• Probable impact of age and hypoxia on proliferation and microRNA expression profile of bone marrow-derived human mesenchymal stem cells. (edu.pl)
  • miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells. (edu.pl)
  • Consequently, phosphorylated BPGAP1 facilitates endosomal ERK signaling transduction to the nucleus, driving cell proliferation and transformation via the ERK-Myc-CyclinA axis. (bvsalud.org)
  • BPGAP1 therefore provides a crucial spatiotemporal checkpoint where JNK and MP1/MEK1 work in concert to regulate endosomal and nuclear ERK signaling in cell proliferation control. (bvsalud.org)
  • Soluble HLA-G is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. (biovendor.com)
  • AKAP12 knockdown in benign meningioma cells SF4433 increases proliferation, cell cycle, migration, invasion, and confers an anaplastic profile. (nature.com)
  • CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. (rndsystems.com)
  • Different conditions can affect survival, proliferation, and differentiation of RAW264.7 cells. (sciforschenonline.org)
  • Their role as the factors directly influencing not only growth and proliferation of cancer cells, but also as the factors modulating their apoptosis or regulating neoangiogenesis process is demonstrated. (czytelniamedyczna.pl)
  • However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
  • Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)
  • As with other germ cell tumors, with the exception of spermatocytic seminoma , embryonal carcinomas are believed to originate from intratubular malignant germ cells. (medscape.com)
  • MicroRNAs are small, non-coding RNA molecules that show promise as biomarkers for testicular malignant germ cell tumors. (medscape.com)
  • In all malignant germ cell tumors, microRNAs from two "clusters" (miR-371-373 and miR-302-367) are overexpressed. (medscape.com)
  • A panel of circulating microRNAs from these clusters (miR-371a-3p, miR-372-3p, miR-373-3p, and miR-367-3p) is highly sensitive and specific for diagnosing malignant germ cell tumors, including embryonal carcinoma and seminoma. (medscape.com)
  • Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
  • Resection of the hard palate may be necessary for the management of benign or malignant tumors or as a donor site for a mucosal graft. (medscape.com)
  • Although squamous cell carcinoma is the most common primary malignant tumor of the oral cavity, the most common tumors of the hard palate are of minor salivary gland origin. (medscape.com)
  • These include benign tumors such as pleomorphic adenomas, as shown below, and malignant tumors such as mucoepidermoid carcinoma, adenoid cystic carcinoma, and polymorphous low-grade adenocarcinoma. (medscape.com)
  • The indications to perform hard palate resection include excision of malignant and benign tumors, to alleviate complications from tumor burden that compromise the function of the oral cavity, and for facial reconstruction such as in cases of eyelid, lip, and nasal ala deformities. (medscape.com)
  • Glioblastoma multiforme (GBM) is the most common and most malignant of the glial tumors. (medscape.com)
  • Tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a death receptor ligand that can induce apoptosis in a variety of cancer cell lines, including androgen-independent PC3 prostate carcinoma cells. (biomedcentral.com)
  • Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
  • 5. Force WR, Glass AA, Benedict CA, Cheung TC, Lama J, Ware CF. Discrete signaling regions in the lymphotoxin-β receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-κB pathways. (southernbiotech.com)
  • This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)
  • Among T cells, CD30 is preferentially expressed on a subset of T cells producing Th2-type cytokines and on CD4 + /CD8 + thymocytes that co-express CD45RO and IL-4 receptor. (rndsystems.com)
  • The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks catalytic activity but contains a motif similar to death domains found in the cytoplasmic regions of members of the tumor necrosis factor receptor family and their downstream targets. (embl-heidelberg.de)
  • TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types. (embl-heidelberg.de)
  • Allopurinol induces innate immune responses through mitogen-activated protein kinase signaling pathways in HL-60 cells. (hirosaki-u.ac.jp)
