• Insulin
  • The changes in insulin resistance are discussed in relation to cellular membrane changes present in myotonic dystrophy. (cun.es)
  • Toxic RNA can lead to a vast range of medical effects including those of insulin resistance, tumors, muscular wasting seen in myotonic dystrophies, impairment of motor skills seen in FXTAS, a variety neurodegenerative syndromes, and more. (wikipedia.org)
  • therapeutic
  • Global Markets Direct's, 'Myotonic Dystrophy-Pipeline Review, H1 2015', provides an overview of the Myotonic Dystrophy's therapeutic pipeline. (kenresearch.com)
  • This report provides comprehensive information on the therapeutic development for Myotonic Dystrophy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. (kenresearch.com)
  • It also reviews key players involved in the therapeutic development for Myotonic Dystrophy and special features on late-stage and discontinued projects. (kenresearch.com)
  • aims
  • Treatment of myotonic muscular dystrophy aims to prevent deformity of the spine and joints to maintain the patient's ability to walk and keep him physically and emotionally healthy, explains the University of Maryland Medical Center. (reference.com)
  • Antisense
  • Antisense therapy can reverse some aspects of myotonic dystrophy (DM): That's the conclusion from a new study in a mouse model, reported in the July 17 issue of Science . (lww.com)
  • There are currently no established treatments, but, one study, focused on myotonic dystrophy type 1, suggests that the use of antisense oligonucleotides (ASOs) known as gapmers can aid in decreasing the mutant RNA repeat transcripts. (wikipedia.org)
  • distinct
  • This new edition retains the same successful structure, but now includes new material on the recognition of the distinct 'type 2 myotonic dystrophy', which had only just been identified at the time of the first edition. (ebooks.com)
  • Now, Laura Ranum, of the University of Minnesota, Minneapolis, and colleagues have revealed that a clinically similar, but genetically distinct type of myotonic dystrophy, DM2, is caused by an expansion of repeat sequence on chromosome 3. (genomenewsnetwork.org)