• tibial nerve
  • Tarsal tunnel syndrome (TTS), also known as posterior tibial neuralgia, is a compression neuropathy and painful foot condition in which the tibial nerve is compressed as it travels through the tarsal tunnel. (wikipedia.org)
  • The posterior tibial artery, tibial nerve, and tendons of the tibialis posterior, flexor digitorum longus, and flexor hallucis longus muscles travel in a bundle through the tarsal tunnel. (wikipedia.org)
  • If the entrapment is high, the entire foot can be affected as varying branches of the tibial nerve can become involved. (wikipedia.org)
  • Regeneration
  • The objective of the present study was to evaluate the effects of immune system augmentation with use of the antigen glatiramer acetate, which is known to affect T-cell immunity, on peripheral nerve regeneration. (ebscohost.com)
  • This workshop focused on identifying promising strategies for optic nerve regeneration. (nih.gov)
  • This report summarizes input from the meeting and serves as guidance for future funding of research that focuses on optic nerve regeneration. (nih.gov)
  • Thus the AGI's goal of restoring vision through promoting successful optic nerve regeneration recognizes the critical importance of understanding and reversing regenerative failure. (nih.gov)
  • To understand progress to date in the sciences relevant to optic nerve regeneration, and more specifically to identify focal areas for funding, the NEI convened a workshop in November 2014 in Washington D.C. The workshop was chaired by Jeffrey Goldberg, University of California San Diego, and William Guido, University of Louisville. (nih.gov)
  • Participants ( see appendix ) represented a variety of research areas relevant to optic nerve regeneration, from developmental neurobiology to visual processing. (nih.gov)
  • If the nerve has been completely divided, axonal regeneration causes a neuroma to form in the proximal stump. (wikipedia.org)
  • conduction
  • Schwann cells (SCs) are critical for myelin sheath thickness and internodal distance, which are important determinants of nerve conduction velocity ( Baumann and Pham-Dinh, 2001 ). (jneurosci.org)
  • In electrodiagnostic testing with nerve conduction studies, there is a normal compound motor action potential amplitude distal to the lesion at day 10, and this indicates a diagnosis of mild neuropraxia instead of axonotmesis or neurotmesis. (wikipedia.org)
  • distal
  • We found that degeneration of the distal nerve stump after a nerve crush is greatly delayed when there is increased potassium channel activity (by overexpression of two different potassium channels, Kir2.1 and dORKΔ-C) or decreased voltage-gated sodium channel activity (using mutations in the para sodium channel). (jneurosci.org)
  • Despite the effect of altering voltage-gated sodium and potassium channel activity, recordings made after nerve crush demonstrated that the distal stump does not fire action potentials. (jneurosci.org)
  • regenerate
  • Based on his clinical work, he breaks down his highly effective methods, showing how dietary changes reducing sugar and wheat, coinciding with an increase of good fats, can dramatically help regenerate nerves and rehabilitate their normal function.Sugar Crush includes a quiz to assess your nerve damage, practical dietary advice, and the latest thinking on ways to prevent and reverse neuropathy. (dymocks.com.au)
  • Based on his clinical work, he breaks down his highly effective methods, showing how dietary changes reducing sugar and wheat, coinciding with an increase of good fats, can dramatically help regenerate nerves and rehabilitate their normal function. (dymocks.com.au)
  • The single audacious goal chosen was to regenerate neurons and their neural connections in the eye and visual system, and this was subsequently separated into two primary goals, replacing degenerated photoreceptors, and regenerating axons in the optic nerve. (nih.gov)
  • peripheral nervou
  • Background: Despite the regenerative potential of the peripheral nervous system, severe nerve lesions lead to loss of target-organ innervation, making complete functional recovery a challenge. (ebscohost.com)
  • The nervous system is divided into two parts: the central nervous system, which consists of the brain and spinal cord, and the peripheral nervous system, which consists of cranial and spinal nerves along with their associated ganglia. (wikipedia.org)
  • RGCs
  • As most of fluorescent retinal neurons in this system are RGCs, these findings indicate that repeated brimonidine treatments may protect RGC health following optic nerve crush. (biomedcentral.com)
  • Normally, in humans and indeed in all mammals, there is no regenerative response, and the failure of injured or degenerating retinal ganglion cells (RGCs) to reconnect their axons through the optic nerve to their natural targets in the brain explains the irreversibility of such vision loss. (nih.gov)
  • protein
  • In this study, we investigated the role of Erbin, a protein that interacts with ErbB2 in remyelination of injured nerves. (jneurosci.org)
  • The term nerve growth factor usually refers to the 2.5S, 26-kDa beta subunit of the protein, the only component of the 7S NGF complex that is biologically active (i.e. acting as signaling molecules). (wikipedia.org)