  • H2O2 activated the nuclear factor-κB (NF-κB) and c-Jun N-terminal kinase (JNK) pathways and induced cell apoptosis, while the overexpression of miR-181a suppressed both pathways and decreased the rate of apoptosis. (edu.pl)
  • In conclusion, this study indicated that miR-181a could improve the survival rate of TM cells after H2O2 treatment by blocking the NF-κB and JNK signaling pathways. (edu.pl)
  • Awaikasaoka N, Inoue T, Kameda T, Fujimoto T, Inouemochita M, Tanihara H. Oxidative stress response signaling pathways in trabecular meshwork cells and their effects on cell viability. (edu.pl)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell growth and tissue development through their distinct signaling pathways. (bvsalud.org)
  • The RAW264.7 cell line is most commonly used to study osteoclast differentiation and its signaling pathways. (sciforschenonline.org)
  • Embryonal carcinoma is a germ cell tumor characterized by primitive epithelial cells with marked pleomorphism and various histologic patterns. (medscape.com)
  • In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
  • The protein is also constitutively expressed on granulocytes and medullary thymic epithelial cells. (rndsystems.com)
  • Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
  • Of the estimated 17,000 primary brain tumors diagnosed in the United States each year, approximately 60% are gliomas. (medscape.com)
  • Single-chain antibodies (scFv) take an important role in the field, because they are less immunogenic than whole antibodies, their smaller size allows faster and deeper penetration into solid tumors, and are by definition recombinant proteins, therefore easier to produce and modify. (biomedcentral.com)
  • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. (ujds.in)
  • Water-soluble component in dried chrysanthemum flower stimulates tumor necrosis factor − a production by mouse macrophage like cell line RAW 264.7. (jomos.org)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
  • One agent that has received considerable attention as a novel apoptosis-inducing agent is tumor necrosis factor-related apoptosis inducing ligand (TRAIL/Apo2L). (biomedcentral.com)
  • Role of Fas ligand expression in promoting escape from immune rejection in a spontaneous tumor model. (southernbiotech.com)
  • CD40 ligand trimer enhances the response of CD8 + T cells to Mycobacterium tuberculosis. (southernbiotech.com)
  • The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for the design of bifunctional antibodies. (biomedcentral.com)
  • Mouse myeloma cell line NS0-derived human CD30 Ligand/TNFSF8. (rndsystems.com)
  • In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
  • A molecular signature response classifier (MSRC) that predicts which patients with RA are unlikely to respond to tumor necrosis factor-α inhibitor (TNFi) therapy would have wide clinical utility. (springer.com)
  • Therefore, we treated 4T1 cells with DMF, a NF-κB inhibitor, in order to determine whether suppression of the NF-κB p65 subunit would LBH589 mouse result in the inhibition of RANKL-mediated EMT. (pdgfreceptor.com)
  • PKC-specific inhibitor or PKCaDN cells abolish this HDE-mediated effect. (cdc.gov)
  • Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes, Biochem. (c19hcq.org)
  • Autophagic cell death was demonstrated by images of punctuated LC3 patterns, a higher percent of acridine orange positive cells, as well as a partial rescue of cell death by autophagy inhibitor 3-methyladenine or chloroquine. (oncotarget.com)
  • Parameswaran N, Patial S. Tumor necrosis factor-α signaling in macrophages. (jomos.org)
  • A greater number of alveolar macrophages produced TNF-α compared to autologous monocytes in sarcoidosis but not in controls and, based on cell size, it was confirmed that this was the product of more mature macrophages and that the secretion of TNF-α by monocytes and macrophages was heterogeneous: not all monocytes and macrophages secrete TNF-α. (ersjournals.com)
  • This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)
  • Although these protocols provide a successful method to culture osteoclasts from RAW264.7 cells, they don't express the issue of having multinucleated cells such as macrophages mixing with osteoclasts in the population. (sciforschenonline.org)
  • Canonical NF-κB pathway activation underlines much of the immune response after SCI including cytokine, chemokine, and apoptosis-related factor production as well as immune cell activation and infiltration. (biomedcentral.com)
