AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Myocardial Reperfusion InjuryMyocardial ReperfusionReperfusion InjuryMyocardial InfarctionReperfusionIschemic PostconditioningCoronary CirculationMyocardiumThrombectomySuctionCreatine KinaseMyocardial IschemiaAngioplasty, Balloon, CoronaryCardioplegic SolutionsIschemic Preconditioning, MyocardialElectrocardiographyCoronary AngiographyThrombolytic TherapyCardiotonic AgentsTime FactorsCoronary VesselsVentricular Function, LeftAnterior Wall Myocardial InfarctionCoronary ThrombosisCreatine Kinase, MB FormPercutaneous Coronary InterventionPeroxidaseHeart Arrest, InducedPerfusionHeartDogsHemodynamicsDisease Models, AnimalRats, WistarRats, Sprague-DawleyMitochondrial Membrane Transport ProteinsMyocardial ContractionTreatment OutcomeMitochondria, HeartP-SelectinNecrosisRandom AllocationMicrocirculationImmunoglobulin Fab FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexMyocytes, CardiacEchocardiographyNeutrophilsIschemic PreconditioningIschemiaRabbitsSwineCoronary DiseaseStentsEndothelium, VascularPredictive Value of TestsProspective StudiesBrain IschemiaAntibodies, MonoclonalMyocardial StunningMalondialdehydeInfarction, Middle Cerebral ArteryIschemic Attack, TransientWarm IschemiaOrgan PreservationL-Lactate DehydrogenaseConstrictionDecanoic AcidsHydroxy AcidsOxidative StressTioproninProtective AgentsApoptosisMice, Inbred C57BLSuperoxide DismutaseFibrinolytic AgentsOrgan Preservation SolutionsNeuroprotective AgentsVentricular PressureFree RadicalsNitric OxideFree Radical ScavengersModels, AnimalNeutrophil InfiltrationReactive Oxygen SpeciesCytoprotectionCerebrovascular CirculationLiverAntioxidantsKidneyAdenosineAllopurinolTissue Plasminogen ActivatorEnzyme InhibitorsStreptokinaseAspartate AminotransferasesHypothermia, InducedCold IschemiaOxygenCerebral Infarction
InfarctionPrimary percutaneous coronary intIschemia and reperfusion injurySTEMIPercutaneousMyocardiumPerfusionApoptosisInfarct sizeIschaemia and reperfusionImprovement of myocardialAbstractManagement of myocardialArrhythmiasAcute reperfusion therapyOxidativeVentricularAttenuates myocardialInjury in ratsDysfunctionSpontaneous reperfusionCardioprotectionCardioprotectiveEchocardiographyInflammatoryOutcomesMechanismsPatientsInfarctionsProteinsMicePostischemicTherapyModelIntracoronaryNecrosisPretreatment
Infarction61
Primary percutaneous coronary int2
Ischemia and reperfusion injury2
STEMI3
  • Since PCI can be administered only at PCI-capable hospitals, geographic factors may affect the choice of reperfusion therapy for STEMI patients. (cdc.gov)
  • PCI access site bleeding was the reperfusion strategy for STEMI patients. (cdc.gov)
  • Conclusions Our findings showed that compared with AT alone, combined AT and intracoronary GPI treatment resulted in improved myocardial reperfusion, better cardiac function, and MACE-free survival benefits at the long-term follow-up for patients with STEMI undergoing PPCI. (jgc301.com)
Percutaneous2
Myocardium4
  • This coupled comorbidity of pathological ischemia and therapeutic reinjury of infarcted myocardium, namely, myocardial ischemia-reperfusion injury (MIRI), is particularly refractory to treatment [ 4 , 5 ]. (hindawi.com)
  • However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)
  • Reperfusion has the potential to salvage ischemic myocardium but paradoxically can cause injury, a phenomenon called as 'reperfusion injury' (IR). (aku.edu)
  • In rats and pigs, BSPC@HM NCs remarkably downregulates Sav1 in IR-injured myocardium, promotes myocardium regeneration, suppresses myocardial apoptosis, and recovers cardiac functions. (scimage.cn)
Perfusion3
  • Ventricular dysrhythmias induced by coronary occlusion alone (without reperfusion) were attenuated markedly by alpha-receptor blockade under conditions in which perfusion (measured with radiolabeled microspheres) within ischemic zones was not affected. (jci.org)
  • Imaging tests such as stress radionuclide myocardial perfusion imaging or stress echocardiography can confirm a diagnosis when a person's history, physical exam, ECG and cardiac biomarkers suggest the likelihood of a problem. (wikipedia.org)
  • Diabetic patients had impaired myocardial perfusion after PCI as measured by myocardial blush grade 0/1 (34% vs 16%, p = 0.002) and lower rates of complete 30-minute STR (45% vs 65%, p = 0.005). (elsevierpure.com)
