• ventricular
  • Under conditions in which cationic inward rectifier channels were blocked, membrane hyperpolarization (−40 to −140 mV) activated an inwardly rectifying whole-cell current in mouse atrial and ventricular myocytes. (ahajournals.org)
  • Reverse transcription polymerase chain reaction and Northern blot analysis confirmed transcriptional expression of ClC-2 in both atrial and ventricular tissues and isolated myocytes of mouse and guinea pig hearts. (ahajournals.org)
  • Ventricular myocyte number increased 156% from day 1 to day 42. (physiology.org)
  • With loss of cardiac cells increasing progressively, infected individual will experience abnormalities in left ventricular systolic and diastolic function, as well as electrical conduction defects manifesting as cardiac dysrhythmias. (wikipedia.org)
  • tissues
  • Decreased lesions in cardiac tissues, reduced cell necrosis, and diminished inflammatory responses are observed in sCAR-Fc treated cells (CITE). (wikipedia.org)
  • Human engineered cardiac tissues (hECTs) are derived by experimental manipulation of pluripotent stem cells, such as human embryonic stem cells (hESCs) and, more recently, human induced pluripotent stem cells (hiPSCs) to differentiate into human cardiomyocytes. (wikipedia.org)
  • Interest in these bioengineered cardiac tissues has risen due to their potential use in cardiovascular research and clinical therapies. (wikipedia.org)
  • These tissues provide a unique in vitro model to study cardiac physiology with a species-specific advantage over cultured animal cells in experimental studies. (wikipedia.org)
  • Intracellular
  • While at Brigham and Women's Hospital and Harvard Medical School he worked with Thomas Woodward Smith, MD, Chief of Cardiovascular Medicine and Professor of Medicine, Harvard Medical School and Ralph A Kelly, MD. At that time he worked as a part of a team to tease out the intracellular cell signaling pathways in response to a paracrine growth factor Neuregulin-1 in the cardiac myocyte. (wikipedia.org)
  • pathways
  • the activation of oxidative stress pathways in utero can program for cardiac dysfunction in adulthood such as responses to ischemia/reperfusion, cardiac function, coronary flow, and hypertension [ 4 - 7 ]. (hindawi.com)
  • stimuli
  • Although Rho-family small G proteins have been implicated in actin organization in many cell types, it is not fully elucidated whether Rho mediates the organization of actin fibers by hypertrophic stimuli in cardiac myocytes. (ahajournals.org)
  • proteins
  • To date, at least seven different PDE4 proteins encoded in the four PDE4 genes have been detected in cardiac cells. (springer.com)
  • These PDE4s are targeted to different subcellular compartments of cardiac myocytes through interaction with several classes of scaffold proteins. (springer.com)
  • For characterization of the growth pattern of cardiac myocytes during posthatching development, cardiac myocytes were enzymatically isolated from the ventricles of 1-, 15-, 29-, and 42-day-old chickens for measurement of myocyte nucleation, length, width, volume, and number, and for immunolabeling of cytoskeletal proteins. (physiology.org)
  • In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. (wikipedia.org)
  • G protein-gated ion channels are a family of transmembrane ion channels in neurons and atrial myocytes that are directly gated by G proteins. (wikipedia.org)
  • atrial
  • Corin converts the atrial natriuretic peptide (ANP) precursor, pro-ANP, to mature ANP, a cardiac hormone that regulates salt-water balance and blood pressure. (wikipedia.org)
  • ischemia
  • PF is an ultrafiltrate of plasma, 18 but it also reflects the composition of cardiac interstitium, at least in cardiac ischemia, 19 and the production and release of macromolecules (including growth factors) in normal and diseased myocardium. (ahajournals.org)
  • myocardium
  • 22 However, whether human PF contains growth factors and peptides specifically synthesized within the myocardium and whether its characteristics reflect cardiac adaptation to chronic overload have not yet been established. (ahajournals.org)
  • Moreover, peak concentrations of T cells in the myocardium during days 7-14 play important roles in both viral clearance and immune mediated cardiac damage. (wikipedia.org)
  • function
  • Of the 11 families of phosphodiesterases found in the human genome, three decades of pharmacological data have clearly implicated PDE3 in cardiac function. (springer.com)
  • 1,2 Both coronary vascular and endocardial endothelium release several diffusible agents that acutely modify cardiac myocyte function. (ahajournals.org)
  • Delivery of Ccna2 into cardiac tissue invokes a regenerative response and markedly enhances cardiac function. (wikipedia.org)
  • Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. (wikipedia.org)
  • This is journal is known for editorials championing novel and esoteric mechanisms pertaining to cardiac function including 'The Heart as the Concertina Pump' and suggesting that stiffness of the great arteries contribute to cardiorenal syndrome. (wikipedia.org)
  • troponin
  • Brunton LL, Hayes JS, Mayer SE (1979) Hormonally specific phosphorylation of cardiac troponin I and activation of glycogen phosphorylase. (springer.com)
  • Treatment of myocytes with Ang II caused a rapid formation of both striated (mature myofibrils) and nonstriated (premyofibrils) actin fibers within 30 minutes, as determined by phalloidin stainings of the polymerized actin and troponin T stainings. (ahajournals.org)
  • cell
  • An automated method measuring cardiac myocyte surface area was described and used as an index of cell growth. (cdc.gov)
  • Average cell volume increased more than 400%, and myocytes lengthened 125%, but cell width only increased 53% during this period. (physiology.org)
  • A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue. (wikipedia.org)
  • The cell membrane of a myocyte has several specialized regions, which may include the intercalated disk and the transverse tubular system. (wikipedia.org)
  • Internalization of the virus into myocytes occurs by binding to coxsackievirus-adenovirus receptors (CAR) located in tight junctions on cell membranes. (wikipedia.org)
  • heart
  • Oxidative stress has been clinically shown to be relevant in the progression of cardiac diseases and heart failure [ 1 , 2 ]. (hindawi.com)
  • Coxsackievirus B3 can cause cardiac damage, eventually resulting in a weakened and enlarged heart that is termed dilated cardiomyopathy. (wikipedia.org)
  • scaffold
  • This 3D scaffold, along with collagen - a major component of the cardiac extracellular matrix - provides the appropriate conditions to promote cardiomyocyte organization, growth and differentiation. (wikipedia.org)
  • interaction
  • It has been demonstrated that altering the dynamics of the RACK2 and RACK1 interaction with PKCε can influence cardiac muscle phenotypes. (wikipedia.org)
  • prevents
  • This irreversible reaction prevents the virus from interacting with cellular receptors (CAR) on cardiac cells, decreasing infectivity of CVB3. (wikipedia.org)