  • Dust samples collected from Nebraska swine confinement facilities (hog dust extract [HDE]) are known to elicit proinflammatory cytokine release from human bronchial epithelial (HBE) cells in vitro. (cdc.gov)
  • Tumour necrosis factor (TNF)-α is thought to be a key early cytokine in the pathogenesis of sarcoidosis, despite conflicting data. (ersjournals.com)
  • The reverse haemolytic plaque assay allows the measurement of cytokine production at a single cell level. (ersjournals.com)
  • Tumour necrosis factor (TNF)-α is a key early cytokine in a variety of chronic inflammatory responses, including fibrosing alveolitis and granulomatous disease 6 - 8 . (ersjournals.com)
  • The current authors have previously demonstrated, using a reverse haemolytic plaque assay (RHPA), that single-cell production of cytokine can be assayed 16 . (ersjournals.com)
  • This technique has an advantage over routine culture conditions, as the development of cytokine product by individual cells can be localised and measured, which therefore allows for the correlation of cytokine production with cell type. (ersjournals.com)
  • Establishment and characterization of two primary breast cancer cell lines from young Indian breast cancer patients mutation analysis. (gitam.edu)
  • In vitro , TRAIL-mediated apoptosis of prostate cancer cell lines can be enhanced by doxorubicin and correlates with the downregulation of the anti-apoptotic protein c-FLIP. (biomedcentral.com)
  • Although the LAT family plays important roles in the development and function of normal tissues, they are frequently increased in cancer cells ( 3 ). (spandidos-publications.com)
  • Prostate cancer cells, either positive or negative for K V 10.1 were treated with the purified construct. (biomedcentral.com)
  • After sensitization with cytotoxic drugs, scFv62-TRAIL induced apoptosis only in K V 10.1-positive cancer cells, but not in non-tumor cells, nor in tumor cells lacking K V 10.1 expression. (biomedcentral.com)
  • Given that cancer cells and astrocytes in glioblastomas coexist in a hypoxic microenvironment, we examined whether astrocytes affect the adaptation of glioblastoma cells to hypoxia. (cancerindex.org)
  • The expression of HIF-1 downstream genes, cancer colony formation, and Matrigel invasion of glioblastoma cells were stimulated by conditioned medium from astrocytes pre-exposed to hypoxia. (cancerindex.org)
  • It is observed that aggregation of genetic alterations is the ground for advancement of a normal cell to cancer cells, which is known as a multi-step carcinogenesis. (ujds.in)
  • Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions. (ujds.in)
  • Capitalizing on the growing importance and relevance of zebrafish (Danio rerio) as an alternate cancer model, we have generated liver-specific, Tet-on-inducible transgenic lines expressing oncogenic Kras(G12V), RhoA, constitutively active RhoA(G14V) or dominant-negative RhoA(T19N). (bvsalud.org)
  • However, multidrug-resistant (MDR) cancer cells may avoid the cytotoxic effects of chemotherapy by glycosylating ceramide. (sphingolipidclub.com)
  • In the present study we examined the relationship between ceramide, ceramide metabolites and expression of the MDR1 gene in human breast cancer cell lines. (sphingolipidclub.com)
  • Four wild-type (drug-sensitive) human breast cancer cell lines (MCF-7, T47D,MDA-MB-231, MDA-MB-435) were used to evaluate the influence of acute and chronic exposure to ceramide and ceramide metabolites on MDR1 mRNA,P-gp, and resistance to chemotherapeutic agents. (sphingolipidclub.com)
  • These data are the first evidence that chronic exposure to ceramide and its metabolites enhances expression of the MDR phenotype in cancer cells. (sphingolipidclub.com)
  • This concerns a direct influence on cancer cells in a primary focus, influence on formation of secondary foci, and also modulation of mechanisms of cell anticancer response. (czytelniamedyczna.pl)
  • Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)
  • Study of single nucleotide polymorphisms of tumor necrosis factors and HSP genes in Nasopharyngeal carcinoma in North East India. (gitam.edu)
  • We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
  • Oral carcinogenesis is known as multifactorial process which engaged plentiful genetic events that transform normal activity of tumor suppressor genes and oncogenes. (ujds.in)