  • Inflammation
  • A shocking look at the link between sugar, inflammation, and a host of preventable chronic diseases-perfect for fans of bestselling author Gary Taubes' The Case Against Sugar-from leading nerve surgeon Dr. Richard Jacoby. (dymocks.com.au)
  • This would include benign tumors or cysts, bone spurs, inflammation of the tendon sheath, nerve ganglions, or swelling from a broken or sprained ankle. (wikipedia.org)
  • neuronal
  • The distribution of EpoR was different from Epo, specifically in some neuronal cell bodies in the dorsal root ganglion, endothelial cells, and Schwann cells of normal nerves. (wikipedia.org)
  • compression
  • If you suffer from ailments your doctors can't seem to diagnose or help-mysterious rashes, unpredictable digestive problems, debilitating headaches, mood and energy swings, constant tiredness-nerve compression is the likely cause. (dymocks.com.au)
  • The flexor retinaculum has a limited ability to stretch, so increased pressure will eventually cause compression on the nerve within the tunnel. (wikipedia.org)
  • Varicose veins (that may or may not be visible) can also cause compression of the nerve. (wikipedia.org)
  • Flat feet may cause an increase in pressure in the tunnel region and this can cause nerve compression. (wikipedia.org)
  • Diabetes makes the peripheral nerve susceptible to nerve compression, as part of the double crush hypothesis. (wikipedia.org)
  • MRI can assess for space occupying lesions or other causes of nerve compression. (wikipedia.org)
  • neurons
  • Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. (wikipedia.org)
  • As its name suggests, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). (wikipedia.org)
  • tissue
  • In vitro, treatment of wild-type bone marrow-derived macrophages with advanced glycation end products (AGEs), which accumulate in diabetic nerve tissue, increased M1 and decreased M2 gene expression in a RAGE-dependent manner. (diabetesjournals.org)
  • numbness
  • Sugar Crush exposes the shocking truth about how a diet high in sugar, processed carbohydrates, and wheat compresses and damages the peripheral nerves of the body, leading to pain, numbness, and tingling in the hands and feet, along with a host of related conditions, including migraines, gall bladder disease, and diabetes. (dymocks.com.au)
  • Nerves respond with altered sensations like tingling and numbness. (wikipedia.org)
  • occur
  • Axonotmesis is usually the result of a more severe crush or contusion than neurapraxia, but can also occur when the nerve is stretched (without damage to the epineurium). (wikipedia.org)
  • damage
  • Thus, we investigated the functional and molecular changes of the bladder in rats, which demonstrated voiding dysfunction induced by nerve damage during nerve-sparing radical pelvic surgery. (mdpi.com)
  • If you have the metabolic syndrome or prediabetes, or are just concerned about your health, it will help you reverse and prevent nerve damage. (dymocks.com.au)
  • What Grain Brain did for wheat, this book by a leading peripheral nerve surgeon now does for sugar, revealing how it causes crippling nerve damage throughout the body-in our feet, organs, and brain-why sugar and carbohydrates are harmful to the body's nerves, and how eliminating them can mitigate and even reverse the damage. (dymocks.com.au)
  • Sugar Crush includes a quiz to assess your nerve damage, practical dietary advice, and the latest thinking on ways to prevent and reverse neuropathy. (dymocks.com.au)
  • Tsai's research includes the identification of neuroprotective molecules that can shield the optic nerve from damage without lowering intraocular pressure, evaluation of medical adherence and surgical outcomes in patients with glaucoma, and development of advanced vision testing techniques. (wikipedia.org)
  • As a result, he has a serious damage of a backbone, two crushed disks and jammed nerve. (wikipedia.org)
  • axons
  • The last (extreme) degree of neurotmesis is transsection, but most neurotmetic injuries do not produce gross loss of continuity of the nerve but rather internal disruption of the architecture of the nerve sufficient to involve perineurium and endoneurium as well as axons and their covering. (wikipedia.org)
  • brain
  • Essential myoclonus occurs in the absence of epilepsy or other apparent abnormalities in the brain or nerves. (wikipedia.org)
  • However
  • However, several patients experienced voiding difficulty despite nerve-sparing radical pelvic surgery. (mdpi.com)
  • cells
  • Immunofluorescence staining using phospho-PEA-15-specific antibody demonstrated that increased phosphorylated PEA-15 co-localized with GFAP, a marker for Müller cells and astroglia in the retina and optic nerve. (unt.edu)
  • In some animal studies Erythropoietin has been shown to protect nerve cells from hypoxia-induced glutamate toxicity. (wikipedia.org)
  • loss
  • Moreover, interventions that diminish or delay loss of Thy-1 promoter activation after optic nerve crush may reflect protection of RGC health. (biomedcentral.com)
  • Electrically, the nerve shows rapid and complete degeneration, with loss of voluntary motor units. (wikipedia.org)
  • growth
  • In addition, multiple attempts at nerve re-growth across the PNS-CNS transition have not been successful. (wikipedia.org)