It results in a necrotizing infection of the renal and perirenal tissue. (medscape.com)
Background: A renal angiomyolipoma is a mixed mesenchymal benign tumor composed of smooth muscle, adipose tissue, and blood vessels. (bvsalud.org)
Histopathology evaluation revealed an angiomyolipoma with a focal lesion and clear cell renal carcinoma within the tumor. (bvsalud.org)
No standardized follow-up modality has been established for angiomyolipomas, so patients should be placed under active surveillance, similar to that carried out in cases of renal cell carcinoma. (bvsalud.org)
Background: Emphysematous pyelonephritis (EPN) is a life-threatening necrotizing infection that results in the presence of gas in the renal parenchyma, collecting system, and surrounding tissues. (bvsalud.org)
KEYTRUDA plus LENVIMA is approved in the U.S., the EU, Japan and other countries for the treatment of advanced renal cell carcinoma (RCC) and certain types of advanced endometrial carcinoma. (streetinsider.com)
KEYTRUDA is indicated for the adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions. (keytrudahcp.com)
Compensatory structural and functional adaptation after radical nephrectomy for renal cell carcinoma according to preoperative stage of chronic kidney disease. (psu.edu)
In the U.S., KEYTRUDA plus LENVIMA is approved for the treatment of patients with advanced endometrial carcinoma that is not microsatellite instability-high or mismatch repair deficient, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation and for adult patients with advanced renal cell carcinoma (RCC) in the first-line setting. (eisai.com)
Alymsys (bevacizumab-maly) is a biosimilar to Avastin (bevacizumab) that is used to treat a variety of cancers, including metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, metastatic renal cell carcinoma, cervical cancer, and epithelial ovarian, fallopian tube, or primary peritoneal cancer. (mdtodate.com)
Alymsys, in combination with interferon alfa, is indicated for the treatment of metastatic renal cell carcinoma (mRCC). (mdtodate.com)
Patients with RCC at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions. (keytrudahcp.com)
Metastatic5
Thus, cryoablation of tumors is a way of achieving autologous, in-vivo tumor lysate vaccine and treat metastatic disease. (wikipedia.org)
MRK ), known as MSD outside of the United States and Canada, and Eisai today provided updates on two Phase 3 trials, LEAP-006 and LEAP-008, evaluating KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, in patients with certain types of metastatic non-small cell lung cancer. (streetinsider.com)
About 25 percent of priapism cases are attributable to sickle cell disease, metastatic cancer or leukemia. (corespirit.com)
Merck also announced that the Phase 3 KEYNOTE-789 trial evaluating KEYTRUDA in combination with pemetrexed plus platinum-based chemotherapy did not meet its dual primary endpoint of OS for the treatment of patients with metastatic nonsquamous non-small cell lung cancer (NSCLC), with epidermal growth factor receptor (EGFR)-genomic tumor mutations, who have previously progressed on a tyrosine kinase inhibitor (TKI), including osimertinib. (ridgwayrecord.com)
Alymsys, in combination with carboplatin and paclitaxel, is indicated for the first-line treatment of patients with unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer (NSCLC). (mdtodate.com)
Radical1
Partial nephroprotective or radical complete nephrectomy with negative surgical margins ≥4 weeks prior to the time of screening. (keytrudahcp.com)
Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in various tumor types, including but not limited to endometrial carcinoma, hepatocellular carcinoma, RCC, head and neck cancer, gastric cancer and esophageal cancer across multiple clinical trials. (streetinsider.com)
BACKGROUND: Emphysematous pyelonephritis (EPN) is a necrotizing infection of the kidney and surrounding tissues with significant mortality. (bvsalud.org)
Specifically in children , a unilateral ligation approach was compared to unilateral surgical nephrectomy before KT (indications for which included polyuria, massive resistant proteinuria, intractable HTN, and recurrent kidney infection). (kireportscommunity.org)
Not only does it represent an alternative to surgical intervention, but it also creates a tumor-specific immune response stimulated by damaged cells. (wikipedia.org)
Early nephrectomy (OR 2.3, p = 0.029) and delayed nephrectomy (OR 2.4, p = 0.015) were associated with increased mortality in patients with ESBL infections. (bvsalud.org)