  • HLA-G differs from the other MHC class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. (biovendor.com)
  • Identification of microRNAs involved in hypoxia- and serum deprivation-induced apoptosis in mesenchymal stem cells. (edu.pl)
  • A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury. (hirosaki-u.ac.jp)
  • Biomarkers for identification of these histologically identical WHO II tumors do not exist. (nature.com)
  • In response to released cytokines from immune cells, perilesional astrocytes modify their phenotype and form the glial scar composed of astrocytes and a dense extracellular matrix within weeks following SCI [ 1 ]. (biomedcentral.com)
  • Increasing number of reports concerning the contribution of cytokines in the process of tumors formation and development has been observed last years. (czytelniamedyczna.pl)
  • Mast cells are cells that reside in the connective tissue and contain a large number of granules, rich in histamine, heparin, chymase, serotonin, and also cytokines. (bvsalud.org)
  • Germ cell tumors show many features of normal embryogenesis, such as pluripotency, as governed by the expression of OCT3/4 (see Immunohistochemistry). (medscape.com)
  • This study evaluated the effects of doxorubicin on c-FLIP expression and tumor growth in combination with Apo2L/TRAIL in a xenograft model. (biomedcentral.com)
  • In mice, doxorubicin did not significantly affect the growth of PC3 xenografts but reduced c-FLIP expression in tumors. (biomedcentral.com)
  • After the TM cells were treated with H2O2, miR-181a expression was significantly lower. (edu.pl)
  • Postinternalization inhibition of adenovirus gene expression and infectious virus production in human T-cell lines. (southernbiotech.com)
  • Astrocytes augmented HIF-1α expression in glioblastoma cells under hypoxia. (cancerindex.org)
  • Low AKAP12 expression in a larger cohort of patients (75) characterized tumor invasiveness, recurrence, and progression, indicating its potential as a prognostic biomarker. (nature.com)
  • We investigated the effects of monocyte-activating stimuli (IFN-gamma, IL-2, LPS, TNF-alpha, and GM-CSF) on the expression and function of CD38, starting from the observation that human monocytes and the derived lines U937, THP-1, and Mono-Mac-6 bear the molecule on their surface. (nih.gov)
  • Recently, this cell line has become a valuable tool to study osteoclast differentiation and activity due to its expression of RANK and differentiation to osteoclast in response to RANKL [7]. (sciforschenonline.org)
  • Exposure of cells to either octanoic acid (C8:0), a C8-ceramide hydrolysis product, or oleic acid (C18:1) did not affect MDR1 expression. (sphingolipidclub.com)
  • This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. (cancerindex.org)
  • Traumatic spinal cord injury (SCI) triggers a chain of events that is accompanied by an inflammatory reaction leading to necrotic cell death at the core of the injury site, which is restricted by astrogliosis and apoptotic cell death in the surrounding areas. (biomedcentral.com)
  • These chronic inflammatory cells then organise spatially into the classic granulomatous response 1 - 5 . (ersjournals.com)
  • The plaques contain lipids, inflammatory cells, smooth muscle. (msdmanuals.com)
  • Combination of doxorubicin with Apo2L/TRAIL resulted in more apoptotic cell death and tumor growth inhibition than Apo2L/TRAIL alone. (biomedcentral.com)
  • For the mode of cell death, we found lapatinib induced a higher percent of dead cells and a lower percent of hypodiploid cells, suggesting non-apoptotic cell death in lapatinib-treated hepatoma cells. (oncotarget.com)
  • Locally instilled tumor necrosis factor α antisense oligonucleotide inhibits allergic inflammation via the induction of Tregs. (jomos.org)
  • The World Health Organization (WHO) histologically classifies tumors into three grades: benign (I), atypical (II) and anaplastic (III) 2 . (nature.com)
  • For in vivo studies, PC3 prostate carcinoma cells were grown subcutaneously in athymic nude mice and tumor growth was measured following treatment with doxorubicin and/or Apo2L/TRAIL. (biomedcentral.com)
  • TRAIL induces apoptosis in a variety of cell lines in vitro and in vivo . (biomedcentral.com)
