Biological ProductsLigandsMolecular StructureDrug Screening Assays, AntitumorStereoisomerismAntineoplastic AgentsXenograft Model Antitumor AssaysCyclizationKiller Cells, NaturalMolecular Sequence DataCell Line, TumorSpiro CompoundsPoriferaAmino Acid SequencePolyketide SynthasesCD40 LigandPlant ExtractsMacrolidesPolyketidesDrug DiscoveryStructure-Activity RelationshipMarine BiologyAntibiotics, AntineoplasticChemistry, OrganicStreptomycesModels, MolecularFas Ligand ProteinBiosynthetic PathwaysAlkenesMice, NudeDepsipeptidesChemistry Techniques, SyntheticTumor Cells, CulturedDiterpenesBase SequenceEnediynesProtein BindingInhibitory Concentration 50AlkaloidsPlants, MedicinalMice, Inbred BALB CCombinatorial Chemistry TechniquesMagnetic Resonance SpectroscopyFuransApoptosisNeoplasmsDrug DesignBinding SitesCell LineLeukemia P388Molecular ConformationKineticsDrug Evaluation, PreclinicalLactonesNeoplasms, ExperimentalIndole AlkaloidsNeoplasm TransplantationDose-Response Relationship, DrugMice, Inbred C57BLAquatic OrganismsSignal TransductionMelanoma, ExperimentalCatalysisPyransCell ProliferationSarcoma 180SesquiterpenesRecombinant ProteinsPyronesPhytotherapyTriterpenesCells, CulturedMultigene FamilyAntineoplastic Agents, PhytogenicActinobacteriaPeptide SynthasesPeptides, CyclicEscherichia coliDrug SynergismTerpenesCrystallography, X-RayEpoxy CompoundsChromatography, High Pressure LiquidCell SurvivalPeptide Biosynthesis, Nucleic Acid-IndependentMutationSubstrate SpecificityHalogenationLactamsMembrane GlycoproteinsCloning, MolecularIndolesCancer VaccinesAntibodies, MonoclonalPeptidesCytotoxicity, ImmunologicXanthonesKetonesProtein Structure, TertiarySmall Molecule Libraries