OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
LovastatinHydroxymethylglutaryl-CoA Reductase InhibitorsMevalonic AcidAnticholesteremic AgentsProtein PrenylationPolyisoprenyl PhosphatesHydroxymethylglutaryl CoA ReductasesSimvastatinCholesterolDrug IncompatibilityPravastatinFarnesolMonascusColestipolAspergillusHydroxymethylglutaryl-CoA-Reductases, NADP-dependentFatty Acids, Monounsaturated
AtorvastatinSimvastatinAltocorMevacorCompoundsCholesterol NaturallyPatientsYeastMonacolinsFoundDrugsLevelsSide effectsHighMemoryBodyDrugTreatStatinsReductaseRosuvastatinConcentrationsAspergillusInhibitory effectHypercholesterolemiaMerckOysterKing TrumpetRiceLipitorInhibitionCholesterol levelsCoenzyme Q10AcidDietarySterolsSubstanceLiverLowerDosesGeneticallyChemicalIncreaseHigherTreatmentBodiesPotentialProduceDoctor
Atorvastatin3
Simvastatin2
Altocor1
Mevacor1
  • Years ago, one drug company saw green when they learned about red yeast rice and created the very first billion-dollar blockbuster statin out of it called "Mevacor" sold generically as "lovastatin. (suzycohen.com)
Compounds2
  • Red yeast rice is effective because it naturally contains cholesterol-lowering 'statin' compounds, such as lovastatin. (consumerlab.com)
  • Red yeast rice contains 14 naturally occurring compounds called monacolins, which block the production of cholesterol in the liver. (suzycohen.com)
Cholesterol Naturally2
Patients1
  • It works to treat patients with low levels of corticosteroids by replacing steroids that are normally produced naturally by the body. (medlineplus.gov)
Yeast2
  • Prior to the CBD debate, the most notable FDA application of §201(ff)(3)(B) involved the monacolin K content of red-yeast rice and whether it was the same "article" as a substance (called lovastatin) found in a drug approved to treat high cholesterol. (wlf.org)
  • But the facts are that some red yeast rice products contain substantial amounts of monacolin K, which is chemically identical to the active ingredient in the cholesterol-lowering drug lovastatin. (eiffelbiotech.com)
Monacolins1
Found2
  • In 1997, FDA took action against a manufacturer for allegedly engineering a product to have lovastatin levels similar to those found in the approved drug and marketing the product to pharmacists based on those similarities. (wlf.org)
  • Savory comes from protein building blocks (amino acids) found naturally in protein-rich foods like meats and cheese. (thegrownetwork.com)
Drugs1
Levels2
Side effects1
High1
Memory1
  • Helping slim down to boost memory naturally without inflicting unfavorable unwanted effects and mechanisms of action. (corporacioneg.com)
Body1
Drug1
  • One of them, monacolin K, is chemically identical to the active ingredient in the cholesterol-lowering drug lovastatin. (nutrivillage.ca)
Treat1
  • It is used to treat conditions in which a woman's ovaries do not produce enough estrogen naturally (hypoestrogenism). (rxwiki.com)
Statins3
  • Lovastatin and other statins have been studied for their chemopreventive and chemotherapeutic effects. (wikipedia.org)
  • Lovastatin is a member of the drug class of statins, used for lowering cholesterol and so preventing cardiovascular disease. (hokto-kinoko.com)
  • Lovastatin is the weakest of these statins with an equivalency of eight. (drmaheshkumar.com)
Reductase10
  • Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. (wikipedia.org)
  • Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. (wikipedia.org)
  • Compactin and lovastatin, natural products with a powerful inhibitory effect on HMG-CoA reductase, were discovered in the 1970s, and taken into clinical development as potential drugs for lowering LDL cholesterol. (wikipedia.org)
  • Lovastatin works by inhibiting the activity of the enzyme HMG-CoA reductase, which acts as the rate limiting step to the synthesis of cholesterol in the body. (funginomi.com)
  • The conversion of HMG-CoA to mevalonate by HMG-CoA reductase is blocked by Lovastatin. (funginomi.com)
  • One particular monocolin called Lovastatin is believed to be converted in the body to a substance that inhibits HMG-CoA reductase, an enzyme that triggers cholesterol production. (realnaturalremedies.com)
