Nerve adult stem cells. Medical search. Frequent questions

These transplantation experiments confirmed that the reprogrammed cells indeed belong to cells of the intended brain regions and the progenitors produced the three major classes of neural cells: neurons, astrocytes and oligodendrocytes,' Zhang says. (cancerlive.net)
Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. (cellsurgicalnetwork.com)
CONCLUSIONS: Transplantation of adult stem/progenitor cells may provide an effective treatment for erectile dysfunction after radical prostatectomy. (cellsurgicalnetwork.com)
Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans. (nanowerk.com)
The research, an important step toward developing new treatments for stroke, Alzheimer's, Parkinson's and other neurological conditions showed that mice afflicted by stroke showed tangible therapeutic improvement following transplantation of these cells. (science20.com)
None of the mice formed tumors, which had been a major setback in prior attempts at stem cell transplantation. (science20.com)
To move forward with stem cell-based therapies, we need to have a reliable source of nerve cells that can be easily grown, differentiate in the way that we want them to and remain viable after transplantation," said Dr. Lipton. (science20.com)
Many regenerative strategies are being investigated including cell therapy, tissue and biomaterials engineering, and transplantation. (nih.gov)
Sex-specific preservation of neuromuscular function and metabolism following systemic transplantation of multipotent adult stem cells in a murine model of progeria. (sralab.org)
Systemic Transplantation of Adult Multipotent Stem Cells Functionally Rejuvenates Aged Articular Cartilage. (sralab.org)
Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing. (sralab.org)
But we realized that cell transplantation may not always be suitable for catastrophic events, such as a heart attack in which there is major myocardial damage. (derstandard.at)
These new transplantation systems enhance the viability of cells and stimulate their outward migration so that they can populate and help regenerate injured tissues. (derstandard.at)
Stem cell transplantation is the removal of stem cells (undifferentiated cells) from a healthy person and their injection into someone who has a serious blood disorder. (msdmanuals.com)
Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
But researchers think that these stem cells have the most potential for producing different kinds of cells and for surviving after transplantation. (msdmanuals.com)
These stem cells are most often used for transplantation. (msdmanuals.com)
The clinical team from Lund headed by Prof. Olle Lindval in collaboration with Prof. Anders Björklund, were the first to show in patients the proof of principle that cell transplantation therapy is feasible approach to treat the patients with Parkinson's disease. (lu.se)
An autologous bone marrow or stem cell transplantation is performed using a person's own stem cells. (medlineplus.gov)

Our idea was to turn skin cells to neural progenitors, cells that can produce cells relating to the neural tissue. (cancerlive.net)
Obtaining stem cells from fatty tissue, bone marrow, or the umbilical cord after the birth of a baby, on the other hand, may be done ethically. (all.org)
Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. (nanowerk.com)
Neurosurgery researchers have used a new, leading-edge stem cell therapy to promote the growth of bone tissue following the removal of cervical discs -- the cushions between the bones in the neck -- to relieve chronic, debilitating pain. (sciencedaily.com)
It used bone marrow-derived adult stem cells to promote the growth of the bone tissue essential for spinal fusion following surgery, as part of a nationwide, multicenter clinical trial of the therapy. (sciencedaily.com)
The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
In this study, we investigated the epigenetic plasticity of adult murine RPE to identify possible mechanisms that prevent mammalian RPE from regenerating retinal tissue. (nih.gov)
The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
Planarians, in contrast, have large numbers of piRNAs in adult pluripotent stem cells, which go on to differentiate and develop into various tissue types. (bionity.com)
Fetal tissue stem cells have the potential of curing most anything. (commutefaster.com)
In 2004 California chose to spend $3 Billion on fetal tissue stem cell research. (commutefaster.com)
Fetal tissue stem cell research, backed heavily by the abortion industry with their corrupt politics has directed literally billions of dollars into horrifically flawed technology. (commutefaster.com)
Researchers have developed a treatment based on an injection of neural stem cells encased in a biodegradable polymer that replaced the brain tissue in rats that had been damaged by stroke. (discovermagazine.com)
Led by British neurobiologist Mike Modo, the team was able to show that the hole in the brains of rats caused by a stroke was completely filled with "primitive" new nerve tissue within seven days. (discovermagazine.com)
Previous stem cell research in rats with stroke damage had seen some success, but was limited by the tendency of the cells, which lack structural support, to migrate into tissue outside the targeted area. (discovermagazine.com)
According to Modo, over a few days they were able to see cells migrating along the scaffold particles and forming a primitive brain tissue that interacts with the host brain. (discovermagazine.com)
They say that if their approach to isolating and growing the cells can be upscaled, it might some day provide the tissue needed for disorders like peripheral nerve disease, Parkinson's and spinal cord injury. (bioedge.org)
By culturing these multipotent cells with proteins and minerals, Dr. Xu has already gotten the hair follicle stem cells to differentiate into skin, nerve, muscle, bone, cartilage, and fat tissue. (loe.org)
For over a decade, she has investigated the impact of adult stem cells on tissue regeneration after neuromuscular injuries and in age-related diseases. (sralab.org)
Even if this ventralizing signal is absent, adult NSCs are still incapable of generating nerve tissue for the upper or dorsal side of the tail. (earth.com)
Embryonic NSCs, on the other hand, produce the ventralizing signal only in the cartilage region which becomes the lower or ventral side of the tail, allowing the dorsal side to develop skeletal and nerve tissue. (earth.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. (x-journals.com)
The hope of most researchers in the field is that one day it will be possible to use stem cells - which possess the ability to develop into many other distinct cell types, such as nerve, heart, or lung cells - to repair damaged tissue from any number of diseases, from Type 1 diabetes to Parkinson's disease, as well as from injuries. (x-journals.com)
The creation of iPS cells from adult cells sidesteps ethical concerns associated with the use of embryonic stem cells, and allows the generation of stem cells matched to a patient's own immune system, avoiding the problem of tissue rejection. (x-journals.com)
He decided he would focus his efforts on manipulating a naturally occurring process in cells, in particular in a type of adult cell called fibroblasts, which give rise to connective tissue. (x-journals.com)
More controversial is stem cell research, which uses the inner cell mass from an embryo or cells derived from adult tissue. (bettercaring.com)
This research project will allow scientists to study for the first time the genetic causes of glaucoma in the tissue that is affected by the disease, the retinal ganglion cells of the optic nerve. (brightfocus.org)
This resource allows Dr. Fingert's team (and other researchers) to investigate how a TBK1 mutation causes optic nerve disease, by studying the function (or dysfunction) of the TBK1 gene in optic nerve tissue rather than a more accessible substitute tissue. (brightfocus.org)
He anticipates launching a clinical trial soon to study the safety of injecting stem cells into disc tissue to repair degenerated discs. (weeksmd.com)
Through fat transfer or fat grafting, we can heal tissue, treat painful nerves and improve appearance. (orlandohealth.com)
Fat contains a significant number of stem cells, the largest of any tissue in the body. (orlandohealth.com)
MSC are specialized adult stem cells that can produce multiple types of cells in the skeletal tissue. (orlandohealth.com)
Several technologies have been described over the past 10 years to create functional heart tissue by using stem cells that have been isolated from other tissues such as bone marrow, skeletal muscle, and umbilical cord blood. (derstandard.at)
This means that CSCs represent a logical source for cardiac regeneration therapy because, unlike other adult stem cells, they are intrinsically programmed to generate cardiac tissue in the lab and thus increase cardiac tissue viability in humans. (derstandard.at)
After injecting these cells into the hearts of animals with damaged myocardial tissue, my colleagues and I have observed an improvement in physiological functions. (derstandard.at)
So we decided to use these stem cells in association with an artificial, netlike matrix to support formation of functional tissue-like structures that can be used in a new therapeutic approach to repair the heart. (derstandard.at)
Using a hybrid therapy that incorporates tissue engineering, we seeded a biodegradable mesh with cardiac stem cells. (derstandard.at)
The mesh acted as a scaffold on which the stems cells were grown into morphologically recognizable cardiac tissue. (derstandard.at)
We then joined the cardiac tissue built from the mesh scaffold onto the diseased structure of the heart to stimulate the regeneration of the optimal cell types for that particular portion of the heart. (derstandard.at)
Restoration of nerve tissue remains highly challenging, mainly due to the limited regeneration capacity of the nervous system and the development of fibrosis. (yjxinhua.com)
Tissue-engineered nerve guidance conduit (NGC) has emerged as a hopeful alternatives to grafts for repairing damaged nerve tissues3,4. (yjxinhua.com)
MSC, in an ultimate contribution to tissue repair, may also directly trans- or de-differentiate into specific cellular phenotypes such as osteoblasts, chondrocytes, lipofibroblasts, myofibroblasts, Schwann cells, and they may somehow recapitulate their neural crest embryonic origin. (bvsalud.org)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)

