AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Cardiomyopathy, DilatedCardiomyopathy, HypertrophicCardiomyopathiesPhenotypeCardiomyopathy, RestrictiveTakotsubo CardiomyopathyCardiomyopathy, Hypertrophic, FamilialChagas CardiomyopathyIdiopathic Pulmonary FibrosisMyocardiumCardiomyopathy, AlcoholicEchocardiographyArrhythmogenic Right Ventricular DysplasiaMutationElectrocardiographyDiabetic CardiomyopathiesScoliosisMyocarditisVentricular Function, LeftHeart VentriclesVentricular Dysfunction, LeftArthritis, JuvenileHeart FailureHeart SeptumPedigreePurpura, Thrombocytopenic, IdiopathicHeartMyocardial ContractionVentricular Outflow ObstructionMyocytes, CardiacDeath, Sudden, CardiacStroke VolumeTachycardia, VentricularCardiac MyosinsFibrosisMice, TransgenicTreatment OutcomeEchocardiography, DopplerDisease Models, AnimalFollow-Up StudiesMyosin Heavy ChainsPeripartum PeriodGenotypeMutation, MissenseVentricular MyosinsMolecular Sequence DataEndomyocardial FibrosisArrhythmias, CardiacSarcomeresEndocardiumPulmonary FibrosisIdiopathic Interstitial PneumoniasMyocardial IschemiaCase-Control StudiesHeart TransplantationHypertrophy, Left VentricularTime FactorsHemodynamicsLamin Type APrognosisRetrospective StudiesPlakophilinsVentricular RemodelingBiopsyCardiac Pacing, ArtificialTroponin TDNA Mutational AnalysisT-Lymphocytopenia, Idiopathic CD4-PositiveDiastoleHeart DiseasesHeterozygoteCardiomegalyDefibrillators, ImplantableSeverity of Illness IndexMice, Inbred C57BLPuerperal DisordersSarcoglycansBase SequenceCardiac CatheterizationSyndromeMice, KnockoutDeath, SuddenProspective StudiesCatheter AblationSystoleMagnetic Resonance Imaging, CineCells, CulturedGenetic Predisposition to DiseaseDesmoglein 2Predictive Value of TestsAmino Acid SequenceDisease ProgressionDystrophinAdrenergic beta-AntagonistsMagnetic Resonance ImagingPregnancy Complications, CardiovascularAllelesGlycogen Storage Disease Type IIbDesminGenetic Testing
VentricularDisarrayArrhythmiasCoronary arteryGeneDiagnosisCardiacYoung athletesMutationCohortManifestationsCardiologyGeneticOccurCalciumSyndromePatientsRiskHeartMedicineStudyGenesInfarctionPediatricFibrosisChildren with cardiomyopathyARVCRestrictiveVariantsMechanismsClinicalAmong affectedDisorderVariantSignsDiseaseCommonlyHereditaryCommonYearsHuman
Ventricular14
  • Patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) have a wide range of presentations, ranging from being asymptomatic to biventricular failure and/or sudden cardiac death. (medscape.com)
  • In more severe cases with left ventricular involvement, patients may present with biventricular congestive heart failure that may mimic dilated cardiomyopathy. (medscape.com)
  • Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. (medscape.com)
  • Circumstances of death and gross and microscopic observations in a series of 200 cases of sudden death associated with arrhythmogenic right ventricular cardiomyopathy and/or dysplasia. (medscape.com)
  • Saguner AM, Brunckhorst C, Duru F. Arrhythmogenic ventricular cardiomyopathy: a paradigm shift from right to biventricular disease. (medscape.com)
  • Prospective evaluation of relatives for familial arrhythmogenic right ventricular cardiomyopathy/dysplasia reveals a need to broaden diagnostic criteria. (medscape.com)
  • Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression. (medscape.com)
  • Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study. (medscape.com)
  • Penetrance of mutations in plakophilin-2 among families with arrhythmogenic right ventricular dysplasia/cardiomyopathy. (medscape.com)
  • Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions. (mdpi.com)
  • Objective: This study aimed to explore the early diagnosis of abnormal left ventricular systolic function of rare pathogenic titin (TTN) mutation gene carriers in familial hypertrophic cardiomyopathy (FHCM) by three-dimensional speckle tracking echocardiography (3D-STE) combined with gene detection. (bvsalud.org)
  • Hypertrophic cardiomyopathy (HCM) is defined by ventricular hypertrophy. (cdc.gov)
  • Cross-sectional studies have demonstrated that athletes may exhibit a higher burden of AF, conduction tissue disease, ventricular arrhythmias, a cardiomyopathy-like phenotype and coronary artery disease. (aerjournal.com)
  • 11 Extreme cavity dilatation, left ventricular (LV) hypertrophy, elevated coronary artery calcium (CAC) scores, acute cardiac biomarker release, myocardial fibrosis and cardiac arrhythmias have all been reported, raising concern of a reverse U-shaped relationship between the volume of exercise and cardiovascular health, with diminishing cardiovascular benefit and potential harm. (aerjournal.com)
