SynthaseCholineProteinsEnzymeHexakisphosphateMonophosphataseGlucose-6-phosphaBiosynthesisMetabolismCalciumPathwayMorphologySignificantly decreasedIsomersHydroxyPhosphataseBindCyclitolsPhosphoinositideMetabolicInhibitionPhosphorylationSerumPhosphatidylinositolSignal TransductionProteinGeneInvestigationStudiesEffectsActivityAdditionGroupsConfiguration
Synthase5
- Unlike lithium, valproate causes a decrease in intracellular inositol-1-phosphate as well, suggesting that myo-inositol-1-P (MIP) synthase is a site of valproate action in the yeast PI cycle. (bgu.ac.il)
- MIP synthase is the rate-limiting step in inositol biosynthesis and is highly regulated in response to inositol. (bgu.ac.il)
- Reduced inositol content and altered morphology in transgenic potato plants inhibited for 1D-myo-inositol 3-phosphate synthase. (mpg.de)
- Using proteomics, the enzymes that constitute the MIB pathway, myo-inositol phosphate synthase (MIPS) and inositol monophosphatase 1 (IMPA1), are identified in tilapia (Oreochromis mossambicus) gill epithelium. (nih.gov)
- it can also be synthesized by the enzyme MIP-synthase (myo-inositol-1-phosphate synthase) and, in addition, it is generated by inositol phospholipid hydrolysis. (ox.ac.uk)
Choline1
- Second, choline-phosphate cytidylyltransferase, localized to the endoplasmic reticulum membrane, catalyzes the conversion of phosphocholine to CDP-choline. (smpdb.ca)
Proteins4
- Under non-pathological conditions, surges of plasma phosphate or calcium, or local drops in the concentration of circulating calcification inhibitors are buffered by acidic serum proteins, notably fetuin-A, via the formation of colloidal calciprotein particles (CPPs) 19 . (nature.com)
- The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
- Tissue damage also may result in denatured proteins that preferentially bind phosphate. (medscape.com)
- Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. (nih.gov)
Enzyme6
- 1L-myo-inositol 1-phosphate cytidylyltransferase (EC 2.7.7.74, CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)), IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS)), L-myo-inositol-1-phosphate cytidylyltransferase) is an enzyme with systematic name CTP:1L-myo-inositol 1-phosphate cytidylyltransferase. (wikipedia.org)
- This enzyme catalyses the following chemical reaction CTP + 1L-myo-inositol 1-phosphate ⇌ {\displaystyle \rightleftharpoons } diphosphate + CDP-1L-myo-inositol This enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate. (wikipedia.org)
- In this investigation, a potentially novel signaling pathway in gentamicin-induced acute kidney injury-worsened by overexpression of proximal tubular enzyme, myo -inositol oxygenase (MIOX)-was elucidated. (jci.org)
- The enzyme has very low activity with L-galactose 1-phosphate (cf. (cathdb.info)
- An enzyme that catalyzes the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the presence of NAD. (nih.gov)
- A parallel Kennedy pathway forms phosphatidylethanolamine from ethanolamine - the only difference being a different enzyme, ethanolamine-phosphate cytidylyltransferase, catalyzing the second step. (smpdb.ca)
Hexakisphosphate2
- Myo -inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. (nature.com)
- As an animal feed additive used in poultry and swine, it can enhance the nutritive value by liberation of inorganic phosphate from phytic acid (myo-inositol hexakisphosphate) , thereby, reduce phosphorus pollution to the environment. (enzymes.bio)
Monophosphatase4
- It has been shown that lithium inhibits yeast inositol monophosphatase (encoded by INM1 and INM2), and both valproate and lithium reduce intracellular inositol. (bgu.ac.il)
- It has also been reported previously that both lithium and inositol mildly up-regulate IMPA1 (encoding mammalian inositol monophosphatase) expression in human cells. (bgu.ac.il)
- Given the substantial evidence for the role of inositol in the mechanism of action of lithium and valproate, the opposing and mild effects of lithium on the genes encoding inositol monophosphatase in yeast and human cells, but the powerful effect of lithium and valproate on INO1 in yeast, it is hypothesized that human hINO1 is a factor in the psychopharmacology of mood stabilizers. (bgu.ac.il)
- Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis. (cathdb.info)
Glucose-6-phospha1
- The myo-inositol biosynthesis (MIB) pathway converts glucose-6-phosphate to the compatible osmolyte myo-inositol that protects cells from osmotic stress. (nih.gov)
Biosynthesis1
- Salinity-induced regulation of the myo-inositol biosynthesis pathway in tilapia gill epithelium. (nih.gov)
Metabolism4
- Inositol metabolism is well characterized in yeast at a molecular level, and yeast is the only eukaryote in which genetic, molecular and functional genomic approaches to identify lithium, valproate and inositol targets may be combined readily. (bgu.ac.il)
- Disturbance of inositol availability or metabolism is associated with various disorders, including neurological conditions and cancers, while supplemental MI has therapeutic potential in conditions such as depression, polycystic ovary syndrome and congenital anomalies. (nih.gov)
- Lithium is a potent noncompetitive inhibitor of inositol monophosphatases, enzymes involved in phosphoinositide (PI) and inositol phosphate metabolism. (elsevierpure.com)
- One gene involved in PI metabolism that maps to a region of interest is 10p12-linked PIP5K2A, a member of the phosphatidylinositol 4-phosphate 5-kinase family. (elsevierpure.com)
Calcium10
- Vascular calcification (VC) is the consequence of pathological deposition of calcium phosphate mineral in soft tissues 1 . (nature.com)
- Several factors govern the calcification process in the vessel wall microenvironment, acting to promote or inhibit calcification in conjunction with local precipitation of calcium and phosphate 8 . (nature.com)
- Primary CPPs (CPP1) are spherical complexes of amorphous calcium and phosphate with fetuin-A with a hydrodynamic radius ( R h ) of less than 100 nm 20 . (nature.com)
- The nanoparticles formed prevent precipitation of calcium and phosphate (i.e., hydroxyapatite formation) 21 . (nature.com)
- Water status, calcium level, glutathione reductase activities increased in myo-inositol treated Capsicum annuum L. (pepper) under drought stress. (deepdyve.com)
- These calcium salts consist primarily of hydroxyapatite crystals or amorphous calcium phosphate. (medscape.com)
- Ectopic calcification can occur in the setting of hypercalcemia and/or hyperphosphatemia when the calcium-phosphate product exceeds 70 mg2/dL2, without preceding tissue damage. (medscape.com)
- These elevated extracellular levels may result in increased intracellular levels, calcium-phosphate nucleation, and crystalline precipitation. (medscape.com)
- Calcium then reacts with bound phosphate ions leading to precipitation of calcium phosphate. (medscape.com)
- Dystrophic calcification occurs in the setting of normal serum calcium and phosphate levels. (medscape.com)
Pathway1
Morphology1
- Furthermore, mood-stabilizing drugs inhibit key enzymes that regulate phosphoinositide production and alter neuronal growth cone morphology in an inositol-reversible manner. (ox.ac.uk)
Significantly decreased1
- Exogenous myo-inositol significantly decreased H2O2, membrane damage and proline levels and AP (except for 5 µM) and CAT activity, compared with untreated plants. (deepdyve.com)
Isomers2
- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. (cathdb.info)
- The group of inositols consists of nine isomers which differ with respect configuration at the carbons. (sichem.de)
Hydroxy1
- The (+) and (-)-chiro-inositols have two axial hydroxy groups, are optically active and form the only pair of enantiomers. (sichem.de)
Phosphatase3
- D-galactose 1-phosphate phosphatase. (cathdb.info)
- Inositol-phosphate phosphatase. (cathdb.info)
- 2021. Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. (nih.gov)
Bind1
- The HDX-MS data showed that both substrates uridine diphosphate glucose-N-acetylglucosamine (UDP-GlcNAc) and 1-L-myo-inositol-1-phosphate (I1P) can bind to CgMshA independently, but the I1P binding is not productive since it binds to an uncorrect site. (ua.edu)
Cyclitols2
- Ünyayar, Serpil 2018-05-29 00:00:00 Drought-stressed plants accumulate cyclitols such as myo-inositol, pinitol, quercitol in the cytosol. (deepdyve.com)