Other researchers have bypassed the pluripotent stem cell stage while turning skin cells into neurons and other specialized cells, Zhang acknowledges, but the new research, just published in Cell Reports , had a different goal. (cancerlive.net)
This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)
In the brain of adult mammals neural stem cells ensure that new nerve cells, i.e. neurons, are constantly formed. (uni-heidelberg.de)
This new type of stem cell, and not the one previously known, is primarily involved in the production of new neurons in the olfactory bulb of adult mice. (uni-heidelberg.de)
They were once believed to form the precursor cells that then differentiate in the olfactory bulb of mice into interneurons, nerve cells that modulate stimuli transmission between interconnecting neurons. (uni-heidelberg.de)
At first, we thought that they could be astrocytes, helper cells that ensure that the neurons are able to do their work. (uni-heidelberg.de)
The researchers determined that the basal - and not the apical - stem cells are responsible for the formation of neurons in the olfactory bulb. (uni-heidelberg.de)
To prove this, they separately labelled both cell populations and then observed whether labelled neurons turned up in the olfactory bulb. (uni-heidelberg.de)
When only apical stem cells were labelled, no new labelled neurons could be detected in the olfactory bulb. (uni-heidelberg.de)
Injured adult neurons regress to an embryonic transcriptional growth state. (ccf.org)
turn into functioning adult neurons? (scienceblogs.com)
But if there is no Intelligent Designer, and instead, things evolved, then it is quite possible that the lack of novel fully formed and hooked up neurons in an adult human (which seems to be the general rule of thumb, for whatever reason) is not necessarily achieved via some highly sensible planned out feature. (scienceblogs.com)
If it turns out that neurogenesis occurs in the adult human nose but that those nascent neurons never enervate, well, that is what we might expect evolution, which is not intelligent but, rather, pragmatic, to come up with. (scienceblogs.com)
But, when the question comes up "Do humans generate new neurons as adults" please make sure that the assumption that they do is not based on this earlier nose research, or on any studies that merely looked for new neuron proteins. (scienceblogs.com)
Prior to this research, creating pure neuronal cells from ES cells had been problematic as the cells did not always differentiate into neurons. (science20.com)
Sometimes they became glial cells, which lack many of the neurons' desirable properties. (science20.com)
As a result, we were able to produce neuronal progenitor cells that differentiate into a virtually pure population of neurons and survive inside the brain. (science20.com)
NIH Common Fund ARRA funding is supporting several research projects that are investigating a variety of approaches to regenerative medicine including the conversion of adult stem cells into embryonic stem cell-like cells, and the generation of neurons (nerve cells) from non-neuronal cells. (nih.gov)
Dr. Marius Wernig and colleagues are developing methods for generating neurons (nerve cells) directly from skin fibroblasts (non-neuronal cells). (nih.gov)
Neurons derived from a patient's skin cells could be used to model neurological diseases, or could be transplanted into the patient to treat neurodegenerative diseases such as Parkinson's disease (1RC4NS073015-01). (nih.gov)
First, we and others have discovered molecular pathways that can be used to coax stem cells to turn into neurons that look and act like real retinal ganglion cells. (newswise.com)
Prof. Lindvall and Dr. Kokaia were the first in the world to show that the brain produces new neurons in response to stroke which opened new possibilities for cell therapy by developing the way to modulate and direct brains this self-repair mechanisms. (lu.se)

Our main focus is to enhance nerve regeneration following spinal cord injury via two strategies: (1) cell therapies within the injured spinal cord and (2) gene therapies within the motor cortex in the brain. (ccf.org)
more specifically, we attempt to identify mechanisms that promote the regeneration of injured nerve fibers. (ccf.org)
Regeneration of Corticospinal Axons into Neural Progenitor Cell Grafts After Spinal Cord Injury. (ccf.org)
Specifically, the lab is developing a multifunctional biodegradable conduit that can be seeded with adult stem cells to facilitate nerve regeneration. (moleculardevices.com)
Changing surface characteristics of scaffolds was a way to promote regeneration and ion implantation was one of the methods to modify surface properties which play a huge role in enhancing the proliferation and integration of cells. (omicsonline.org)
Nerve regeneration. (omicsonline.org)
A research team led by the University of Southern California (USC) has recently managed to significantly improve the regeneration of lizard tails through stem-cell therapy. (earth.com)
To achieve this, the scientists have initially investigated how lizard tails form during adult regeneration in comparison to embryonic development. (earth.com)
The result revealed that such conduit could significantly induce Nestin and MAP2 gene expression in the PC12 cells and, thus, it is a viable option for effective cell differentiation and nerve regeneration. (yjxinhua.com)
Research is performed to understand mechanisms involved in regeneration and repair after peripheral nerve injury in both experimental and clinical studies, including rehabilitation, in health and disease. (lu.se)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

