation
  • A shocking look at the link between sugar, inflammation, and a host of preventable chronic diseases-perfect for fans of bestselling author Gary Taubes' The Case Against Sugar-from leading nerve surgeon Dr. Richard Jacoby. (dymocks.com.au)
  • This would include benign tumors or cysts, bone spurs, inflammation of the tendon sheath, nerve ganglions, or swelling from a broken or sprained ankle. (wikipedia.org)
  • neuronal
  • The distribution of EpoR was different from Epo, specifically in some neuronal cell bodies in the dorsal root ganglion, endothelial cells, and Schwann cells of normal nerves. (wikipedia.org)
  • compression
  • If you suffer from ailments your doctors can't seem to diagnose or help-mysterious rashes, unpredictable digestive problems, debilitating headaches, mood and energy swings, constant tiredness-nerve compression is the likely cause. (dymocks.com.au)
  • The flexor retinaculum has a limited ability to stretch, so increased pressure will eventually cause compression on the nerve within the tunnel. (wikipedia.org)
  • Varicose veins (that may or may not be visible) can also cause compression of the nerve. (wikipedia.org)
  • Flat feet may cause an increase in pressure in the tunnel region and this can cause nerve compression. (wikipedia.org)
  • Diabetes makes the peripheral nerve susceptible to nerve compression, as part of the double crush hypothesis. (wikipedia.org)
  • MRI can assess for space occupying lesions or other causes of nerve compression. (wikipedia.org)
  • tissue
  • In vitro, treatment of wild-type bone marrow-derived macrophages with advanced glycation end products (AGEs), which accumulate in diabetic nerve tissue, increased M1 and decreased M2 gene expression in a RAGE-dependent manner. (diabetesjournals.org)
  • numbness
  • Sugar Crush exposes the shocking truth about how a diet high in sugar, processed carbohydrates, and wheat compresses and damages the peripheral nerves of the body, leading to pain, numbness, and tingling in the hands and feet, along with a host of related conditions, including migraines, gall bladder disease, and diabetes. (dymocks.com.au)
  • Nerves respond with altered sensations like tingling and numbness. (wikipedia.org)
  • axonotmesis
  • Axonotmesis is usually the result of a more severe crush or contusion than neurapraxia, but can also occur when the nerve is stretched (without damage to the epineurium). (wikipedia.org)
  • protein
  • The term nerve growth factor usually refers to the 2.5S, 26-kDa beta subunit of the protein, the only component of the 7S NGF complex that is biologically active (i.e. acting as signaling molecules). (wikipedia.org)
  • damage
  • If you have the metabolic syndrome or prediabetes, or are just concerned about your health, it will help you reverse and prevent nerve damage. (dymocks.com.au)
  • What Grain Brain did for wheat, this book by a leading peripheral nerve surgeon now does for sugar, revealing how it causes crippling nerve damage throughout the body-in our feet, organs, and brain-why sugar and carbohydrates are harmful to the body's nerves, and how eliminating them can mitigate and even reverse the damage. (dymocks.com.au)
  • Sugar Crush includes a quiz to assess your nerve damage, practical dietary advice, and the latest thinking on ways to prevent and reverse neuropathy. (dymocks.com.au)
  • As a result, he has a serious damage of a backbone, two crushed disks and jammed nerve. (wikipedia.org)