• protein
  • Biologists and physicians were able to identify the individual building blocks that make up each myofibril (including the largest protein molecules in the world) and how they are arranged in the finished myofibril. (idw-online.de)
  • To confirm that the homologous recombination event resulted in a allele for protein expression, myofibrils were purified from tibialis anterior, which in +/+ mice expresses high levels of MyHC-IId/x and IIb. (nih.gov)
  • For protein structures inside cells, see Myofibril . (wikipedia.org)
  • titin
  • Accordingly, the results of mechanical measurements demonstrated that competition with native titin by recombinant titin fragments from Z-disc-remote, I-band or A-band regions did not affect passive myofibril stiffness. (uni-bielefeld.de)
  • These results indicate that it is actin-titin association near the Z-disc, but not along the remainder of the sarcomere, that helps to anchor the titin molecule at its N-terminus and maintain a high stiffness of the relaxed cardiac myofibril. (uni-bielefeld.de)
  • results indicate
  • Our results indicate that by incorporating various myofibril inhomogeneities such as skew and domain effect in the theoretical model, a variety of observations in single fiber diffraction under different experimental conditions can be reproduced in the simulation. (osapublishing.org)
  • Spontaneous
  • These new findings are implemented into the computer models again, so that a comprehensive understanding of the physical mechanisms of spontaneous assembly of the myofibrils can be obtained step by step. (idw-online.de)
  • structures
  • For the first time, it is now possible to investigate how the formation of regular structures and the generation of mechanical forces go hand in hand during the self-assembly of myofibrils. (idw-online.de)
  • mechanisms
  • These findings are the first to implicate a functional role of dusp27 as a gene required for myofiber maturation and provide an animal model for analyzing the mechanisms governing myofibril assembly. (biologists.org)
  • Formation
  • Based on the biological data, computer models will be developed that map different variants for the pattern formation process of myofibrils. (idw-online.de)
  • mature
  • In mature myofibrils, a scaffold of elastic biofilaments alternates with so-called molecular motors that convert chemical energy into mechanical work. (idw-online.de)
  • length
  • Based on the framework of sliding-filament theory and on the cross-bridges dynamics, a mathematical model for the simulation of the force response and length change of individual myofibril is presented. (springer.com)
  • individual
  • However, how the individual building blocks of myofibrils arrange themselves into such highly regular patterns during embryonic development or during healing processes (e.g. after sports injuries) is still a matter of controversy in science. (idw-online.de)
  • development
  • A study of the developing leg muscle in a 12-day chick embryo using electron microscopy proposes a mechanism for the development of myofibrils. (wikipedia.org)
  • A model experiment is described which demonstrates the importance of the rate of tension development in causing myofibril splitting. (biologists.org)
  • presence
  • Myofibrils which lengthen by several per cent in the presence of ATP and magnesium ions were prepared by teasing indirect flight muscle of Drosophila in solutions containing ethylenediaminetetraacetate. (rupress.org)