• 24.11
  • Localization of neprilysin (EC 3.4.24.11) mRNA in rat brain by in situ hybridization. (ndsl.kr)
  • The distribution of the messenger RNA (mRNA) coding for neprilysin (EC 3.4.24.11) has been studied by in situ hybridization in the adult rat brain. (ndsl.kr)
  • amyloid beta
  • Neprilysin-deficient knockout mice show both Alzheimer's-like behavioral impairment and amyloid-beta deposition in the brain, providing strong evidence for the protein's association with the Alzheimer's disease process. (wikipedia.org)
  • One hypothesis for the strong dependence of Alzheimer's incidence on age focuses on the declining production of somatostatin in the brains of elderly people, which thus depresses the activity of neprilysin and promotes aggregation of unprocessed amyloid beta. (wikipedia.org)
  • Reduction of amyloid-beta levels in mouse eye tissues by intravitreally delivered neprilysin. (wikipedia.org)
  • peptidase
  • The peptidase M13 family believed to activate or inactivate oligopeptide (pro)-hormones such as opioid peptides, neprilysin is another member of this group, in the case of the metallopeptidases and aspartic, the nucleophiles clan or family for example MA, is an activated water molecule. (wikipedia.org)
  • modulate
  • in other types, most notably lung cancers, neprilysin is downregulated, and thus unable to modulate the pro-growth autocrine signaling of cancer cells via secreted peptides such as mammalian homologs related to bombesin. (wikipedia.org)
  • human
  • To address this issue, a lentiviral vector expressing human neprilysin (Lenti-Nep) was tested in transgenic mouse models of amyloidosis. (jneurosci.org)
  • To further investigate the role of neprilysin in amyloid deposition, a lentiviral vector expressing human neprilysin (Lenti-Nep) was prepared and tested in transgenic models of amyloidosis. (jneurosci.org)
  • show
  • On the other hand, the globus pallidus, the substantia nigra, and the central gray matter, which show a high or a moderate amount of neprilysin, did not contain any neprilysin mRNA. (ndsl.kr)
  • levels
  • higher levels of inappropriately oxidized neprilysin have been found in Alzheimer's patients compared to cognitively normal elderly people. (wikipedia.org)