  • 14. Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells. (nih.gov)
  • 15. Interaction of the HMG-CoA reductase inhibitor lovastatin and nitric oxide in cardiomyocyte cell death. (nih.gov)
  • 18. Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's lymphoma ascites tumor in mice. (nih.gov)
  • This extract contains small amounts of naturally occurring HMG-CoA reductase inhibitors. (naturalnews.com)
Rosuvastatin1
  • In other words you would need theoretically and it doesn't work out exactly but you would need about eight milligrams of lovastatin to equal the effect that you get with one milligram of rosuvastatin. (drmaheshkumar.com)
Concentrations3
  • Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, and may account for the in vivo effect of grapefruit juice concentrate decreasing the metabolic clearance of lovastatin, and increasing its plasma concentrations. (wikipedia.org)
  • Higher concentrations of lovastatin are in the caps then the stems, more concentrated on the mature gills, and especially in the spores. (liquidfungi.com)
  • Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. (naturalnews.com)
Aspergillus3
  • In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk patients were undertaken, in which dramatic reductions in LDL cholesterol were observed, with very few adverse effects. (wikipedia.org)
  • Lovastatin can also be found naturally in Red Yeast Rice and is manufactured commercially from Aspergillus terreus. (funginomi.com)
  • Lovastatin: A high retina known from hours of Aspergillus array. (ajw-service.de)
Inhibitory effect1
  • 9. Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. (nih.gov)
Hypercholesterolemia2
  • Lovastatin is a statin drug, used for lowering cholesterol in those with hypercholesterolemia to reduce risk of cardiovascular disease. (galchimia.com)
  • How do you lower familial hypercholesterolemia naturally? (allclearmister.com)
Merck1
  • Alfred W. Alberts (died on June 16, 2018, at 87) discovered a chemical compound that led to the cholesterol-lowering drug lovastatin in the late 1970s when he was working for Merck. (nih.gov)
Oyster3
King Trumpet1
  • King Trumpet - contains high amounts of ergothioneine, a naturally occurring antioxidant amino acid. (lifesourcevitamins.com)
Rice6
  • The inclusion of lovastatin in red yeast rice and the lack of dietary supplement regulation by the FDA raise safety concerns for health care professionals as well as for patients. (nih.gov)
  • In each of three well-developed research studies, the effects of a putative active ingredient (lovastatin in Chinese Red Yeast Rice, EGCG in Green Tea, Hypericin in St. Johnís wort) will be compared to the combination of compounds (Monacolins, Catechins, Hyperforin/Hypericin) which naturally occur in these botanicals. (nih.gov)
  • Red yeast rice contains naturally-occurring substances called monocolins. (realnaturalremedies.com)
  • One of the main ingredients, Red yeast rice, contains plant sterols (β-sitosterol, Campesterol, Stigmasterol, and Sapogenin) and Lovastatin, which have been found to be very effective in lowering cholesterol to the normal ranges. (johnway.je)
  • Some red yeast rice supplements have been shown to lower cholesterol, because they contain monacolin K. This has the same chemical makeup as lovastatin , a cholesterol-lowering medicine. (healthline.com)
  • But today, red yeast rice supplements are most commonly advertised for lowering cholesterol naturally. (universityhealthnews.com)
Lipitor1
  • Lipitor has appetite loss listed as a potential side effect, this would, naturally, cause weight loss. (rlservice.ru)
Inhibition3
  • 3. Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells. (nih.gov)
  • 13. Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells. (nih.gov)
  • This study sought to investigate the relationship of cholesterol synthesis inhibition by several naturally occurring oxysterols to depression of vascular endothelial cell monolayer barrier function, determined as an increase in albumin transfer across cultured endothelial monolayers. (nih.gov)
