• Although the tumor is composed of gonadal tissue, it is not necessarily located in an ovary or testicle. (wikipedia.org)
  • The LCOHs also include carcinosarcomas (malignant mixed Müllerian tumors of the ovary), borderline epithelial tumors (also known as low malignant potential tumors), malignant sex cord-stromal tumors, and malignant germ cell tumors. (nebraska.edu)
  • The LCOHs also include carcinosarcomas (malignant mixed M{\"u}llerian tumors of the ovary), borderline epithelial tumors (also known as low malignant potential tumors), malignant sex cord-stromal tumors, and malignant germ cell tumors. (nebraska.edu)
  • To achieve better definition of these tumors, we examined the histologic, histochemical, and ultrastructural features of four unclassified SCSTs with spindle-cell features, and compared their immunohistochemical features with those of 24 other SCSTs of the testis and ovary. (elsevierpure.com)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Leydig cell tumors (see the image below) are rare testicular tumors of the gonadal interstitium that may be hormonally active and lead to feminizing or virilizing syndromes. (medscape.com)
  • Leydig cell tumor. (medscape.com)
  • Unlike germ cell tumors, however, Leydig cell tumors show relative lack of sensitivity to radiotherapy and chemotherapy agents. (medscape.com)
  • Leydig cell tumors may be an incidental finding of a testicular mass on scrotal ultrasonography performed for other conditions. (medscape.com)
  • Magnetic resonance imaging: Can reveal small nonpalpable Leydig cell tumors that are not visible on ultrasound. (medscape.com)
  • Radical orchiectomy was once the primary treatment for Leydig cell tumors, and it remains in use for malignant cases. (medscape.com)
  • The etiology of Leydig cell tumors remains unknown. (medscape.com)
  • Unlike germ cell testicular tumors, Leydig cell neoplasms are not associated with cryptorchidism . (medscape.com)
  • In the United States, Leydig cell testicular neoplasms are the most common sex cord-stromal tumors and comprise 1-3% of all testicular neoplasms. (medscape.com)
  • In a study of 20 patients with Leydig cell tumors who were treated with conservative surgery, follow-up for a mean of 15 years found 100% disease-free survival, with no local recurrences or metastases. (medscape.com)
  • Leydig cell tumors are rare testicular tumors of the male gonadal interstitium. (medscape.com)
  • Although uncommon, Leydig cell tumors comprise 1-3% of all testicular neoplasms. (medscape.com)
  • Leydig cell tumors are usually benign, but malignant variants also occur. (medscape.com)
  • Leydig cell tumors were once managed primarily with radical orchiectomy . (medscape.com)
  • Although variable staining for S-100 protein was found in 5 of the 12 other SCSTs (4 Leydig cell, 6 Sertoli-Leydig cell, and 2 unclassifiable ovarian SCSTs), reactivity for smooth muscle actin was present in only 1 Sertoli-Leydig cell tumor. (elsevierpure.com)
  • This staging system applies to postpubertal germ cell tumors of the testis and malignant sex cord-stromal tumors of the testis. (nih.gov)
  • Unclassified sex cord-stromal tumors (SCSTs) of the testis comprised predominantly of spindle cells can be difficult to classify. (elsevierpure.com)
  • Renshaw, AA, Gordon, M & Corless, CL 1997, ' Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells ', Modern Pathology , vol. 10, no. 7, pp. 693-700. (elsevierpure.com)
  • A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. (harvard.edu)
  • Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia In Situ, and Germ Cell Tumors of the Testis. (harvard.edu)
  • A preliminary study investigating the detection of lymphovascular invasion in germ cell tumors of the testis with double staining for OCT4/CD34. (harvard.edu)
  • BACKGROUND: The adult granulosa cell tumor of the testis is a rare sex-cord/stromal tumor, with a potentiality for late recurrence and metastasis. (bvsalud.org)
  • The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
  • Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. (roche.com)
  • Testicular cancer represents 1% of adult neoplasms and 5% of urological tumours, with three to ten new cases per 100,000 males/per year in Western societies [ 6 ]. (uroweb.org)
  • EN":"Top five tumours most diagnosed in Veneto and proportion with the total number of tumours by sex"},"freq_title_inc_asl":{"IT":"Primi cinque tumori pi\u00f9 frequentemente diagnosticati nella ASLX e proporzione sul totale dei tumori per sesso. (registrotumoriveneto.it)
  • EN":"Exclusions: DCO, lost to follow-up, incompatible morfology or topografy according to 2016 AIRTUM monography 'La sopravvivenza dei pazienti oncologici in Italia', multiple tumours cases on the same site. (registrotumoriveneto.it)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Methods: Transcriptome sequencing and immunohistochemistry were performed on a series of mucinous cystic neoplasms. (johnshopkins.edu)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
  • Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. (roche.com)
  • Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. (roche.com)
  • These data support the concept that this tumor likely arises from ectopic primitive gonadal tissue and/or stromal cells with capacity to transdifferentiate to ovarian cortical cells. (johnshopkins.edu)
