Progressive multifocal leukoencViremiaImportant cause of allograftTransplantationMembranous NephropathyPolyomavirusRecipientsInfectionDiabeticTransplantLupus NephritisAllograft failurePatientsPolyomavirusesRenal DiseaseGraft rejectionImmunosuppressive AgentsSV40HemorrhagicViralAsymptomaticEpstein-BarrUrothelial cellsDiseasesPolyomaviridaeExtentStatisticallyFrequentInfectionsNegativeTreatmentTropism
Progressive multifocal leukoenc5
- BK virus is associated with nephropathy in renal transplant and non-renal solid organ transplant patients, JC virus with progressive multifocal leukoencephalopathy, and Merkel cell virus with Merkel cell cancer. (wikipedia.org)
- It was also under development for the prevention of smallpox, Ebola and Marburg infections and Equine encephalitis infections (as a countermeasure against bioterrorism), cancer and polyomaviruses associated nephropathy (PVAN) caused by BK virus and progressive multifocal leukoencephalopathy (PML) caused by John cunningham virus. (globaldata.com)
- JC virus is associated with progressive multifocal leukoencephalopathy in immunocompromised patients. (cytopathology.ca)
- The John Cunningham virus (JCV) is an ubiquitous human polyomavirus that was first discovered in 1971 from patients with progressive multifocal leukoencephalopathy (PML) [ 1 ]. (biomedcentral.com)
- Activated BKPyV and JCPyV viruses lead to the development of BK Virus Associated Nephropathy and Progressive Multifocal Leukoencephalopathy, respectively. (edu.au)
Viremia4
- A third difference is the lower level of viremia in JC virus nephropathy in comparison to BK virus. (cytopathology.ca)
- CMV infection 9 (19,7 % at 5th year), BK viremia 5 (12.4 % at 5th year), post-transplant diabetes in 10 (23.4 % at 5th year), and lymphocele in 3 (6,4 % at 5th year). (revistanefrologia.com)
- The risk factors associated BKV viremia and BKV associated nephropathy (BKVN) and response to therapy were also evaluated in this study. (otdjournal.com)
- BK virus associated disease was totally detected in 14 patients (13,1%) (12 viremia/6 BKVN) of 107 patients. (otdjournal.com)
Important cause of allograft2
- Polyomavirus BK nephropathy (PVBKN) is an important cause of allograft dysfunction in patients with kidney transplantation [ 1 ]. (biomedcentral.com)
- BK virus (BKV) nephropathy is an important cause of allograft failure in renal transplant recipients that is linked to highly potent immunosuppressive therapy. (otdjournal.com)
Transplantation13
- [ 1 ] Transplantation is the renal replacement modality of choice for patients with end-stage renal disease, especially those with diabetic nephropathy and pediatric patients. (medscape.com)
- The faculty have a variety of clinical protocols dealing with diabetic nephropathy, bone disease, progression of kidney disease, kidney transplantation, vitamin deficiency in chronic kidney disease, end-stage renal disease, transplantation and nutrition in patients with acute kidney injury. (usc.edu)
- Donor testing prior to kidney transplantation for genetic mark ers, BKPyV viruria, virus genotyping, or VLP/Vp1.specific.specific antibody levels is not recommended at the present time. (guidelinecentral.com)
- Early diagnosis and treatment of Polyomavirus BK Nephropathy (PVBKN) is a challenging issue in the management of patients with kidney transplantation. (biomedcentral.com)
- After immunosuppression, following transplantation, the virus activates, replicates, and damages urothelial cells as well as renal parenchymal tubules. (biomedcentral.com)
- Living donor kidney transplantation, improving access and breaking down barriers to transplantation, BK virus nephropathy, disorders of sodium and water balance and cardiovascular disease prevention in the kidney transplant population. (unc.edu)
- After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
- Despite the high incidence of reactivation of the JC virus in recipients of renal transplantation, a small fraction of patients eventually show JC virus-associated nephropathy, which may lead to rejection of the transplant [ 11 ]. (biomedcentral.com)