Apoptosis6
  • The pathophysiological nature of MIRI is the short-term disturbance of myocardial energy and metabolism caused by reflow after ischemia and hypoxia in the coronary artery and the dynamic changes in apoptosis and the prosurvival signaling pathways in response to related injury factors. (hindawi.com)
  • Dexmedetomidine pretreatment can obviously relieve myocardial ischemia-reperfusion injury and cardiomyocyte apoptosis in rats probably by activating the Janus kinase 2/signal transducers and activators of transcription 3 signaling pathway. (ijpsonline.com)
  • Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
  • In conclusion, myocardial damage in MI is mainly due to ischemic necrosis and inflammatory mechanisms while apoptosis is the main mechanism of cell death in IR in addition to limited ischemic necrosis. (aku.edu)
  • H(2) saline treatment attenuated I/R-induced cardiac cell apoptosis, presenting as significant improvement of heart function parameters 24h after reperfusion, including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVEDP), +(dP/dt)max and -(dP/dt)max. (molecularhydrogenstudies.com)
  • Also, curcumin reduces cell apoptosis induced by myocardial IRI, curcumin reduces cell apoptosis induced by myocardial IRI and activates the Nrf-2/HO-1 signaling pathway during myocardial. (edu.iq)
Infarct size3
  • Oral dosing of rats with SCN-, before acute ischemia-reperfusion injury (30 min occlusion, 24 h or 4 week recovery), significantly reduced the infarct size as a percentage of the total reperfused area (54% versus 74%), and increased the salvageable area (46% versus 26%) as determined by MRI imaging. (ku.dk)
  • We show that Bbeta(15-42) robustly and reproducibly reduced infarct size in all models of ischemia-reperfusion. (bris.ac.uk)
  • End points included final myocardial blush grade, complete ST-segment resolution (STR) 30 minutes after PCI, and final infarct size as determined by technetium-99m single proton emission computed tomography measured between days 5 and 14. (elsevierpure.com)
Ischaemia and reperfusion4
  • Modelling myocardial ischaemia and reperfusion. (ox.ac.uk)
  • The model is sufficiently complete to simulate calcium-overload arrhythmias during ischaemia and reperfusion-induced arrhythmias. (ox.ac.uk)
  • In summary, we have developed a biochemically and biophysically detailed model that provides a novel approach to studying myocardial ischaemia and reperfusion. (ox.ac.uk)
  • British Library EThOS: Aspects of ischaemia and reperfusion injury in the isolated rat heart. (bl.uk)
Improvement of myocardial1
  • We performed a meta-analysis to evaluate the role of aspiration thrombectomy (AT) combined with intracoronary administration of glycoprotein IIb/IIIa inhibitors (GPI) in the improvement of myocardial reperfusion and clinical outcomes. (jgc301.com)
Abstract2
  • abstract = "Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. (bris.ac.uk)
  • Klier M, Ayhan A, Dannenberg L, Gorressen S, Polzin A, Elvers M. Role of Platelets in Processes of Myocardial Healing After Myocardial Ischemia and Reperfusion in Mice [abstract]. (isth.org)
Management of myocardial1
Arrhythmias4
  • This case shows that potentially lethal arrhythmias can arise during reperfusion and that ventricular fibrillation during reperfusion may be self-terminating. (bmj.com)
  • We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-γ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)
  • The clinician must be aware of these arrhythmias, in addition to reperfusion strategies, and must treat those that require intervention to avoid exacerbation of ischemia and subsequent hemodynamic compromise. (medscape.com)
  • However, those that result in hypotension, increase myocardial oxygen requirements, and/or predispose the patient to develop additional malignant ventricular arrhythmias should be aggressively monitored and treated. (medscape.com)
Acute reperfusion therapy2
  • citation needed] The 12 lead ECG is used to classify patients into one of three groups: those with ST segment elevation or new bundle branch block (suspicious for acute injury and a possible candidate for acute reperfusion therapy with thrombolytics or primary PCI), those with ST segment depression or T wave inversion (suspicious for ischemia), and those with a so-called non-diagnostic or normal ECG. (wikipedia.org)
