• gene
  • Phosphoinositide-3-kinase enhancer (PIKE) proteins encoded by the PIKE/CENTG1 gene are members of the gamma subgroup of the Centaurin superfamily of small GTPases. (readbyqxmd.com)
  • The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. (wikipedia.org)
  • evolutionary
  • Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design. (biomedcentral.com)
  • There is an increased realization of the need to understand a tumor's evolutionary history using both spatial and longitudinal genomic information and to identify driver events and mutational processes that contribute to tumor initiation, maintenance, progression and subclonal diversification. (biomedcentral.com)
  • We also describe how subclonal diversity might contribute to the limitations of targeted therapies and how it can be leveraged to study the evolutionary history of a tumor and to optimize clinical trial design. (biomedcentral.com)
  • The left panel shows the evolutionary history of each tumor, the middle panel represents a snapshot of the tumor at a given time, and the right panel shows the potential future development. (biomedcentral.com)
  • Single snapshots of Tumors B and C may suggest that they have identical evolutionary processes, but their past and future evolution actually follow different patterns. (biomedcentral.com)
  • The subclonal diversity within a tumor if viewed as a snapshot, rather than longitudinally, provides little information about the future evolutionary routes that subclonal populations might take. (biomedcentral.com)
  • cells
  • Within host cells, L. pneumophila establishes a replicative haven by delivering numerous effector proteins into the host cytosol, many of which target membrane trafficking by manipulating the function of Rab GTPases. (readbyqxmd.com)