Cholesterol levels1
Coenzyme Q103
  • A naturally occurring antioxidant known as Coenzyme Q10 or CoQ10, which is often taken for this purpose, has never been shown in a clinical study to be effective. (ttuhsc.edu)
  • Another key ingredient is CoEnzyme Q10 (CoQ10), also known as Ubiquinone and Ubidecarenone, which is a vitamin-like substance that is naturally produced by the body. (johnway.je)
  • Coenzyme Q10 (CoQ10), a naturally occurring antioxidant, is synthesized in our bodies and is critical for the production of energy, especially in our tissues and organs that have high-energy requirements such as the heart, liver, skeletal muscles. (thecompounder.com)
Acid1
  • Folic acid is a naturally occurring substance that is important for the formation of red and white blood cells. (freezingblue.com)
Dietary1
  • Vitamin D (also referred to as calciferol) is a fat-soluble vitamin that is naturally present in a few foods, added to others, and available as a dietary supplement. (nih.gov)
Sterols2
  • Plant stanols and sterols, also called phytosterols, occur naturally in plant sources such as peanuts, beans, olive oil and peanut oil. (scientificpsychic.com)
  • Sterols and plant sterols (such as beta-sitosterol and sitostanol) are substances that occur naturally in certain plants. (cholesterolfreefoods.com)
Substance1
  • Cholesterol is a fatty substance that occurs naturally in the body. (healthncare.info)
Liver2
  • Patients with liver disease should not take lovastatin. (wikipedia.org)
  • Lovastatin is associated with various adverse effects such as myopathy and abnormal liver function test results, which can lead to serious problems if patients are not monitored and treated. (nih.gov)
Lower3
  • lower it beets lower blood pressure naturally youtube and can create the thinking of being as long as it is the first side effect of the symptoms in blood vessels. (cnrs.fr)
  • Shi Bucun sat down lower your diastolic blood pressure naturally on the ground, shook his dizzy head that had already been hit, couldn't help touching the lovely head of the purple-eyed golden cat, and comforted It's okay, it's okay! (kedirikota.go.id)
  • At how can I lower my blood pressure naturally at home this time, another figure shot from a distance, it was a woman in red, a quasi-holy fifth heaven, beautiful and magnificent Everyone saw the identity of the person who came, this woman was too shocking Yu Qingcheng, why is she here! (kedirikota.go.id)
Doses1
  • Two doses of alpha-blockers for the women naturally produce testosterone levels in the treatment of the second fingers. (brauchfamilychiropractic.com)
Genetically1
  • For now, as the lab manager of a research team led by Professor Clay Wang , he is genetically engineering enzymes that naturally exist in fungi. (usc.edu)
Chemical1
Increase1
  • Where they'll naturally increase their worth in the therapies for asthma are natural. (versal-service.ru)
Higher1
  • 4. Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. (nih.gov)
Treatment2
  • The primary uses of lovastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease. (wikipedia.org)
  • Lowering cholesterol naturally by eating a healthy diet, exercising regularly, not smoking and limiting exposure to secondhand smoke is often the only treatment they need. (allclearmister.com)
Bodies1
  • Most of the chemicals that do not naturally occur in our bodies are typically harmful, regardless of whether they are available "over-the-counter" or not. (scalarlight.co.uk)
Potential2
  • Owing to its potential to disrupt infant lipid metabolism, lovastatin should not be taken while breastfeeding. (wikipedia.org)
  • 12. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach. (nih.gov)
Produce1
  • Some brands of estrogen are also to relieve symptoms of low estrogen in young women who do not produce enough estrogen naturally. (medlineplus.gov)
Doctor1
  • This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on lovastatin should be promptly mentioned to the prescribing doctor. (wikipedia.org)