CytokineDifferentiationGenesTumorLymphomaPeripheralBone marrowInfusionAutologousVitroMalignantLymphocytesImmunoTherapyPotentMethodsPhasesPatientsActivationTherapyPresentCommonResultsMacrophagesHelperNewbornTumor cellsMonocytesPeripheral bloodSubsetsAntigenHumoralImmune cellsLineageDifferentially expressedResponsesEliminateProteinsTranscriptionTreatmentPatientHighEffectFunctionStudySpecificComparisonReleaseSignificant
Cytokine2
- IL-4-mediated STAT6 activation induces high levels of transcription of GATA3, a master regulator of Th2 cell differentiation, and enforced expression of GATA3 induces Th2 cytokine expression. (nih.gov)
- Then, we have performed in vitro experiments such as cytokine measurement, effector cell activation, and cytotoxicity against anti-HLA-A2 antibody-expressing target cells. (bvsalud.org)
Differentiation1
Genes2
- However, it remains unclear whether the expression of other Th2-specific genes is induced directly by GATA3. (nih.gov)
- The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
Tumor6
- Background Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a promising immunotherapeutic approach for patients with advanced solid tumors. (bmj.com)
- CD4 + TIL demonstrated an effector T cell response with cytotoxicity toward autologous tumor in a major histocompatibility complex class II-dependent manner. (bmj.com)
- Conclusions Despite methods which often focus on CD8+T cells, our study supports the importance of prospective identification of neoantigen-specific CD4 + T cells within TIL products as they are a potent source of tumor-specific effectors. (bmj.com)
- B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
- If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
- This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Lymphoma5
- Lymphoma b cell. (lookformedical.com)
- Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
- Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
- A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
- Varnimcabtagene autoleucel (var-cel) is an academic anti-CD19 chimeric antigen receptor (CAR) product used for the treatment of non-Hodgkin lymphoma (NHL) in the CART19-BE-01 trial. (bvsalud.org)
Peripheral1
- The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Bone marrow2
- Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
- In the NSG mouse model, A2-CHAR-T cells could identify and eradicate HLA-A2 antibody-producing B cells even when those cells are localized in the bone marrow. (bvsalud.org)
Infusion2
- Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
- While numerous advances have been made, the contribution of neoantigen-specific CD4 + T cells within TIL infusion products remains underexplored and therefore offers a significant opportunity for progress. (bmj.com)
Autologous1
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Vitro2
- Cells grown in vitro from neoplastic tissue. (lookformedical.com)
- A2-CHAR expressing T cells could selectively eliminate HLA-A2 antibody-producing B cells in vitro. (bvsalud.org)
Malignant2
- A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
- Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Lymphocytes2
- They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
- A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
ImmunoTherapy1
- The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Potent1
- CHAR technology generates potent and functional human cytotoxic T cells to target alloreactive HLA class I antibody-producing B cells. (bvsalud.org)
Methods2
- Methods We analyzed infused TIL products from metastatic melanoma patients previously treated with ACT for the presence of neoantigen-specific T cells. (bmj.com)
- METHODS: All consecutive patients receiving CAR T-cell therapy at our institution were prospectively followed-up. (bvsalud.org)
Phases1
- BACKGROUND: We described the real-life epidemiology and causes of infections on the different therapy phases in patients undergoing chimeric antigen receptor (CAR) T-cells directed towards CD19+ or BCMA+ cells. (bvsalud.org)
Patients3
- Here we report updated outcomes of patients with NHL treated with var-cel. (bvsalud.org)
- B-cell recovery was compared with patients with acute lymphoblastic leukaemia (ALL). (bvsalud.org)
- In conclusion, in patients with NHL, the toxicity of var-cel was manageable, while B-cell recovery was significantly prolonged compared to ALL. (bvsalud.org)
Activation1
- It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)
Therapy2
- CONCLUSIONS: Infections after CAR T-cell therapy were frequent. (bvsalud.org)
- We aimed to develop a targeted therapy for DSA desensitization and ABMR, generating T cells with a chimeric HLA antibody receptor (CHAR) that specifically eliminates DSA-producing B cells. (bvsalud.org)
Present1
- Results We discovered that neoantigen-specific TIL clones were predominantly CD4 + T cells and were present in both therapeutic responders and non-responders. (bmj.com)
Common1
- The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
Results1
- These results were validated by paired TCR and single cell RNA sequencing, which elucidated transcriptomic profiles distinct to neoantigen-specific CD4 + TIL. (bmj.com)
Macrophages2
- Once the pathogen is elim- recognition occurs through molecules intracel ular pathogens by activating inated, the innate immune response cal ed pattern recognition receptors, macrophages or cytotoxic T cel s is resolved, al owing restoration of which include Tol -like receptors that then destroy the pathogen. (nih.gov)
- LPS-activated macrophages returned to their inactivated original shape, i.e., they looked like naïve macrophages, through the treatment with high concentrations of cordycepin (40 microg/ml). (researchgate.net)