Disarray2
  • Mice expressing the human FHC-causing mutation R403Q in the myosin heavy chain gene (MYH6) recapitulate the human phenotype, including cytoskeletal disarray and increased arrhythmia susceptibility. (bvsalud.org)
  • However, the broader phenotype includes abnormal cardiomyocyte orientation (disarray), myocardial ischaemia and electrical abnormalities, which seem to manifest before overt hypertrophy. (cdc.gov)
Arrhythmias3
  • Familial hypertrophic cardiomyopathy (FHC) patients are advised to avoid strenuous exercise due to increased risk of arrhythmias. (bvsalud.org)
  • The nature and magnitude of changes vary by sporting discipline, ethnicity, age and sex, and can overlap with mild phenotypes of conditions associated with arrhythmias and sudden cardiac death (SCD). (aerjournal.com)
  • airway seconds: patients or arrhythmias altering above-described or external Nerves of cardiomyopathy for the Motility regression population to create him in sexual health institutions browsing life, action, or acute entire mutations. (augenta.net)
Coronary artery1
Gene1
  • CRISPR gene-editing therapies for hypertrophic cardiomyopathy. (cdc.gov)
Diagnosis2
  • Because the phenotype can vary widely, even among affected siblings, symptomatology (or lack thereof) by itself is insufficient for diagnosis. (wikipedia.org)
  • Based on symptoms at time of presentation, the differential diagnosis may include other hereditary and/or nutritional causes of (dilated) cardiomyopathy and (cyclic or idiopathic) neutropenia. (wikipedia.org)
Cardiac5
  • [ 2 , 28 ] In the United States, in a series of 286 cases of sudden cardiac death in athletes, hypertrophic cardiomyopathy was the most common cause, and ARVD was reported in only 4% cases. (medscape.com)
  • Hypertrophic cardiomyopathy (HCM) is widely recognized as one of the most common inheritable cardiac disorders. (bvsalud.org)
  • Hypertrophic cardiomyopathy (HCM) is a primary cardiac disorder characterized by abnormal heart muscle thickening and caused by heterozygous pathogenic variants in genes encoding sarcomeric proteins. (cdc.gov)
  • Heart failure (see the images below) may be caused by myocardial failure but may also occur in the presence of near-normal cardiac function under conditions of high demand. (medscape.com)
  • OBJECTIVES: This study aimed to explore the impact of myocardial bridging (MB) on early development of cardiac allograft vasculopathy and long-term graft survival after heart transplantation.BACKGROUND: MB has been reported to be associated with acceleration of proximal plaque development and endothelial dysfunction in native coronary atherosclerosis. (stanford.edu)
Young athletes1
  • Corrado D, Basso C, Schiavon M, Thiene G. Screening for hypertrophic cardiomyopathy in young athletes. (medscape.com)
Mutation1
Cohort1
  • 4 A cohort of nearly 650,000 individuals participating in physical activity at half these recommended levels, at the recommended levels and at three times the recommended levels, gained 1.8, 3.4 and 4.3 years of life, respectively. (aerjournal.com)
Manifestations3
  • Cardiomyopathy is one of the more severe manifestations of Barth Syndrome. (wikipedia.org)
  • Extracardiac manifestations include palmoplantar keratosis and curly hair seen in individuals with autosomal-recessive inheritance. (medscape.com)
  • Orthopaedic manifestations of wild-type transthyretin amyloidosis are frequent and characteristic, including idiopathic bilateral carpal tunnel syndrome, idiopathic lumbar canal stenosis, atraumatic rupture of the brachial biceps tendon, and, more rarely, finger disease and rotator cuff. (mdpi.com)
Cardiology2
  • Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology. (medscape.com)
  • Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. (medscape.com)
Genetic3
  • Thus, it is vitally important to take familial histories of Barth Syndrome patients to determine genetic risk. (wikipedia.org)
  • Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank. (cdc.gov)
  • What are the contributions of rare and common genetic variation to risk of hypertrophic cardiomyopathy (HCM)? (cdc.gov)
Occur1
Calcium1
Syndrome2
  • While cardiomyopathy can be life-threatening, it is commonly resolved or substantially improved in Barth Syndrome patients after puberty. (wikipedia.org)
  • Clinical presentation in Barth Syndrome is highly variable, with the only common denominator being early-onset and pronounced cardiomyopathy. (wikipedia.org)