A second advance comes from the virus that delivers genes to reprogram the adult skin cells into a different and more flexible form. (cancerlive.net)
Methylome states of photoreceptor-related genes in adult RPE and embryonic retina (which mostly contain progenitors) were very similar. (nih.gov)
Furthermore, Eggan noted that genetic analyses of the fused cells revealed that the somatic cell genes characteristic of adult cells had all been switched off, while those characteristic of embryonic cells had been switched on. (news-medical.net)
With the exception of a few genes one way or the other -- which is perhaps because these cells are now tetraploid -- the hybrid cells are indistinguishable from human embryonic stem cells," he said. (news-medical.net)
Thanks to human induced pluripotent stem cell (iPSC) and gene-editing technologies, it's possible to derive every kind of brain cell type, insert dementia -related genes and study them in culture. (jax.org)
MEF2C is a transcription factor that turns on specific genes which then drive stem cells to become nerve cells. (science20.com)
MEF2C helps this process first by turning on the genes that, when expressed, make stem cells into nerve cells. (science20.com)
It then turns on other genes that keep those new nerve cells from dying. (science20.com)
Single-cell RNA sequencing gives us our first insights into what genes are important in terms of the division behavior of individual cells. (myscience.ch)
The new findings will form the basis of future experiments to investigate in detail how specific genes control the activity of stem cells. (myscience.ch)
Jessberger sums up the next research objectives: "Imaging and single-cell RNA sequencing have given us completely new insights that we will use in the future to systematically regulate the activity of certain genes in the future. (myscience.ch)
These four genes then produced transcription factors turning on and off other genes, and pushing the cell to "dedifferentiate" into stem cells. (x-journals.com)
In the paper, the researchers demonstrated that they could use purified proteins to transform adult cells all the way back to the most primitive embryonic-like cells, avoiding the problems associated with inserting genes. (x-journals.com)
It introduces normal genes into specific cells of people with certain disorders to overcome the effects of defective genes that may cause or have a part to play in the development of the condition. (bettercaring.com)
This therapy may also be used to reverse the process of cell death in people who do not have defective genes and would help the remaining cells to operate more efficiently or even regrow. (bettercaring.com)
They will do this by using a virus to activate four genes (OCT4, SOX2, KLF4, and c-MYC) in the skin cells. (brightfocus.org)
Activation of these four genes induces the skin cells to become stem cells-cells that have the ability to divide and eventually form any cell type in the body, including optic nerve cells. (brightfocus.org)
Previous studies have suggested that TBK1 and other glaucoma genes may cause disease by disrupting how cells recycle and degrade their accumulating "garbage. (brightfocus.org)
Chimeras can pass on genes from embryonic stem cells to their offspring. (eurostemcell.org)
Researchers can precisely alter the genes of ES cells in the lab, put the cells back into blastocysts, and produce new mice that contain the modified genes. (eurostemcell.org)
Scientists use genetically altered mice made from ES cells to study genes involved in many human diseases. (eurostemcell.org)
By triggering certain genes, researchers may be able to cause the stem cells to specialize and become the cells that need to be replaced. (msdmanuals.com)
One way to induce these cells is to inject them with material that affects their genes, a process called reprogramming. (msdmanuals.com)
For gene therapy, a combinatorial approach with multiple target genes, as well as more complex optogenetic approaches are studied, while for cell-therapy human induced pluripotent stem cells and human induced neuronal cells are investigated. (lu.se)
We have the same genes everywhere in the cells of the body, yet certain types of protein are expressed in the brain, while others are expressed in the liver. (lu.se)

The petition recognizes that many "Canadians suffer from debilitating illnesses and diseases" and that the petitioners "support ethical stem cell research that has already shown encouraging potential to provide cures and therapies for these illnesses and diseases. (lifesitenews.com)
HACK: In their search for regenerative cell therapies that might some day cure Parkinson's, Alzheimer's, and other diseases, scientists have studied adult stem cells found in the hair follicles of mice. (loe.org)
Newswise - There is great interest among glaucoma patients, scientists and doctors alike, in discovering regenerative therapies for the optic nerve and translating them from the laboratory to the clinic - and stem cell therapy is one of several promising approaches being studied. (newswise.com)
Dr. Goldberg is a leading expert in therapies to regenerate the optic nerve and is part of the Catalyst for Cure team. (newswise.com)
Stem cell therapies already exist in medical practice. (derstandard.at)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

In particular, the absence of iPSC cells rules out the formation of tumors by pluripotent cells in the recipient, a major concern involving stem cell therapy. (cancerlive.net)
Human embryonic stem cells (ESCs) are pluripotent cells, meaning cells that can make any other cell in the body. (eurostemcell.org)
If an inner cell mass is taken from a mouse blastocyst and given the right nutrients, the pluripotent cells can grow in the laboratory. (eurostemcell.org)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)

Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
Transplanting organs, tissues or cells from one person to another. (mayo.edu)
Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
Understanding how tissues are normally maintained by their resident stem cells is key to advancing and applying regenerative medicine. (nih.gov)
Stem cells exist naturally in the body to replace damaged cells and tissues. (schoolscience.co.uk)
However, researchers believe it has to do with mesenchymal stem cells (MSC) found within fatty tissues. (orlandohealth.com)
In adults, stem cells act as a repair system for the body, replenishing specialised cells, and maintaining the normal turnover of regenerative organs such as blood, skin or intestinal tissues. (derstandard.at)
Through medical research, stem cells can now be grown and transformed into a variety of specialised cells with characteristics consistent with tissues such as muscles or nerves. (derstandard.at)
Researchers are learning how cells assemble into complex tissues, such as the layers of the brain, by attempting to grow primitive organs in the lab. (eurostemcell.org)
anoxia - an absence of oxygen supply to an organ's tissues leading to cell death. (brainline.org)
apoptosis - cell death that occurs naturally as part of normal development, maintenance, and renewal of tissues within an organism. (brainline.org)
Researchers hope to use stem cells to repair or replace cells or tissues damaged or destroyed by such disorders as Parkinson disease, diabetes, and spinal injuries. (msdmanuals.com)
All tissues originate from stem cells. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
Cells Tissues Organs. (cancercentrum.se)

