Myocardium oxygen consumption. Medical search. Frequent questions

In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)

Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
If pressures are too low in the coronary vasculature, then the myocardium risks ischemia (restricted blood flow) with subsequent myocardial infarction or cardiogenic shock. (wikipedia.org)
Puerarin can also significantly reduce the production of myocardial lactic acid caused by ischemia, and improve the metabolism of infarcted myocardium. (sanxinherbs.com)
The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death ( infarction ) of heart muscle tissue ( myocardium ). (medicalxpress.com)
Trimetazidine-Teva is an anti-hypoxic drug stimulating the metabolism of the myocardium and sensorineural organs in case of ischemia. (cosmicnootropic.com)

Supports contractility of the myocardium, prevents the decrease in intracellular content of ATP and phosphocreatine. (lekarstwo.ru)
In addition treatment with T. terrestris decreased the leakage of CK-MB and LDH enzymes from myocardium, there was a significant improvement in cardiac function as evidenced by correction of MAP, HR, LVEDP and contractility and relaxation. (scialert.net)
3) Do interventions that decrease dT/T improve contractility without increasing myocardial oxygen consumption and/or ATP utilization? (upenn.edu)
The therapy is aimed at increased contractility while decreasing afterload and includes β 1 -adrenergic agents and phosphodiesterase III inhibitors, which act by increasing the intracellular calcium (Ca) concentration, thus markedly increasing myocardial energy consumption and risk of arrhythmias. (biomedcentral.com)
Trimetazidine can stimulate the metabolism of cardiomyocytes and brain neuronal cells , thereby stabilizing oxygen consumption and myocardial contractility. (cosmicnootropic.com)

This finding shows that ischemic but noninfarcted myocardium can exist in a state of hibernation without cell death. (medscape.com)
If CPP can not be maintained at a high enough pressure, the coronary arteries and underlying myocardium become ischemic. (wikipedia.org)
Many modifying factors may influence the absolute time periods of salvage ability (collaterals, intermittent occlusion, myocardial oxygen consumption, ischemic preconditioning, persistence of residual blood flow, recruitment of collaterals, hibernating). (thoracickey.com)

Thioredoxin-interacting protein (Txnip) is a regulator of metabolism and an inhibitor of the antioxidant thioredoxins, but little is known about its roles in the myocardium. (jci.org)
Deletion of Txnip in the myocardium results in mitochondrial dysfunction with decreased expression of transcripts encoding mitochondrial metabolism. (jci.org)
FFAs overload results in a switch in myocardial substrate utilization, causing changes in myocardial energy metabolism and an increase in baseline oxygen consumption. (fortunejournals.com)
We investigated the role of oxygen flux in the patient with T2DM and HFpEF extending beyond the heart with focuses on cellular metabolism, perivascular fibrosis with endothelial dysfunction, hematologic changes, and renal effects with neurohormonal considerations in the patient with HFpEF and T2DM. (uthscsa.edu)
The purpose of this report is to describe the contribution of propionate as an adjunct source of oxidative metabolism in aerobic myocardium. (lvhn.org)
Notably, all hypoxic and PHDI-preconditioned CDCs had decreased oxygen consumption and increased glycolytic metabolism. (ox.ac.uk)

As time from symptom onset (artery occlusion) to reperfusion increases, the myocardium available to salvage decreases, which raises the risk of mortality ( 1 , 2 , 3 , 4 and 5 ). (thoracickey.com)

Accumulation of toxic lipid intermediates in myocardium provokes damage of cellular membrane integrity, organelle dysfunction and apoptosis with consequent decrease in myocardial performance. (fortunejournals.com)
Studies indicate that hypertensive patients have reduced SIRT3 expression, leading to an upsurge in reactive oxygen species (ROS) levels and mitochondrial dysfunction. (mdpi.com)