  • METHODS: In 2015-17, 3,857 patients who received acute reperfusion therapy were captured in the All New Zealand Acute Coronary Syndrome Quality Improvement (ANZACS-QI) registry. (ox.ac.uk)
Oxidative6
  • In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
  • Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
  • The proposed mechanisms of the detrimental effects of free fatty acids include: (1) accumulation of toxic intermediates of fatty acid metabolism, such as long chain acyl-CoA thioesters and long chain acylcarnitines, (2) inhibition of glucose utilization, particularly glycolysis, during ischemia and/or reperfusion, and (3) uncoupling of oxidative metabolism from electron transfer. (elsevierpure.com)
  • The resulted data showed that curcumin alleviates myocardial inflammatory responses and oxidative stress during myocardial IRI. (edu.iq)
Ventricular4
  • Alpha receptor blockade with either phentolamine or prazosin significantly reduced the number of premature ventricular complexes during coronary reperfusion (321 +/- 62-14 +/- 10 premature ventricular complexes, P less than 0.001), abolished early ventricular fibrillation (from 25% in controls to 0%), and prevented the increase in idioventricular rate seen with coronary reperfusion. (jci.org)
  • A patient in whom self-terminating ventricular fibrillation was a manifestation of myocardial reperfusion. (bmj.com)
  • Reperfusion was thought to be responsible for the ventricular fibrillation because the arrhythmia started while the ST segment was returning to the baseline during an episode of silent ischaemia that was probably caused by coronary spasm. (bmj.com)
  • Acute treatment with troglitazone increases susceptibility to ventricular fibrillation during myocardial ischemia and reperfusion. (diabetesjournals.org)
Attenuates myocardial2
  • The aim of the study is to investigate the effects of curcumin in attenuates myocardial ischemia and reperfusion-induced proinflammatory response through activation of the Nrf-2/HO-1 signaling pathway. (edu.iq)
  • Inconclusion, this study demonstrates that curcumin attenuates myocardial IRI by inhibiting proinflammatory cytokines through a mechanism that may be related to activation of the Nrf-2/HO-1 signaling pathway. (edu.iq)
Injury in rats1
  • To evaluate the effects of dexmedetomidine on myocardial ischemia-reperfusion injury in rats and its anti-apoptotic role, as well as the mechanism by which it regulates Janus kinase 2/signal transducers and activators of transcription 3 signal. (ijpsonline.com)
Dysfunction1
  • Hypercholesterolemia causes endothelial and myocardial dysfunction, as well as aggravates ischemia/reperfusion (I/R)-induced myocardial injury. (nih.gov)
Spontaneous reperfusion3
  • This study sought to determine the prevalence of spontaneous reperfusion of an infarct-related artery (IRA) and associated myocardial salvage in the absence of thrombolysis or angioplasty. (elsevierpure.com)
  • however, myocardial salvage (9% ± 9% vs -2% ± 7% left ventricle, p = 0.01), and salvage index (0.62 ± 0.37 vs 0.19 ± 0.33, p = 0.01) were greater in patients with spontaneous reperfusion. (elsevierpure.com)
  • In conclusion, increased FG and previously diagnosed DM were associated with less spontaneous reperfusion and less myocardial reperfusion after PPCI, resulting in worse clinical outcomes. (wustl.edu)
Cardioprotection2
  • While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia-reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to address and have inadequately understood mechanisms. (hindawi.com)
  • Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)
Cardioprotective2
Echocardiography1
  • To study the potential of myocardial contrast echocardiography (MCE) to assess serial changes of microvascular flow during ischemia-reperfusion. (uniroma1.it)
Inflammatory7
  • Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
  • Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
  • Commercial kits were used to measure the levels of serum myocardial enzymes and inflammatory factors. (spandidos-publications.com)
  • Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)
  • The aim of this study was to study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. (molecularhydrogenstudies.com)
  • H(2) saline has an anti-inflammatory effect on rat hearts with regional myocardial I/R. (molecularhydrogenstudies.com)