A receptor of the same name plays a vital role, controlling the speed at which the cells multiply and monitoring the cell differentiation process. (uni-heidelberg.de)
To ensure that cells to be transplanted are healthy and normal, the ImageXpress Micro System is used to analyze different cell lines, cell populations, cell differentiation properties in a high throughput fashion. (moleculardevices.com)
In this study, it was observed that the ion implantation stimulated the neural proliferation and the implantation of different ions on cell culture surfaces was essential to determine the effects of this technique on adhesion, proliferation, differentiation and apoptosis properties of cells in details. (omicsonline.org)
Dr. Fernando Camargo and colleagues are developing a novel experimental paradigm for studying stem cell biology in which individual stem cells are tagged and their activity, lifespan, and differentiation within the context of highly complex cell populations is monitored. (nih.gov)
Dr. Nobuaki Kikyo and colleagues are working to identify factors derived from egg cells that can reprogram an adult nucleus into an embryonic state, and to apply these factors to reprogram the differentiation status of living cells. (nih.gov)
The learning resource provides an overview of stem cells, explains differentiation, embryonic, adult and induced pluripotent stem cells, theraputic stem cell cloning and stem cells as potential treatment for heart disease and nerve damage. (schoolscience.co.uk)
Ghasemi-Mobarakeh L, Prabhakaran MP, Tian L, Shamirzaei-Jeshvaghani E, Dehghani L, Ramakrishna S. Structural properties of scaffolds: Crucial parameters towards stem cells differentiation. (wjgnet.com)
For this reason, our group has recently described and patented a method to obtain cardiac stem cells (CSCs) from small biopsies of myocardium and grow them through several generations in the laboratory without losing differentiation potential. (derstandard.at)
Many research endeavors have revealed the effective role of the electrical force on cellular adhesion, proliferation, differentiation and migration of nerve cells8,14. (yjxinhua.com)
Using a self-stimulated neural conductive channel to create a suitable scaffold for the growth and differentiation of neural-like cells can be desirable20. (yjxinhua.com)

It is further speculated that those who support human embryonic stem cell research are also seeking human embryos for the purposes of human cloning. (all.org)
Scientists have transformed stem cells from adult human bone marrow into nerve cells by transplanting them into damaged chicken embryos. (bbc.co.uk)
A type of undifferentiated stem cell found in embryos. (mayo.edu)
We can just take fruit fly embryos or fruit fly adults, and isolate stem cells from them and study what it is that makes the stem cells special. (thenakedscientists.com)
They are made from cells found in very early human embryos, called blastocysts. (eurostemcell.org)
Stem cells can be obtained from the embryos that are not used. (msdmanuals.com)
Because the embryos then lose the ability to grow into a complete human being, the use of stem cells from embryos is controversial. (msdmanuals.com)

The international MESEMS trial, which recently reported its final results, showed that mesenchymal stem cell therapy was safe and well tolerated by people with MS, but was not effective at reducing inflammation in people with active forms of MS. (msif.org)
Mesenchymal stem cells (MSCs - sometimes referred to as mesenchymal stromal cells or bone marrow stromal cells) are adult stem cells that can produce many different types of cells, including muscle, cartilage and nerve cells. (msif.org)
The MESEMS (mesenchymal stem cells for MS) trial, which was partly funded by MSIF, took place in centres in North America, Europe and Australia. (msif.org)
This naturally occurring process - called MET (mesenchymal to ephithelial cell transition) - pushes fibroblasts closer to a stem-cell-like state. (x-journals.com)
Mesenchymal stem cells (MSCs) play a critical role in response to stress such as infection. (bvsalud.org)

Stem cells are characterised by their unique ability to constantly renew themselves and differentiate into a diverse range of other specialised cell types. (derstandard.at)
Many areas of science use mouse ESCs to study how blastocysts grow into adults and to study what signals direct stem cells to differentiate into specialised cells. (eurostemcell.org)
Another challenging area is controlling exactly how ESCs differentiate into numerous specialised cell types. (eurostemcell.org)
They will multiply and differentiate extensively to make the many types of cells needed to form the entire animal. (eurostemcell.org)

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging. (sralab.org)

Now researchers have identified a blend of naturally occurring fibers such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer. (nanowerk.com)
Your body's ability to self-heal nerves in the brain can be compromised by a toxic internal environment - will researchers look for the diet connection? (naturalnews.com)
The Heidelberg researchers were able to disprove the single stem cell type theory and the assumption that apical stem cells are responsible for neurogenesis. (uni-heidelberg.de)
Originally, the researchers in the Neurobiology department were investigating how this allegedly lone stem cell population in the mouse brain behaves in various situations. (uni-heidelberg.de)
Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. (news-medical.net)
In theory, researchers can induce embryonic stem cells to mature into a variety of specialized cells. (news-medical.net)
For that reason, many researchers believe stem cells offer promise for creating populations of specialized cells that can be used to rejuvenate organs, such as the pancreas or heart, that are damaged by disease or trauma. (news-medical.net)
Stem cells also provide a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. (news-medical.net)
Eggan, Melton and their colleagues decided to pursue their alternative route after other researchers had shown that genetic reprogramming can occur when mouse somatic cells are fused to mouse embryonic stem cells. (news-medical.net)
In the studies published in Science, the researchers combined human fibroblast cells with human embryonic stem cells in the presence of a detergent-like substance that caused the two cell types to fuse. (news-medical.net)
The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. (news-medical.net)
The researchers were also able to further confirmed that fusion occurred by studying the chromosomal makeup of the fused cells. (news-medical.net)
The researchers also performed fusion experiments using pelvic bone cells as the somatic cells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. (news-medical.net)
iPSCs "can be turned into disease-relevant cells such as nerve cells, allowing researchers to study disease biology in the very types of cells that become affected. (jax.org)
Using MEF2C, the researchers created colonies of pure neuronal progenitor cells, a stage of development that occurs before becoming a nerve cell, with no tumors. (science20.com)
For the new study, which will be published in Biomaterials , the researchers used the polymer PLGA to construct tiny balls one-tenth of a millimeter thick, and loaded them with neural stem cells. (discovermagazine.com)
Researchers at the University of Pennsylvania School of Medicine have found that hair follicles are a rich source of adult stem cells which can be differentiated into nerve cells, smooth muscle cells and skin pigment cells. (bioedge.org)
The researchers, led by PhD candidate Sara Bottes and postdocs Baptiste Jaeger and Gregor Pilz, employed state-of-the-art microscopy and genetic analyses (using single-cell RNA sequencing) of stem cells and their daughter cells to analyze the formation of new nerve cells. (myscience.ch)
The researchers also used single-cell RNA sequencing of stem cells and their daughter cells to demonstrate that stem cells with different division behavior (few cell divisions as opposed to long-lasting stem cell activity) can be differentiated on the basis of their molecular composition and gene expression profiles. (myscience.ch)
The researchers identified the most active compounds, then looked at their effects on stem cell creation when used singly and in combination. (x-journals.com)
The researchers found two chemicals - ALK5 inhibitor SB43142 and MEK inhibitor PD0325901 - used in combination were highly effective in promoting the transformation of fibroblasts into stem cells. (x-journals.com)
Today, the regrowth of Prometheus' liver has become a symbol to medical researchers for the possible renewal of damaged human organs through the use of human stem cells. (derstandard.at)
But medical researchers hope to be able to use technologies derived from stem cell research to treat a much wider variety of diseases. (derstandard.at)
Researchers are learning how to create many different specialised cell types found in the body by exposing ESCs to different signalling molecules and growth conditions. (eurostemcell.org)