Through balloon inflations and deflations synchronized with the natural heartbeat the IABP increases diastolic aortic pressure, which enhances diastolic blood flow to the coronary arteries and vital organs, as well as reduces systolic aortic pressure, which reduces afterload and oxygen consumption of the myocardium and increases cardiac output. (cochrane.org)
There were no significant differences among groups compared with placebo hearts for aortic flow, heart rate x aortic pressure product, or myocardial oxygen consumption, although performance tended to decline in the 10 mM group. (lvhn.org)

Inflammatory signaling in cardiomyocytes usually occurs as an early response to myocardial injury and entails cytosolic and mainly mitochondrial reactive oxygen species (ROS) overproduction [ 10 , 11 ]. (hindawi.com)

As the stenosis progresses, patients are unable to increase stroke volume, and as a result, they are unable to increase cardiac output so as to compensate for increases in myocardial oxygen demand. (medscape.com)
As the ventricular radius increases, however, ventricular wall tension rises, increasing both the oxygen consumption of the myocardium and the total internal work of the muscle. (brainkart.com)
The recumbent position increases venous return, stretching the myocardium and increasing wall stress, which increases oxygen demand. (rxharun.com)
If angina is not relieved, unmet myocardial oxygen demand increases further, making MI more likely. (rxharun.com)

RR reduced hyopoxia induced pancreatic injury either by increasing intracellular oxygen diffusion or by acting as an anti-oxidant. (doctorschar.com)

As the myocardium deteriorates further, the cardiac output falls, and a compensatory increase in sympathetic activity occurs to maintain organ perfusion and cardiac output. (brainkart.com)

Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
That is, when the ventricular myocardium is working, it extracts oxygen from the coronary blood and produces adenosine as a byproduct of ATP use. (wikipedia.org)
RR decreased the oxygen consumption of myocardium and oxygen consumption index, decreased coronary artery resistance, and had no effect on coronary blood flow in anaesthetised dogs. (doctorschar.com)

This concept of an adaptive process that shuts down the contractile process and decreases myocardial oxygen demand in the presence of chronically or intermittently reduced blood flow has generated considerable interest in clinical and experimental settings. (medscape.com)

Although the clinical use of thiazolidinediones in type 2 diabetes is based on effects of these agents in adipose tissue, liver, and skeletal muscle to improve glycemic control, PPAR-γ is also expressed in myocardium ( 4 - 6 ). (diabetesjournals.org)
It is believed that shortcomings in oxygen diffusion or utilization and the resulting hypoxia thereafter may play a role in underlying the clinical sequelae of patients with T2DM and HFpEF, with implications in the long-term decline of extra-cardiac tissue. (uthscsa.edu)

Cardiogenic shock is a severe condition in which a suddenly weakened heart is not able to pump enough blood to meet the body's energy needs, so not enough oxygen will reach the body's organs. (cochrane.org)
The reduced blood pressure leads to hypoperfusion and so reduced oxygen supply to vital organs and the corresponding clinical signs. (cochrane.org)

The new Ca sensitizer levosimendan enhances cardiac performance without increasing myocardial energy demand and oxygen consumption. (biomedcentral.com)

The cytoprotective effect is caused by an increase in the energy potential, activation of oxidative decarboxylation, and rationalization of oxygen consumption (increased aerobic glycolysis and blockade of fatty acid oxidation). (lekarstwo.ru)

DCM entails the damage of the myocardium through fibrosis, steatosis, apoptosis, and hypertrophy [ 3 ] and results from the switch of substrate supply to free fatty acids (FFA) that follows the reduced levels of insulin, glucose transporters, and glucose consumption [ 4 , 5 ]. (hindawi.com)

We report that CDC culture can be optimized by preconditioning the cells under hypoxia (2% oxygen), which may reflect the physiological oxygen level of the stem cell niche. (ox.ac.uk)

Additionally, myocardial hypertrophy results in increased wall tension and myocardial oxygen consumption. (medscape.com)

