Loading...



  • cardiac
  • While generally asymptomatic, coronary artery disease may ultimately manifest in ischemic cardiac attacks, such as angina pectoris or myocardial infarction. (thefreedictionary.com)
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • cerebral
  • Neuroglobin (Ngb), a protein related to myoglobin and hemoglobin but expressed predominantly in the brain, is induced by neuronal hypoxia and cerebral ischemia and protects against hypoxic or ischemic neuronal injury. (pnas.org)
  • In studies on rats subjected to focal cerebral ischemia induced by middle cerebral artery (MCA) occlusion ( 16 ), intraventricular administration of a Ngb antisense oligonucleotide increased infarct volume and associated neurological deficits, whereas a Ngb-expressing adeno-associated vector, delivered intracerebrally, reduced infarct size and neurological impairment. (pnas.org)
  • It is also used in cases of cerebral ischemia, ocular ischemic syndrome and other ocular disease caused by disturbed arterial circulation and may also have some effect on decreasing the severity of withdrawal symptoms caused by the cessation of chronic alcohol use. (wikipedia.org)
  • rats
  • Shiao Ding, Yang Yang, and Ju Mei, "Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats," Evidence-Based Complementary and Alternative Medicine , vol. 2016, Article ID 3803657, 9 pages, 2016. (hindawi.com)
  • occlusion
  • Hypertension-related cognitive impairment and dementia may be a consequence of a single infarct due to occlusion of a "strategic" larger vessel or multiple lacunar infarcts due to occlusive small vessel disease resulting in subcortical white matter ischemia. (wikipedia.org)
  • Thus
  • Thus ischemia decreased the rate of oxidative phosphorylation through cytochrome oxidase selectively in intact subsarcolemmal mitochondria. (nih.gov)
  • global
  • Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Myocardial Ischemia - Pipeline Review, H1 2018, provides comprehensive information on the therapeutics under development for Myocardial Ischemia (Cardiovascular), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (marketresearch.com)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Myocardial Ischemia (Cardiovascular). (marketresearch.com)
  • After 45 min of global ischemia, oxidative phosphorylation was decreased only in the subsarcolemmal population of mitochondria with all substrates tested. (nih.gov)
  • study
  • The investigators believe that their sensor might open new possibilities to study the myocardium under a variety of conditions, especially under ongoing ischemia/infarct. (medgadget.com)
  • cardiac
  • While generally asymptomatic, coronary artery disease may ultimately manifest in ischemic cardiac attacks, such as angina pectoris or myocardial infarction. (thefreedictionary.com)
  • Some inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10), NF-κB p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. (springer.com)
  • rats
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • Transplantation of bone marrow-derived MNCs and infusion of AM were performed in 40 rats immediately after hindlimb ischemia was created. (ahajournals.org)
  • ischemic
  • Treatment with meldonium therefore shifts the myocardial energy metabolism from fatty acid oxidation to the more favorable oxidation of glucose, or glycolysis, under ischemic conditions. (wikipedia.org)
  • 15kDa compared to 18, 80 and 37kDa for MYO, CK-MB and cTnT respectively, its rapid release into plasma after myocardial injury - 60 minutes after an ischemic episode, and its relative tissue specificity. (wikipedia.org)
  • heart
  • These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, especially the heart. (wikipedia.org)
  • 2009). 3-(R)-[3-(2-Methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine Bromhydrate (F 15845) Prevents ischemia-induced heart remodeling by reduction of the intracellular Na+ Overload. (wikipedia.org)
  • damage
  • Propofol sedation in total knee replacement : effects on oxidative stress and ischemia-reperfusion damage," Der Anaesthesist , vol. 62, no. 7, pp. 537-542, 2013. (hindawi.com)
  • Model
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • 2009). Myocardial protection by F 15845, a persistent sodium current blocker, in an ischemia-reperfusion model in the pig. (wikipedia.org)
  • blood
  • Due to the high contrast between the blood pool and the myocardium it is common to get what looks like a thin subendocardial area of ischaemia called the Gibbs artifact, this however, is less common with newer technology allowing higher resolution imaging. (wikipedia.org)
  • sensitive
  • Visceral structures are highly sensitive to stretch, ischemia and inflammation, but relatively insensitive to other stimuli that normally evoke pain in other structures, such as burning and cutting. (wikipedia.org)
  • electrical
  • Compared to sham treated animals, which exhibited aberrant electrical activity and larger myocardial scars, hpECM injected rat hearts showed a significant reduction in scar volume along with normal electrical activity of the surviving tissue, as determined by optical mapping. (sigmaaldrich.com)