Kansas State University scientists helped discover new details about an intricate process in cells. (nanowerk.com)
The Heidelberg scientists also found out that both stem cell types and precursor cells in the mouse brain communicate with one another via so-called notch interactions. (uni-heidelberg.de)
SCNT involves transferring the nuclei of adult cells, called somatic cells, into oocytes in which scientists have removed the nuclei. (news-medical.net)
The scientists knew that if their studies were successful, it would provide the research community with a new option for producing reprogrammed cells using embryonic stem cells, which are more plentiful and easier to obtain than unfertilized human eggs. (news-medical.net)
This way, scientists are now closer to understand how the stem cells of planarians maintain the flexibility necessary to regenerate body parts without destroying themselves at the same time. (bionity.com)
Scientists at the Burnham Institute for Medical Research have, for the first time, genetically programmed embryonic stem (ES) cells to become nerve cells when transplanted into the brain, according to a study published today in The Journal of Neuroscience. (science20.com)
Scientists have isolated adult stem cells in human hair follicles. (loe.org)
Scientists at Toronto University and the Toronto Western Research Institute of Canada managed to reduce some of the paralysis of rats with spinal cord injury with cells transplanted from adult mice brain cells. (sci-info-pages.com)
For the first time, scientists at the University of Zurich have been able to observe stem cells in the adult mouse brain that divide over the course of several months to create new nerve cells. (myscience.ch)
Embryonic stem cells have captured the imagination of scientists and non-scientists alike. (eurostemcell.org)
The immense value of this technique for science and medicine was recognized in 2007 when the Nobel Prize in Medicine was awarded to three scientists who pioneered the use of ES cells to create genetically modified mice . (eurostemcell.org)
Scientists are developing ways of enabling (inducing) other cells (such as a blood or skin cell) to act as stem cells. (msdmanuals.com)

Spinal fusion is used following surgery for degenerative disc disease, where the cushioning cartilage has worn away, leaving bone to rub against bone and herniated discs, where the discs pinch or compress nerves. (sciencedaily.com)
However, adult NSCs produce a molecular system blocking skeletal and nerve formation and encouraging cartilage growth, thus "ventralizing" both sides of the tail. (earth.com)

Cookson, a cell biologist who studies the underlying pathways that lead to Parkinson's disease and related disorders, explains that a typical iPSC project would involve reverting a cell line from a patient with a given mutation back to the wild-type (or "normal") sequence, to compare the two. (jax.org)
Conditions such as stroke, Alzheimer's, Parkinson's and Huntington's disease destroy brain cells, causing speech and memory loss and other debilitating consequences. (science20.com)
Parkinson's occurs when cells in the part of the brain that controls movement die. (bettercaring.com)
The main objective of the Stem Cell Center´s Neuroscience Program is to study the properties of neural stem cells (NSCs) and explore the possibilities to use these cells for treatment of neurodegenerative diseases such as Parkinson's disease and stroke. (lu.se)

After the progenitor was implanted into newborn mice, neural cells seemed to grow normally, without forming obvious defects or tumors, Zhang says. (cancerlive.net)
The following year, he led a research team that tracked the chemical signals received by newly made nerve cells in adult mice hippocampus. (wikipedia.org)
This process, known as adult neurogenesis, helps mice maintain their sense of smell. (uni-heidelberg.de)
We found that we could create new nerve cells from stem cells, transplant them effectively and make a positive difference in the behavior of the mice," said Dr. Lipton. (science20.com)
They then determined if the new cells could provide cognitive benefits to the stroke-afflicted mice. (science20.com)
Brain cells from adult mice were implanted into the spinal cords of the rats at two and eight weeks after injury. (sci-info-pages.com)
These adult mice brain cells, when implanted into the spinal cord, create a sheath (kind of insulation) around the nerve fibers - very much like the plastic insulation you find around electric cables in your home. (sci-info-pages.com)
In a study published , the group of Sebastian Jessberger, a professor at the University of Zurich's Brain Research Institute, has shown that stem cells in the hippocampus of mice are active over a period of several months. (myscience.ch)
In humans, mice and other mammals, the embryo is a ball of approximately 100 cells at this stage. (eurostemcell.org)

From "adult stem cells" to "xenotransplantation," learn about common and specialized regenerative medicine terms. (mayo.edu)
Lizards have been around for more than 250 million years, and in all that time no lizard has ever regrown a tail with dorsoventral patterning, until now," said study lead author Thomas Lozito, an assistant professor of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine at USC. (earth.com)

When the nerve fibers of the brain lose its protective coating, called myelin, the brain sends adult stem cells to regenerate a new myelin sheet. (naturalnews.com)
This last approach-regrowing optic nerve fibers back to the brain-has been the most challenging but it's also the most exciting. (newswise.com)
They are densely innervated by slow-adapting type I mechanoreceptor nerve fibers and serve as critical transmitters for light touch and hair movement stimuli. (medscape.com)

Looking for new sources of multipotent stem cells? (bioedge.org)
These multipotent stem cells contain certain proteins - called markers - that have previously been found only in embryonic stem cells. (loe.org)

IPSC cells can generate any cell type, which could be a problem for cell-based therapy to repair damage due to disease or injury in the nervous system. (cancerlive.net)
In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
Ph.D., professor and director of cellular engineering, has contracted with the National Institutes of Health to generate a collection of engineered iPSC brain cell lines for the Alzheimer's research community. (jax.org)
Consequently, the team of Drs. Fingert and Tucker has used a stem cell-based approach to generate RGCs in culture. (brightfocus.org)
NSCs are derived from the embryonic stem (ES) cells or fetal and adult nervous system, and can generate different type of neural cells. (lu.se)
Rather than ignoring the result, she chose to follow up on indications that it was possible that radial glial cells generate nerve cells. (lu.se)
I wanted to find out in which cells a specific transcription factor was expressed, but what I observed led me to believe that it might be possible that the glial cells in the developing brain generate nerve cells", explains Götz. (lu.se)

