• Myeloproliferative
  • The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone marrow in which excess cells are produced. (wikipedia.org)
  • There are four main myeloproliferative diseases, which can be further categorized by the presence of the Philadelphia chromosome:[citation needed] In 2008, the World Health Organization listed these diagnoses as types of MPD: Chronic myelogenous leukemia (BCR-ABL1-positive) Chronic neutrophilic leukemia Polycythemia vera Primary myelofibrosis Essential thrombocythemia Chronic eosinophilic leukemia (not otherwise specified) Mastocytosis All MPNs arise from precursors of the myeloid lineages in the bone marrow. (wikipedia.org)
  • citation needed] Depending on the nature of the myeloproliferative neoplasm, diagnostic tests may include red cell mass determination (for polycythemia), bone marrow aspirate and trephine biopsy, arterial oxygen saturation and carboxyhaemoglobin level, neutrophil alkaline phosphatase level, vitamin B12 (or B12 binding capacity), serum urate or direct sequencing of the patient's DNA. (wikipedia.org)
  • Trials of these inhibitors are in progress for the treatment of the other myeloproliferative neoplasms. (wikipedia.org)
  • It is currently classified as a myeloproliferative neoplasm, in which the proliferation of an abnormal clone of hematopoietic stem cells in the bone marrow and other sites results in fibrosis, or the replacement of the marrow with scar tissue. (wikipedia.org)
  • sarcoma
  • Their research and discovery in the abstract of Li and Dr. Fraumeni's paper described their method and results as, "A search of the Cancer Family Registry of the National Cancer Institute revealed 24 kindreds with the syndrome of sarcoma, breast carcinoma, and other neoplasms in young patients. (wikipedia.org)
  • While malignant fibrous histiocytoma (MFH) - now generally called "pleomorphic undifferentiated sarcoma" - primary in bone is known to occur occasionally, current paradigms tend to consider MFH a "wastebasket" diagnosis, and the current trend is toward using specialized studies (i.e. genetic and immunohistochemical tests) to classify these undifferentiated tumors into other tumor classes. (wikipedia.org)
  • tissue
  • A neoplasm is a tissue whose cells have lost its normal differentiation. (wikipedia.org)
  • Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common features, such as looking similar, having special secretory granules, and often producing biogenic amines and polypeptide hormones. (wikipedia.org)
  • tumors
  • Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells form secondary tumors. (wikipedia.org)
  • Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. (wikipedia.org)
  • Bone tumors may be classified as "primary tumors", which originate in bone or from bone-derived cells and tissues, and "secondary tumors" which originate in other sites and spread (metastasize) to the skeleton. (wikipedia.org)
  • Multiple granular cell tumors may seen in the context of LEOPARD syndrome, due to a mutation in the PTPN11 gene. (wikipedia.org)
  • Gardner syndrome, also known as Gardner's syndrome or familial colorectal polyposis, is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon together with tumors outside the colon. (wikipedia.org)
  • syndrome
  • The presence of multiple histiocytomas is now a well recognized syndrome. (wikipedia.org)
  • Gardner syndrome can be identified based on oral findings, including multiple impacted and supernumerary teeth, multiple jaw osteomas which give a "cotton-wool" appearance to the jaws, as well as multiple odontomas, congenital hypertrophy of the retinal pigment epithelium (CHRPE), in addition to multiple adenomatous polyps of the colon. (wikipedia.org)
  • patients
  • To assess the safety of intermittent vismodegib in patients with multiple BCCs (BCNS and non-BCNS) during months 8-28. (clinicaltrials.gov)
  • To assess resistance of SEBs to treatments in patients with multiple BCCs (BCNS and non-BCNS) treated intermittently during months 8-28. (clinicaltrials.gov)
  • evaluate
  • In 1982, the stimulation of expression from the MMTV-LTR (Mouse mammary tumor virus-Long terminal repeat) was done by multiple rounds of pregnancy and lactation to evaluate the relevance of a cellular proto-oncogene, c-myc. (wikipedia.org)
  • cases
  • the terms idiopathic and primary mean that in these cases the disease is of unknown or spontaneous origin. (wikipedia.org)
  • currently
  • The following grading scheme is currently recommended for all gastroenteropancreatic neuroendocrine neoplasms by the World Health Organisation: If mitotic count and ki67 are discordant, the figure which gives the highest grade is used. (wikipedia.org)
  • determine
  • Many of the genes driving the growth at primary site can determine the dissemination and colonization at the ectopic site. (wikipedia.org)