With each infusion, any change in myocardial oxygen tension was recorded using mass spectrometry, and oxygen consumption (MV̇O 2 ) was calculated. (johnshopkins.edu)
Injection of 20° C blood CP resulted in a mean increase in intramyocardial oxygen tension (Po 2 ) of 7 mm Hg. (johnshopkins.edu)

however, the heart's own myocardium (heart muscle) must, itself, be supplied for its own muscle function. (wikipedia.org)
Angina Decubitus/Angina pectoris (Latin for squeezing of the chest) - is chest pain, discomfort, or tightness that occurs when an area of the heart muscle is receiving decreased blood oxygen supply. (rxharun.com)
Your heart muscle needs a constant supply of oxygen. (rxharun.com)
When the heart muscle has to work harder, it needs more oxygen. (rxharun.com)
See also Acute coronary syndromes Two subtypes of troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle ( myocardium ). (wikidoc.org)

At the same time, the consumption of nitrates is reduced, after 2 weeks of treatment, exercise tolerance is increased, blood pressure drops decrease. (lekarstwo.ru)

It is usually accompanied by a modestly increased heart rate and a sometimes markedly higher BP, which increase oxygen demand. (rxharun.com)

In this prospective randomized clinical trial we studied effects of levosimendan on myocardium of polytrauma victims with a history of CAD who subsequently developed AHF as diagnosed by invasive monitoring and transthoracic echocardiography. (biomedcentral.com)

Exercise capacity and peak oxygen consumption in asymptomatic patients with chronic aortic regurgitation. (uib.no)

The consumption of alkaline reduced water produced by domestic electrolysis devices was approved in Japan in 1965 by the Ministry of Health, Labour and Welfare for the cure of gastro-intestinal disorders. (mdpi.com)

The level of troponin is measured in the bloodstream and it is used to differentiate between unstable angina (no elevation of troponin, the myocardium is not irreversibly damaged) versus either non ST elevation MI or ST elevation MI (heart attack) in patients with chest pain . (wikidoc.org)

Considering the prevalence of coronary heart disease among diabetic patients, surprisingly little is known about the effects of PPAR-γ activation in myocardium. (diabetesjournals.org)
Underlying this pathologic tandem are the effects that long-standing hyperglycemia has on the ability of the HFpEF heart to adequately deliver oxygen. (uthscsa.edu)

In response to the progressive narrowing of the aortic valve opening, the LV myocardium becomes hypertrophic in order to generate increased pressure during systole and thus force blood past the obstruction. (medscape.com)
Furthermore, the hypertrophic LV requires a higher CPP to maintain myocardial oxygen supply in the setting of increased end-diastolic pressure. (medscape.com)

Cardiosphere-derived cells (CDCs), which can be isolated from heart explants, are a promising candidate cell source for infarcted myocardium regeneration. (ox.ac.uk)

Crystalloid CP infused at either 4°C or 10°C was as effective as 20°C blood CP, despite the absence of oxygen use by hearts treated with crystalloid CP. (johnshopkins.edu)

One feature of the failing myocardium is the loss of its ability to maintain stroke volume in the face of increased arterial impedance to ejection. (brainkart.com)

Oxygen consumption is one of the most critical factors in indexing heart failure disease burden, warranting a probe into the role of SGLT2i on oxygen utility in HFpEF and T2DM. (uthscsa.edu)

Anatomy18

Organisms13

Diseases21

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Psychiatry and Psychology7

Phenomena and Processes77

Anthropology, Education, Sociology and Social Phenomena8

Technology, Industry, Agriculture13

Information Science1

Health Care18

Reducing oxygen demand of the myocardium1

Ischemia8

Contractility5

Ischemic3

Metabolism6

Reperfusion1

Dysfunction2

Aortic pressure2

Mitochondrial1

Increases4

Intracellular1

Cardiac output1

Coronary blood3

Decreases1

Tissue2

Organs2

Myocardial energy1

Aerobic1

Glucose1

Hypoxia1

Hypertrophy1

Tension2

Heart muscle5

Decrease1

Markedly1

Clinical1

Chronic1

Alkaline1

Angina1

Effects2

Pressure2

Source1

Hearts1

Ability1

Indexing heart failure1