• ventricular
  • Under conditions in which cationic inward rectifier channels were blocked, membrane hyperpolarization (−40 to −140 mV) activated an inwardly rectifying whole-cell current in mouse atrial and ventricular myocytes. (ahajournals.org)
  • Reverse transcription polymerase chain reaction and Northern blot analysis confirmed transcriptional expression of ClC-2 in both atrial and ventricular tissues and isolated myocytes of mouse and guinea pig hearts. (ahajournals.org)
  • Ventricular myocyte number increased 156% from day 1 to day 42. (physiology.org)
  • With loss of cardiac cells increasing progressively, infected individual will experience abnormalities in left ventricular systolic and diastolic function, as well as electrical conduction defects manifesting as cardiac dysrhythmias. (wikipedia.org)
  • tissues
  • Decreased lesions in cardiac tissues, reduced cell necrosis, and diminished inflammatory responses are observed in sCAR-Fc treated cells (CITE). (wikipedia.org)
  • Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human embryonic stem cells (hESCs) and, more recently, human induced pluripotent stem cells (hiPSCs) to differentiate into human cardiomyocytes. (wikipedia.org)
  • Interest in these bioengineered cardiac tissues has risen due to their potential use in cardiovascular research and clinical therapies. (wikipedia.org)
  • These tissues provide a unique in vitro model to study cardiac physiology with a species-specific advantage over cultured animal cells in experimental studies. (wikipedia.org)
  • calcium
  • Intracellular calcium homeostasis in cardiac myocytes. (ahajournals.org)
  • Calcium homeostasis in cardiac myocytes results from the integrated function of transsarcolemmal Ca2+ influx and efflux pathways modulated by membrane potential and from intracellular Ca2+ uptake and release caused predominantly by SR function. (ahajournals.org)
  • Modulation of cardiac rate and contraction through calcium-dependent and independent means are of central import to the ability of an organism to adapt to its environment. (bl.uk)
  • In cardiac myocytes, NAADP is thought to stimulate calcium release from acidic stores which then bolsters filling and release during CICR. (bl.uk)
  • In contractile myocytes, photorelease of NAADP caused significant increase in calcium transient amplitude and velocity of transient upstroke and decay. (bl.uk)
  • These studies were further supported by those performed in isolated, skinned cardiac muscle fibers, showing that in vitro phosphorylation of cTnI by PKCε or Serine-43/45 mutation to Glutamate to mimic phosphorylation desensitized myofilaments to calcium and decreased maximal tension and filament sliding speed. (wikipedia.org)
  • G protein-gated ion channels are primarily found in CNS neurons and atrial myocytes, and affect the flow of potassium (K+), calcium (Ca2+), sodium (Na+), and chloride (Cl−) across the plasma membrane. (wikipedia.org)
  • Intracellular
  • While at Brigham and Women's Hospital and Harvard Medical School he worked with Thomas Woodward Smith, MD, Chief of Cardiovascular Medicine and Professor of Medicine, Harvard Medical School and Ralph A Kelly, MD. At that time he worked as a part of a team to tease out the intracellular cell signaling pathways in response to a paracrine growth factor Neuregulin-1 in the cardiac myocyte. (wikipedia.org)
  • pathways
  • the activation of oxidative stress pathways in utero can program for cardiac dysfunction in adulthood such as responses to ischemia/reperfusion, cardiac function, coronary flow, and hypertension [ 4 - 7 ]. (hindawi.com)
  • atrial
  • G protein-gated ion channels are a family of transmembrane ion channels in neurons and atrial myocytes that are directly gated by G proteins. (wikipedia.org)
  • Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt-water balance and blood pressure. (wikipedia.org)
  • ischemia
  • PF is an ultrafiltrate of plasma, 18 but it also reflects the composition of cardiac interstitium, at least in cardiac ischemia, 19 and the production and release of macromolecules (including growth factors) in normal and diseased myocardium. (ahajournals.org)
  • Adenovirus