However, ESBL infections were associated with poor prognosis when patients underwent nephrectomy compared conservative/minimally invasive management. (bvsalud.org)
Surgical2
Surgical nephrectomies can be open, laparoscopic, or robot-assisted. (kireportscommunity.org)
The benefits of ureteral ligation over surgical nephrectomy include a less invasive procedure with smaller incisions and less risk for bleeding. (kireportscommunity.org)
Pyelonephritis1
Indications for unilateral nephrectomy include unilateral tumors, living kidney donation, severe unilateral kidney trauma, recurrent pyelonephritis in a refluxing non- or minimally-functioning kidney, atrophic kidney, and in the setting of a non-functioning, dysplastic kidney resulting in severe hypertension (HTN). (kireportscommunity.org)
Bladder2
In men older than 50 years, the presentation of cystitis is difficult to differentiate from that of obstructive prostatism due to prostatic hyperplasia, transitional cell carcinoma of the bladder , or acute or chronic bacterial prostatitis. (medscape.com)
In a developing country, hematuria is suggestive of schistosomiasis, which can be associated with salmonellosis and squamous cell malignancies of the bladder. (medscape.com)
Metastases2
Various adjuvant immunotherapy and chemotherapy treatments can be combined with cryoablation to sustain systemic anti-tumor response with regression of metastases, including: Injection of immunomodulating drugs (i.e.: therapeutic antibodies) and vaccine adjuvants (saponins) directly into the cryoablated, necrotized tumor lysate, immediately after cryoablation Administration of autologous immune enhancement therapy, including: dendritic cell therapy, CIK cell therapy Combinatorial ablation and immunotherapy Photoimmunotherapy Sidana Abhinav (2014). (wikipedia.org)
This cryoimmunologic response may contribute to controlling metastases far from the primary breast tumor. (wikipedia.org)
Kidneys2
However, there are circumstances when kidneys do not behave as they should, and nephrectomy is more beneficial than leaving a dysfunctional kidney. (kireportscommunity.org)
Currently, nephrectomies are not performed with Multicystic Dysplastic Kidneys (MCDK). (kireportscommunity.org)
Bone1
urgent intervention indicated Definition:A dysfunction characterised by insufficiently wholesome hematapoietic cell manufacturing by the bone marrow. (ehd.org)
Scenario1
Conclusion: Limited evidence is available to dictate management of collision tumors of the kidney in the scenario of tuberous sclerosis complex, so a multidisciplinary approach that includes urology, oncology, genetics, and nephrology intervention needs to be considered. (bvsalud.org)
Proteinuria2
Congenital Finnish-type nephrotic syndrome is characterized by massive proteinuria, and treatment often involves daily albumin infusions, intensified nutrition, and initial therapy with NSAID and renin-Angiotension-Aldosterone system inhibition (RAASi), thereby reducing proteinuria (aka medical nephrectomy, discussed later). (kireportscommunity.org)
However, there are times when unilateral nephrectomy is undertaken initially to reduce proteinuria while simultaneously preserving residual kidney function. (kireportscommunity.org)
Cancers1
Cryoimmunotherapy, also referred to as cryoimmunology, is an oncological treatment for various cancers that combines cryoablation of tumor with immunotherapy treatment. (wikipedia.org)
Primary2
The primary endpoint of the study is OS, and secondary endpoints include progression-free survival (PFS) and objective response rate (ORR) as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 modified for mesothelioma, safety and quality of life. (merck.com)
The dual primary endpoints are PFS, as assessed by blinded independent central review (BICR) per Response Evaluation Criteria in Solid Tumors Version (RECIST) v1.1 (RECIST v1.1 has been modified for this study to follow a maximum of 10 target lesions in total and a maximum of 5 target lesions per organ), and OS. (eisai.com)
Treatment1
Sequential nephrectomy is also sometimes done in severe treatment-resistant nephrotic syndrome in an older child. (kireportscommunity.org)
Include2
Two risk factors for testicular torsion include undescended testicles and testicular tumors. (corespirit.com)
Indications for bilateral nephrectomy include autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD) owing to their large sizes. (kireportscommunity.org)
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