The novelty is that this is a combined cell and gene therapy approach," Suzuki explains, noting that the bone marrow stem cells on their own had a modest effect, possibly by releasing their own protective factors. (wisc.edu)
A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)

We found they could be induced to mature into nerve cells, hair follicles, muscle cells and gut endoderm cells. (news-medical.net)
Although stem cells from human hair follicles are much harder to come by, and less versatile than embryonic stem cells, they're less controversial in today's political and religious debates over the ethics of stem cell research. (loe.org)

The picture shows the development over time from the stem cell ( in red ) via its daughter cells (orange and yellow depending on their stage of development) into new nerve cells ( green ) that have formed in the adult hippocampus over the course of several months. (myscience.ch)
So, there is the new technology of creating stem cells and neural stem cells are created throughout life in the hippocampus brain region of rats and humans. (thenakedscientists.com)

Jianfeng Lu, Zhang's postdoctoral research associate at the UW-Madison Waisman Center, removed skin cells from monkeys and people, and exposed them to Sendai virus for 24 hours. (cancerlive.net)
Second, the neural progenitors have a greater ability to grow daughter cells for research or therapy. (cancerlive.net)
A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells - without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC. (wisc.edu)
No harm comes to the person whose stem cells are obtained for research in such a fashion. (all.org)
There are those in the government and scientific community who say more money must be spent on human embryonic stem cell research because it holds the most promise for helping people with conditions such as Alzheimer's disease. (all.org)
Alzheimer's researcher Ned Potter said, however, that human embryonic stem cell research would not help the Alzheimer's patient at all. (all.org)
Contrary to the impression many people have, research involving human embryonic stem cells is not new. (all.org)
Yet, human embryonic stem cell research has thus far been unsuccessful in the quest to develop any therapeutic treatments. (all.org)
Therefore, it is speculated that those who support human embryonic stem cell research are clamoring loudly for taxpayer dollars because private companies know human embryonic stem cell research is neither worth their time nor their money. (all.org)
On the other hand, research involving adult stem cells has not only been around for a long time, it has also been used successfully for decades! (all.org)
While stem cell research and human cloning are complex topics, the facts are readily available. (all.org)
As a result of his research into understanding how adult neural stem cells mature, Song was named the co-recipient of the 2008 Young Investigator Award from the Society for Neuroscience. (wikipedia.org)
In 2009, he participated in a research team that used the drug mTOR to rescue impaired nerve cells found damaged in patients suffering from schizophrenia. (wikipedia.org)
Following this discovery, his research team also determined that DNA modifications in non-dividing brain cells were not as stable as previously thought. (wikipedia.org)
A research team led by Dr Francesca Ciccolini at the Interdisciplinary Center for Neurosciences (IZN) of Heidelberg University recently discovered a second stem cell population in the mouse brain. (uni-heidelberg.de)
Research in the Sakaguchi Lab at Iowa State University focuses on experimental strategies for the rescue and repair of the damaged nervous system using stem cell approaches. (moleculardevices.com)
By isolating and reprogramming brain cells with dementia-causing genetic mutations, a team at JAX offers a powerful new research tool. (jax.org)
Ward was on a research team that achieved the first successful merger of stem cell-derived cell types and CRISPR screening technologies. (jax.org)
The team was led by Stuart A. Lipton, M.D., Ph.D., professor and director of the Del E. Webb Neuroscience, Aging, and Stem Cell Research Center at Burnham. (science20.com)
The announcement of the stroke research came on the same day that U.S. President Obama lifted restrictions on experiments using embryonic stem cells, and provided a vivid example of the potential medical breakthroughs that stem cell research could eventually bring about. (discovermagazine.com)
Unlike previous experiments which managed to ease paralysis in laboratory animals, this research managed to do it with adult brain cells, rather than embryonic stem cells (or cells from fetuses). (sci-info-pages.com)
What is the current status of research on stem cell therapy for glaucoma? (newswise.com)
The study shows that brain stem cells are active over a long period, and thus provides new insights for stem cell research. (myscience.ch)
The research makes great strides in addressing a major practical challenge in the development of stem-cell-based medicine. (x-journals.com)
I believe that the field will quickly adopt this method, accelerating iPS cell research significantly. (x-journals.com)
The research team is using this approach to produce a collection of cultured optic nerve cells from several patients that carry a particular glaucoma-causing mutation in the TBK1 gene, and also cells from several individuals without glaucoma. (brightfocus.org)
Research groups are gathered within five main research clusters: MultiPark, Stem Cell Center and Epilepsy Center. (lu.se)
Lund center for Stem Cell Biology and Cell Therapy is one of six Swedish strategic centers of excellence in life sciences, supported by the Swedish Foundation for Strategic Research. (lu.se)
The possibility to isolate and propagate NSCs and their potential applications in cell therapy have attracted a lot of research interest in recent years. (lu.se)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
What happened next would change the way the research community viewed these cells. (lu.se)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

Its stem cells contain the proteins SMEDWI-2 and SMEDWI-3. (bionity.com)
Next, the team will force the stem cells to become optic nerve cells by growing them in culture media containing a specialized mix of growth factors and proteins. (brightfocus.org)
Plasma cells help your body fight infection by producing proteins called antibodies . (medlineplus.gov)

This enabled them to observe that specific stem cell populations are active over months and that they can divide repeatedly. (myscience.ch)
[ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)

Immediately after injury 8 rats each were injected intracavernously with phosphate buffered saline (vehicle control), fibroblasts (cell control), rat multipotent stromal cells (cell treatment) or p75 derived multipotent stromal cells (cell treatment). (cellsurgicalnetwork.com)
Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)

But the benefits using these types of stem cells have ranged from marginal, to transient, to nil. (derstandard.at)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)

Professor Lozito and his team used gene-editing tools to make embryonic NSCs unresponsive to the ventralizing signal and they implanted them into adult tail stumps. (earth.com)
The team will use these cells to study the mechanism by which a known glaucoma gene, TANK binding kinase 1 (TBK1), leads to RGC loss and eye disease. (brightfocus.org)
In the first aim of the project, the team of Drs. Fingert and Tucker is collecting skin cells from patients with known glaucoma-causing mutations in the TBK1 gene. (brightfocus.org)
In the second aim, the team is using the optic nerve cells produced in aim 1 to investigate how defects in the TBK1 gene lead to optic nerve damage. (brightfocus.org)
Main emphasis of Epilepsy Center is to explore mechanisms underlying epileptogenesis, and develop gene- and cell-therapy based treatment strategies for epilepsy. (lu.se)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)

