- p53 may be helpful in differentiating between certain reactive and neoplastic lesions, e.g., reactive urothelial changes (patchy and weak) v. urothelial neoplasia (~60% pos. (nordiqc.org)
- Pathological reports showed premalignant and malignant lesions (metaplasia, dysplasia, or carcinoma) in 102 (1.95%) patients. (hasekidergisi.com)
- This apparently contradictory feature may be the foundation of the reversible transformation of precancerous lesions. (biomedcentral.com)
- Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
- However, the relative paucity of pre-cancer-to-cancer longitudinal studies, together with the challenges of interpreting clonality in the face of non-Mendelian genetics, have made it difficult to determine whether ecDNAs arise early in tumorigenesis and contribute to the transformation of dysplasia into cancer. (nature.com)
- Barrett's oesophagus: from metaplasia to dysplasia and cancer. (nordiqc.org)
- Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. (hasekidergisi.com)
- Metaplasia was significantly more common in females (male-to-female ratio=3:10, p=0.022), whereas no significant relationship was found between sex and dysplasia (male-to-female ratio=8:10, p=0.167) and between sex and carcinoma (male-to-female ratio=7:10, p=0.173). (hasekidergisi.com)
- Claudin-2 expression was examined by immunohistochemistry on tissue microarrays, containing EAC, high grade dysplasia (HGD), low grade dysplasia (LGD), Barrett's esophagus (BE), columnar cell metaplasia (CM), squamous cell carcinoma (SCC), and squamous epithelium (SE) cases. (biomedcentral.com)
- Our studies identify a novel role of a tight junction protein in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma. (biomedcentral.com)
- Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo malignant transformation, to form carcinoma ex-pleomorphic adenoma, a risk that increases with time (9.5% chance to convert into malignancy in 15 years). (wikipedia.org)
- The tumor extends through normal glandular parenchyma in the form of finger-like pseudopodia, but this is not a sign of malignant transformation. (wikipedia.org)
- Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
- When squamous cell carcinoma occurs in the breast, it typically originates either in the epidermis, the nipple, or perhaps as the malignant transformation of a deep-seated epidermal cyst . (breast-cancer.ca)
- Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? (biomedcentral.com)
- Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. (biomedcentral.com)
- Moreover, malignant transformation cannot be accurately predicted in individual patients using either technique [ 6 , 7 ]. (biomedcentral.com)
- Several HPV types, especially high-risk types (HPV-HR), mediate squamous intraepithelial lesion (SIL) development that may progress to cervical cancer through several mechanisms such as keratinocytes malignant transformation, however many other factors contribute to the disease progression, such as tobacco use, long-duration oral contraceptive use and multiparity [ 3 ]. (biomedcentral.com)
- 2 reported three cases of osseous metaplasia of the thyroid gland in female patients with thyroid nodules who were diagnosed with nodular hyperplasia with osseous metaplasia and mature bone formation. (jkaoms.org)
- The biopsy showed a neoplastic lesion predominantly seen in the subcutaneous tissue exhibiting nodular appearance separated by thick fibrous bands. (org.pk)
- Hürthle cells are observed in both neoplastic and nonneoplastic conditions of the thyroid gland (eg, Hashimoto thyroiditis , nodular and toxic goiter ). (medscape.com)
- p53 binding decreases its control with cell proliferation and increases genetic instability, leading to neoplastic transformation. (nordiqc.org)
- Pleomorphic adenoma (or benign mixed tumor) is a common benign salivary gland neoplasm characterised by neoplastic proliferation of epithelial (ductal) cells along with myoepithelial components, having a malignant potentiality. (wikipedia.org)
- progenitor proliferation and neoplastic transformation. (coxsignal.com)
- The proliferation of oncocytes gives rise to hyperplastic and neoplastic nodules. (medscape.com)
- Primary myelofibrosis is a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells. (medscape.com)
- Primary myelofibrosis results from neoplastic transformation of a multipotent bone marrow stem cell. (msdmanuals.com)
- These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
- In particular, they can be seen in both the cellular phase of the disease, when the neoplastic clonal expansion can cause the splenomegaly. (cap.org)
- Osseous metaplasia is usually caused by osteoblasts differentiating from fibroblasts secondary to inflammation, tissue damage, exposure to substances such as bone morphogenetic proteins released from neoplastic cells, or dystrophic calcification in necrotic tissue. (jkaoms.org)
- Osteosarcoma is a malignant primary bone tumor that is characterized by neoplastic osteoblasts that produce osteoid. (medscape.com)
- These devices have been shown to increase reported as atypical squamous cells of undetermined sig- the amount of cells captured from the transformation nificance (ASCUS), 39% were downgraded to negative zone and to increase the amount of dysplastic cells col- on further review. (finder-articles.com)
- The tumor is encapsulated and some cells have been found to be neoplastic and extend through the capsule, increasing the risk of recurrence. (rdhmag.com)
- This finding suggests that an embryonic origin need not be postulated for such cells, which may appear later in life because of cellular alteration or metaplasia of pituitary cells, which are also of ectodermal origin. (craniopharyngiomas.com)
- Many theories have been proposed to explain this condition: retrograde menstruation theory, metaplastic, transformation, the migration of cells through the lymphatic system or via hematogenous spread, Iatrogenic during CS. (blogspot.com)
- Identifying neoplastic Reed-Sternberg cells or Hodgkin cells is essential for the diagnosis. (cap.org)
- Size of the transformation zone or size and location of the lesion (when present) should be such that it can be fully covered by the tip of the largest cryotherapy probe (applicable for cryotherapy only). (iarc.fr)
- This is a phenomenon of metaplasia that occurs in inflammatory disorders, such as thyroiditis, or other situations that result in cellular stress. (medscape.com)
- Through these collaborative efforts , BETRNet can accelerate the integration and transformation of important research findings generated from individual laboratory-based, clinical, or population studies into clinical applications. (nih.gov)
- 6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)
- We review the clinical, radiographic, and histologic features and common causes of osseous metaplasia and report a rare case of osseous metaplasia of the palate. (jkaoms.org)
- Based on clinical and radiographic examination, the clinical diagnosis was osseous metaplasia of the right palate, and we planned to excise the mass under general anesthesia. (jkaoms.org)
- The L2-IL1B mouse model is characterized by IL-1β-mediated inflammation, which leads to a Barrett-like metaplasia in the transition zone between the squamous forestomach and glandular cardia/stomach. (oncotarget.com)
- Satisfactory for evaluation (describe presence or absence of endocervical/transformation zone component and any other quality indicators, e.g., partially obscuring blood, inflammation, etc. (pathologika.com)
- Claudin-2 expression may be involved at early stages of transformation in inflammatory bowel disease-associated neoplasia [ 23 ]. (biomedcentral.com)
- We report a case of osseous metaplasia of the maxilla, a rare benign tumor in an uncommon region. (jkaoms.org)
- First of all, no other neoplastic elements are to be present in the tumor. (breast-cancer.ca)
- Osseous metaplasia has been reported to occur systemically other than intra-oral portion. (jkaoms.org)
- The long-term risks of polycythemia vera (PV) include leukemic and fibrotic transformation, which occur in fewer than 5% and 10% of patients, respectively, at 10 years. (medscape.com)
- It results from the transformation of non-osseous connective tissue into mature bone. (jkaoms.org)