Patients1
  • For this reason, most patients have left myocardial thickening (hypertrophy). (wikipedia.org)
Risk1
  • 2 A meta-analysis in almost 900,000 individuals demonstrated that the physically active group had a 35% reduction in the risk of cardiovascular death and 33% reduction in all-cause mortality. (aerjournal.com)
Heart2
  • A more cautious approach is necessary in individuals with established heart disease, where the volume and intensity of exercise may need to be moderated. (aerjournal.com)
  • Insight: The ebook to re-enter one's high parts, to enhance hypertrophic of one's suitable animals, to guide the heart of congestive digitoxin. (augenta.net)
Medicine1
  • Recent advances in techniques to analyze biological "omics" information could allow for the development of a personalized medicine platform, and there is growing awareness that an integrated approach based on the concept of system biology may be an excessively naïve view of the multiple contributors and complexity of an individual's HF phenotype. (go.jp)
Study1
  • 2) to determine the era change of the in-home insulin guidelines, and 3) to measure the functions of inner mediator study on the 01-SEP-2000 of failure kidney sliding MI in the second cardiomyopathy. (augenta.net)
Genes3
  • This is particularly important in genes associated with dilated cardiomyopathy (DCM), which can cause heart failure and sudden death. (nih.gov)
  • They sequenced both genes in 52 patients with idiopathic sinus node disease, and then carried out whole exome sequencing in family members of patients with potential disease variants in either gene. (libsyn.com)
  • Using a discovery set of 1,703 candidate genes and informatic tools, we identified rare and damaging variants in 56% of affected individuals. (chop.edu)
Infarction1
  • The most common cause of acquired DCM is ischemic injury , such as that caused by prior myocardial infarction from coronary artery disease. (nih.gov)
Pediatric4
  • It may affect multiple body systems (though mainly characterized by pronounced pediatric-onset cardiomyopathy), and is potentially fatal. (wikipedia.org)
  • METHODS: A cross-section of children with HCM from 9 tertiary-care pediatric heart centers in the U.S. and Canada were enrolled in this prospective NHLBI study of cardiac biomarkers in pediatric cardiomyopathy (ClinicalTrials.gov Identifier: NCT01873976). (bvsalud.org)
  • Low levels of myocardial fibrosis are common in pediatric patients with HCM seen at referral centers. (chop.edu)
  • Longitudinal studies of myocardial fibrosis and serum biomarkers are warranted to determine their predictive value for adverse outcomes in pediatric patients with HCM. (chop.edu)
Fibrosis4
  • The structural abnormalities in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) result from the fatty infiltration and fibrosis of the RV myocardium. (medscape.com)
  • The disease manifests more frequently in active individuals, when mechanical sheer stress can cause cell membrane damage, inflammation, and fibrosis in genetically predisposed RV. (medscape.com)
  • BACKGROUND: Myocardial fibrosis, as diagnosed on cardiac magnetic resonance imaging (cMRI) by late gadolinium enhancement (LGE), is associated with adverse outcomes in adults with hypertrophic cardiomyopathy (HCM), but its prevalence and magnitude in children with HCM have not been established. (bvsalud.org)
  • Cardiac imaging and biomarkers for assessing myocardial fibrosis in children with hypertrophic cardiomyopathy. (chop.edu)
Children with cardiomyopathy3
  • In children with cardiomyopathy, the severity of heart failure (HF) varies. (bvsalud.org)
  • In this study, we evaluated the correlation of copeptin level with functional HF grading, B-type natriuretic peptide (BNP), and echocardiography variables in children with cardiomyopathy. (bvsalud.org)
  • In forty-two children with cardiomyopathy with a median (IQR) age of 13.1 years (2.5-17.2) and a median follow-up of 2.5 years (2.2-2.7), seven (16.7%) children had at least one adverse outcome. (bvsalud.org)
ARVC8
  • The goal of clinical management of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) is to reduce mortality, prevent disease progression, improve symptoms and quality of life, limit heart failure symptoms, and improve functional capacity. (medscape.com)
  • Prevention of sudden cardiac death is a major goal of treatment in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC). (medscape.com)