We investigated the effects of transplanting nonhematopoietic adult bone marrow stem/progenitor cells (multipotent stromal cells) into the corpus cavernosum in a rat model of bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)
MATERIALS AND METHODS: Multipotent stromal cells were isolated from the bone marrow of transgenic green fluorescent protein rats by plastic adherence (rat multipotent stromal cells) or magnetic activated cell sorting using antibodies against p75 low affinity nerve growth factor receptor (p75 derived multipotent stromal cells). (cellsurgicalnetwork.com)
Rats injected with typical multipotent stromal cells had partial erectile function rescue compared with animals that received p75 derived multipotent stromal cells. (cellsurgicalnetwork.com)
Enzyme-linked immunosorbent assay suggested that basic fibroblast growth factor secreted by p75 derived multipotent stromal cells protected the cavernous nerve after bilateral cavernous nerve crush injury. (cellsurgicalnetwork.com)

In addition to its significant practical advantages, the development of the technique deepens the understanding of the biology behind the transformation of adult human cells into stem cells. (x-journals.com)
If he could manipulate such a fundamental process to encourage MET and the formation of stem cells, Ding reasoned, such a method would be both safer and more direct than hijacking other aspects of biology, for example those directly involved in cancer. (x-journals.com)
Antony Rosen, professor of medicine, cell biology and pathology and director of the Rheumatology Division, has been named the Mary Betty Stevens Professor of Medicine. (jh.edu)
Development: For advances in developmental biology and stem cells. (lu.se)

Obtaining stem cells from a human embryo is highly unethical. (all.org)
There is only one way to obtain stem cells from a developing human embryo, and it involves killing the embryo. (all.org)
And, since these cell types are derived from three different parts of the embryo, this really demonstrated the ability of these cells to give rise to a variety of different cell types. (news-medical.net)
Embryonic stem cells are grown from cells found in the embryo when it is just a few days old. (eurostemcell.org)
An outer layer of cells, or trophectoderm , will form the placenta that supports the embryo as it grows inside the uterus. (eurostemcell.org)
The process of cell maturation and specialization that would normally take place in the embryo stops. (eurostemcell.org)
The sperm fertilizes the egg and the resulting cell divides, forming an embryo. (msdmanuals.com)
Embryonic stem cells are stem cells derived from the inner cell mass of an early, preimplantation stage embryo known as a blastocyst. (bvsalud.org)

Eventually, the process could produce cells used to treat conditions like spinal cord injury and ALS. (cancerlive.net)
Dr. Steenblock has repaired spinal cord damage and other critical nerve elements using adult stem cells. (commutefaster.com)
Dr. Michael Fehlings, lead researcher, said even some cells in the spinal cord itself could be used (rather than brain cells). (sci-info-pages.com)
The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
Typical symptoms of relapses may be referable to demyelinating pathology involving the optic nerves (e.g. optic neuritis), brainstem (e.g. internuclear ophthalmoplegia) or spinal cord (e.g. partial myelitis), although non-specific symptoms referable to the cerebral hemispheres or other brain regions can also occur (Katz Sand and Lublin, 2013). (medscape.com)

His laboratory is developing novel stem cell approaches for glaucoma, and working steadily towards a translational program to bring discoveries out of the laboratory and into human testing once safety and efficacy in pre-clinical models is established. (newswise.com)
He adds that the now available evidence of long-lasting stem cells division has implications for future therapeutic approaches: "We now know that there really are stem cells that divide over a period of many months. (myscience.ch)

HMGB1, ATP, DNA) as well as pathogen-associated molecular patterns (LPS, single strand RNA) can activate MSCs located in the parenchyma and around vessels to upregulate the expression of growth factors and chemoattractant molecules that influence immune cell recruitment and stem cell mobilization. (bvsalud.org)

Later in the disease when patients have lost considerable numbers of retinal ganglion cells and optic nerve axons, and have thereby lost considerable vision, stem cells may be useful to replace lost ganglion cells and restore the connections from the eye to the brain. (newswise.com)
Our laboratory and a number of other laboratories have made considerable progress on the two main fronts of bringing stem cell therapy to optic nerve restoration for glaucoma. (newswise.com)
Retinal ganglion cells (RGCs) form the optic nerve, which carries vision from the eye to the brain. (brightfocus.org)
The team will force the skin cells to take on features of optic nerve cells in a two stage process. (brightfocus.org)
Overactivity of this degradation system, known as autophagy, may lead to optic nerve cell death and glaucoma. (brightfocus.org)
In aim 2, this team will use the optic nerve cell cultures produced in aim 1 to test for signs of over-activation of autophagy. (brightfocus.org)
Specifically, they are measuring a key marker of activation of autophagy, called LC3-II, in the optic nerve cells. (brightfocus.org)
Dr. Fingert believes that these experiments and the data they produce will reveal the basic mechanisms that lead to optic nerve damage, vision loss, and glaucoma. (brightfocus.org)
Further studies of the autophagy pathway using these stem cell-derived optic nerve cells may provide additional insights into the causes of glaucoma at the molecular level and may also suggest new therapeutic interventions to reduce autophagy activity and treat or prevent disease. (brightfocus.org)

It may be performed using cells from the patient's own body (autologous transplant) or cells from a donor (allogeneic transplant). (mayo.edu)
An allogeneic transplant uses someone else's stem cells. (medlineplus.gov)

They were long considered to be the only stem cell population in the adult mouse brain as well as the main driver of nerve cell formation," explains Dr Ciccolini. (uni-heidelberg.de)
The notch activity decides, as it were, whether a stem cell remains a stem cell or develops into a nerve cell," explains Katja Baur, a doctoral researcher in Francesca Ciccolini's working group. (uni-heidelberg.de)
Combining two modern methods - two-photon microscopy and single-cell RNA sequencing - has enabled us to identify precisely the stem cells that can divide over the course of months,' explains Jessberger. (myscience.ch)
Johns Hopkins' molecular biologist Jin Zhang explains how she uses light to see where and when within cells specific molecular processes occur and what happens when they go wrong. (curiouscatblog.net)

We suspect that the apical stem cells intervene in the activation of the notch signal pathway and can inhibit proliferation and neurogenesis," she adds. (uni-heidelberg.de)
Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)

Thirteen days later, Lu was able to harvest a stem cell called an induced neural progenitor. (cancerlive.net)
The next step was to determine whether the transplanted neural progenitor cells became nerve cells that integrated into the existing network of nerve cells in the brain. (science20.com)

Stem cells create new nerve cells in the brain throughout life. (myscience.ch)