  • Continuous interleukin-6 application in vivo via macroencapsulation of interleukin-6-expressing COS-7 cells induces massive gliosis. (uni-bielefeld.de)
  • Although much has been learnt about their individual functions in both cell and animal models, the physiological and pathophysiological consequences of their signaling crosstalk in multi-cellular context in vivo remain largely unknown, especially in liver development and liver tumorigenesis. (bvsalud.org)
  • In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)
  • The present review spotlights on understanding the molecular mechanism and the genetic factors which is responsible for alteration in the cell which leads to oral squamous cell carcinoma. (ujds.in)
  • Biologic implications of genetic changes in head and neck squamous cell carcinogenesis. (ujds.in)
  • [ 2 , 3 ] About 3-10% of pure germ cell tumors are embryonal carcinomas, and embryonal carcinomas are present in more than 80% of mixed germ cell tumors. (medscape.com)
  • [ 8 ] In the vast majority of cases, IGCNU occurs adjacent to invasive germ cell tumors, including embryonal carcinomas. (medscape.com)
  • Embryonal carcinomas are aggressive germ cell tumors. (medscape.com)
  • Although serum alpha fetoprotein (AFP) has been reported in association with embryonal carcinomas, most of those cases were probably misclassified as such and in truth represented mixed cases of embryonal carcinomas and yolk sac tumors . (medscape.com)
  • Association of embryonal carcinomas with syncytiotrophoblastic giant cells may cause increases in serum human chorionic gonadotropin (hCG) levels. (medscape.com)
  • Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease. (ujds.in)
  • Human primary explant-derived TM cells were cultured in fibroblast medium and then treated with different concentrations of H2O2 for 2 h. (edu.pl)
  • Osteoclasts can be obtained by isolating primary bone marrow monocytes or by using macrophage cell lines. (sciforschenonline.org)
  • Disadvantages of primary cells include the difficulty of obtaining a true homogenous population, sensitivity, and requirement of additional nutrients. (sciforschenonline.org)
  • Primary cutaneous signet-ring cell melanoma: a clinico-pathologic and immunohistochemical research of two circumstances Am J Dermatopathol. (ehd.org)
  • PKCa and PKCe activities were inhibited using isoform-specific pharmacologic inhibitors and genetically modified dominant-negative (DN) expressing cell lines. (cdc.gov)
  • Radiation is used as adjuvant to treat progressive tumors since there are no efficient chemotherapies for the management of high-grade tumors that fail treatments. (nature.com)
  • TRAIL is normally present as a membrane protein (memTRAIL) on immune effector cells, like natural killer cells. (biomedcentral.com)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • of EMT markers, cell migration, and invasion. (pdgfreceptor.com)
  • DMF inhibited the upregulation of EMT markers, cell migration, and invasion in 4T1 cells (Figure 4B-4C). (pdgfreceptor.com)
  • Role of PDL-1 in NSCLC chemoresistance was assessed using CRISPR/Cas9 knockdown and various functional assays including MTT, cell invasion, sphere formation, and cell apoptosis. (cdc.gov)
  • Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor. (cdc.gov)
  • Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines, Virol. (c19hcq.org)
  • In this study, we found that lapatinib induced cytotoxicity in human hepatoma Huh7, HepG2 and HA22T cells. (oncotarget.com)
  • In conclusion, lapatinib induced autophagic cell death and the growth of human hepatoma cells. (oncotarget.com)
  • Pathologically, at an early stage, there is an influx of mononuclear cells followed by lymphocytes. (ersjournals.com)
  • Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species. (cri.or.th)
  • Wiesel, T. N. & Hubel, D. H. Effects of visual deprivation on morphology and physiology of cells in the cats lateral geniculate body. (nature.com)
  • As a result of the their roles in energy production, mitochondria also generate reactive oxygen species (ROS) that may have a toxic effects in cells. (frontiersin.org)
  • Interestingly, antidepressant medication can restore the mitochondrial oxidant/antioxidant balance, and therefore help to rescue the negative effects of mitochondrial dysregulation (green lines). (frontiersin.org)
  • 10. Mongini PK, Inman JK, Han H, Kalled SL, Fattah RJ, McCormick S. Innate immunity and human B cell clonal expansion: effects on the recirculating B2 subpopulation. (southernbiotech.com)
