• It is important to note that, unlike digested carbohydrates (in the form of monosaccharides) and proteins (in the form of amino acids), digested lipids (in the form of chylomicrons) bypass the hepatic portal system, avoiding first pass metabolism. (wikipedia.org)
  • Chylomicrons transport lipids absorbed from the intestine to adipose, cardiac, and skeletal muscle tissue, where their triglyceride components are hydrolyzed by the activity of the lipoprotein lipase, allowing the released free fatty acids to be absorbed by the tissues. (wikipedia.org)
  • Once triglyceride stores are distributed, the chylomicron returns APOC2 to the HDL (but keeps APOE), and, thus, becomes a chylomicron remnant, now only 30-50 nm. (wikipedia.org)
  • The hyperchylomicronemia syndrome is a disorder characterized by extreme hypertriglyceridemia, the presence of chylomicrons, and one or more of the following clinical manifestations: eruptive xanthomas, lipaemia retinalis, hepatosplenomegaly, recurrent abdominal pain, and/ or acute pancreatitis. (wikipedia.org)
  • Type I is a rare disorder characterized by severe elevations in chylomicrons and extremely elevated triglycerides, always reaching well above 1000 mg/dL and not infrequently rising as high as 10,000 mg/dL or more. (medscape.com)
  • Chylomicrons are assembled in intestinal mucosal cells from dietary lipids (primarily TAG). (pharmacy180.com)
  • ApoB48 and APOE are important to identify the chylomicron remnant in the liver for endocytosis and breakdown. (wikipedia.org)
  • Patients with a deficiency of LPL or apo C-II show a dramatic accumulation of chylomicrons in the plasma (type I hyperlipoproteinemia, or familial LPL deficiency) even if fasted. (pharmacy180.com)
  • Among the most important metabolic derangements giving rise to impaired metabolism and clearance of chylomicrons and VLDLs are obesity, insulin resistance/metabolic syndrome, and diabetes mellitus (DM). (acc.org)
  • It was shown that oxidized cholesterols markedly delay the clearance of chylomicrons from plasma compared to rats given TG alone, However, there was no difference in the clearance of chylomicrons containing oxidized cholesterols vs. purified cholesterol, although the presence of oxysterols did appear to exacerbate the removal of these particles from circulation. (edu.au)
  • The impaired clearance of chylomicrons containing oxidized cholesterols was not due to impaired lipolysis and slower conversion to the remnant form. (edu.au)
  • The assembly of lipid and lipoprotein components into a chylomicron. (ppdictionary.com)
  • Some of the lipid so released can then be repackaged into nascent VLDL particles and then secreted into the central circulation. (acc.org)
  • Chylomicrons are responsible for delivering lipid derived from dietary and biliary sources to the liver. (acc.org)
  • Dietary oxidized cholesterols are absorbed through the intestine and incorporated into lymph chylomicrons. (edu.au)
  • The aim of this study was to investigate the effect of oxidized cholesterols on the metabolism of nascent chylomicrons in vivo. (edu.au)
  • In conclusion, dietary oxysterols appear to have the potential to adversely affect chylomicron metabolism. (edu.au)