  • Internalization of the virus into myocytes occurs by binding to coxsackievirus-adenovirus receptors (CAR) located in tight junctions on cell membranes. (wikipedia.org)
  • vivo
  • Incubation of myocytes with exoenzyme C3 for 48 hours completely ADP-ribosylated Rho in vivo. (ahajournals.org)
  • We provide direct evidence for the first time of in vivo myocyte division in 6-wk-old chicken hearts. (physiology.org)
  • To test the role of Smad5 specifically in cardiac myocytes in vivo, and to circumvent embryonic lethality and extrinsic defects seen in Smad5-null mice, we generated a cardiac-specific deletion of Smad5 using the Cre/lox system. (ahajournals.org)
  • sarcomeric
  • In conclusion, mice with cardiac-specific deletion of Smad5 develop dilated cardiomyopathy and heart failure as a result of sarcomeric disarray and myocyte disruption. (ahajournals.org)
  • In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. (wikipedia.org)
  • myocardium
  • 22 However, whether human PF contains growth factors and peptides specifically synthesized within the myocardium and whether its characteristics reflect cardiac adaptation to chronic overload have not yet been established. (ahajournals.org)
  • Moreover, peak concentrations of T cells in the myocardium during days 7-14 play important roles in both viral clearance and immune mediated cardiac damage. (wikipedia.org)
  • cell
  • An automated method measuring cardiac myocyte surface area was described and used as an index of cell growth. (cdc.gov)
  • Here, we review the current knowledge in the field focusing on the withdrawal of cardiac myocytes from the cell cycle during the transition from neonatal to adult stages. (ahajournals.org)
  • Average cell volume increased more than 400%, and myocytes lengthened 125%, but cell width only increased 53% during this period. (physiology.org)
  • In order to evaluate their presence and biological activity, we studied the effect of PF and serum obtained from patients undergoing cardiac surgery on the phenotype and cell growth of isolated adult rat myocytes. (ahajournals.org)
  • In many of these disorders, particularly those leading to chronic heart failure, myocyte cell death/loss is usually accompanied by an increase in fibrous tissue content (1). (springer.com)
  • A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue. (wikipedia.org)
  • The cell membrane of a myocyte has several specialized regions, which may include the intercalated disk and the transverse tubular system. (wikipedia.org)
  • Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. (wikipedia.org)
  • proteins
  • For characterization of the growth pattern of cardiac myocytes during posthatching development, cardiac myocytes were enzymatically isolated from the ventricles of 1-, 15-, 29-, and 42-day-old chickens for measurement of myocyte nucleation, length, width, volume, and number, and for immunolabeling of cytoskeletal proteins. (physiology.org)
  • heart
  • Oxidative stress has been clinically shown to be relevant in the progression of cardiac diseases and heart failure [ 1 , 2 ]. (hindawi.com)
  • Coxsackievirus B3 can cause cardiac damage, eventually resulting in a weakened and enlarged heart that is termed dilated cardiomyopathy. (wikipedia.org)
  • hECTs also express key cardiac genes (α-MHC, SERCA2a and ACTC1) nearing the levels seen in the adult heart. (wikipedia.org)
  • This is journal is known for editorials championing novel and esoteric mechanisms pertaining to cardiac function including 'The Heart as the Concertina Pump' and suggesting that stiffness of the great arteries contribute to cardiorenal syndrome. (wikipedia.org)
  • rats
  • The increased activity of pyruvate dehydrogenase (PDH) kinase induced in hearts of rats by starvation for 48 h was maintained following preparation of cardiac myocytes, and it was also maintained, though at a decreased level, after 25 h of culture in medium 199. (biochemj.org)
  • The PDH kinase activity of myocytes from fed rats was increased to that of starved rats after 25 h of culture with n-octanoate, dibutyryl cyclic AMP or both agents together. (biochemj.org)
  • prevents
  • This irreversible reaction prevents the virus from interacting with cellular receptors (CAR) on cardiac cells, decreasing infectivity of CVB3. (wikipedia.org)