In Alzheimer's, it is the degeneration of the nerve cells that cause the problem because they lose their ability to connect with each other. (all.org)
A promising new approach to finding effective treatments is to study human brain cells that carry mutations found in Alzheimer's patients. (jax.org)
A reduction in the number of newly formed nerve cells has been observed, for example, in the context of depression and Alzheimer's disease, and has been associated with reduced memory performance in these conditions. (myscience.ch)
Since we now know that there are stem cells that can divide over a longer period, our aim is to increase the division activity of these cells and thus the formation of new nerve cells, for example in the context of neurodegenerative conditions such as Alzheimer's disease. (myscience.ch)

Even when the neuronal cells were created successfully, they often died in the brain following transplant-a process called programmed cell death or apoptosis. (science20.com)
MEF2C also protected the cells from apoptosis once inside the brain. (science20.com)
A study by Hashem et al using induced pluripotent stem cell-derived cardiomyocytes indicated that LAMP2 protein deficiency in Danon disease results in autophagic flux impairment, which in turn causes excessive oxidative stress and, subsequently, cardiomyocyte apoptosis. (medscape.com)

They used genetically modified animals whose neural stem cells were dyed green using a dye active in the cell nucleus. (uni-heidelberg.de)
He adds that by engineering disease-causing mutations in a set of genetically diverse iPS cells, "the project is designed to ensure reproducibility of data across laboratories and to explore the effect of natural variation in dementia. (jax.org)

The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)

These neural stem cells are located in the subventricular zone near the lateral cerebral ventricle. (uni-heidelberg.de)

A stem cell is a type of cell found throughout the body of all human beings. (all.org)
The human brain has similar stem cells that are involved in the formation of brain tumours. (uni-heidelberg.de)
The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells. (news-medical.net)
This approach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used to produce human stem cells. (news-medical.net)
One of the key findings from the study was that the fusion cells have the characteristics of human embryonic stem cells. (news-medical.net)
So, while this does not obviate the need for human oocytes, it demonstrates that this general approach of cell fusion is an interesting one that should be further explored. (news-medical.net)
Unlike embryonic stem cells, iPSCs are derived from adult human cells. (jax.org)
Dr. James L. Sherley and colleagues are investigating the conversion of human adult stem cells (ASCs) into embryonic stem cell-like cells with the goal of developing tools for the exact identification of human ASCs, and advancing ASCs as effective cellular medicines for human disease (3DP1OD000805-03S1). (nih.gov)
Now, for the first time, Pathologist Dr. George Xu, at the University of Pennsylvania, has isolated a new adult stem cell in the human hair follicle. (loe.org)
If cells from the paralyzed human patient could be transplanted, we may eventually have an effective treatment. (sci-info-pages.com)
This is the first example in human cells of how reprogramming speed can be accelerated. (x-journals.com)
The creation of human iPS cells was first announced in December 2007 by two labs, one in Japan and another in Wisconsin. (x-journals.com)
The question for us at University of Rome "Sapienza" in Italy is: Why not use stem cells to repair the human heart? (derstandard.at)
The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)
To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)

A type of stem cell found in organs of the body that can be used for regenerative interventions. (mayo.edu)
Caused by damage to brain cells rather than deficits in speech or hearing organs. (brainline.org)

Gelatin is a natural biopolymer which is widely exploited in the fabrication of scaffolds due to its high biodegradability, biocompatibility and great cell adhesion12,13. (yjxinhua.com)

Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS. (jneurosci.org)
Until now, scientific investigations on neurogenesis have concentrated on the so-called apical stem cells. (uni-heidelberg.de)

In both cases, neural stem cells (NSCs) play a crucial role. (earth.com)
Yet, even if embryonic NSCs are implanted into adult tail stumps, they still respond to the ventralizing signal and cannot develop into dorsal structures. (earth.com)

These adult brain cells, neural precursor cells, can only evolve into cells of the nervous system. (sci-info-pages.com)
Ultimately, it is unclear whether the eponymous Merkel cell is truly a histiogenic precursor of Merkel cell carcinoma. (medscape.com)

Stem cells from umbilical cords are usually used only in children because umbilical cord blood does not contain enough stem cells to use in adults. (msdmanuals.com)

Further studies showed that the newly discovered stem cell type differs from the known population in its morphology as well as its function. (uni-heidelberg.de)

First, early in the disease, they may protect retinal ganglion cells from degenerating - providing a neuroprotective effect. (newswise.com)

There are more than 70 diseases or conditions-including leukemia, immune system and other blood disorders, cancers, and autoimmune diseases-that respond well when adult stem cell therapy is used. (all.org)
In addition, they are transplanting stem cells engineered as delivery vehicles for therapeutic factors to treat blinding ocular diseases such as glaucoma. (moleculardevices.com)
However, the process of making iPSCs from patients with these diseases, and the subsequent genetic engineering of the cell lines, is "difficult, expensive and time consuming," says Ward. (jax.org)
Adults with chronic pulmonary diseases including chronic obstructive pulmonary disease (COPD) and asthma, congestive heart failure, coronary artery disease, cerebrovascular disease, diabetes mellitus, and chronic kidney disease have been shown to be at increased risk of RSV-associated hospitalization. (cdc.gov)

During the 2015-16 Zika virus epidemic, Song continued to collaborate with Ming as they produced the first direct evidence that Zika causes microcephaly by selectively attacking brain-building stem cells. (wikipedia.org)

Third, the progenitor cells are already well along the path toward specialization, and cannot become, say, liver or muscle cells after implantation. (cancerlive.net)

Anatomy90

Organisms11

Diseases16

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes50

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Transplantation19

Tissue48

Neurons22

Regeneration11

Genes25

Therapies7

Pluripotent cells4

Tissues16

Differentiation10

Embryos7

Mesenchymal5

Differentiate4

Progenitor cells isolated1

Researchers24

Scientists12

Cartilage2

Parkinson's4

Mice9

Regenerative medicine2

Fibers3

Multipotent stem2

Generate7

Bone marrow stem cells2

Hair follicles2

Hippocampus2

Research32

Proteins3

Populations2

Fibroblasts2

Types of stem cells2

Gene7

Stromal cells4

Biology4

Embryo8

Spinal cord5

Approaches2

MSCs1

Optic nerve9

Allogeneic transplant2

Explains4

Proliferation2

Neural progenitor2

Create new nerve cells1

Alzheimer's4

Apoptosis3

Genetically2

Peripheral1

Subventricular zone1

Human15

Organs2

Scaffolds1

Neurogenesis2

NSCs2

Precursor2

Umbilical cord1

Newly1

Retinal gangl1

Diseases4

Brain-building s1

Implantation1