- BK Polyomavirus Associated Nephropathy (BKVAN) is an important emerging complication of renal transplantation. (amhsr.org)
- Raval M, Gulbis A, Bollard C, Leen A , Chemaly R , Shpall E , Lahoti A , Kebriaei P . Evaluation and management of BK virus-associated nephropathy following allogeneic hematopoietic cell transplantation. (viictr.org)
- Cytomegalovirus (CMV) is a beta variant of the Herpes Simplex Virus (HSV), a highly prevalent opportunistic pathogen with over 50% of adults infected worldwide by age [ 1. De Matos SB, Meyer R, de Mendonça Lima FW. Cytomegalovirus infection after renal transplantation: Occurrence, clinical features, and the cutoff for antigenemia in a university hospital in Brazil. Infect Chemother. 2017; 49: 255-261. [ CrossRef ] ">1 ]. (lidsen.com)
- BKV causes disease during transplantation, including BKV-associated nephropathy (BKVN) in kidney transplantation which is an increasing problem and leads to renal injury and graft loss. (novacyt.com)
- To prevent the post-transplantation diseases caused by both viruses there is increasing monitoring for BKV and EBV DNAemia after transplantation and in patients undergoing immunosuppression. (novacyt.com)
Membranous Nephropathy1
- Although membranous nephropathy is the pathology most frequently encountered, other glomerular diseases, such as focal and segmental glomerulosclerosis (FSGS), are rare. (clinicalcasereportsjournal.com)
Polyomavirus12
- Another human polyomavirus, Merkel cell polyomavirus, tent of human infection caused by these viruses has not was recently discovered and has tentatively been linked to been described to date. (cdc.gov)
- WU polyomavirus (WUPyV) ( 1 ) and KI polyomavirus As a step toward determining the potential pathogenicity of (KIPyV) ( 2 ) are newly described human polyomavi- these viruses, we developed serologic assays to assess the ruses most closely related to JC virus (JCV) and BK virus extent of infection by WUPyV and KIPyV in humans. (cdc.gov)
- Routine immunohistochemistry study for polyomavirus BK nephropathy in transplanted kidney biopsies, is it recommended? (biomedcentral.com)
- Polyomavirus is a non-enveloped double stranded DNA virus which exists latently in the human body. (biomedcentral.com)
- In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
- BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)
- BK and JC viruses are members of polyomavirus family. (cytopathology.ca)
- Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. (cytopathology.ca)
- Overview of JC polyomarvirus, BK polyomavirus and other polyomavirus infections. (cytopathology.ca)
- The John Cunningham virus (JCV) is the established etiological agent of the polyomavirus-associated nephropathy among renal transplant recipients. (biomedcentral.com)
- After DNA extraction, the simultaneous detection and quantification of JCV and BK polyomavirus (BKV) were conducted using a Real-time quantitative PCR method. (biomedcentral.com)
- BK virus (BKV) is a polyomavirus and Epstein-Barr Virus (EBV) is a gamma herpesvirus, both viruses can cause disease in humans. (novacyt.com)
Recipients4
- A review on JC virus infection in kidney transplant recipients. (cytopathology.ca)
- Structural and antigenic studies have revealed that JCV is closely related to BKV, which was coincidently discovered and associated with nephropathy and graft rejection in renal transplant recipients [ 2 ]. (biomedcentral.com)
- There have been some reports regarding JCV-associated nephropathy in BKV negative renal transplant recipients. (biomedcentral.com)
- Finally, PBDC levels were significantly reduced in patients with BK virus nephropathy compared to recipients with stable graft function, despite lower overall immunosuppression. (johnshopkins.edu)
Infection4
- After primary infection of urothelial cells, virus DNA will be integrated into the host's genome. (biomedcentral.com)
- It is noted that only a few tubules are showing cytopathic effects, which is common for JC virus infection as opposed to the more diffuse tubular cell changes related to BK virus infection. (cytopathology.ca)