- Inositols belong to the cyclitols. (sichem.de)
Phosphoinositide1
- Investigation of the H(+)-myo-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling. (ox.ac.uk)
Metabolic3
- Objective To our knowledge, data on comparison of myo-inositol and metformin on clinical, metabolic and genetic parameters in subjects with polycystic ovary syndrome (PCOS) are limited. (medscape.com)
- This study was carried out to compare myo-inositol and metformin on clinical, metabolic and genetic parameters in subjects with PCOS. (medscape.com)
- [ 14 ] The aim of this study, therefore, was to compare myo-inositol and metformin on clinical, metabolic and genetic parameters in these patients. (medscape.com)
Inhibition1
- 2. Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling. (nih.gov)
Phosphorylation2
- The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. (antibodies-online.com)
- Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. (nih.gov)
Serum2
- Conclusions Overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-α. (medscape.com)
- We initiated a program to investigate prospectively serum metabolites associated with cancer risk, and found strong inverse associations between energy and lipid metabolites and aggressive prostate cancer, including for inositol-1-phosphate, glycerophospholipids and fatty acids, as well as TCA cycle compounds alpha-ketoglutarate and citrate. (nih.gov)
Phosphatidylinositol1
- This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. (antibodies-online.com)
Signal Transduction1
- Myo-inositol can play a role as effective as proline in signal transduction and in regulating concentrations of reactive oxygen species within tolerable ranges and in maintaining cell turgor by binding water molecules. (deepdyve.com)
Protein1
- The replacement of refined wheat flour with amaranth flour significantly enhanced the nutritional bread value resulting in high protein, mineral, fiber, and myo-inositol phosphates content of the final product 8 - 9 . (researchsquare.com)
Gene2
- 001). RT-PCR demonstrated that compared with metformin, myo-inositol downregulated gene expression of interleukin-1 (IL-1) ( P =.02) in PBMCs of subjects with PCOS. (medscape.com)
- We did not observe any significant effect of myo-inositol intake compared with metformin on other hormonal profiles, plasma nitric oxide (NO) or gene expression of IL-8 and tumour necrosis factor alpha (TNF-α). (medscape.com)
Investigation3
- Most drug candidates currently under clinical investigation for VC (e.g., bisphosphonates, phosphate-binders, vitamin K, or magnesium) act by correcting the imbalance of calcification promoters (i.e., hyperphosphatemia) and inhibitors in VC-affected individuals. (nature.com)
- Synthetic myo-inositol was used in the investigation of drought stress tolerance in pepper plants. (deepdyve.com)
- The neuronal-specific HMIT (H(+)-myo-inositol transporter) represents a potential regulator of inositol signalling in neurons that warrants further investigation. (ox.ac.uk)
Studies2
- A few studies have reported beneficial effects of myo-inositol on insulin sensitivity, androgens [ 8 ] and inflammatory markers. (medscape.com)
- Complexation studies on inositol-phosphates III. (nih.gov)
Effects2
- [ 10 ] In contrast to metformin, no side effects have been reported following treatment with myo-inositol. (medscape.com)
- Myo-inositol may become a useful instrument to eliminate the negative effects of drought environments. (deepdyve.com)
Activity2
- Here we report the design of a series of inositol phosphate analogs as crystallization inhibitors, among which 4,6-di- O -(methoxy-diethyleneglycol)- myo -inositol-1,2,3,5-tetrakis(phosphate), (OEG 2 ) 2 -IP4, displays increased in vitro activity, as well as more favorable pharmacokinetic and safety profiles than IP6 after subcutaneous injection. (nature.com)
- Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells. (nih.gov)
Addition1
- [ 9 ] In addition, myo-inositol intake improved reproductive axis functioning in patients with PCOS, reducing the hyperinsulinaemic state. (medscape.com)
Groups1
- Subjects were randomly allocated into two groups to receive either myo-inositol (N=30) or metformin (N=30) for 12 weeks. (medscape.com)