  • Virilizing ovarian tumors (VOT) and ovarian stromal hyperthecosis (OH) are the most common hyperandrogenism etiologies in the postmenopausal women. (usp.br)
  • Results: Mucinous cystic neoplasm of the liver exhibited significantly increased RNA expression of ovarian stromal markers WT1, PR, and ER2 and sex cord stromal markers SF-1, inhibin-α, and calretinin compared with nonneoplastic liver. (johnshopkins.edu)
  • Staining for S-100 protein and smooth muscle actin was also observed in three of six granulosa cell minors and both juvenile granulosa cell tumors. (elsevierpure.com)
  • Taken together, the histologic, histochemical, immunohistochemical, and ultrastructural features of the spindle-cell tumors are similar to those of granulosa cell tumors. (elsevierpure.com)
  • Background: Granulosa cell tumors (GCTs) are the most common ovarian tumors in mares. (bvsalud.org)
  • OBJECTIVE: Adult granulosa cell tumors (AGCTs) are rare malignancies that accounts for approximately 1% of ovarian neoplasms. (bvsalud.org)
  • A gonadal tissue neoplasm is a tumor having any histology characteristic of cells or tissues giving rise to the gonads. (wikipedia.org)
  • A gonadal tissue neoplasm should not be confused with a urogenital neoplasm, though the two topics are often studied together. (wikipedia.org)
  • Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
  • The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
  • A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
  • Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • GU tract pathologies can arise potentially at any stage of a person's life: newborns and infants can start showing signs and symptoms of congenital GU abnormalities, early or delayed puberty can become a burden for adolescents, STDs remain a major public health concern in sexually active teens and adults, and the potential for gonadal or cervical malignancy is constantly looming in particular cases. (lecturio.com)
  • In humans, these tumors demonstrate variable degrees of malignancy and surgical resection is often curative. (kipdf.com)
  • It does not apply to spermatocytic tumors (no AJCC staging system), nonmalignant sex cord-/gonadal -stromal tumors (no AJCC staging system), prepubertal germ cell tumors (no AJCC staging system), hematolymphoid tumors (hematologic malignancies staging system), and paratesticular neoplasms (no AJCC staging system). (nih.gov)
  • The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. (ijpmonline.org)
  • Objectives: Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. (johnshopkins.edu)
  • The molecular biology of mucinous cystic neoplasm of the liver remains poorly studied. (johnshopkins.edu)
  • Conclusions: Mucinous cystic neoplasm of the liver recapitulates ovarian stroma at the morphologic, DNA, RNA, and protein levels. (johnshopkins.edu)
  • Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
  • Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
  • Generally, solid tumors are best treated with surgical excision, while systemic neoplastic processes (ie, systemic lymphoma, metastatic conditions) are most effectively managed with use of systemic chemotherapy. (kipdf.com)
  • Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)
  • Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. (ijpmonline.org)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)
  • Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
  • Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (roche.com)
  • Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. (roche.com)
  • These tissues arise from the sex cord and stromal cells. (wikipedia.org)
  • Three of the spindle-cell tumors were composed of relatively short spindled cells with prominent nuclear grooves and intermixed epithelioid cells. (elsevierpure.com)
  • The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. (harvard.edu)
  • Arise from sex cord cells (e.g. (amboss.com)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • Microscopic examination of tumor Tumor Inflammation cells after surgery or biopsy Biopsy Removal and pathologic examination of specimens from the living body. (lecturio.com)
  • They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
  • Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
  • Biomarkers in Testicular Cancer: Classic Tumor Markers and Beyond. (harvard.edu)
  • Evaluation usually includes ultrasonography, CT or MRI, and measurement of tumor markers (eg, cancer antigen 125). (merckmanuals.com)
  • Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)
  • 20s1_Tumors Sec I.qxd 8/23/2005 12:16 PM Page 559 CHAPTER 20 Overview of Tumors Section I: Clinical Avian Neoplasia and Oncology Section II: A R. (kipdf.com)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • 2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors. (roche.com)
  • Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
  • [5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)
  • Because of its rarity, this tumor is poorly understood, particularly in terms of its molecular features. (bvsalud.org)
  • Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
  • Estrogen excess and feminizing syndromes may occur from the peripheral aromatization of testosterone or from the direct production of estradiol by the tumor itself. (medscape.com)
  • Paraneoplastic syndromes due to tumor-mediated factors lead to various presentations. (medscape.com)