- As with BKV nephropathy, serologic studies support reactivation of endogenous JCV rather than a primary infection [ 12 , 13 ]. (biomedcentral.com)
- The primary infection of these viruses is usually asymptomatic and latent which is activated as a consequence of immunosuppression. (edu.au)
Diabetic5
- To investigate how serum procalcitonin (PCT) levels are affected in diabetic patients with and without nephropathy, and to determine whether PCT may be indicative of an inflammation in these patients. (otdjournal.com)
- The study included 175 patients [75 diabetic nephropathy (group 1), 75 non-nephropathy diabetic (group 2) and 25 non-diabetic nephropathy (group 3)], and 75 healthy volunteers. (otdjournal.com)
- r= -0.415) values in nephropathy patients (diabetic and non-diabetic). (otdjournal.com)
- Patients with diabetic nephropathy were compared to those with a eGFR of 60 ml/min or more with those below eGFR 60 ml/min. (otdjournal.com)
- There was no significant increase in PCT values of diabetic and diabetic nephropathy patients. (otdjournal.com)
Transplant5
- In kidney transplant patients with proven PyVAN and the absence of BKPyV-DNAemia in blood, urine, and graft tissue, JCPyV-associated nephropathy should be considered and specific QNAT be sought on urine, blood, and allograft tissue. (guidelinecentral.com)
- BK virus damages the transplant kidney. (seekhealthz.com)
- BK virus is associated with nephropathy and ureteral stenosis in kidney transplant patients. (cytopathology.ca)
- Although both BK and JC viruses can cause nephropathy in kidney transplant patients, there are many differences between the two. (cytopathology.ca)
- BK Virus (BKV) is an opportunistic pathogen that actively replicates in those with impaired immunity and its emergence is attributed to the use of more potent immunosuppressive drugs following renal transplant. (amhsr.org)
Lupus Nephritis1
- These cytokines are members of the tumor necrosis factor family that promote B-cell survival and autoantibody production associated with certain autoimmune diseases, including IgA nephropathy (IgAN) and lupus nephritis. (stocktitan.net)
Allograft failure1
- Validation of a noninvasive prognostic signature for allograft failure following BK virus associated nephropathy. (cornell.edu)
Patients7
- However, virus-infected cells were identified just after IHC study in 4 (22.2%) of patients. (biomedcentral.com)
- There was a statistically significant coexistence between BK and JC viruses among our patients ( P = 0.029). (biomedcentral.com)
- fThree patients (two AMR patients and one ATI patient) had BK virus replication (1 copy of BK virus VP1 mRNA per picogram total RNA from urinary cells) in the urine collected at the time of biopsy. (koeki-data.org)
- None of the three patients had BK virus nephropathy (negative for SV40 staining in the biopsy tissue). (koeki-data.org)
- Saunders IM, Lahoti A , Chemaly RF , Trevino C, Westmoreland M, Hosing C . Topical cidofovir-induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections. (viictr.org)
- Also, there is some emerging data that JC and BK virus might be protective for the kidney relatives of patients with APOL1 nephropathy. (nephronpower.com)
- BRISBANE, Calif., June 07, 2023 (GLOBE NEWSWIRE) -- Vera Therapeutics, Inc. (Nasdaq: VERA), a late-stage biotechnology company focused on developing and commercializing transformative treatments for patients with serious immunological diseases, today announced initiation of the pivotal Phase 3 clinical trial (ORIGIN 3) of atacicept for the treatment of IgA nephropathy (IgAN). (stocktitan.net)
Polyomaviruses1
- Polyomaviruses are non-enveloped double-stranded DNA viruses with circular genomes of around 5000 base pairs. (wikipedia.org)
Renal Disease1
- APOL1 gene nephropathy has now emerged as a potential new entity given the linkage to African American ancestry and having these alleles that were protective against sleeping sickness and then leading to more HTN proteinuric and non proteinuric renal disease in AA. (nephronpower.com)
Graft rejection1