  • Beta-blocker therapy should be considered in all patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) irrespective of arrhythmias. (medscape.com)
  • Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) is an inherited cardiomyopathy characterized by structural and functional abnormalities in the right ventricle (RV) resulting in ventricular arrhythmias. (medscape.com)
  • Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) is an inherited disorder, as it is already present in the fetus. (medscape.com)
  • Because of the diagnostic challenge, the exact incidence and prevalence of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) remains unknown, as clinically silent cases may go unrecognized. (medscape.com)
  • Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/ARVC) is an important cause of sudden cardiac death in young adults, accounting for 11% of all cases and 22% of cases among athletes. (medscape.com)
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC) with predominant left ventricular involvement may present as DCM [ Sen-Chowdhry et al 2008 ]. (nih.gov)
Restrictive2
  • This predictive value was superior in patients with dilated and restrictive cardiomyopathies (0.97 (CI 0.927-1.036), p (bvsalud.org)
  • Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. (nih.gov)
Variants2
  • They used data from over 479,000 individuals in the UK Biobank and looked for associations between the three LDL-lowering variants and 80 different phenotypes. (libsyn.com)
  • CONCLUSIONS: Compound splicing and T659I Tnni3k variants reduce cardiac Tnni3k expression and Tnni3k levels are associated with cardiac and glucose metabolism-related phenotypes. (bvsalud.org)
Mechanisms1
  • Enrichment in this discovery candidate gene set suggests multigenic mechanisms underlie sub-phenotype-specific causes and presentations of cardiomyopathy. (chop.edu)
Clinical2
  • Clinical presentation in Barth Syndrome is highly variable, with the only common denominator being early-onset and pronounced cardiomyopathy. (wikipedia.org)
  • Peripartum or pregnancy-associated cardiomyopathy (PPCM/PACM) that occurs during or soon after pregnancy was once considered distinct from DCM, but is now recognized as a part of the clinical spectrum of DCM. (nih.gov)
Among affected1
  • The severity of the condition varies among affected individuals, even in members of the same family. (beds.ac.uk)
Disorder1
  • Family History of Eating Disorder and the Broad Autism Phenotype in Autism. (cdc.gov)
Variant1
  • At conception, each sib of an affected individual usually has a 25% chance of being affected with JLNS, a 50% chance of being a carrier of a JLNS-causing pathogenic variant and potentially at risk for LQTS, and a 25% chance of being unaffected and not a carrier. (nih.gov)
Signs2
  • C36281 Integumentary System Finding C100104 Signs or Symptoms C99147 Neonatal Research Network Terminology C34830 Cardiomyopathy Cardiomyopathy A disease of the heart muscle or myocardium proper. (nih.gov)
  • Signs and symptoms of familial dilated cardiomyopathy can include an irregular heartbeat (arrhythmia), shortness of breath (dyspnea), extreme tiredness (fatigue), fainting episodes (syncope), and swelling of the legs and feet. (beds.ac.uk)
Disease3
  • They ran a proteomic panel including 440 cytokines on 90 individuals, including individuals with active disease, inactive disease, and healthy controls. (libsyn.com)
  • Our next paper is entitled, "Familial Sinus Node Disease Caused By Gain of GIRK Channel Function," and comes from Johanna Kuß, Birgit Stallmeyer, Marie-Cécile Kienitz, and Eric Schulze-Bahr, from University Hospital Münster. (libsyn.com)
  • This means that patients with mitochondrial disease and endocrine manifestations need specialist follow up because some of the other manifestations, such as stroke-like episodes and cardiomyopathy, are potentially life threatening. (biomed.news)
Commonly1
Hereditary1
  • In individuals without hereditary hemophilia A, factor VIII inhibitors may occur spontaneously as autoantibodies, resulting in a condition known as 'acquired hemophilia. (nih.gov)
Common1
  • [ 19 ] It is estimated that it affects 1 in 1000-5000 population and is more common in individuals of Greek and Italian origin. (medscape.com)
Years1
  • It usually takes many years for symptoms of familial dilated cardiomyopathy to cause health problems. (beds.ac.uk)
Human1
  • Coexpedia is a database of context-associated co-expression networks inferred from individual series of microarray samples for human and mouse of GEO. (coexpedia.org)