Congenital adrenal hypTesticularCorticalOvarianOvaryTestisMalignantFetal adrenalStromalGranulosaGermCortexMonoclonal antibodyGonadsTeratomasGlandAndrogenSteroid hormonesGlandsTestesImmunohistochemicalHormonesTissueSecretionMalesMinimalExperimentalMammalianFrequencyNormalAssayCancerMechanismsIntermediatePresence
Congenital adrenal hyp3
- Congenital or genetic causes include McCune-Albright syndrome (MAS), familial male-limited precocious puberty (FMPP), and congenital adrenal hyperplasia (CAH). (medscape.com)
- Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. (medscape.com)
- Testicular adrenal rest tumors (TARTs), commonly occurring in males with congenital adrenal hyperplasia, may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)-sensitive cells in the testes. (bvsalud.org)
Testicular7
- Testicular Leydig cells stained moderately to intensely, as did a testicular Leydig cell tumor. (elsevierpure.com)
- Seminomas and testicular germ cell tumors were negative. (elsevierpure.com)
- Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (roche.com)
- Inhibin A is a sensitive and specific marker for testicular sex cordstromal tumors. (roche.com)
- This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
- With a diagnosis of testicular tumor, right orchiectomy was performed. (bvsalud.org)
- Altogether, this study suggests that the HFT is unresponsive to ACTH, which would indicate that a TART does not arise from fetal testicular cells chronically exposed to ACTH in utero. (bvsalud.org)
Cortical2
- Adrenal cortical adenomas, hyperplasias, and carcinomas all contained areas of StAR staining. (elsevierpure.com)
- 2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors. (roche.com)
Ovarian7
- An ovarian Leydig cell tumor stained intensely, whereas granulosa cell tumors were negative. (elsevierpure.com)
- Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. (roche.com)
- Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. (roche.com)
- Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. (roche.com)
- [5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)
- Gliomatosis peritoneii, which presents as a deposition of mature glial cells in the peritoneum, is almost exclusively seen in conjunction with cases of ovarian teratoma. (mdwiki.org)
- Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
Ovary1
- 1-2 In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex. (roche.com)
Testis2
- Giant cell formation in the testis, which is usually accompanies germinal celldegeneration/atrophy was observed at the dose of 50 mg/kg and above. (europa.eu)
- Fetal testis and adrenal tissue produced high levels of testosterone and cortisol, respectively, indicating viability. (bvsalud.org)
Malignant4
- The tumor was histologically diagnosed as malignant Sertoli cell tumor pT1N0M0. (bvsalud.org)
- Thoracoscopic left upper lobectomy was performed 64 months after the operation, and the pathological diagnosis was metastasis of malignant Sertoli cell tumor. (bvsalud.org)
- A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
- Most are malignant except the insulin-producing tumors (INSULINOMA). (lookformedical.com)
Fetal adrenal2
- The neocortex of the fetal adrenal glands displayed only minimal StAR staining, whereas moderate to intense staining was found in the fetal zone. (elsevierpure.com)
- In contrast to fetal adrenal tissues, the expression of ACTH receptor MC2R was either absent or expressed at extremely low levels in ex vivo HFT tissue and no clear response to ACTH in gene expression or steroid hormone production was observed. (bvsalud.org)
Stromal1
- Fetal ovaries contained sporadic stromal cells displaying intense StAR staining, particularly in the hilar region. (elsevierpure.com)
Granulosa1
- Primordial follicles of adult ovaries did not contain STAR, whereas antral follicles stained intensely in the thecal layer, with occasional staining of granulosa cells. (elsevierpure.com)
Germ2
- Atrazine (ATZ) is an environmental pollutant that interferes with several aspects of mammalian cellular processes including germ cell development, immunological, reproductive and neurological functions. (frontiersin.org)
- They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
Cortex4
- The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner mitochondrial membranes, is mediated by the steroidogenic acute regulatory protein (StAR). (elsevierpure.com)
- We conclude that StAR is localized to normal and neoplastic cells in the gonads and adrenal cortex, which produce large amounts of pregnenolone. (elsevierpure.com)