- Secondly, JC virus nephropathy seems to be associated with a less aggressive and more protracted clinical course when compared with BK virus with lower rate of graft rejection and better survival. (cytopathology.ca)
Immunosuppressive Agents1
- After being diagnosed with JC virus-associated nephropathy, one of the patient's immunosuppressive agents was changed and the patient's creatinine returned to the baseline. (cytopathology.ca)
SV402
- All these biopsy samples were evaluated with routine renal biopsy stains as well as IHC for SV40 (Simvian Virus 40) antigen. (biomedcentral.com)
- In most of the clinics, antibody for the anti-large T antigen of Simian virus 40 (SV40) is used. (biomedcentral.com)
Hemorrhagic1
- Unlike hemorrhagic cystitis and BKPyV-associated nephropathy, BKPyV-associated pneumonia is rare, with only seven known cases worldwide. (biomedcentral.com)
Viral2
- After binding to molecules on the cell surface, the virion is endocytosed and enters the endoplasmic reticulum - a behavior unique among known non-enveloped viruses - where the viral capsid structure is likely to be disrupted by action of host cell disulfide isomerase enzymes. (wikipedia.org)
- Monitor sirolimus blood concentrations (obtain trough level 3-4 days after a loading dose), renal function, lipids, urine protein and for viral infections (eg, BK virus-associated nephropathy). (cancertherapyadvisor.com)
Asymptomatic2
- Most of these viruses are very common and typically asymptomatic in most human populations studied. (wikipedia.org)
- The virus induces cytopathic changes in renal cells with commonly asymptomatic presentation, but if left untreated, leads to nephropathy and graft loss. (amhsr.org)
Epstein-Barr1
- The risk of PTLD appears greatest in those individuals who are Epstein-Barr Virus (EBV) seronegative, a population that includes many young children. (astellascares.com)
Urothelial cells1
- Both BK and JC viruses can infect urothelial cells and renal tubular cells and give rise to characteristic cytopathic effects (DeCoy cells) that can sometimes exhibit overlapping features with high-grade urothelial carcinoma. (cytopathology.ca)
Diseases1
- Case studies in cost effectiveness of molecular diagnostics for infectious diseases: pulmonary tuberculosis, enteroviral meningitis, and BK virus nephropathy. (medscape.com)
Polyomaviridae2
- Polyomaviridae is a family of viruses whose natural hosts are primarily mammals and birds. (wikipedia.org)
- Polyomaviridae family consists of small circular dsDNA viruses. (edu.au)
Extent2
- 14 species are known to infect humans, while others, such as Simian Virus 40, have been identified in humans to a lesser extent. (wikipedia.org)
- In addition, the extent of the histological changes in JC-virus nephropathy is lower with more patchy tubular involvement and more focal cytopathologic changes. (cytopathology.ca)
Statistically1
- Our Phase 2 results have shown that atacicept targets the source of IgA nephropathy and improves kidney function as measured by statistically and clinically significant reductions in proteinuria. (stocktitan.net)
Frequent2
- Firstly, JC virus nephropathy is not as frequent and not as well studied as the BK virus-related nephropathy in the literature. (cytopathology.ca)
- Due to high and ubiquitous distribution of these viruses, frequent studies are required to develop a better understanding regarding the epidemiology and pathobiology of these viruses in Asia. (edu.au)
Infections1
- Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections. (medscape.com)
Negative1
- PCR performed on his blood sample is negative for BK virus DNA amplification twice in a row. (cytopathology.ca)
Treatment1
- Bifidobacterium as an oral delivery carrier of interleukin-12 for the treatment of Coxsackie virus B3-induced myocarditis in the Balb/c mice. (medscape.com)
Tropism1
- However, in general virus-cell interactions are mediated by commonly occurring molecules on the cell surface, and therefore are likely not a major contributor to individual viruses' observed cell-type tropism. (wikipedia.org)