  • Silymarin protects against its toxic principle α-amanitin by preventing its uptake through hepatocyte membranes and inhibiting the effects of tumour necrosis factor-α, which exacerbates lipid peroxidation. (springer.com)
  • There is an intense effort invested into the search for innovative therapies that can complement classical chemotherapy, radiation and surgery to overcome the limitations derived from chemo-resistance, toxicity of non-specific drugs and incomplete elimination of tumor tissue. (biomedcentral.com)
  • These cells not only demonstrated a 3-foldincrease in resistance to doxorubicin and a 9-fold increase in resistance to paclitaxel, but also showed increased efflux of rhodamine. (sphingolipidclub.com)
  • Using a rat compression model of SCI, we transplanted SPC-01 cells or injected saline into the lesion 7 days after SCI induction. (biomedcentral.com)
  • CCL20 was secreted in a hypoxia-dependent manner from astrocytes and busted the hypoxic induction of HIF-1α in glioblastoma cells. (cancerindex.org)
  • However, it is not clear whether TNF production in disease sites is a feature of all mononuclear cells that traffic there or whether it is a subset phenomenon. (ersjournals.com)
  • Structure, anti-tumor activity, and potential anti-tumor mechanism of a fungus polysaccharide from Fomes officinalis. (hirosaki-u.ac.jp)
  • The mechanism behind malignancy and tumor genesis is unknown, limiting development of alternative therapies. (nature.com)
  • The exact mechanism associated with this growth and expansion remains unclear, although it is known that several types of cells, including mast cells, do play a role in such phenomena 4 . (bvsalud.org)
  • Migration was analyzed by Boyden chamber assays using Falcon cell culture inserts. (pdgfreceptor.com)
  • The skin manifestations occur along the lines of Blaschko, which represent the routes of embryonic cell migration. (medscape.com)
  • In vitro experiments show that PC3 cells are partially susceptible to Apo2L/TRAIL and that susceptibility is enhanced by doxorubicin. (biomedcentral.com)
  • Bone marrow stromal cells reduce ischemia-induced astrocytic activation in vitro. (uni-bielefeld.de)
  • Acute exposure ofMCF-7 and MDA-MB-231 cells to C8-glucosylceramide (10 μg/ml culture medium), a cell-permeable analog of glucosylceramide, increased MDR1 mRNA levels by 2- and 4-fold, respectively. (sphingolipidclub.com)
  • Acute Myocardial Infarction (MI) Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. (msdmanuals.com)
  • Mitochondria are the cellular powerhouse of eukaryotic cells, and they also regulate brain function through oxidative stress and apoptosis. (frontiersin.org)
  • Mitochondria are the main energy factories of eukaryotic cells. (frontiersin.org)
  • Macroautophagy (thereafter designated as autophagy) is a self-digestive system conserved in all eukaryotic cells. (spandidos-publications.com)
  • CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. (rndsystems.com)
  • Treatment with IFN-gamma produced a dose- and time-dependent up-regulation of CD38 in monocytes and monocytic lines, which was paralleled by increased ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities. (nih.gov)
  • Caminero A, Comabella M, Montalban X. Tumor necrosis factor alpha (TNF α), anti TNF α and demyelination revisited: an ongoing story. (jomos.org)
  • Especially, the potassium channel K V 10.1 (Ether-á-go-go) is attractive as target since this surface protein is virtually not detected in normal tissue outside the central nervous system, but is expressed in approximately 70% of tumors from different origins. (biomedcentral.com)
  • When used as donor grafts, hard palate tissue offers the advantages of an epithelial lining, minimal postoperative graft shrinkage, and ready availability compared to other donor sites/materials. (medscape.com)
  • In the periapical granuloma cases, mast cells were found in eight cases (50%), located in the granulation tissue. (bvsalud.org)
  • Mast cells were detected in both cysts and periapical granuloma, located in the capsule and granulation tissue, respectively. (bvsalud.org)
  • Following treatments, cells were evaluated for Annexin-V staining. (bdbiosciences.com)
  • CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using the monoclonal antibody Ki-1. (rndsystems.com)