• clinical
  • 3. Utilize patient demographics and clinical history, including information on underlying disorders, specific timeline of lesional development, lesional morphologic features, and anatomic site to enhance specificity of diagnosis. (opusmedicus.com)
  • skin
  • Occasionally, a chemical that has been applied to the skin topically or by intradermal injection can be eliminated by the transepidermal route to produce a perforating disorder. (blogspot.com)
  • disease
  • The inflammatory bowel diseases (IBD), ulcerative colitis and Crohn's disease, are immune-modulated disorders of the gastrointestinal (GI) tract that also have a number of manifestations outside the gut. (clinicaladvisor.com)
  • Some add a fifth disease to the primary perforating disorders, that is perforating periumbilical calcific elastosis with its periumbilical keratotic papules (perforating substance is calcified elastic tissue), a grinding sound can be heard on performing a biopsy! (blogspot.com)
  • primary
  • It is possible that these primary perforating disorders might be due to defects in the epidermal keratinocytes, hair follicle, collagen and elastic fibres, respectively, with the elimination being the final pathway but it should be noted that in perforating folliculitis, the follicular epithelium shows one or more perforations INTO the dermis. (blogspot.com)
  • The manner in which the primary bullous disorders are contaminated by herpesviridae remains unclear. (blogspot.com)