Helper3
- Depending on the specific cytokines with the pathogen or antigen to gens, and induce clustering and they produce, helper T cel s can fur- activate the response. (nih.gov)
- After activation, CD4+ helper T (Th) cells differentiate into distinct effector subsets. (gsea-msigdb.org)
- Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. (gsea-msigdb.org)
Newborn1
- Diversity of biological molecules in newborn and adult immune cells contributes to differences in cell function and atopic properties. (frontiersin.org)
Tumor cells1
- METHODS: To address this issue, we have developed a 65-kDa multispecific antibody construct, CLN-978, with affinities tuned to optimize the killing of low-CD19 expressing tumor cells. (bvsalud.org)
Monocytes1
- In order to explore the unique miRNA profiling that contribute to altered immune in neonates, we comprehensively analyzed the functional miRNA signatures of eight leukocyte subsets (polymorphonuclear cells, monocytes, CD4 + T cells, CD8 + T cells, natural killer cells, B cells, plasmacytoid dendritic cells, and myeloid dendritic cells) from both neonatal and adult umbilical cord and peripheral blood samples, respectively. (frontiersin.org)
Peripheral blood1
- By using proteomic tools, we identified at least 34 differentially expressed proteins between adult peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs). (frontiersin.org)
Subsets2
- We observed distinct miRNA profiles between adult and neonatal blood leukocyte subsets, including unique miRNA signatures for each cell lineage. (frontiersin.org)
- With this functional approach, we provide intact differential miRNA expression profiling of specific immune cell subsets between neonates and adults. (frontiersin.org)
Antigen2
- Aim: To investigate real-world chimeric antigen receptor (CAR) T-cell therapy treatment patterns. (bvsalud.org)
- This study tracks outcomes in patients with relapsed/refractory large B-cell lymphoma who received chimeric antigen receptor (CAR) T-cell therapy between 2017 and 2020. (bvsalud.org)
Humoral1
- Massachusetts Medical School, immune response, including both cell-mediated and humoral responses. (nih.gov)
Immune cells2
- Interaction between AGE-modified plaque components and immune cells is believed to have an important role in the development of vascular complications in diabetes. (aai.org)
- Differences in the expression of biological molecules in the immune cells of newborns and adults contribute to diverse cell function and atopic properties ( 1 - 5 ). (frontiersin.org)
Lineage1
- This study thus demonstrates that Tfh is a distinct Th cell lineage. (gsea-msigdb.org)
Differentially expressed1
- Mono Mac 6 cells revealed the highest fraction of differentially expressed genes, dominated by up-regulation of various cytokines and chemokines. (nih.gov)
Responses1
- Although alcohol can alter the is professor and vice chair for actions of all cell populations involved in the innate and adaptive immune responses, the effect in many cases is a subclinical immunosuppression that becomes clinically research in the Department relevant only after a secondary insult (e.g., bacterial or viral infection or other tissue of Medicine, associate dean damage). (nih.gov)
Eliminate2
- The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
- RESULTS: Human T cells redirected by CLN-978 could eliminate target cells expressing less than 300 copies of CD19 on their surface. (bvsalud.org)
Proteins1
- BEAS-2B cells revealed weaker changes in a limited set of inflammatory response proteins. (nih.gov)
Transcription1
- Tfh cell generation was regulated by ICOS ligand (ICOSL) expressed on B cells and was dependent on interleukin-21 (IL-21), IL-6, and signal transducer and activator of transcription 3. (gsea-msigdb.org)
Treatment1
- The study describes where patients received CAR T-cell therapy (inpatient/outpatient), rates of adverse events potentially related to CAR T-cell treatment and how much healthcare the patients received. (bvsalud.org)
Patient2
- Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
- Patient & methods: Relapsed/refractory large B-cell lymphoma patients who received CAR T-cell therapy were identified. (bvsalud.org)
High1
- BACKGROUND: Despite significant progress in the development of T cell-engaging therapies for various B-cell malignancies, a high medical need remains for the refractory disease setting, often characterized by suboptimal target levels. (bvsalud.org)
Effect2
- In the present study, we characterized an indoor dust sample representative for German households and investigated its effect on human airway cells. (nih.gov)
- To explore the effect of IL-6 on the activity and secretory function of B cells and analyze its effect on clinical indicators and efficacy in wAIHA patients. (bvsalud.org)
Function1
- Moreover, we observed a decrease in adenosine deaminase and an increase in arginase-1 in neonatal mononuclear cells (MNCs), which was associated with impaired immune function ( 6 ). (frontiersin.org)
Study1
- Our goal in this study was to describe the effects of indoor dust on human monocyte, epithelial, and lymphocyte cell lines. (nih.gov)
Specific1
- Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
Comparison1
- Genes up-regulated in comparison of Th1 cells versus Th17 cells. (gsea-msigdb.org)
Release1
- In primates, we observed a long serum half-life, deep and sustained depletion of normal B cells, and remarkable tolerability, in particular, reduced cytokine release when CLN-978 was administered subcutaneously. (bvsalud.org)
Significant1
- No significant changes were observed in Jurkat cells. (nih.gov)