- The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. (roche.com)
- Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. (roche.com)
Monoclonal antibody1
- Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
Gonads1
- Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol. (absoluteastronomy.com)
Teratomas1
- Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
Gland2
- The sex steroids (estrogen or testosterone) come from either the adrenal gland or the gonad, independent of the hypothalamic-pituitary portion of the pubertal axis. (medscape.com)
- The gland consists of numerous cell types, which specialize in making and releasing specific hormones. (pharmaceuticalintelligence.com)
Androgen2
- Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens. (wikipedia.org)
- Synthesis:Estriol is only produced in significant amounts during pregnancy as it is made by the placenta from 16-Hydroxydehydroepiandrosterone sulfate , an androgen steroid made in the fetal liver and adrenal glands.The human. (absoluteastronomy.com)
Steroid hormones1
- To investigate this, we cultured HFT tissue with and without ACTH for up to 5 days, and quantified adrenal steroid hormones and expression of adrenal steroidogenic enzymes. (bvsalud.org)
Glands1
- In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. (absoluteastronomy.com)
Testes2
- Fetal testes displayed intense Leydig cell staining. (elsevierpure.com)
- Immature sperm cells in the testes do not mature past an early stage, as sensitivity to androgens is required in order for spermatogenesis to complete. (wikipedia.org)
Immunohistochemical1
- Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
Hormones3
- The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in those with the condition. (wikipedia.org)
- It is used to produce hormones and cell membranes and is transported in the blood plasma of all mammals. (absoluteastronomy.com)
- These hormones are made in the cell bodies and then transported to the axon terminals. (pharmaceuticalintelligence.com)
Tissue3
- Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. (lookformedical.com)
- A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
- Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
Secretion1
- Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary. (roche.com)
Males1
- The cells of unaffected XY individuals then masculinize by, among other things, enlarging the genital tubercle into a penis, which in females becomes the clitoris, while what in females becomes the labia fuses to become the scrotum of males (where the testicles will later descend). (wikipedia.org)
Minimal2
- There was minimal to moderate staining in the adrenal glomerulosa and faciculata and minimal staining in the reticularis, while the medulla was negative. (elsevierpure.com)
- [4] Symptoms may be minimal if the tumor is small. (mdwiki.org)
Experimental2
- ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)
- When in vitro experimental models are exposed to ATZ, they are faced with increased levels of reactive oxygen species (ROS), cytotoxicity and decreased growth rate at dosages that may vary with cell types. (frontiersin.org)
Mammalian1
- It is an essential structural component of mammalian cell membranes. (absoluteastronomy.com)
Frequency1
- Lyons VG, Payne NL, McCoy CE (2018) Optimization techniques for miRNA expression in low frequency immune cell populations. (hudson.org.au)
Normal1
- It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
Assay2
- This results in differing cytotoxic responses that are influenced by the nature of target cells, assay types and concentrations of ATZ. (frontiersin.org)
- Chollangi T, Clabault H, Thibeault A, Yong HE, Narula S, Menkhorst E, Sanderson JT, Vaillancourt C, Murthi P (2018) An electrical impedance-based assay to examine functions of various placental cell types in vitro. (hudson.org.au)
Cancer3
- Tumors or cancer of the LIVER. (lookformedical.com)
- Tumors or cancer of the PANCREAS. (lookformedical.com)
- Tumors or cancer of the SKIN. (lookformedical.com)
Mechanisms1
- Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)
Intermediate1
- Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Presence1
- The presence of StAR in cells that do not express cholesterol side-chain cleavage enzyme cytochrome P450, including renal distal tubules, Sertoli cells, and fetal oocytes, suggests that StAR has roles in metabolic processes in addition to stimulating pregnenolone synthesis. (elsevierpure.com)