  • Zhang Y, Sun Q, He B, Xiao J, Wang Z, Sun X. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. (molecularhydrogenstudies.com)
Outcomes2
  • For a study, researchers sought to determine the effect of shift work on reperfusion damage, which is a significant driver of clinical outcomes in AMI. (physiciansweekly.com)
  • 125 mg/dl or previously diagnosed diabetes mellitus (DM) and studied for electrocardiographic signs of myocardial reperfusion (both spontaneous and after PPCI) and clinical outcomes. (wustl.edu)
Mechanisms5
  • However, while myocardial reperfusion is well established, the process itself can trigger myocardial reperfusion injury by causing further cardiomyocyte death through multiple pathophysiological mechanisms [ 3 - 5 ]. (hindawi.com)
  • Conceptual diagram of the development and unknown mechanisms of myocardial ischemia-reperfusion injury. (hindawi.com)
  • The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. (spandidos-publications.com)
  • However, despite numerous studies on myocardial I/R injury, deeper insight into the underlying mechanisms of myocardial I/R injury is needed. (spandidos-publications.com)
  • However, few studies have focused on the role of miR-132 in myocardial I/R injury and the underlying mechanisms. (spandidos-publications.com)
Patients3
  • For patients outside the recommended time frame for PCI, reperfusion strategy includes pharmacoinvasive therapy with fibrinolysis, followed by either rescue PCI or routine early PCI. (cdc.gov)
  • Serum levels of free fatty acids frequently are elevated in patients with myocardial ischemia. (elsevierpure.com)
  • Results: Patients with a QRS score more than 4 had significantly worse EF, longer time to admission, fewer patients without ST-segment resolution, higher WMSI, fewer patients with myocardial blush grade (MBG) 3, more patients with MBG 1, and more patients with three-vessel disease than patients with a QRS score less than 4. (ekb.eg)
Infarctions1
  • In the US, about 1.0 million myocardial infarctions occur annually. (msdmanuals.com)
Proteins2
  • Supplementation also decreased antibody recognition of HOCl-damaged myocardial proteins. (ku.dk)
  • Cardiac markers or cardiac enzymes are proteins that leak out of injured myocardial cells through their damaged cell membranes into the bloodstream. (wikipedia.org)
Mice1
Postischemic1
  • This approach has potential application in the evaluation and management of postischemic reperfusion in humans. (uniroma1.it)
Therapy1
  • This study reports a bioinspired strategy to overcome the multiple systemic barriers against myocardial siRNA delivery, and holds profound potential for gene therapy against cardiac injuries. (scimage.cn)
Model3
  • The left anterior descending coronary artery was ligated to construct the model of myocardial ischemia-reperfusion. (ijpsonline.com)
  • The effects of acidified sodium nitrite (NaNO2) which releases nitric oxide, a substance which is thought to be indistinguishable from endothelium-derived relaxing factor, were investigated in a 6-h model of myocardial ischemia (MI) with reperfusion in open-chest, anesthetized cats. (aspetjournals.org)
  • A rat model of myocardial I/R injury was constructed by ligating the left anterior descending coronary artery, which was subsequently treated with GRh2. (spandidos-publications.com)
Intracoronary1
  • Intracoronary methoxamine (0.1 microM) in animals depleted of myocardial catecholamines by 6-hydroxydopamine pretreatment did not affect idioventricular rate before coronary occlusion. (jci.org)
Necrosis1
  • It also decreased neutrophil infiltration, 3-nitrotyrosine level, expression of intercellular adhesion molecule 1(ICAM-1) and myeloperoxidase (MPO) activity in the area at risk zones (AAR) of rat hearts subjected to regional myocardial I/R, and attenuated the increase of I/R induced proinflammatory cytokine tumor necrosis factor-α (TNF-a) and interleukin-1β (IL-1b) levels in the AAR. (molecularhydrogenstudies.com)
Pretreatment1
  • Alternative sympatholytic interventions including pretreatment with 6-hydroxydopamine to deplete myocardial norepinephrine from 8.8 +/- 1.4 to 0.83 +/- 0.2 ng/mg protein and render the heart unresponsive to tyramine (120 microgram/kg) attenuated dysrhythmias induced by both coronary occlusion and reperfusion in a fashion identical to that seen with alpha-receptor blockade. (jci.org)